{"id":"https://openalex.org/W3129649883","doi":"https://doi.org/10.1002/eahr.500083","title":"The Ethics of Repurposing Previously Collected Research Biospecimens in an Infectious Disease Pandemic","display_name":"The Ethics of Repurposing Previously Collected Research Biospecimens in an Infectious Disease Pandemic","publication_year":2021,"publication_date":"2021-02-23","ids":{"openalex":"https://openalex.org/W3129649883","doi":"https://doi.org/10.1002/eahr.500083","mag":"3129649883","pmid":"https://pubmed.ncbi.nlm.nih.gov/33620774","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8014521"},"language":"en","primary_location":{"id":"doi:10.1002/eahr.500083","doi":"https://doi.org/10.1002/eahr.500083","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eahr.500083","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eahr.500083","source":{"id":"https://openalex.org/S4210204946","display_name":"Ethics & Human Research","issn_l":"2578-2355","issn":["2578-2355","2578-2363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethics & Human Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eahr.500083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088916473","display_name":"Benjamin E. Berkman","orcid":"https://orcid.org/0000-0002-9098-0799","observed_orcids":["https://orcid.org/0000-0002-9098-0799"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin E. Berkman","raw_affiliation_strings":["Faculty member at the National Institutes of Health (NIH) Department of Bioethics and the deputy director of the National Human Genome Research Institute's Bioethics Core at the NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty member at the National Institutes of Health (NIH) Department of Bioethics and the deputy director of the National Human Genome Research Institute's Bioethics Core at the NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043638463","display_name":"Anna C. Mastroianni","orcid":"https://orcid.org/0000-0002-6127-1993","observed_orcids":["https://orcid.org/0000-0002-6127-1993"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna C. Mastroianni","raw_affiliation_strings":["Professor of law at the University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of law at the University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054967844","display_name":"Leila Jamal","orcid":"https://orcid.org/0000-0003-1132-2411","observed_orcids":["https://orcid.org/0000-0003-1132-2411"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leila Jamal","raw_affiliation_strings":["Affiliated scholar in the NIH Department of Bioethics, a genomics education specialist at the National Cancer Institute, and serves as the associate director for cancer genomics in the Johns Hopkins/NIH Genetic Counseling master's degree program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated scholar in the NIH Department of Bioethics, a genomics education specialist at the National Cancer Institute, and serves as the associate director for cancer genomics in the Johns Hopkins/NIH Genetic Counseling master's degree program","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145311948","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008185826","display_name":"Coleman Solis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Coleman Solis","raw_affiliation_strings":["Fellow at the NIH Department of Bioethics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fellow at the NIH Department of Bioethics","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074502941","display_name":"Holly A. Taylor","orcid":"https://orcid.org/0000-0001-6811-9356","observed_orcids":["https://orcid.org/0000-0001-6811-9356"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly A. Taylor","raw_affiliation_strings":["Faculty member at the NIH Department of Bioethics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty member at the NIH Department of Bioethics","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035453461","display_name":"Sara Chandros Hull","orcid":"https://orcid.org/0000-0001-8742-4997","observed_orcids":["https://orcid.org/0000-0001-8742-4997"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Chandros Hull","raw_affiliation_strings":["Faculty member at the NIH Department of Bioethics and the director of the National Human Genome Research Institute's Bioethics Core at the NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty member at the NIH Department of Bioethics and the director of the National Human Genome Research Institute's Bioethics Core at the NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":null,"fwci":1.0984,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75533194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"2","first_page":"2","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/informed-consent","display_name":"informed consent","score":0.7009999752044678},{"id":"https://openalex.org/keywords/infectious-disease-pandemics","display_name":"infectious disease pandemics","score":0.734000027179718},{"id":"https://openalex.org/keywords/public-health-ethics","display_name":"public health ethics","score":0.5519999861717224},{"id":"https://openalex.org/keywords/research-ethics","display_name":"research ethics","score":0.550000011920929},{"id":"https://openalex.org/keywords/regulatory-uncertainty","display_name":"regulatory uncertainty","score":0.5889999866485596},{"id":"https://openalex.org/keywords/public-health-authorities","display_name":"public health authorities","score":0.5249999761581421},{"id":"https://openalex.org/keywords/pandemic-response","display_name":"pandemic response","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.9153374433517456},{"id":"https://openalex.org/C2780253743","wikidata":"https://www.wikidata.org/wiki/Q132382","display_name":"Presumption","level":2,"score":0.7558227181434631},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.7090923190116882},{"id":"https://openalex.org/C153997805","wikidata":"https://www.wikidata.org/wiki/Q42240","display_name":"Research ethics","level":2,"score":0.5733597278594971},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5369019508361816},{"id":"https://openalex.org/C98184364","wikidata":"https://www.wikidata.org/wiki/Q1780131","display_name":"Argument (complex analysis)","level":2,"score":0.5207754969596863},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.49825549125671387},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.44702836871147156},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.4275778532028198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34939640760421753},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.326190322637558},{"id":"https://openalex.org/C39549134","wikidata":"https://www.wikidata.org/wiki/Q133080","display_name":"Public relations","level":1,"score":0.32125431299209595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30127549171447754},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.24234744906425476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11106559634208679},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10387364029884338},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007258","descriptor_name":"Informed Consent","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D011634","descriptor_name":"Public Health","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D018070","descriptor_name":"Biological Specimen Banks","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/eahr.500083","doi":"https://doi.org/10.1002/eahr.500083","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eahr.500083","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eahr.500083","source":{"id":"https://openalex.org/S4210204946","display_name":"Ethics & Human Research","issn_l":"2578-2355","issn":["2578-2355","2578-2363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethics & Human Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8014521","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8014521","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethics Hum Res","raw_type":"Text"},{"id":"pmid:33620774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33620774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethics & human research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/eahr.500083","doi":"https://doi.org/10.1002/eahr.500083","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eahr.500083","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eahr.500083","source":{"id":"https://openalex.org/S4210204946","display_name":"Ethics & Human Research","issn_l":"2578-2355","issn":["2578-2355","2578-2363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethics & Human Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3129649883.pdf","grobid_xml":"https://content.openalex.org/works/W3129649883.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W35152798","https://openalex.org/W1577018805","https://openalex.org/W1970343076","https://openalex.org/W1981497398","https://openalex.org/W1982788878","https://openalex.org/W1995701781","https://openalex.org/W2052609495","https://openalex.org/W2058080948","https://openalex.org/W2061276405","https://openalex.org/W2080053493","https://openalex.org/W2109720070","https://openalex.org/W2143318038","https://openalex.org/W2531587846","https://openalex.org/W2736989773","https://openalex.org/W2967947435","https://openalex.org/W3010956505","https://openalex.org/W3013654036","https://openalex.org/W3014051579","https://openalex.org/W3023059761","https://openalex.org/W3109120803","https://openalex.org/W3165226756"],"related_works":["https://openalex.org/W3089877697","https://openalex.org/W3181401769","https://openalex.org/W3040737502","https://openalex.org/W3094531779","https://openalex.org/W2922803209","https://openalex.org/W3044670775","https://openalex.org/W3034048017","https://openalex.org/W6939221966","https://openalex.org/W3026600754","https://openalex.org/W4388087819"],"abstract_inverted_index":{"In":[0,43],"the":[1,88,92,125,136],"early":[2],"days":[3],"of":[4,56,128],"a":[5,52,80,113],"pandemic,":[6,71],"repurposing":[7],"biospecimens":[8,62,94],"from":[9],"established":[10],"research":[11,61],"projects":[12],"could":[13],"prove":[14],"to":[15,39,65,123,138,145],"be":[16,51],"extraordinarily":[17],"useful":[18],"in":[19,54,85,112],"achieving":[20],"substantial":[21],"and":[22,32],"timely":[23],"public":[24,129],"health":[25,130],"benefits.":[26],"Nonetheless,":[27],"there":[28,49],"are":[29,75,143],"potential":[30],"ethical":[31,126],"regulatory":[33],"uncertainties":[34],"that":[35,48,103],"may":[36,134],"impede":[37],"access":[38],"those":[40],"valuable":[41],"biospecimens.":[42],"this":[44],"article,":[45],"we":[46],"argue":[47],"should":[50],"presumption":[53],"favor":[55],"using":[57],"previously":[58],"collected":[59],"identifiable":[60,93],"without":[63],"reconsent":[64,107],"directly":[66],"address":[67,124],"an":[68],"infectious":[69],"disease":[70],"assuming":[72],"certain":[73],"conditions":[74],"met.":[76],"This":[77,119],"argument":[78],"fills":[79],"unique":[81],"yet":[82],"critical":[83],"gap":[84],"decision-making":[86],"where":[87],"specific":[89],"consent":[90],"accompanying":[91],"would":[95],"not":[96,117],"otherwise":[97],"permit":[98],"repurposing.":[99],"Further,":[100],"it":[101],"suggests":[102],"even":[104],"if":[105],"gaining":[106],"is":[108,116],"feasible,":[109],"doing":[110],"so":[111],"fast-moving":[114],"crisis":[115],"necessary.":[118],"analysis":[120],"also":[121],"attempts":[122],"concerns":[127],"authorities":[131],"who":[132],"already":[133],"have":[135],"power":[137],"use":[139],"such":[140],"specimens":[141],"but":[142],"reluctant":[144],"do":[146],"so.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}