{"id":"https://openalex.org/W3128046355","doi":"https://doi.org/10.1128/msystems.01296-20","title":"Harnessing Machine Learning To Unravel Protein Degradation in Escherichia coli","display_name":"Harnessing Machine Learning To Unravel Protein Degradation in Escherichia coli","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3128046355","doi":"https://doi.org/10.1128/msystems.01296-20","mag":"3128046355","pmid":"https://pubmed.ncbi.nlm.nih.gov/33531410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7857536"},"language":"en","primary_location":{"id":"doi:10.1128/msystems.01296-20","doi":"https://doi.org/10.1128/msystems.01296-20","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.01296-20","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/msystems.01296-20","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073537973","display_name":"Natan Nagar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Natan Nagar","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048176560","display_name":"Noa Ecker","orcid":"https://orcid.org/0000-0003-1984-2139","observed_orcids":["https://orcid.org/0000-0003-1984-2139"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Noa Ecker","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043606014","display_name":"Gil Loewenthal","orcid":"https://orcid.org/0000-0003-4029-216X","observed_orcids":["https://orcid.org/0000-0003-4029-216X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gil Loewenthal","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0000-0003-4029-216X","affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086925096","display_name":"Oren Avram","orcid":"https://orcid.org/0000-0003-1984-2139","observed_orcids":["https://orcid.org/0000-0003-1984-2139"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oren Avram","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0000-0003-1984-2139","affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023074065","display_name":"Daniella Ben\u2010Meir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniella Ben-Meir","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069431410","display_name":"Dvora Biran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dvora Biran","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090578319","display_name":"Eliora Z. Ron","orcid":"https://orcid.org/0000-0003-2615-8685","observed_orcids":["https://orcid.org/0000-0003-2615-8685"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eliora Ron","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070736617","display_name":"Tal Pupko","orcid":"https://orcid.org/0000-0001-9463-2575","observed_orcids":["https://orcid.org/0000-0001-9463-2575"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Tal Pupko","raw_affiliation_strings":["Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0000-0001-9463-2575","affiliations":[{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070736617"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":2.1435,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.88767149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.06939999759197235,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/protein-half-life","display_name":"protein half-life","score":0.9070000052452087},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9520000219345093},{"id":"https://openalex.org/keywords/proteome","display_name":"proteome","score":0.44699999690055847},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.6449999809265137},{"id":"https://openalex.org/keywords/classifiers","display_name":"machine learning classifiers","score":0.628000020980835},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antibiotic-targets","display_name":"antibiotic targets","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.805366039276123},{"id":"https://openalex.org/C111424310","wikidata":"https://www.wikidata.org/wiki/Q5282669","display_name":"Dispose pattern","level":2,"score":0.7123374938964844},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6708599328994751},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.6297690272331238},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5040244460105896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43579670786857605},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3769995868206024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37590736150741577},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33762484788894653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33366096019744873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.328744500875473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11667704582214355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1128/msystems.01296-20","doi":"https://doi.org/10.1128/msystems.01296-20","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.01296-20","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},{"id":"doi:10.1101/2020.10.04.325795","doi":"https://doi.org/10.1101/2020.10.04.325795","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.04.325795","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/05/2020.10.04.325795.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7857536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7857536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Text"},{"id":"pmid:33531410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33531410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:14a68527806f4b45bf2bac5665f46503","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/14a68527806f4b45bf2bac5665f46503","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSystems, Vol 6, Iss 1 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/msystems.01296-20","doi":"https://doi.org/10.1128/msystems.01296-20","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.01296-20","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1587755284","display_name":null,"funder_award_id":"802/16","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3128046355.pdf","grobid_xml":"https://content.openalex.org/works/W3128046355.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W19761145","https://openalex.org/W86745980","https://openalex.org/W1541504929","https://openalex.org/W1552342234","https://openalex.org/W1561745984","https://openalex.org/W1586521119","https://openalex.org/W1590559618","https://openalex.org/W1595533141","https://openalex.org/W1783180009","https://openalex.org/W1965092590","https://openalex.org/W1975304761","https://openalex.org/W1982829391","https://openalex.org/W1985217551","https://openalex.org/W1986224264","https://openalex.org/W1987573660","https://openalex.org/W1988272131","https://openalex.org/W1993888597","https://openalex.org/W1995015675","https://openalex.org/W1999879806","https://openalex.org/W2010601153","https://openalex.org/W2011332001","https://openalex.org/W2011769238","https://openalex.org/W2016319093","https://openalex.org/W2021242983","https://openalex.org/W2021259459","https://openalex.org/W2025714022","https://openalex.org/W2030813162","https://openalex.org/W2036321220","https://openalex.org/W2041350348","https://openalex.org/W2050642108","https://openalex.org/W2053622917","https://openalex.org/W2057021995","https://openalex.org/W2059318369","https://openalex.org/W2059377906","https://openalex.org/W2060211561","https://openalex.org/W2061659241","https://openalex.org/W2071008800","https://openalex.org/W2071056869","https://openalex.org/W2071603139","https://openalex.org/W2079279399","https://openalex.org/W2080752012","https://openalex.org/W2081621757","https://openalex.org/W2084082495","https://openalex.org/W2084140927","https://openalex.org/W2088750317","https://openalex.org/W2094333496","https://openalex.org/W2096173332","https://openalex.org/W2097424323","https://openalex.org/W2097912418","https://openalex.org/W2099102896","https://openalex.org/W2101234009","https://openalex.org/W2104049102","https://openalex.org/W2110227935","https://openalex.org/W2111967267","https://openalex.org/W2114850508","https://openalex.org/W2120664505","https://openalex.org/W2122558314","https://openalex.org/W2127169206","https://openalex.org/W2128551987","https://openalex.org/W2128558671","https://openalex.org/W2132644745","https://openalex.org/W2140337827","https://openalex.org/W2149653886","https://openalex.org/W2154335467","https://openalex.org/W2156465034","https://openalex.org/W2157265496","https://openalex.org/W2158217645","https://openalex.org/W2159046366","https://openalex.org/W2159457776","https://openalex.org/W2162494237","https://openalex.org/W2166080631","https://openalex.org/W2321408000","https://openalex.org/W2463195069","https://openalex.org/W2582743722","https://openalex.org/W2755517617","https://openalex.org/W2762890495","https://openalex.org/W2783734426","https://openalex.org/W2788593837","https://openalex.org/W2793216206","https://openalex.org/W2796836297","https://openalex.org/W2799948245","https://openalex.org/W2803220159","https://openalex.org/W2805030993","https://openalex.org/W2806543441","https://openalex.org/W2899760200","https://openalex.org/W2903950532","https://openalex.org/W2962756421","https://openalex.org/W4318750741","https://openalex.org/W7097482137"],"related_works":["https://openalex.org/W7133295446","https://openalex.org/W6902876509","https://openalex.org/W7030097369","https://openalex.org/W2045886533","https://openalex.org/W1552342234","https://openalex.org/W1965305472","https://openalex.org/W2900901123","https://openalex.org/W4392402190","https://openalex.org/W4411628758","https://openalex.org/W1989185632"],"abstract_inverted_index":{"Abstract":[0],"Degradation":[1],"of":[2,30,67,90,118,130,139],"intracellular":[3],"proteins":[4,36,92,114,133,155],"in":[5,51,134,161],"Gram-negative":[6],"bacteria":[7,135],"regulates":[8],"various":[9],"cellular":[10],"processes":[11],"and":[12,87,101,136,145],"serves":[13],"as":[14,152],"a":[15,42,78,108],"quality":[16],"control":[17],"mechanism":[18],"by":[19,56],"eliminating":[20],"damaged":[21],"proteins.":[22],"To":[23],"understand":[24],"what":[25],"causes":[26],"the":[27,31,62,65,116,119,137,140],"proteolytic":[28],"machinery":[29],"cell":[32],"to":[33,60,82,106,111],"degrade":[34],"some":[35],"while":[37],"sparing":[38],"others,":[39],"we":[40,97],"employed":[41],"quantitative":[43],"pulsed-SILAC":[44],"(Stable":[45],"Isotope":[46],"Labeling":[47],"with":[48],"Amino":[49],"acids":[50],"Cell":[52],"culture)":[53],"method":[54],"followed":[55],"mass":[57],"spectrometry":[58],"analysis":[59],"determine":[61],"half-lives":[63,144],"for":[64,127,148],"proteome":[66],"exponentially":[68],"growing":[69],"Escherichia":[70],"coli":[71],",":[72],"under":[73],"standard":[74],"conditions.":[75],"We":[76],"developed":[77],"likelihood-based":[79],"statistical":[80],"test":[81],"find":[83],"actively":[84],"degraded":[85,154],"proteins,":[86],"identified":[88],"dozens":[89],"novel":[91],"that":[93],"are":[94],"fast-degrading.":[95],"Finally,":[96],"used":[98],"structural,":[99],"physicochemical":[100],"protein-protein":[102],"interaction":[103],"network":[104],"descriptors":[105],"train":[107],"machine-learning":[109],"classifier":[110],"discriminate":[112],"fast-degrading":[113],"from":[115],"rest":[117],"proteome.":[120],"Our":[121],"combined":[122],"computational-experimental":[123],"approach":[124],"provides":[125],"means":[126],"proteomic-based":[128],"discovery":[129],"fast":[131],"degrading":[132],"elucidation":[138],"factors":[141],"determining":[142],"protein":[143,149],"have":[146],"implications":[147],"engineering.":[150],"Moreover,":[151],"rapidly":[153],"may":[156],"play":[157],"an":[158],"important":[159],"role":[160],"pathogenesis,":[162],"our":[163],"findings":[164],"could":[165],"identify":[166],"new":[167],"potential":[168],"antibacterial":[169],"drug":[170],"targets.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-02-15T00:00:00"}
