{"id":"https://openalex.org/W3128048583","doi":null,"title":"Clinical applicability of renin-angiotensin system inhibitors in cancer treatment.","display_name":"Clinical applicability of renin-angiotensin system inhibitors in cancer treatment.","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3128048583","mag":"3128048583","pmid":"https://pubmed.ncbi.nlm.nih.gov/33575074","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7868760"},"language":"en","primary_location":{"id":"pmid:33575074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33575074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7868760/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Huirong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]},{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]},{"id":"https://openalex.org/I4210156460","display_name":"Shanghai Skin Disease Hospital","ror":"https://ror.org/05v6r7450","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huirong Jiang","raw_affiliation_strings":["Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China","Shanghai Skin Disease Hospital, Tongji University School of Medicine Shanghai 200443, China","Department of Pharmacy, Changhai Hospital, Second Military Medical University Shanghai 200433, China","Bengbu Medical College Bengbu 233030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210137389"]},{"raw_affiliation_string":"Shanghai Skin Disease Hospital, Tongji University School of Medicine Shanghai 200443, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210156460"]},{"raw_affiliation_string":"Department of Pharmacy, Changhai Hospital, Second Military Medical University Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Bengbu Medical College Bengbu 233030, China","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021186274","display_name":"Zongguang Tai","orcid":"https://orcid.org/0000-0001-5603-745X","observed_orcids":["https://orcid.org/0000-0001-5603-745X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]},{"id":"https://openalex.org/I4210156460","display_name":"Shanghai Skin Disease Hospital","ror":"https://ror.org/05v6r7450","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongguang Tai","raw_affiliation_strings":["Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China","Shanghai Skin Disease Hospital, Tongji University School of Medicine Shanghai 200443, China","Department of Pharmacy, Changhai Hospital, Second Military Medical University Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210137389"]},{"raw_affiliation_string":"Shanghai Skin Disease Hospital, Tongji University School of Medicine Shanghai 200443, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210156460"]},{"raw_affiliation_string":"Department of Pharmacy, Changhai Hospital, Second Military Medical University Shanghai 200433, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064470143","display_name":"Zhongjian Chen","orcid":"https://orcid.org/0000-0003-3789-7096","observed_orcids":["https://orcid.org/0000-0003-3789-7096"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210156460","display_name":"Shanghai Skin Disease Hospital","ror":"https://ror.org/05v6r7450","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongjian Chen","raw_affiliation_strings":["Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai\u00a0200443, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai\u00a0200443, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210156460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034976685","display_name":"Quangang Zhu","orcid":"https://orcid.org/0000-0002-0574-4020","observed_orcids":["https://orcid.org/0000-0002-0574-4020"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210156460","display_name":"Shanghai Skin Disease Hospital","ror":"https://ror.org/05v6r7450","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quangang Zhu","raw_affiliation_strings":["Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai\u00a0200443, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai\u00a0200443, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210156460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054981332","display_name":"Leilei Bao","orcid":"https://orcid.org/0000-0003-4403-4598","observed_orcids":["https://orcid.org/0000-0003-4403-4598"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Leilei Bao","raw_affiliation_strings":["Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210137389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6759,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.57949309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"318","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/renin","display_name":"renin","score":0.6269999742507935},{"id":"https://openalex.org/keywords/angiotensin","display_name":"angiotensin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5720000267028809},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.5210000276565552},{"id":"https://openalex.org/keywords/biological-mechanisms","display_name":"biological mechanisms","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6130723357200623},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5830637812614441},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5811928510665894},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.561271607875824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5459902882575989},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5317474603652954},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4222133457660675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35789600014686584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35480958223342896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21572324633598328},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07748812437057495},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:33575074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33575074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7868760","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7868760/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:3128048583","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/33575074","pdf_url":null,"source":{"id":"https://openalex.org/S198195518","display_name":"American Journal of Cancer Research","issn_l":"2156-6976","issn":["2156-6976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320994","host_organization_name":"e-Century Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310320994"],"host_organization_lineage_names":["e-Century Publishing Corporation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Cancer Research","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7868760","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7868760/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W108690756","https://openalex.org/W1572941886","https://openalex.org/W1603491949","https://openalex.org/W1908328565","https://openalex.org/W1972442346","https://openalex.org/W1974426796","https://openalex.org/W1977202406","https://openalex.org/W1982022497","https://openalex.org/W1983143756","https://openalex.org/W1984601093","https://openalex.org/W1998284148","https://openalex.org/W2005299533","https://openalex.org/W2006043903","https://openalex.org/W2011472261","https://openalex.org/W2022540958","https://openalex.org/W2025975691","https://openalex.org/W2036468190","https://openalex.org/W2043067852","https://openalex.org/W2050048832","https://openalex.org/W2052639292","https://openalex.org/W2055486924","https://openalex.org/W2058184342","https://openalex.org/W2064951158","https://openalex.org/W2067533776","https://openalex.org/W2075340577","https://openalex.org/W2078669402","https://openalex.org/W2080202443","https://openalex.org/W2084093508","https://openalex.org/W2084659308","https://openalex.org/W2094546405","https://openalex.org/W2098054841","https://openalex.org/W2105473163","https://openalex.org/W2108984461","https://openalex.org/W2110820285","https://openalex.org/W2131783235","https://openalex.org/W2138378181","https://openalex.org/W2139788242","https://openalex.org/W2142080475","https://openalex.org/W2149639441","https://openalex.org/W2156906256","https://openalex.org/W2157466080","https://openalex.org/W2158303916","https://openalex.org/W2171157655","https://openalex.org/W2235680094","https://openalex.org/W2298838354","https://openalex.org/W2378788102","https://openalex.org/W2408718111","https://openalex.org/W2437072683","https://openalex.org/W2468605296","https://openalex.org/W2523072775","https://openalex.org/W2530581041","https://openalex.org/W2554614845","https://openalex.org/W2589308094","https://openalex.org/W2610604306","https://openalex.org/W2764256970","https://openalex.org/W2766366755","https://openalex.org/W2769324078","https://openalex.org/W2783720008","https://openalex.org/W2788133225","https://openalex.org/W2794407877","https://openalex.org/W2805403778","https://openalex.org/W2889646458","https://openalex.org/W2892162725","https://openalex.org/W2899736836","https://openalex.org/W2946244504","https://openalex.org/W2946860574","https://openalex.org/W2971618971","https://openalex.org/W2994913654","https://openalex.org/W2995199227","https://openalex.org/W3024642578"],"related_works":["https://openalex.org/W2764256970","https://openalex.org/W2094546405","https://openalex.org/W3144804456","https://openalex.org/W2060737915","https://openalex.org/W7097900337","https://openalex.org/W4324282118","https://openalex.org/W3197330108","https://openalex.org/W4324282160","https://openalex.org/W2142080475","https://openalex.org/W4324282189"],"abstract_inverted_index":{",":[0],"an":[1],"essential":[2],"component":[3],"of":[4,15,26],"RAS,":[5],"on":[6],"tumors,":[7],"and":[8,23],"we":[9,18],"discuss":[10],"the":[11,20],"underlying":[12],"biological":[13],"mechanism":[14],"RASi.":[16],"Furthermore,":[17],"outline":[19],"research":[21],"progress":[22],"potential":[24],"use":[25],"RASi":[27,32],"in":[28,38],"tumor":[29],"treatment.":[30],"Overall,":[31],"may":[33],"be":[34],"a":[35],"promising":[36],"adjunct":[37],"cancer":[39],"therapy.":[40]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-02-15T00:00:00"}