{"id":"https://openalex.org/W3129264759","doi":null,"title":"Antiviral activity of a standardized root water extract of Eurycoma longifolia (Physta\u00ae) against dengue virus.","display_name":"Antiviral activity of a standardized root water extract of Eurycoma longifolia (Physta\u00ae) against dengue virus.","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W3129264759","mag":"3129264759","pmid":"https://pubmed.ncbi.nlm.nih.gov/33597402"},"language":"en","primary_location":{"id":"pmid:33597402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33597402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical biomedicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019593827","display_name":"Annie George","orcid":"https://orcid.org/0000-0001-6806-018X","observed_orcids":["https://orcid.org/0000-0001-6806-018X"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]},{"id":"https://openalex.org/I4210093242","display_name":"Biotropics Malaysia (Malaysia)","ror":"https://ror.org/00jsvb253","country_code":"MY","type":"company","lineage":["https://openalex.org/I4210093242"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"A George","raw_affiliation_strings":["Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia","Research and Development Department, Biotropics Malaysia Berhad, Lot 21, Jalan U1/19, Section U1, Hicom-Glenmarie Industrial Park, 40150 Shah Alam, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]},{"raw_affiliation_string":"Research and Development Department, Biotropics Malaysia Berhad, Lot 21, Jalan U1/19, Section U1, Hicom-Glenmarie Industrial Park, 40150 Shah Alam, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210093242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059028537","display_name":"Keivan Zandi","orcid":"https://orcid.org/0000-0001-9728-5038","observed_orcids":["https://orcid.org/0000-0001-9728-5038","https://orcid.org/0000-0001-5107-8754"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Zandi","raw_affiliation_strings":["Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008205784","display_name":"Julia E. Biggins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118611","display_name":"Integrated BioTherapeutics (United States)","ror":"https://ror.org/027a0b050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118611"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Biggins","raw_affiliation_strings":["IBT BioServices, 21 Firstfield Rd, Suite 100, Gaithersburg, Maryland 20878, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBT BioServices, 21 Firstfield Rd, Suite 100, Gaithersburg, Maryland 20878, United States of America","institution_ids":["https://openalex.org/I4210118611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103014131","display_name":"Sasikala M. Chinnappan","orcid":"https://orcid.org/0000-0002-7917-872X","observed_orcids":["https://orcid.org/0000-0002-7917-872X"]},"institutions":[{"id":"https://openalex.org/I4210093242","display_name":"Biotropics Malaysia (Malaysia)","ror":"https://ror.org/00jsvb253","country_code":"MY","type":"company","lineage":["https://openalex.org/I4210093242"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"S Chinnappan","raw_affiliation_strings":["Research and Development Department, Biotropics Malaysia Berhad, Lot 21, Jalan U1/19, Section U1, Hicom-Glenmarie Industrial Park, 40150 Shah Alam, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, Biotropics Malaysia Berhad, Lot 21, Jalan U1/19, Section U1, Hicom-Glenmarie Industrial Park, 40150 Shah Alam, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210093242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006223029","display_name":"Pouya Hassandarvish","orcid":"https://orcid.org/0000-0003-0364-5587","observed_orcids":["https://orcid.org/0000-0003-0364-5587"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]},{"id":"https://openalex.org/I4405268432","display_name":"Tropical Infectious Diseases Research & Education Centre","ror":"https://ror.org/00yaank91","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332","https://openalex.org/I4405268432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"P Hassandarvish","raw_affiliation_strings":["Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603 Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332","https://openalex.org/I4405268432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087929260","display_name":"Ashril Yusof","orcid":"https://orcid.org/0000-0002-8117-6440","observed_orcids":["https://orcid.org/0000-0002-8117-6440"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"A Yusof","raw_affiliation_strings":["Exercise Science, Sports Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exercise Science, Sports Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2293,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64748963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"36","issue":"2","first_page":"412","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.24879999458789825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14478","display_name":"Papaya Research and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eurycoma-longifolia","display_name":"Eurycoma longifolia","score":1.0},{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/standardized-herbal-extract","display_name":"standardized herbal extract","score":0.7379999756813049},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.7459999918937683},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.8389999866485596},{"id":"https://openalex.org/keywords/denv-1","display_name":"DENV-1","score":0.7229999899864197},{"id":"https://openalex.org/keywords/dengue-virus-type-2","display_name":"dengue virus type 2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/denv-3","display_name":"DENV-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/denv-4","display_name":"DENV-4","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.9058157205581665},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8043972253799438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7005051970481873},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5711804032325745},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4986081123352051},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4593757390975952},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.451150119304657},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.4434349536895752},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.33944475650787354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16342172026634216},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.087127685546875}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:33597402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33597402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical biomedicine","raw_type":"Journal Article"},{"id":"mag:3129264759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33597402/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313596731","https://openalex.org/W4417242852","https://openalex.org/W7133443241","https://openalex.org/W4392706654","https://openalex.org/W2996666287","https://openalex.org/W1965074927","https://openalex.org/W4282824862","https://openalex.org/W121571087","https://openalex.org/W3197034570","https://openalex.org/W2917687248"],"abstract_inverted_index":{")":[0],"was":[1,61],"the":[2,35,54,59],"lowest":[3],"for":[4,21,27],"DENV-2":[5],"at":[6,29,63],"28.9.":[7],"The":[8,66],"dengue":[9,91],"virus":[10],"(DENV)":[11],"replication":[12],"measured":[13],"by":[14],"qRT-PCR":[15],"showed":[16],"a":[17,41,86],"reduction":[18],"of":[19,32,68],"100%":[20],"DENV-1,":[22],"DENV-2,":[23],"DENV-3":[24],"and":[25,49],"80%":[26],"DENV-4":[28],"day":[30,64],"2":[31],"exposure.":[33],"In":[34],"in":[36,53,78,89],"vivo":[37],"AG129":[38],"mouse":[39],"model,":[40],"lower":[42,46],"weight":[43],"reduction,":[44],"30%":[45],"viral":[47],"load":[48],"12%":[50],"higher":[51],"platelet":[52,79],"extract":[55,67],"group":[56],"compared":[57],"to":[58],"control":[60],"observed":[62],"6.":[65],"E.":[69,81],"longifolia":[70,82],"has":[71],"potential":[72],"anti-dengue":[73],"properties":[74],"with":[75],"improving":[76],"trends":[77],"counts.":[80],"supplementation":[83],"is":[84],"potentially":[85],"two-pronged":[87],"approach":[88],"treating":[90],"fever.":[92]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-03-01T00:00:00"}