{"id":"https://openalex.org/W3127655574","doi":"https://doi.org/10.28982/josam.842133","title":"Effects of Vitamin D on doxorubucin-induced lung injury and TRPM2 immunoreactivity in rats","display_name":"Effects of Vitamin D on doxorubucin-induced lung injury and TRPM2 immunoreactivity in rats","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3127655574","doi":"https://doi.org/10.28982/josam.842133","mag":"3127655574"},"language":"en","primary_location":{"id":"doi:10.28982/josam.842133","doi":"https://doi.org/10.28982/josam.842133","is_oa":true,"landing_page_url":"https://doi.org/10.28982/josam.842133","pdf_url":null,"source":{"id":"https://openalex.org/S4210219070","display_name":"Journal of Surgery and Medicine","issn_l":"2602-2079","issn":["2602-2079"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318303","host_organization_name":"Journal of Surgery and Medicine","host_organization_lineage":["https://openalex.org/P4310318303"],"host_organization_lineage_names":["Journal of Surgery and Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.28982/josam.842133","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016642922","display_name":"Alper Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0002-8975-1008","observed_orcids":["https://orcid.org/0000-0002-8975-1008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alper YAL\u00c7IN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021630439","display_name":"Ahmet T\u00fcrk","orcid":"https://orcid.org/0000-0003-0903-3522","observed_orcids":["https://orcid.org/0000-0003-0903-3522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmet T\u00dcRK","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037501626","display_name":"Hasan Ayd\u0131n","orcid":"https://orcid.org/0000-0002-1955-6178","observed_orcids":["https://orcid.org/0000-0002-1955-6178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hasan AYDIN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077720795","display_name":"Erkan Y\u0131lmaz","orcid":"https://orcid.org/0000-0001-7355-3878","observed_orcids":["https://orcid.org/0000-0001-7355-3878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erkan YILMAZ","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034551651","display_name":"Ibrahi\u0307m Seyfetti\u0307n \u00c7eli\u0307k","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0130\u0307brahim Seyfettin \u00c7EL\u0130K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007520178","display_name":"Fatih \u00dc\u00e7karde\u015f","orcid":"https://orcid.org/0000-0003-0677-7606","observed_orcids":["https://orcid.org/0000-0003-0677-7606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatih \u00dc\u00c7KARDE\u015e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3479,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55886896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"4","issue":"12","first_page":"1236","last_page":"1239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.18860000371932983,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.16279999911785126,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trpm2","display_name":"TRPM2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.7200000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.824999988079071},{"id":"https://openalex.org/keywords/lung-histopathology","display_name":"lung histopathology","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5401363372802734},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5380368828773499},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5336872339248657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5159069299697876},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44755107164382935},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.43906939029693604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43406182527542114},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.43314090371131897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4244765341281891},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.42245370149612427},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.41663578152656555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40850555896759033},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3262917697429657},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2879334092140198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1289922297000885}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.28982/josam.842133","doi":"https://doi.org/10.28982/josam.842133","is_oa":true,"landing_page_url":"https://doi.org/10.28982/josam.842133","pdf_url":null,"source":{"id":"https://openalex.org/S4210219070","display_name":"Journal of Surgery and Medicine","issn_l":"2602-2079","issn":["2602-2079"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318303","host_organization_name":"Journal of Surgery and Medicine","host_organization_lineage":["https://openalex.org/P4310318303"],"host_organization_lineage_names":["Journal of Surgery and Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Medicine","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/842133","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/josam/article/842133","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3971ca2aabb347808b50d1aff6f94132","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3971ca2aabb347808b50d1aff6f94132","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Surgery and Medicine, Vol 4, Iss 12, Pp 1236-1239 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.28982/josam.842133","doi":"https://doi.org/10.28982/josam.842133","is_oa":true,"landing_page_url":"https://doi.org/10.28982/josam.842133","pdf_url":null,"source":{"id":"https://openalex.org/S4210219070","display_name":"Journal of Surgery and Medicine","issn_l":"2602-2079","issn":["2602-2079"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318303","host_organization_name":"Journal of Surgery and Medicine","host_organization_lineage":["https://openalex.org/P4310318303"],"host_organization_lineage_names":["Journal of Surgery and Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgery and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1490290899","https://openalex.org/W1791262955","https://openalex.org/W1975182539","https://openalex.org/W2010183849","https://openalex.org/W2024000108","https://openalex.org/W2028764252","https://openalex.org/W2052407224","https://openalex.org/W2054257339","https://openalex.org/W2067775666","https://openalex.org/W2070216734","https://openalex.org/W2072354493","https://openalex.org/W2086080661","https://openalex.org/W2086536837","https://openalex.org/W2095530348","https://openalex.org/W2097467471","https://openalex.org/W2098832705","https://openalex.org/W2150266161","https://openalex.org/W2166786094","https://openalex.org/W2167318614","https://openalex.org/W2282432598","https://openalex.org/W2317055602","https://openalex.org/W2519260758","https://openalex.org/W2609071178","https://openalex.org/W2912401318","https://openalex.org/W2915050750","https://openalex.org/W2944128273","https://openalex.org/W2969605497","https://openalex.org/W3024721043","https://openalex.org/W3081622926","https://openalex.org/W3106644222"],"related_works":["https://openalex.org/W7143292379","https://openalex.org/W4401817282","https://openalex.org/W7128611799","https://openalex.org/W4366351857","https://openalex.org/W4386467136","https://openalex.org/W2157599135","https://openalex.org/W4322705173","https://openalex.org/W3179649741","https://openalex.org/W3168607240","https://openalex.org/W4394774536"],"abstract_inverted_index":{"Aim:":[0],"Although":[1],"doxorubicin":[2],"(DOX)":[3],"is":[4],"a":[5,43,90,115,225,243],"commonly":[6],"used":[7],"chemotherapeutic":[8],"agent,":[9],"it":[10],"causes":[11],"significant":[12],"toxic":[13],"side":[14],"effects":[15,25],"on":[16,30,99,123,228],"many":[17],"organs.":[18],"This":[19],"study":[20],"aims":[21],"to":[22,149,182,207],"investigate":[23],"the":[24,127,130,150,178,183,208,218,246],"of":[26,36,52,62,93,118,129,248],"vitamin":[27],"D":[28],"(VD)":[29],"DOX-induced":[31,249],"lung":[32,132,151,229,250],"injury":[33],"and":[34,114,133,144,159,186,188,195],"expression":[35,197],"transient":[37],"receptor":[38],"potential":[39],"melastatin":[40],"2":[41],"(TRPM2),":[42],"Ca2":[44],"+":[45],"permeable":[46],"cation":[47],"channel.":[48],"Methods:":[49],"A":[50],"total":[51,155,160],"24":[53],"Wistar":[54],"albino":[55],"rats":[56,138],"were":[57,139,147,164],"separated":[58],"into":[59],"four":[60],"groups":[61],"six":[63],"rats,":[64],"as":[65],"follows:":[66],"The":[67,73],"control":[68,184],"group":[69,75,88,103,180,210,220],"received":[70,76,89],"no":[71],"medications.":[72],"VD":[74,79,108,211,223],"200":[77,106],"IU/kg":[78,107],"via":[80,109],"an":[81,110],"oral":[82],"dropper":[83],"(o.d.)":[84],"for":[85,112],"14-days.":[86],"DOX":[87,96,121,179,209],"single":[91,116],"dose":[92,117],"10":[94,119],"mg/kg":[95,120],"intraperitoneally":[97],"(i.p.)":[98],"day":[100,124],"8.":[101,125],"DOX+VD":[102,219],"was":[104,175],"administered":[105],"o.d.":[111],"14-days,":[113],"i.p.":[122],"At":[126],"end":[128],"experiment,":[131],"serum":[134],"samples":[135],"from":[136],"all":[137],"collected.":[140],"Masson\u2019s":[141],"trichrome":[142],"staining":[143],"streptavidin-biotin-peroxidase":[145],"complex":[146],"applied":[148],"tissue":[152],"sections.":[153],"Serum":[154],"antioxidant":[156],"status":[157,162],"(TAS)":[158],"oxidant":[161],"(TOS)":[163],"assessed":[165],"by":[166,232],"enzyme-linked":[167],"immunosorbent":[168],"assay":[169],"(ELISA)":[170],"method.":[171],"Results:":[172],"Histopathological":[173],"damage":[174,230],"observed":[176],"in":[177,217,245],"compared":[181,206],"group,":[185],"biochemical":[187],"immunohistochemical":[189],"evaluation":[190],"revealed":[191],"that":[192,238],"TOS":[193],"level":[194,201],"TRPM2":[196,239],"increased":[198],"while":[199],"TAS":[200],"decreased":[202],"significantly":[203,213],"(P<0.001).":[204,221],"Additionally,":[205],"administration":[212],"reversed":[214],"these":[215],"values":[216],"Conclusion:":[222],"showed":[224],"protective":[226],"effect":[227],"induced":[231],"DOX.":[233],"Our":[234],"data":[235],"also":[236],"suggest":[237],"channel":[240],"may":[241],"have":[242],"role":[244],"pathophysiology":[247],"damage.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-15T00:00:00"}