{"id":"https://openalex.org/W3127837814","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00662","title":"In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders","display_name":"In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3127837814","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00662","mag":"3127837814","pmid":"https://pubmed.ncbi.nlm.nih.gov/33523652"},"language":"en","primary_location":{"id":"doi:10.1021/acs.bioconjchem.0c00662","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.0c00662","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015990328","display_name":"Julien C. Vantourout","orcid":"https://orcid.org/0000-0002-0602-069X","observed_orcids":["https://orcid.org/0000-0002-0602-069X"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]},{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julien C. Vantourout","raw_affiliation_strings":["Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G11XL, U.K","GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G11XL, U.K","institution_ids":["https://openalex.org/I181647926"]},{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047259251","display_name":"Andrew M. Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. Mason","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033571314","display_name":"Josephine Yuen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josephine Yuen","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056311566","display_name":"Graham L. Simpson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham L. Simpson","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025624562","display_name":"Ghotas Evindar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghotas Evindar","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019124089","display_name":"Letian Kuai","orcid":"https://orcid.org/0000-0001-6215-5663","observed_orcids":["https://orcid.org/0000-0001-6215-5663"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Letian Kuai","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079358911","display_name":"Michael J. Hobbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Hobbs","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074663347","display_name":"Emma V. Edgar","orcid":"https://orcid.org/0000-0003-4202-8215","observed_orcids":["https://orcid.org/0000-0003-4202-8215"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma Edgar","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005290782","display_name":"Saul Needle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saul Needle","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006543775","display_name":"Xiaopeng Bai","orcid":"https://orcid.org/0000-0002-4016-5876","observed_orcids":["https://orcid.org/0000-0002-4016-5876"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaopeng Bai","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102980444","display_name":"Steve Wilson","orcid":"https://orcid.org/0000-0001-8768-7906","observed_orcids":["https://orcid.org/0000-0001-8768-7906"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steve Wilson","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002258281","display_name":"Paul Scott\u2010Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Scott-Stevens","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053007311","display_name":"William Traylen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Traylen","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kim Lambert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kim Lambert","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neil Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil Young","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063861810","display_name":"Shenaz B. Bunally","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shenaz Bunally","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108716684","display_name":"Scott G. Summerfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Scott G. Summerfield","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Snell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Snell","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033978614","display_name":"Rakesh Lad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rakesh Lad","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102809204","display_name":"Eric Shi","orcid":"https://orcid.org/0000-0002-9050-8347","observed_orcids":["https://orcid.org/0000-0002-9050-8347"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Shi","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steven Skinner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Skinner","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037531375","display_name":"Lisa M. Shewchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Shewchuk","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006881457","display_name":"Allan J. B. Watson","orcid":"https://orcid.org/0000-0002-1582-4286","observed_orcids":["https://orcid.org/0000-0002-1582-4286"]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Allan J.B. Watson","raw_affiliation_strings":["University of St Andrews, North Haugh, St Andrews KY16 9ST, U.K"],"raw_orcid":"https://orcid.org/0000-0002-1582-4286","affiliations":[{"raw_affiliation_string":"University of St Andrews, North Haugh, St Andrews KY16 9ST, U.K","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059463978","display_name":"Chun\u2010wa Chung","orcid":"https://orcid.org/0000-0002-2480-3110","observed_orcids":["https://orcid.org/0000-0002-2480-3110"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chun-wa Chung","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":"https://orcid.org/0000-0002-2480-3110","affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111594781","display_name":"Sandeep Pal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sandeep Pal","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108778306","display_name":"Dennis A. Holt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis A. Holt","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556409","display_name":"Lara S. Kallander","orcid":"https://orcid.org/0000-0002-6369-7031","observed_orcids":["https://orcid.org/0000-0002-6369-7031"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara S. Kallander","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049284467","display_name":"Joanne Prendergast","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Prendergast","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052342229","display_name":"Katrina Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina Rivera","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007792801","display_name":"David G. Washburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Washburn","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058528099","display_name":"Mark R. Harpel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark R. Harpel","raw_affiliation_strings":["GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005867783","display_name":"Christopher C. Arico-Muendel","orcid":"https://orcid.org/0000-0001-6079-2159","observed_orcids":["https://orcid.org/0000-0001-6079-2159"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Arico-Muendel","raw_affiliation_strings":["GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline US, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053406715","display_name":"Albert Isidro\u2010Llobet","orcid":"https://orcid.org/0000-0001-9108-5916","observed_orcids":["https://orcid.org/0000-0001-9108-5916"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Albert Isidro-Llobet","raw_affiliation_strings":["GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K"],"raw_orcid":"https://orcid.org/0000-0001-9108-5916","affiliations":[{"raw_affiliation_string":"GlaxoSmithKline U.K., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005867783","https://openalex.org/A5053406715","https://openalex.org/A5058528099"],"corresponding_institution_ids":["https://openalex.org/I188950975","https://openalex.org/I4210114143"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4905,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.53142644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"32","issue":"2","first_page":"279","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.6600000262260437},{"id":"https://openalex.org/keywords/drug-half-life-extension","display_name":"drug half-life extension","score":0.8579999804496765},{"id":"https://openalex.org/keywords/protein-conjugation","display_name":"protein conjugation","score":0.44600000977516174},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.5740000009536743},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.5809999704360962},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7897815704345703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7499251365661621},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7105898261070251},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.7049424648284912},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5938657522201538},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5772496461868286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5416615009307861},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.43837448954582214},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42400458455085754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33067357540130615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11613839864730835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08423018455505371},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0572587251663208},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055395","descriptor_name":"Bone Morphogenetic Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.bioconjchem.0c00662","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.0c00662","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:33523652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33523652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320310234","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1535035454","https://openalex.org/W1968367652","https://openalex.org/W1968753037","https://openalex.org/W1989284914","https://openalex.org/W1999025300","https://openalex.org/W2001051952","https://openalex.org/W2002815709","https://openalex.org/W2006939445","https://openalex.org/W2007981437","https://openalex.org/W2009294887","https://openalex.org/W2031166423","https://openalex.org/W2035776098","https://openalex.org/W2042625602","https://openalex.org/W2052810066","https://openalex.org/W2080622379","https://openalex.org/W2105289513","https://openalex.org/W2106135796","https://openalex.org/W2112979860","https://openalex.org/W2113033841","https://openalex.org/W2129596910","https://openalex.org/W2135856985","https://openalex.org/W2137216204","https://openalex.org/W2138788677","https://openalex.org/W2155441883","https://openalex.org/W2161551526","https://openalex.org/W2161892929","https://openalex.org/W2168229944","https://openalex.org/W2168848424","https://openalex.org/W2215818478","https://openalex.org/W2302120143","https://openalex.org/W2402208796","https://openalex.org/W2507267809","https://openalex.org/W2536988219","https://openalex.org/W2675921257","https://openalex.org/W2734380512","https://openalex.org/W2735588562","https://openalex.org/W2743058732","https://openalex.org/W2766836053","https://openalex.org/W2810554715","https://openalex.org/W2887126066","https://openalex.org/W2906697612","https://openalex.org/W2947141589","https://openalex.org/W2948205513","https://openalex.org/W3005945993"],"related_works":["https://openalex.org/W2982115804","https://openalex.org/W2808652114","https://openalex.org/W2948205513","https://openalex.org/W4396852044","https://openalex.org/W4405558855","https://openalex.org/W4405429526","https://openalex.org/W3020395804","https://openalex.org/W3091450474","https://openalex.org/W4285104108","https://openalex.org/W2126818728"],"abstract_inverted_index":{"Reducing":[0],"the":[1,9,28,34,52,64,105,109,136,141],"required":[2],"frequence":[3],"of":[4,11,27,38,54,70,81,83,102,115,122,131,167],"drug":[5],"dosing":[6],"can":[7],"improve":[8],"adherence":[10],"patients":[12],"to":[13,32,42,62,147,157,163,184],"chronic":[14],"treatments.":[15],"Hence,":[16],"drugs":[17,39,172],"with":[18,86,118,150,173],"longer":[19],"in":[20,35,65,74,108,135],"vivo":[21,36,66],"half-lives":[22,114],"are":[23],"highly":[24],"desirable.":[25],"One":[26],"most":[29],"promising":[30],"approaches":[31],"extend":[33,63],"half-life":[37,67,100,130,142,186],"is":[40,153],"conjugation":[41,156],"human":[43],"serum":[44],"albumin":[45],"(HSA).":[46],"In":[47,91,176],"this":[48,177],"work,":[49],"we":[50],"describe":[51],"use":[53],"AlbuBinder":[55,84,158],"1,":[56],"a":[57,99,129,164,181],"small-molecule":[58,71],"noncovalent":[59],"HSA":[60,110],"binder,":[61],"and":[68,98],"pharmacology":[69],"BMP1/TLL":[72,87],"inhibitors":[73,88],"humanized":[75],"mice":[76],"(HSA":[77],"KI/KI).":[78],"A":[79],"series":[80],"conjugates":[82],"1":[85,159],"were":[89],"prepared.":[90],"particular,":[92],"conjugate":[93,127],"c":[94],"showed":[95,128],"good":[96],"solubility":[97],"extension":[101,143,187],">20-fold":[103],"versus":[104],"parent":[106],"molecule":[107,169],"KI/KI":[111],"mice,":[112,138],"reaching":[113],">48":[116],"h":[117,134],"maintained":[119],"maximal":[120],"inhibition":[121],"plasma":[123],"BMP1/TLL.":[124],"The":[125],"same":[126],"only":[132],"3":[133],"wild-type":[137],"suggesting":[139],"that":[140,155],"was":[144],"principally":[145],"due":[146],"specific":[148],"interactions":[149],"HSA.":[151],"It":[152],"envisioned":[154],"should":[160],"be":[161],"applicable":[162],"wide":[165],"range":[166],"small":[168],"or":[170],"peptide":[171],"short":[174],"half-lives.":[175],"context,":[178],"AlbuBinders":[179],"represent":[180],"viable":[182],"alternative":[183],"existing":[185],"technologies.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-02-15T00:00:00"}