{"id":"https://openalex.org/W3127430331","doi":"https://doi.org/10.3389/fnut.2020.606124","title":"Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial","display_name":"Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3127430331","doi":"https://doi.org/10.3389/fnut.2020.606124","mag":"3127430331","pmid":"https://pubmed.ncbi.nlm.nih.gov/33598475","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7882499"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2020.606124","doi":"https://doi.org/10.3389/fnut.2020.606124","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2020.606124","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2020.606124/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnut.2020.606124/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034875109","display_name":"Philippa A. Jackson","orcid":"https://orcid.org/0000-0002-9492-134X","observed_orcids":["https://orcid.org/0000-0002-9492-134X"]},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Philippa A. Jackson","raw_affiliation_strings":["Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","University of Northumbria at Newcastle [United Kingdom]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I32394136"]},{"raw_affiliation_string":"University of Northumbria at Newcastle [United Kingdom]","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080326810","display_name":"Joanne S. Forster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanne Forster","raw_affiliation_strings":["Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","University of Northumbria at Newcastle [United Kingdom]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I32394136"]},{"raw_affiliation_string":"University of Northumbria at Newcastle [United Kingdom]","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009434927","display_name":"Julie Khan","orcid":"https://orcid.org/0000-0003-1802-9832","observed_orcids":["https://orcid.org/0000-0003-1802-9832"]},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie Khan","raw_affiliation_strings":["Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","University of Northumbria at Newcastle [United Kingdom]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I32394136"]},{"raw_affiliation_string":"University of Northumbria at Newcastle [United Kingdom]","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002244549","display_name":"Camille Pouchieu","orcid":"https://orcid.org/0000-0002-7373-4545","observed_orcids":["https://orcid.org/0000-0002-7373-4545"]},"institutions":[{"id":"https://openalex.org/I4405267950","display_name":"Activ'Inside (France)","ror":"https://ror.org/054gdez93","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Camille Pouchieu","raw_affiliation_strings":["Activ'Inside, Beychac et Caillau, France","Activ'Inside"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Activ'Inside, Beychac et Caillau, France","institution_ids":["https://openalex.org/I4405267950"]},{"raw_affiliation_string":"Activ'Inside","institution_ids":["https://openalex.org/I4405267950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071779666","display_name":"S\u00e9verine Dubreuil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267950","display_name":"Activ'Inside (France)","ror":"https://ror.org/054gdez93","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9verine Dubreuil","raw_affiliation_strings":["Activ'Inside, Beychac et Caillau, France","Activ'Inside"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Activ'Inside, Beychac et Caillau, France","institution_ids":["https://openalex.org/I4405267950"]},{"raw_affiliation_string":"Activ'Inside","institution_ids":["https://openalex.org/I4405267950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032772518","display_name":"David Gaudout","orcid":"https://orcid.org/0000-0002-3255-8274","observed_orcids":["https://orcid.org/0000-0002-3255-8274"]},"institutions":[{"id":"https://openalex.org/I4405267950","display_name":"Activ'Inside (France)","ror":"https://ror.org/054gdez93","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Gaudout","raw_affiliation_strings":["Activ'Inside, Beychac et Caillau, France","Activ'Inside"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Activ'Inside, Beychac et Caillau, France","institution_ids":["https://openalex.org/I4405267950"]},{"raw_affiliation_string":"Activ'Inside","institution_ids":["https://openalex.org/I4405267950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038482662","display_name":"Benjamin Moras","orcid":"https://orcid.org/0000-0001-9307-9333","observed_orcids":["https://orcid.org/0000-0001-9307-9333"]},"institutions":[{"id":"https://openalex.org/I4405267950","display_name":"Activ'Inside (France)","ror":"https://ror.org/054gdez93","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Moras","raw_affiliation_strings":["Activ'Inside, Beychac et Caillau, France","Activ'Inside"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Activ'Inside, Beychac et Caillau, France","institution_ids":["https://openalex.org/I4405267950"]},{"raw_affiliation_string":"Activ'Inside","institution_ids":["https://openalex.org/I4405267950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040026047","display_name":"Line Pourtau","orcid":"https://orcid.org/0000-0003-3315-2222","observed_orcids":["https://orcid.org/0000-0003-3315-2222"]},"institutions":[{"id":"https://openalex.org/I4405267950","display_name":"Activ'Inside (France)","ror":"https://ror.org/054gdez93","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405267950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Line Pourtau","raw_affiliation_strings":["Activ'Inside, Beychac et Caillau, France","Activ'Inside"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Activ'Inside, Beychac et Caillau, France","institution_ids":["https://openalex.org/I4405267950"]},{"raw_affiliation_string":"Activ'Inside","institution_ids":["https://openalex.org/I4405267950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071941446","display_name":"Florent Joffre","orcid":"https://orcid.org/0000-0002-5028-5302","observed_orcids":["https://orcid.org/0000-0002-5028-5302"]},"institutions":[{"id":"https://openalex.org/I4210152875","display_name":"Institut des Corps Gras","ror":"https://ror.org/04z5hhb71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florent Joffre","raw_affiliation_strings":["ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","institution_ids":["https://openalex.org/I4210152875"]},{"raw_affiliation_string":"Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070819093","display_name":"Carole Vaysse","orcid":"https://orcid.org/0000-0003-1769-2106","observed_orcids":["https://orcid.org/0000-0003-1769-2106"]},"institutions":[{"id":"https://openalex.org/I4210152875","display_name":"Institut des Corps Gras","ror":"https://ror.org/04z5hhb71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Vaysse","raw_affiliation_strings":["ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","institution_ids":["https://openalex.org/I4210152875"]},{"raw_affiliation_string":"Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057327919","display_name":"Kar\u00e8ne Bertrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152875","display_name":"Institut des Corps Gras","ror":"https://ror.org/04z5hhb71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kar\u00e8ne Bertrand","raw_affiliation_strings":["ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","institution_ids":["https://openalex.org/I4210152875"]},{"raw_affiliation_string":"Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065987370","display_name":"H\u00e9l\u00e8ne Abrous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152875","display_name":"Institut des Corps Gras","ror":"https://ror.org/04z5hhb71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210152875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Abrous","raw_affiliation_strings":["ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITERG, Nutrition-Health & Lipid Biochemistry Department, Can\u00e9jan, France","institution_ids":["https://openalex.org/I4210152875"]},{"raw_affiliation_string":"Equipe Nutrition, Sant\u00e9 et Biochimie des Lipides","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045749402","display_name":"David Vauzour","orcid":"https://orcid.org/0000-0001-5952-8756","observed_orcids":["https://orcid.org/0000-0001-5952-8756"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Vauzour","raw_affiliation_strings":["Faculty of Medicine and Health Sciences, Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom","Norwich Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom","institution_ids":["https://openalex.org/I1118541"]},{"raw_affiliation_string":"Norwich Medical School","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063758900","display_name":"Julie Brossaud","orcid":"https://orcid.org/0000-0003-0831-9852","observed_orcids":["https://orcid.org/0000-0003-0831-9852"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210138593","display_name":"NutriNeuro","ror":"https://ror.org/04hw9c755","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I4210088668","https://openalex.org/I4210138593","https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Brossaud","raw_affiliation_strings":["Hormone Laboratory, Nuclear Medicine, CHU Bordeaux, UMR INRA 1286, University Bordeaux, Bordeaux, France","Nutrition et Neurobiologie int\u00e9gr\u00e9e"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormone Laboratory, Nuclear Medicine, CHU Bordeaux, UMR INRA 1286, University Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I3018323443","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Nutrition et Neurobiologie int\u00e9gr\u00e9e","institution_ids":["https://openalex.org/I4210138593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109161438","display_name":"Jean Benoit Corcuff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210138593","display_name":"NutriNeuro","ror":"https://ror.org/04hw9c755","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I4210088668","https://openalex.org/I4210138593","https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Benoit Corcuff","raw_affiliation_strings":["Hormone Laboratory, Nuclear Medicine, CHU Bordeaux, UMR INRA 1286, University Bordeaux, Bordeaux, France","Nutrition et Neurobiologie int\u00e9gr\u00e9e"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormone Laboratory, Nuclear Medicine, CHU Bordeaux, UMR INRA 1286, University Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I3018323443","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Nutrition et Neurobiologie int\u00e9gr\u00e9e","institution_ids":["https://openalex.org/I4210138593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054040611","display_name":"Lucile Capuron","orcid":"https://orcid.org/0000-0002-2060-5918","observed_orcids":["https://orcid.org/0000-0002-2060-5918"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210138593","display_name":"NutriNeuro","ror":"https://ror.org/04hw9c755","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I4210088668","https://openalex.org/I4210138593","https://openalex.org/I4210160189"]},{"id":"https://openalex.org/I4210160189","display_name":"Institut Polytechnique de Bordeaux","ror":"https://ror.org/054qv7y42","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210160189"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucile Capuron","raw_affiliation_strings":["Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, Bordeaux, France","Nutrition et Neurobiologie int\u00e9gr\u00e9e"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, Bordeaux, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4210138593","https://openalex.org/I4210160189"]},{"raw_affiliation_string":"Nutrition et Neurobiologie int\u00e9gr\u00e9e","institution_ids":["https://openalex.org/I4210138593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037389181","display_name":"David O. Kennedy","orcid":"https://orcid.org/0000-0002-9746-8771","observed_orcids":["https://orcid.org/0000-0002-9746-8771"]},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David O. Kennedy","raw_affiliation_strings":["Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","University of Northumbria at Newcastle [United Kingdom]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I32394136"]},{"raw_affiliation_string":"University of Northumbria at Newcastle [United Kingdom]","institution_ids":["https://openalex.org/I32394136"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5034875109"],"corresponding_institution_ids":["https://openalex.org/I32394136"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":5.9024,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98026965,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"606124","last_page":"606124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saffron-extract","display_name":"saffron extract","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mood","display_name":"mood","score":0.4779999852180481},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6079999804496765},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6919999718666077},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6359999775886536},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.6110000014305115},{"id":"https://openalex.org/keywords/interpersonal-relationships","display_name":"interpersonal relationships","score":0.6610000133514404},{"id":"https://openalex.org/keywords/stress-resilience","display_name":"stress resilience","score":0.6209999918937683},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5350000262260437},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.6915839910507202},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.6756916642189026},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6585748791694641},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5765922665596008},{"id":"https://openalex.org/C2779571273","wikidata":"https://www.wikidata.org/wiki/Q15041677","display_name":"Crocus sativus","level":2,"score":0.5625151991844177},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5243270993232727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48153191804885864},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.4773994982242584},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.461859792470932},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3993799090385437},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.36840611696243286},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3464730679988861},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3336688280105591},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.11626046895980835},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3389/fnut.2020.606124","doi":"https://doi.org/10.3389/fnut.2020.606124","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2020.606124","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2020.606124/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7882499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7882499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:33598475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33598475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:45426","doi":null,"is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/id/eprint/45426/1/fnut-07-606124.pdf","pdf_url":"http://nrl.northumbria.ac.uk/id/eprint/45426/1/fnut-07-606124.pdf","source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:79128","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/79128/1/fnut_Saffron_Anxiety_Final.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/id/eprint/79128/1/fnut_Saffron_Anxiety_Final.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:HAL:hal-03312620v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-03312620","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, 2021, 7, ⟨10.3389/fnut.2020.606124⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c85a7eb5b1ce40d18bb58ca41b47f752","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c85a7eb5b1ce40d18bb58ca41b47f752","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 7 (2021)","raw_type":"article"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/112294","doi":null,"is_oa":true,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/112294","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I15057530","host_organization_name":"Universit\u00e9 de Bordeaux","host_organization_lineage":["https://openalex.org/I15057530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"}],"best_oa_location":{"id":"doi:10.3389/fnut.2020.606124","doi":"https://doi.org/10.3389/fnut.2020.606124","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2020.606124","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnut.2020.606124/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3127430331.pdf","grobid_xml":"https://content.openalex.org/works/W3127430331.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1031162000","https://openalex.org/W1950423950","https://openalex.org/W1965646109","https://openalex.org/W1967240735","https://openalex.org/W1972304037","https://openalex.org/W1983060391","https://openalex.org/W1988632498","https://openalex.org/W1993039880","https://openalex.org/W1994714011","https://openalex.org/W1995788203","https://openalex.org/W1996299251","https://openalex.org/W1999317538","https://openalex.org/W2001866454","https://openalex.org/W2002172036","https://openalex.org/W2004762037","https://openalex.org/W2032021469","https://openalex.org/W2040149516","https://openalex.org/W2040513770","https://openalex.org/W2041237855","https://openalex.org/W2043705607","https://openalex.org/W2059865440","https://openalex.org/W2060537141","https://openalex.org/W2060944416","https://openalex.org/W2063909696","https://openalex.org/W2065228730","https://openalex.org/W2079035358","https://openalex.org/W2079210585","https://openalex.org/W2092075716","https://openalex.org/W2099297340","https://openalex.org/W2117309811","https://openalex.org/W2122464624","https://openalex.org/W2124601805","https://openalex.org/W2129934104","https://openalex.org/W2132322340","https://openalex.org/W2139095467","https://openalex.org/W2150174579","https://openalex.org/W2165167678","https://openalex.org/W2166281097","https://openalex.org/W2168039303","https://openalex.org/W2168552382","https://openalex.org/W2337056081","https://openalex.org/W2429180991","https://openalex.org/W2561321161","https://openalex.org/W2562000122","https://openalex.org/W2613057533","https://openalex.org/W2627088574","https://openalex.org/W2771266440","https://openalex.org/W2791010381","https://openalex.org/W2902929476","https://openalex.org/W2924871619","https://openalex.org/W2947531029","https://openalex.org/W3030123025","https://openalex.org/W3088292277","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4414800389","https://openalex.org/W4410617967","https://openalex.org/W2627088574","https://openalex.org/W7164897750","https://openalex.org/W2337056081","https://openalex.org/W7129012435","https://openalex.org/W4407967221","https://openalex.org/W4385787674","https://openalex.org/W3042630400","https://openalex.org/W4313652832"],"abstract_inverted_index":{"Anxiety,":[0],"stress,":[1,25,128],"and":[2,8,22,73,77,105,129,144,158,176,194,233],"low":[3,71],"mood":[4,20,72],"are":[5],"closely":[6],"related":[7],"may":[9,234],"contribute":[10,235],"to":[11,17,24,47,86,149,213,225,236],"depressive":[12,39,130,228],"symptoms.":[13],"Among":[14],"non-pharmacological":[15],"solutions":[16],"improve":[18,226],"subclinical":[19,68,227],"symptoms":[21,229],"resilience":[23,238],"natural":[26],"products":[27],"such":[28],"as":[29,31],"saffron\u2014identified":[30],"promising":[32],"following":[33,218],"preliminary":[34],"beneficial":[35],"effects":[36,122,146],"in":[37,64,84,100,147,199,206,230],"major":[38],"disorder\u2014represent":[40],"a":[41,87,94,112,116,135,150],"relevant":[42],"strategy.":[43],"This":[44],"study":[45,92],"aimed":[46],"assess":[48],"the":[49,79,169,181,184,214,240],"efficacy":[50],"of":[51,70,82,123,140,183,242],"8":[52,119],"weeks'":[53],"supplementation":[54,193],"with":[55,67,191,197],"30":[56],"mg":[57],"standardized":[58],"saffron":[59,83,113,124,170,192,220],"extract":[60,114,171,223],"on":[61,125],"emotional":[62],"well-being":[63],"healthy":[65,103,231],"adults":[66],"feelings":[69,131],"anxiety":[74],"and/or":[75],"stress":[76],"evaluate":[78],"acute":[80,145,219],"effect":[81],"response":[85,148],"lab-based":[88,151],"psychosocial":[89,152],"stressor.":[90],"The":[91,202],"adopted":[93],"double-blind,":[95],"randomized,":[96],"parallel":[97],"groups":[98],"design":[99],"which":[101],"56":[102],"male":[104],"female":[106],"individuals":[107,232],"(18\u201354":[108],"years)":[109],"received":[110,168],"either":[111],"or":[115],"placebo":[117],"for":[118],"weeks.":[120],"Chronic":[121],"subjective":[126],"anxiety,":[127],"were":[132,154,164,195],"assessed":[133],"using":[134],"questionnaire":[136],"battery":[137],"[including":[138],"Profile":[139],"Mood":[141],"State-2,":[142],"(POMS)]":[143],"stressor":[153,215],"measured":[155],"through":[156],"psychological":[157],"physiological":[159],"parameters.":[160],"Urinary":[161,186],"crocetin":[162,187],"levels":[163,188],"quantified.":[165],"Participants":[166],"who":[167],"reported":[172],"reduced":[173],"depression":[174,200],"scores":[175],"improved":[177],"social":[178],"relationships":[179],"at":[180],"end":[182],"study.":[185],"increased":[189,237],"significantly":[190],"correlated":[196],"change":[198],"scores.":[201],"typical":[203],"stress-induced":[204],"decrease":[205],"heart":[207],"rate":[208],"variability":[209],"(HRV)":[210],"during":[211],"exposure":[212],"was":[216],"attenuated":[217],"intake.":[221],"Saffron":[222],"appears":[224],"against":[239],"development":[241],"stress-related":[243],"psychiatric":[244],"disorders.":[245],"Clinical":[246],"trials":[247],"number:":[248],"NCT03639831.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-02-15T00:00:00"}