{"id":"https://openalex.org/W3129947428","doi":"https://doi.org/10.21203/rs.3.rs-127246/v1","title":"Acteoside Repressed Microglia M1 Polarization Through Inhibited NF-\u03baB Signalling Pathway and AMPK-Mediated Mitochondria Function Recovery","display_name":"Acteoside Repressed Microglia M1 Polarization Through Inhibited NF-\u03baB Signalling Pathway and AMPK-Mediated Mitochondria Function Recovery","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3129947428","doi":"https://doi.org/10.21203/rs.3.rs-127246/v1","mag":"3129947428"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-127246/v1","doi":"https://doi.org/10.21203/rs.3.rs-127246/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-127246/v1","pdf_url":"https://www.researchsquare.com/article/rs-127246/v1.pdf?c=1631881919000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-127246/v1.pdf?c=1631881919000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ying-Qi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Qi Li","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419230","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0002-0528-5776","observed_orcids":["https://orcid.org/0000-0002-0528-5776"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038170438","display_name":"Siqi Jiang","orcid":"https://orcid.org/0000-0001-8787-1172","observed_orcids":["https://orcid.org/0000-0001-8787-1172"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Qi Jiang","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080964131","display_name":"Yuanyuan Shi","orcid":"https://orcid.org/0000-0003-1593-1767","observed_orcids":["https://orcid.org/0000-0003-1593-1767"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan-Yuan Shi","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021669690","display_name":"Xiaoli Jiang","orcid":"https://orcid.org/0000-0003-4628-3256","observed_orcids":["https://orcid.org/0000-0003-4628-3256"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Li Jiang","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103434941","display_name":"Shanshan Wu","orcid":"https://orcid.org/0000-0001-6417-8340","observed_orcids":["https://orcid.org/0000-0001-6417-8340"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan-Shan Wu","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Zhou","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764850","display_name":"Huiying Wang","orcid":"https://orcid.org/0000-0001-7219-122X","observed_orcids":["https://orcid.org/0000-0001-7219-122X"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Ying Wang","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435520","display_name":"Ping Li","orcid":"https://orcid.org/0000-0002-4926-3835","observed_orcids":["https://orcid.org/0000-0002-4926-3835","https://orcid.org/0009-0007-5051-464X"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Li","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001468927","display_name":"Fei Li","orcid":"https://orcid.org/0000-0001-8721-5183","observed_orcids":["https://orcid.org/0000-0001-8721-5183"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Li","raw_affiliation_strings":["China Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0001-8721-5183","affiliations":[{"raw_affiliation_string":"China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001468927"],"corresponding_institution_ids":["https://openalex.org/I161716053"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/verbascoside","display_name":"verbascoside","score":1.0},{"id":"https://openalex.org/keywords/cistanche-tubulosa","display_name":"Cistanche tubulosa","score":0.9660000205039978},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/microglial-polarization","display_name":"microglial polarization","score":0.921999990940094},{"id":"https://openalex.org/keywords/m1-m2-microglia","display_name":"M1/M2 microglia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.859000027179718},{"id":"https://openalex.org/keywords/ucp2","display_name":"UCP2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.925000011920929},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9629999995231628},{"id":"https://openalex.org/keywords/arginine-biosynthesis","display_name":"arginine biosynthesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pantothenate-and-coa-biosynthesis","display_name":"pantothenate and CoA biosynthesis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bv2-cells","display_name":"BV-2 cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8028537034988403},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7438977956771851},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5959866046905518},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5684950947761536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5667778253555298},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5536905527114868},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.5198462605476379},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.46777477860450745},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4662799835205078},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4273306727409363},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.33890610933303833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23247367143630981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19295719265937805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16854840517044067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15140211582183838},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14234814047813416},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1324007213115692},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.11567404866218567},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-127246/v1","doi":"https://doi.org/10.21203/rs.3.rs-127246/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-127246/v1","pdf_url":"https://www.researchsquare.com/article/rs-127246/v1.pdf?c=1631881919000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-127246/v1","doi":"https://doi.org/10.21203/rs.3.rs-127246/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-127246/v1","pdf_url":"https://www.researchsquare.com/article/rs-127246/v1.pdf?c=1631881919000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2285366244","display_name":null,"funder_award_id":"2019YFC1711000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6226943013","display_name":"\u57fa\u4e8ePPAR\u03b3\u901a\u8def\u7684\u7ba1\u82b1\u8089\u82c1\u84c9\u201c\u5f02\u75c5\u540c\u6cbb\u201d\u6548\u5e94\u7269\u8d28\u53d1\u73b0\u53ca\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"81860773","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G632651758","display_name":null,"funder_award_id":"BK20181327","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G684086630","display_name":null,"funder_award_id":"81873185","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3129947428.pdf","grobid_xml":"https://content.openalex.org/works/W3129947428.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1966558304","https://openalex.org/W2098961218","https://openalex.org/W2104901632","https://openalex.org/W2953968192","https://openalex.org/W2968357745","https://openalex.org/W2981019182","https://openalex.org/W3002225545","https://openalex.org/W3015655714","https://openalex.org/W3036986324","https://openalex.org/W3043350475","https://openalex.org/W3048984574","https://openalex.org/W3056264410","https://openalex.org/W3089352106","https://openalex.org/W3092578114","https://openalex.org/W3093381072","https://openalex.org/W3093732257","https://openalex.org/W3103572666"],"related_works":["https://openalex.org/W2990857782","https://openalex.org/W4389818102","https://openalex.org/W2551162315","https://openalex.org/W2592364944","https://openalex.org/W7160257816","https://openalex.org/W3087504526","https://openalex.org/W2954290075","https://openalex.org/W2971783404","https://openalex.org/W2794441065","https://openalex.org/W7161146820"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Alzheimer's":[2],"disease":[3],"(AD)":[4],"is":[5],"the":[6,25,46,57,81,98,144,149,212],"most":[7],"frequent":[8],"type":[9],"of":[10,49,59,117,199],"dementia.":[11],"While":[12],"acteoside":[13],"(ACT),":[14],"a":[15,203],"compound":[16],"isolated":[17],"from":[18],"Cistanche":[19],"tubulosa,":[20],"possesses":[21],"neuroprotective":[22],"properties.":[23],"However,":[24],"underlying":[26],"mechanism":[27,198],"in":[28,39,88,101,121],"regulating":[29],"microglia":[30,62,139,217],"polarization":[31,94,141],"remains":[32],"ill-defined.":[33],"Methods:":[34],"Herein,":[35],"AlCl3-induced":[36],"AD":[37],"model":[38],"zebrafish":[40],"larvae":[41],"was":[42],"applied":[43],"to":[44,55,73,97,163,182,210],"uncover":[45],"therapeutic":[47],"efficacy":[48],"ACT.":[50],"BV-2":[51,103],"cells":[52],"were":[53,71,152],"used":[54],"demonstrate":[56],"role":[58],"ACT":[60,78,109,136,159,178,200],"on":[61,207],"polarization.":[63,218],"RNA-Sequence,":[64],"HPLC-Q-TOF-MS,":[65],"western":[66],"blot":[67],"and":[68,84,95,129,170,185,201,216],"molecular":[69,190],"docking":[70],"combined":[72],"confirm":[74],"its":[75],"mechanism.":[76],"Results:":[77],"significantly":[79],"ameliorated":[80],"experimental":[82],"dyskinesia":[83],"nervous":[85],"system":[86],"disorders":[87],"zebrafish.":[89],"Subsequently,":[90],"it":[91],"suppressed":[92],"M1":[93,140],"promoted":[96],"M2":[99],"phenotype":[100],"LPS-induced":[102],"cells.":[104],"We":[105],"first":[106],"demonstrated":[107],"that":[108],"exerted":[110],"profound":[111],"transcriptomic":[112],"impact,":[113],"which":[114],"involved":[115],"regulation":[116],"key":[118],"signaling":[119],"pathways":[120,151],"inflammation,":[122],"arginine":[123],"biosynthesis,":[124,131],"as":[125,127,187],"well":[126],"pantothenate":[128],"CoA":[130],"correlating":[132],"with":[133,174],"mitochondria":[134,165],"function.":[135],"treatment":[137],"reduced":[138],"by":[142,155,189],"inhibiting":[143],"NF-\u03baB":[145,184],"signalling":[146],"pathway.":[147],"And":[148],"metabolic":[150,175],"further":[153],"confirmed":[154],"HPLC-Q-TOF-MS.":[156],"In":[157],"addition,":[158],"rectified":[160],"excessive":[161],"ROS":[162],"restore":[164],"function":[166],"through":[167],"AMPK-mediated":[168],"PGC-1\u03b1":[169],"UCP-2":[171],"upregulation,":[172],"consistent":[173],"changes.":[176],"Intriguingly,":[177],"may":[179],"directly":[180],"bind":[181],"both":[183],"AMPK\u03b1,":[186],"evidenced":[188],"docking.":[191],"Conclusions:":[192],"The":[193],"research":[194],"provided":[195],"an":[196],"infusive":[197],"illustrated":[202],"new":[204],"perspective":[205],"based":[206],"mitochondrial":[208],"dysfunction":[209],"reveal":[211],"connection":[213],"between":[214],"metabolism":[215]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}
