{"id":"https://openalex.org/W3130040234","doi":"https://doi.org/10.1080/10826068.2021.1885046","title":"Optimization of fermentation conditions and medium compositions for the production of chrysomycin a by a marine-derived strain Streptomyces sp. 891","display_name":"Optimization of fermentation conditions and medium compositions for the production of chrysomycin a by a marine-derived strain Streptomyces sp. 891","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3130040234","doi":"https://doi.org/10.1080/10826068.2021.1885046","mag":"3130040234","pmid":"https://pubmed.ncbi.nlm.nih.gov/33600297"},"language":"en","primary_location":{"id":"doi:10.1080/10826068.2021.1885046","doi":"https://doi.org/10.1080/10826068.2021.1885046","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826068.2021.1885046","pdf_url":null,"source":{"id":"https://openalex.org/S113958752","display_name":"Preparative Biochemistry & Biotechnology","issn_l":"1082-6068","issn":["1082-6068","1532-2297"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preparative Biochemistry & Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029363554","display_name":"Hong-Jin Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Jin Ni","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026977528","display_name":"Sun-Yan Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sun-Yan Lv","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058169355","display_name":"Ying-Tao Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Tao Sheng","raw_affiliation_strings":["Collaborative Innovation Center of Green Pharmaceutics of Delta Yangzi Region, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Green Pharmaceutics of Delta Yangzi Region, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044197907","display_name":"Xiaohe Chu","orcid":"https://orcid.org/0000-0001-6398-5917","observed_orcids":["https://orcid.org/0000-0001-6398-5917"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-He Chu","raw_affiliation_strings":["Collaborative Innovation Center of Green Pharmaceutics of Delta Yangzi Region, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Green Pharmaceutics of Delta Yangzi Region, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100320798","display_name":"Huawei Zhang","orcid":"https://orcid.org/0000-0002-2430-3845","observed_orcids":["https://orcid.org/0000-0002-2430-3845"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua-Wei Zhang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044197907","https://openalex.org/A5100320798"],"corresponding_institution_ids":["https://openalex.org/I55712492"],"apc_list":null,"apc_paid":null,"fwci":4.1374,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.95537923,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"51","issue":"10","first_page":"998","last_page":"1003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fermentation-optimization","display_name":"fermentation optimization","score":0.7760000228881836},{"id":"https://openalex.org/keywords/medium-composition","display_name":"medium composition","score":0.6460000276565552},{"id":"https://openalex.org/keywords/marine-sediments","display_name":"marine sediment","score":0.5220000147819519},{"id":"https://openalex.org/keywords/antibiotic-production","display_name":"antibiotic production","score":0.6169999837875366},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.5389999747276306},{"id":"https://openalex.org/keywords/cornstarch","display_name":"corn starch","score":0.9700000286102295},{"id":"https://openalex.org/keywords/soy-flour","display_name":"soybean flour","score":0.9700000286102295},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.4359999895095825},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.4729999899864197},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C61460702","wikidata":"https://www.wikidata.org/wiki/Q207490","display_name":"Erlenmeyer flask","level":2,"score":0.9077391028404236},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.8822122812271118},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6660892367362976},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.5952696800231934},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5490992665290833},{"id":"https://openalex.org/C2779078344","wikidata":"https://www.wikidata.org/wiki/Q5171066","display_name":"Corn steep liquor","level":3,"score":0.5479325652122498},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5316696166992188},{"id":"https://openalex.org/C145890019","wikidata":"https://www.wikidata.org/wiki/Q1593672","display_name":"Yeast extract","level":3,"score":0.49995923042297363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4881385266780853},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.4449974000453949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24222716689109802},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23473557829856873},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.21992367506027222},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.181894451379776},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/10826068.2021.1885046","doi":"https://doi.org/10.1080/10826068.2021.1885046","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826068.2021.1885046","pdf_url":null,"source":{"id":"https://openalex.org/S113958752","display_name":"Preparative Biochemistry & Biotechnology","issn_l":"1082-6068","issn":["1082-6068","1532-2297"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preparative Biochemistry & Biotechnology","raw_type":"journal-article"},{"id":"pmid:33600297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33600297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preparative biochemistry & biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2193033955","display_name":null,"funder_award_id":"2018YFC0311004","funder_id":"https://openalex.org/F4320321537","funder_display_name":"State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center"},{"id":"https://openalex.org/G594447707","display_name":null,"funder_award_id":"41776139","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6703749743","display_name":null,"funder_award_id":"2018YFC0311004","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321537","display_name":"State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center","ror":"https://ror.org/001ycj259"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W175749650","https://openalex.org/W1995112729","https://openalex.org/W2012289229","https://openalex.org/W2046092521","https://openalex.org/W2067168516","https://openalex.org/W2071202191","https://openalex.org/W2143671446","https://openalex.org/W2145046451","https://openalex.org/W2329420844","https://openalex.org/W2402272478","https://openalex.org/W2412589092","https://openalex.org/W2416638291","https://openalex.org/W2531875592","https://openalex.org/W2567289819","https://openalex.org/W2751184883"],"related_works":["https://openalex.org/W4394013470","https://openalex.org/W6958776553","https://openalex.org/W2365251035","https://openalex.org/W2372454415","https://openalex.org/W2362714742","https://openalex.org/W2370509767","https://openalex.org/W2368060891","https://openalex.org/W2361968616","https://openalex.org/W2371908074","https://openalex.org/W2393092181"],"abstract_inverted_index":{"Chrysomycin":[0],"A":[1,84,106,167,196],"is":[2,179],"one":[3],"of":[4,33,39,55,82,165,194],"the":[5,80,140,163,189,200],"valuable":[6],"drug":[7],"leads":[8],"used":[9],"to":[10,23,173],"treat":[11],"infectious":[12],"diseases":[13],"such":[14],"as":[15,108],"tuberculosis":[16],"and":[17,36,70,88,132,197],"methicillin-resistant":[18],"Staphylococcus":[19],"aureus.":[20],"In":[21],"order":[22],"increase":[24],"its":[25,99],"yield,":[26],"this":[27],"work":[28],"firstly":[29],"focuses":[30],"on":[31,79],"optimization":[32,92],"fermentation":[34,56,101,110,142],"conditions":[35,57,102,170],"medium":[37,71,143],"compositions":[38],"a":[40],"wild-type":[41],"chrysomycin":[42,83,105,166,195],"A-producing":[43],"strain":[44],"Streptomyces":[45],"sp.":[46],"891":[47],"from":[48],"marine":[49],"sediment.":[50],"By":[51,137],"single-factor":[52],"experiment,":[53],"effects":[54],"(fermentation":[58],"time,":[59],"seed":[60,114],"age,":[61],"initial":[62,118],"pH,":[63],"inoculum":[64,121],"amount,":[65],"liquid":[66,124],"loading,":[67],"shaking":[68,133],"speed)":[69],"composition":[72],"(carbon":[73],"sources,":[74,76],"nitrogen":[75],"inorganic":[77],"salts)":[78],"yield":[81,164],"were":[85,107],"carefully":[86],"evaluated":[87],"analyzed":[89],"followed":[90],"by":[91,181],"at":[93],"shake-flask":[94],"level.":[95],"The":[96],"results":[97],"indicated":[98],"optimal":[100,141],"for":[103,191],"producing":[104],"follows:":[109],"time":[111],"168":[112],"h,":[113,117],"age":[115],"48":[116],"pH":[119],"6.5,":[120],"amount":[122],"5.0%,":[123],"loading":[125],"30":[126],"mL":[127],"in":[128,199],"250-mL":[129],"Erlenmeyer":[130],"flask":[131],"speed":[134],"220":[135],"rpm.":[136],"orthogonal":[138],"test,":[139],"constitutes":[144],"40":[145],"g/L":[146,149,153,158],"glucose,":[147],"20":[148],"corn":[150],"starch,":[151],"25":[152],"hot-pressed":[154],"soybean":[155],"flour,":[156],"3":[157],"CaCO3.":[159],"Verification":[160],"tests":[161],"suggested":[162],"under":[168],"optimized":[169],"reaches":[171],"up":[172],"3648":[174],"\u00b1":[175],"119":[176],"mg/L,":[177],"which":[178],"increased":[180],"almost":[182],"5":[183],"times.":[184],"These":[185],"findings":[186],"definitely":[187],"pave":[188],"way":[190],"scale-up":[192],"preparation":[193],"application":[198],"pharmaceutical":[201],"industry.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}