{"id":"https://openalex.org/W3130029068","doi":"https://doi.org/10.15406/ijfcm.2020.04.00199","title":"Lipoprotein metabolism with a focus on COVID 19 kidney patients","display_name":"Lipoprotein metabolism with a focus on COVID 19 kidney patients","publication_year":2020,"publication_date":"2020-09-07","ids":{"openalex":"https://openalex.org/W3130029068","doi":"https://doi.org/10.15406/ijfcm.2020.04.00199","mag":"3130029068"},"language":"en","primary_location":{"id":"doi:10.15406/ijfcm.2020.04.00199","doi":"https://doi.org/10.15406/ijfcm.2020.04.00199","is_oa":true,"landing_page_url":"https://doi.org/10.15406/ijfcm.2020.04.00199","pdf_url":"https://medcraveonline.com/IJFCM/IJFCM-04-00199.pdf","source":{"id":"https://openalex.org/S4210223777","display_name":"International Journal of Family & Community Medicine","issn_l":"2577-8269","issn":["2577-8269"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320093","host_organization_name":"MedCrave Group","host_organization_lineage":["https://openalex.org/P4310320093"],"host_organization_lineage_names":["MedCrave Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Family & Community Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://medcraveonline.com/IJFCM/IJFCM-04-00199.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042688329","display_name":"T\u00e2nia Leme da Rocha Martinez","orcid":"https://orcid.org/0000-0002-1027-6954","observed_orcids":["https://orcid.org/0000-0002-1027-6954"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tania Leme da Rocha Martinez","raw_affiliation_strings":["Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067613651","display_name":"Anita L R Saldanha","orcid":"https://orcid.org/0000-0002-1763-2157","observed_orcids":["https://orcid.org/0000-0002-1763-2157"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anita LR Saldanha","raw_affiliation_strings":["Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013655806","display_name":"Maril\u00e9ia Scartezini","orcid":"https://orcid.org/0009-0005-2639-9982","observed_orcids":["https://orcid.org/0009-0005-2639-9982"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marileia Scartezini","raw_affiliation_strings":["Federal University of Paran\u00e1 , Paran\u00e1 , Brazil","Federal University of Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Paran\u00e1 , Paran\u00e1 , Brazil","institution_ids":["https://openalex.org/I52418104"]},{"raw_affiliation_string":"Federal University of Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056815784","display_name":"Ana Paula Pantoja Margeotto","orcid":"https://orcid.org/0000-0003-1191-4644","observed_orcids":["https://orcid.org/0000-0003-1191-4644"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula Pantoja Margeotto","raw_affiliation_strings":["Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101247995","display_name":"Abel Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Abel Pereira","raw_affiliation_strings":["Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department , BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Nephrology Department, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043680967","display_name":"Andr\u00e9 Luis Valera Gasparoto","orcid":"https://orcid.org/0009-0000-0412-6469","observed_orcids":["https://orcid.org/0009-0000-0412-6469","https://orcid.org/0000-0002-6175-1989"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Luis Valera Gasparoto","raw_affiliation_strings":["Intensive Care Unit, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo -Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, BP -A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo -Brazil","institution_ids":["https://openalex.org/I4210114248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30106001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"5","first_page":"123","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.19869999587535858,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.9879999756813049},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.984000027179718},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.824999988079071},{"id":"https://openalex.org/keywords/hepatic-lipase","display_name":"hepatic lipase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.4560000002384186},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6800000071525574},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8519999980926514},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.6819999814033508},{"id":"https://openalex.org/keywords/chylomicrons","display_name":"chylomicrons","score":0.7770000100135803},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.753000020980835},{"id":"https://openalex.org/keywords/antithrombotic-activity","display_name":"antithrombotic activity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.7838588953018188},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.7327294945716858},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6221432685852051},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.603058934211731},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5101462006568909},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4814850091934204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47324758768081665},{"id":"https://openalex.org/C8004288","wikidata":"https://www.wikidata.org/wiki/Q2619230","display_name":"Intermediate-density lipoprotein","level":5,"score":0.43427667021751404},{"id":"https://openalex.org/C11772777","wikidata":"https://www.wikidata.org/wiki/Q423126","display_name":"Chylomicron","level":5,"score":0.42323800921440125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3561282157897949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33933788537979126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3206775188446045},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.1404285430908203}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15406/ijfcm.2020.04.00199","doi":"https://doi.org/10.15406/ijfcm.2020.04.00199","is_oa":true,"landing_page_url":"https://doi.org/10.15406/ijfcm.2020.04.00199","pdf_url":"https://medcraveonline.com/IJFCM/IJFCM-04-00199.pdf","source":{"id":"https://openalex.org/S4210223777","display_name":"International Journal of Family & Community Medicine","issn_l":"2577-8269","issn":["2577-8269"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320093","host_organization_name":"MedCrave Group","host_organization_lineage":["https://openalex.org/P4310320093"],"host_organization_lineage_names":["MedCrave Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Family & Community Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15406/ijfcm.2020.04.00199","doi":"https://doi.org/10.15406/ijfcm.2020.04.00199","is_oa":true,"landing_page_url":"https://doi.org/10.15406/ijfcm.2020.04.00199","pdf_url":"https://medcraveonline.com/IJFCM/IJFCM-04-00199.pdf","source":{"id":"https://openalex.org/S4210223777","display_name":"International Journal of Family & Community Medicine","issn_l":"2577-8269","issn":["2577-8269"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320093","host_organization_name":"MedCrave Group","host_organization_lineage":["https://openalex.org/P4310320093"],"host_organization_lineage_names":["MedCrave Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Family & Community Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3130029068.pdf","grobid_xml":"https://content.openalex.org/works/W3130029068.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W152075184","https://openalex.org/W1902852842","https://openalex.org/W1970055375","https://openalex.org/W1978979590","https://openalex.org/W1981618554","https://openalex.org/W1988681200","https://openalex.org/W1993734343","https://openalex.org/W2013433783","https://openalex.org/W2019295985","https://openalex.org/W2019757163","https://openalex.org/W2020711578","https://openalex.org/W2038607614","https://openalex.org/W2055776201","https://openalex.org/W2056631770","https://openalex.org/W2063470450","https://openalex.org/W2072933848","https://openalex.org/W2077576735","https://openalex.org/W2084744450","https://openalex.org/W2085959182","https://openalex.org/W2087757733","https://openalex.org/W2089751418","https://openalex.org/W2091015159","https://openalex.org/W2117245915","https://openalex.org/W2165240826","https://openalex.org/W2414176479","https://openalex.org/W2738994915","https://openalex.org/W3018178930","https://openalex.org/W3022331416","https://openalex.org/W3033925668","https://openalex.org/W3037756962","https://openalex.org/W6657446507"],"related_works":["https://openalex.org/W4253824388","https://openalex.org/W2065296859","https://openalex.org/W2189446142","https://openalex.org/W4248189062","https://openalex.org/W2053130274","https://openalex.org/W59596669","https://openalex.org/W24976608","https://openalex.org/W57842633","https://openalex.org/W2413042576","https://openalex.org/W2347003007"],"abstract_inverted_index":{"This":[0],"article":[1],"presents":[2],"the":[3,47,80,88,93,97,107,112,129,136,142,145,161],"role":[4,131],"of":[5,17,38,49,60,139,155],"lipids,":[6],"apoproteins":[7],"and":[8,10,15,28,35,40,46,53,101,153,179,193,197,211],"lipoproteins":[9],"their":[11,41],"metabolic":[12,42,226],"pathways.":[13],"Definition":[14],"function":[16,175],"fatty":[18],"acids,":[19],"triglycerides,":[20],"phospholipids,":[21],"cholesterol,":[22],"chylomicron,":[23],"VLDL,":[24],"LDL,":[25],"HDL,":[26],"IDL":[27],"Lp":[29],"(a)":[30],"are":[31,44,56,85,116,182,200],"described.":[32],"Both":[33],"exogenous":[34],"endogenous":[36],"cycles":[37],"lipids":[39,158],"pathways":[43],"presented":[45],"roles":[48],"both":[50],"lipoprotein":[51,188],"lipase":[52,55,189],"hepatic":[54],"included":[57],"for":[58,151],"means":[59],"better":[61],"understanding.":[62],"The":[63],"major":[64],"cardiovascular":[65],"risk":[66],"that":[67,91,111,159,181],"LDL":[68,102],"cholesterol":[69,103,124,140],"represents":[70],"is":[71,96,168,191],"outlined":[72],"as":[73,75],"well":[74],"its":[76,133,172,185,218],"atherogenic":[77],"role.":[78],"During":[79],"COVID":[81,202,231],"19":[82,203,232],"pandemic":[83],"there":[84],"alterations":[86],"in":[87,99,128,135,165,176,221,234],"lipid":[89,119],"profile":[90],"worsen":[92],"risk.":[94],"There":[95],"decrease":[98],"HDL":[100,123,147],"fractions":[104],"acutely":[105],"during":[106],"infection,":[108],"pointing":[109],"out":[110],"main":[113],"deleterious":[114],"effects":[115],"due":[117],"to":[118,122,144,170,205,216,230],"changes":[120,227],"mainly":[121],"diminution.":[125],"As":[126],"seen":[127],"HDL\u2019s":[130],"description,":[132],"protagonism":[134],"reverse":[137],"transport":[138],"from":[141],"periphery":[143],"liver,":[146],"particles":[148,196],"have":[149],"affinity":[150],"binding":[152],"neutralization":[154],"pathogen":[156],"associated":[157],"mediate":[160],"excessive":[162],"immune":[163],"reaction":[164],"sepsis.":[166],"It":[167],"important":[169],"emphasize":[171],"already":[173],"mentioned":[174],"immunomodulation,":[177],"antithrombosis":[178],"antioxidation,":[180],"diminished":[183],"with":[184],"lowering.":[186],"Also":[187],"activity":[190],"lessened":[192],"thus":[194],"VLDL":[195],"consequently":[198],"triglycerides":[199],"increased.":[201],"added":[204],"chronic":[206],"kidney":[207,223,235],"disease":[208],"present":[209],"repercussions":[210],"higher":[212],"detrimental":[213],"effects,":[214],"not":[215],"mention":[217],"causative":[219],"action":[220],"acute":[222],"disease.":[224],"Lipoprotein":[225],"can":[228],"signalize":[229],"aetiology":[233],"diseases.":[236]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}