{"id":"https://openalex.org/W3127214588","doi":"https://doi.org/10.1056/nejme2101705","title":"STEP 1 for Effective Weight Control \u2014 Another First Step?","display_name":"STEP 1 for Effective Weight Control \u2014 Another First Step?","publication_year":2021,"publication_date":"2021-02-10","ids":{"openalex":"https://openalex.org/W3127214588","doi":"https://doi.org/10.1056/nejme2101705","mag":"3127214588","pmid":"https://pubmed.ncbi.nlm.nih.gov/33567184"},"language":"en","primary_location":{"id":"doi:10.1056/nejme2101705","doi":"https://doi.org/10.1056/nejme2101705","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme2101705","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049720282","display_name":"Julie R. Ingelfinger","orcid":"https://orcid.org/0000-0001-9039-2703","observed_orcids":["https://orcid.org/0000-0001-9039-2703"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie R. Ingelfinger","raw_affiliation_strings":["From Tufts University School of Medicine, Boston, and the Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough (C.J.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Tufts University School of Medicine, Boston, and the Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough (C.J.R.)","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210146345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047044979","display_name":"Clifford james Rosen","orcid":"https://orcid.org/0000-0003-3436-8199","observed_orcids":["https://orcid.org/0000-0003-3436-8199"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford J. Rosen","raw_affiliation_strings":["From Tufts University School of Medicine, Boston, and the Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough (C.J.R.)","Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Tufts University School of Medicine, Boston, and the Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough (C.J.R.)","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210146345"]},{"raw_affiliation_string":"Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough","institution_ids":["https://openalex.org/I4210146345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"384","issue":"11","first_page":"1066","last_page":"1067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/weight-management","display_name":"weight management","score":0.7360000014305115},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6700000166893005},{"id":"https://openalex.org/keywords/weight-maintenance","display_name":"weight maintenance","score":0.890999972820282},{"id":"https://openalex.org/keywords/behavioral-weight-management","display_name":"behavioral weight management","score":0.574999988079071},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.9919999837875366},{"id":"https://openalex.org/keywords/weight-regain","display_name":"weight regain","score":0.8420000076293945},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.7879999876022339},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6110000014305115},{"id":"https://openalex.org/keywords/lorcaserin","display_name":"lorcaserin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/fenfluramine","display_name":"fenfluramine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/amphetamine","display_name":"amphetamine","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9300246238708496},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7954437732696533},{"id":"https://openalex.org/C3019408017","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Weight control","level":3,"score":0.5785834789276123},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5718284845352173},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.5262726545333862},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5234959721565247},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.4972720444202423},{"id":"https://openalex.org/C2779638493","wikidata":"https://www.wikidata.org/wiki/Q418928","display_name":"Fenfluramine","level":4,"score":0.485202819108963},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4636726379394531},{"id":"https://openalex.org/C34320749","wikidata":"https://www.wikidata.org/wiki/Q17087302","display_name":"Weight management","level":4,"score":0.44454336166381836},{"id":"https://openalex.org/C2781083316","wikidata":"https://www.wikidata.org/wiki/Q3025599","display_name":"Dexfenfluramine","level":5,"score":0.41898685693740845},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.4176613688468933},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.34401935338974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29276174306869507},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25782036781311035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20689356327056885},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099194","descriptor_name":"Semaglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004763","descriptor_name":"Glucagon-Like Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejme2101705","doi":"https://doi.org/10.1056/nejme2101705","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme2101705","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:33567184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33567184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1994014704","https://openalex.org/W2192722195","https://openalex.org/W2394582105","https://openalex.org/W2572398654","https://openalex.org/W2754824139","https://openalex.org/W2789727743","https://openalex.org/W2890827307","https://openalex.org/W3046790675","https://openalex.org/W3118501255","https://openalex.org/W3127371223"],"related_works":["https://openalex.org/W2764121475","https://openalex.org/W3080118574","https://openalex.org/W2898878987","https://openalex.org/W2137185566","https://openalex.org/W2154356626","https://openalex.org/W2084037276","https://openalex.org/W2288349424","https://openalex.org/W3118501255","https://openalex.org/W2394666650","https://openalex.org/W2397236421"],"abstract_inverted_index":{"Given":[0],"the":[1,56,61],"worldwide":[2],"increase":[3],"in":[4],"obesity,":[5],"with":[6,74],"attendant":[7],"coexisting":[8],"conditions":[9],"and":[10,24,37,58,65],"increased":[11],"risk":[12],"of":[13,29,48,76],"death,":[14],"there":[15],"is":[16,40],"a":[17,71],"pressing":[18],"need":[19],"to":[20,81],"address":[21],"weight":[22,30,53],"loss":[23,54],"maintenance":[25],"strategies.1-3":[26],"Behavioral":[27],"methods":[28],"control":[31],"fail":[32],"more":[33],"often":[34],"than":[35],"not,":[36],"bariatric":[38],"surgery":[39],"invasive":[41],"and,":[42,94],"often,":[43],"eventually":[44],"followed":[45],"by":[46,55],"regain":[47],"weight.1-3":[49],"Medications":[50],"approved":[51,78],"for":[52],"Food":[57],"Drug":[59],"Administration,":[60],"European":[62],"Medicines":[63],"Agency,":[64],"other":[66],"regulatory":[67],"bodies":[68],"have":[69],"had":[70],"troubling":[72],"history,":[73],"withdrawal":[75],"several":[77],"drugs":[79],"owing":[80],"serious":[82],"adverse":[83],"events;":[84],"among":[85],"these":[86],"are":[87],"various":[88],"amphetamines":[89],"(addiction),":[90],"fenfluramine":[91],"(cardiac":[92],"toxicity),":[93],"most":[95],"recently,":[96],"lorcaserin":[97],"(cancer":[98],"risk).4,5":[99],".":[100,101,102]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-15T00:00:00"}
