{"id":"https://openalex.org/W3129366389","doi":"https://doi.org/10.1080/14740338.2021.1893303","title":"Safety evaluation of emicizumab prophylaxis in individuals with haemophilia A","display_name":"Safety evaluation of emicizumab prophylaxis in individuals with haemophilia A","publication_year":2021,"publication_date":"2021-02-22","ids":{"openalex":"https://openalex.org/W3129366389","doi":"https://doi.org/10.1080/14740338.2021.1893303","mag":"3129366389","pmid":"https://pubmed.ncbi.nlm.nih.gov/33612049"},"language":"en","primary_location":{"id":"doi:10.1080/14740338.2021.1893303","doi":"https://doi.org/10.1080/14740338.2021.1893303","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14740338.2021.1893303","pdf_url":null,"source":{"id":"https://openalex.org/S20709540","display_name":"Expert Opinion on Drug Safety","issn_l":"1474-0338","issn":["1474-0338","1744-764X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Safety","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032209285","display_name":"Cassandra P. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassandra P. Wang","raw_affiliation_strings":["Department of Pediatrics, University of California-San Diego School of Medicine, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California-San Diego School of Medicine, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004338432","display_name":"Guy A. Young","orcid":"https://orcid.org/0000-0001-6013-1254","observed_orcids":["https://orcid.org/0000-0001-6013-1254"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Young","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Los Angeles/University of Southern California Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6013-1254","affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Children\u2019s Hospital Los Angeles/University of Southern California Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033166660","display_name":"Courtney D. Thornburg","orcid":"https://orcid.org/0000-0002-5665-8958","observed_orcids":["https://orcid.org/0000-0002-5665-8958"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Courtney D. Thornburg","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Rady Children\u2019s Hospital San Diego/University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Rady Children\u2019s Hospital San Diego/University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033166660"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"],"apc_list":null,"apc_paid":null,"fwci":0.2641,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.24207921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"4","first_page":"387","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emicizumab","display_name":"emicizumab","score":1.0},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9440000057220459},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6639999747276306},{"id":"https://openalex.org/keywords/factor-ix","display_name":"factor IX","score":0.4169999957084656},{"id":"https://openalex.org/keywords/factor-x","display_name":"factor X","score":0.859000027179718},{"id":"https://openalex.org/keywords/factor-viii-replacement","display_name":"factor VIII replacement","score":0.5989999771118164},{"id":"https://openalex.org/keywords/inhibitors","display_name":"inhibitors","score":0.4659999907016754},{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.949999988079071},{"id":"https://openalex.org/keywords/bleeding-events","display_name":"bleeding events","score":0.621999979019165},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8863203525543213},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.6353280544281006},{"id":"https://openalex.org/C2777878052","wikidata":"https://www.wikidata.org/wiki/Q3312044","display_name":"Thrombotic microangiopathy","level":3,"score":0.6319403648376465},{"id":"https://openalex.org/C2777232031","wikidata":"https://www.wikidata.org/wiki/Q2092064","display_name":"Haemophilia A","level":3,"score":0.5857210159301758},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4491906464099884},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.38327762484550476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37180864810943604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3432185649871826},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3390054702758789},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.292677640914917},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10132968425750732}],"mesh":[{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/14740338.2021.1893303","doi":"https://doi.org/10.1080/14740338.2021.1893303","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14740338.2021.1893303","pdf_url":null,"source":{"id":"https://openalex.org/S20709540","display_name":"Expert Opinion on Drug Safety","issn_l":"1474-0338","issn":["1474-0338","1744-764X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Safety","raw_type":"journal-article"},{"id":"pmid:33612049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33612049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug safety","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W9267630","https://openalex.org/W89057783","https://openalex.org/W1908103937","https://openalex.org/W1923220400","https://openalex.org/W1967890046","https://openalex.org/W1974965024","https://openalex.org/W1976624075","https://openalex.org/W1994744646","https://openalex.org/W2047720977","https://openalex.org/W2063255503","https://openalex.org/W2064698716","https://openalex.org/W2104352313","https://openalex.org/W2106722871","https://openalex.org/W2114583616","https://openalex.org/W2117019199","https://openalex.org/W2117437723","https://openalex.org/W2138906847","https://openalex.org/W2139120000","https://openalex.org/W2169013901","https://openalex.org/W2181230016","https://openalex.org/W2290515360","https://openalex.org/W2319373517","https://openalex.org/W2400928773","https://openalex.org/W2475781394","https://openalex.org/W2494788155","https://openalex.org/W2512428256","https://openalex.org/W2519773016","https://openalex.org/W2538265957","https://openalex.org/W2557933930","https://openalex.org/W2734287351","https://openalex.org/W2760006373","https://openalex.org/W2760631163","https://openalex.org/W2766748635","https://openalex.org/W2784786061","https://openalex.org/W2805799263","https://openalex.org/W2808215790","https://openalex.org/W2810278106","https://openalex.org/W2888898681","https://openalex.org/W2896093944","https://openalex.org/W2901294079","https://openalex.org/W2919343333","https://openalex.org/W2921103796","https://openalex.org/W2936143155","https://openalex.org/W2941723412","https://openalex.org/W2945243639","https://openalex.org/W2946033191","https://openalex.org/W2955601811","https://openalex.org/W2965671309","https://openalex.org/W2980900975","https://openalex.org/W2982889022","https://openalex.org/W2983360063","https://openalex.org/W2984553535","https://openalex.org/W3004382344","https://openalex.org/W3034586995","https://openalex.org/W3044387360","https://openalex.org/W3094536207","https://openalex.org/W3096067264","https://openalex.org/W4205177117","https://openalex.org/W4232737301","https://openalex.org/W4235469187"],"related_works":["https://openalex.org/W4389508613","https://openalex.org/W2901613838","https://openalex.org/W2974663101","https://openalex.org/W3100229667","https://openalex.org/W3213074143","https://openalex.org/W4415456276","https://openalex.org/W3216863639","https://openalex.org/W2888898681","https://openalex.org/W4300817375","https://openalex.org/W4401770228"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Emicizumab":[1,54],"is":[2,28,38,55],"a":[3,134],"bispecific-humanized":[4],"monoclonal":[5],"antibody":[6],"that":[7],"improves":[8],"hemostasis":[9],"by":[10],"bridging":[11],"activated":[12,25],"factor":[13,16,34,148],"IX":[14],"and":[15,37,49,66,75,104,112,170],"X":[17],"to":[18,31,63,150,159,168,174],"substitute":[19],"for":[20,70,122],"the":[21,71,82,102,126,161],"function":[22],"of":[23,106,128,136,164],"missing":[24],"FVIII.":[26],"It":[27],"an":[29,88],"alternative":[30],"prophylaxis":[32,149],"with":[33,40,45,48,93,114,133],"VIII":[35],"replacement":[36],"associated":[39],"improved":[41],"outcomes":[42],"in":[43,57,81,108,131,166,172],"individuals":[44],"hemophilia":[46,118],"A":[47],"without":[50],"inhibitors.":[51],"AREAS":[52],"COVERED:":[53],"efficacious":[56],"reducing":[58],"bleeding":[59],"events":[60],"when":[61],"compared":[62],"on-demand":[64],"treatment":[65,177],"factor-based":[67],"prophylaxis.":[68],"Except":[69],"few":[72],"thrombotic":[73,76],"microangiopathy":[74],"event":[77],"cases":[78],"mainly":[79],"seen":[80],"HAVEN":[83],"1":[84],"trial,":[85],"emicizumab":[86,107,165],"has":[87],"overall":[89],"excellent":[90],"safety":[91,105],"profile":[92],"minimal":[94],"side":[95],"effects.":[96],"EXPERT":[97],"OPINION:":[98],"Knowledge":[99],"gaps":[100],"include":[101,124],"efficacy":[103],"younger":[109],"age":[110],"groups":[111],"those":[113],"mild":[115],"or":[116],"moderate":[117],"A.":[119],"Future":[120],"directions":[121],"research":[123],"exploring":[125],"risk":[127],"inhibitor":[129,139],"recurrence":[130],"patients":[132],"history":[135],"high":[137],"titer":[138],"who":[140,145],"have":[141],"been":[142],"successfully":[143],"tolerized,":[144],"switch":[146],"from":[147],"emicizumab,":[151],"as":[152,154],"well":[153],"conducting":[155],"'real":[156],"world":[157],"studies'":[158],"evaluate":[160],"patient's":[162],"perception":[163],"regard":[167],"ease":[169],"tolerability":[171],"order":[173],"optimize":[175],"individualized":[176],"plans.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}
