{"id":"https://openalex.org/W3127088480","doi":"https://doi.org/10.1186/s13287-020-02083-x","title":"microRNA-186 in extracellular vesicles from bone marrow mesenchymal stem cells alleviates idiopathic pulmonary fibrosis via interaction with SOX4 and DKK1","display_name":"microRNA-186 in extracellular vesicles from bone marrow mesenchymal stem cells alleviates idiopathic pulmonary fibrosis via interaction with SOX4 and DKK1","publication_year":2021,"publication_date":"2021-02-03","ids":{"openalex":"https://openalex.org/W3127088480","doi":"https://doi.org/10.1186/s13287-020-02083-x","mag":"3127088480","pmid":"https://pubmed.ncbi.nlm.nih.gov/33536061","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7860043"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-020-02083-x","doi":"https://doi.org/10.1186/s13287-020-02083-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-020-02083-x","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-02083-x","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-02083-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101665313","display_name":"Jing Zhou","orcid":"https://orcid.org/0000-0002-5205-8111","observed_orcids":["https://orcid.org/0000-0002-5205-8111"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006159577","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0001-6660-7823","observed_orcids":["https://orcid.org/0000-0001-6660-7823"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Lin","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080389601","display_name":"Xiuhua Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuhua Kang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhicheng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhicheng Liu","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324999","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-5343-2371","observed_orcids":["https://orcid.org/0000-0002-5343-2371"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China. zhangweiliuxing1@163.com","Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China"],"raw_orcid":"https://orcid.org/0000-0002-5343-2371","affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China. zhangweiliuxing1@163.com","institution_ids":["https://openalex.org/I4210164024"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100642989","display_name":"Fei Xu","orcid":"https://orcid.org/0000-0002-5566-490X","observed_orcids":["https://orcid.org/0000-0002-5566-490X"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Xu","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China. drFeiXuuue@163.com","Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China. drFeiXuuue@163.com","institution_ids":["https://openalex.org/I4210164024"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China","institution_ids":["https://openalex.org/I4210164024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100324999","https://openalex.org/A5100642989"],"corresponding_institution_ids":["https://openalex.org/I4210164024"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":3.7139,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.95801501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"96","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.3747999966144562,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/sox4","display_name":"SOX4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.6150000095367432},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7088656425476074},{"id":"https://openalex.org/C2777491412","wikidata":"https://www.wikidata.org/wiki/Q18036610","display_name":"DKK1","level":4,"score":0.6322402358055115},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.511870801448822},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4964831471443176},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.491972416639328},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.43805450201034546},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42486122250556946},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.41517043113708496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3906871974468231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3774833083152771},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.3324251174926758},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3010220229625702},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.20487064123153687},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13720938563346863},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0652381181716919},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13287-020-02083-x","doi":"https://doi.org/10.1186/s13287-020-02083-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-020-02083-x","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-02083-x","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:33536061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33536061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7860043","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7860043/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f95832c9fa7748c693955edc5e6870d7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f95832c9fa7748c693955edc5e6870d7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-020-02083-x","doi":"https://doi.org/10.1186/s13287-020-02083-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-020-02083-x","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-020-02083-x","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326696","display_name":"Jiangxi Provincial Department of Science and Technology","ror":"https://ror.org/00t30yz20"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3127088480.pdf","grobid_xml":"https://content.openalex.org/works/W3127088480.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W305660721","https://openalex.org/W2005196931","https://openalex.org/W2015636676","https://openalex.org/W2016438005","https://openalex.org/W2019806278","https://openalex.org/W2055496201","https://openalex.org/W2100835225","https://openalex.org/W2164075697","https://openalex.org/W2278555975","https://openalex.org/W2296319095","https://openalex.org/W2467547511","https://openalex.org/W2507845781","https://openalex.org/W2521144675","https://openalex.org/W2527222933","https://openalex.org/W2554099988","https://openalex.org/W2585403859","https://openalex.org/W2601417051","https://openalex.org/W2614892234","https://openalex.org/W2725377209","https://openalex.org/W2736691594","https://openalex.org/W2737138474","https://openalex.org/W2762444536","https://openalex.org/W2772308990","https://openalex.org/W2776317681","https://openalex.org/W2784709509","https://openalex.org/W2785527513","https://openalex.org/W2802141696","https://openalex.org/W2906042262","https://openalex.org/W2907407196","https://openalex.org/W2917695714","https://openalex.org/W2947679403","https://openalex.org/W2949127669","https://openalex.org/W2972039602","https://openalex.org/W2975581465","https://openalex.org/W2981000288","https://openalex.org/W3001664821","https://openalex.org/W3004664033","https://openalex.org/W3007511370","https://openalex.org/W3008667790","https://openalex.org/W3027652091","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3036135754","https://openalex.org/W4413258221","https://openalex.org/W7165051677","https://openalex.org/W4412531813","https://openalex.org/W4288426656","https://openalex.org/W4400053022","https://openalex.org/W4220866136","https://openalex.org/W4400015581","https://openalex.org/W4386424323","https://openalex.org/W4289101040"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"reports":[2],"have":[3],"identified":[4],"that":[5],"human":[6],"bone":[7],"marrow":[8],"mesenchymal":[9],"stem":[10],"cell-derived":[11],"extracellular":[12],"vesicles":[13],"(BMSC-EVs)":[14],"with":[15,51],"their":[16],"cargo":[17],"microRNAs":[18],"(miRNAs)":[19],"are":[20],"a":[21,41,57,62,76,101,187,235],"promising":[22],"therapeutic":[23,86,237],"approach":[24],"for":[25,239],"the":[26,52,70,83,170,183,195],"treatment":[27],"of":[28,38,54,72,79,88,185,190,197,210],"idiopathic":[29],"pulmonary":[30],"fibrosis":[31],"(IPF).":[32],"Therefore,":[33],"we":[34,65,104,132],"explored":[35],"whether":[36,67,134],"delivery":[37],"microRNA-186":[39],"(miR-186),":[40],"downregulated":[42,164],"miRNA":[43],"in":[44,56,84,94,160,165,169],"IPF,":[45,232],"by":[46,96,109,141,174,219],"BMSC":[47],"EVs":[48],"could":[49,176],"interfere":[50],"progression":[53,159],"IPF":[55,158,166],"murine":[58],"model.":[59],"METHODS:":[60],"In":[61,215],"co-culture":[63],"system,":[64],"assessed":[66],"BMSC-EVs":[68,89,95,110,151,175,220],"modulated":[69],"activation":[71,138,155,204,229],"fibroblasts.":[73,112],"We":[74],"established":[75],"mouse":[77],"model":[78],"PF":[80,140,207],"to":[81],"evaluate":[82],"vivo":[85],"effects":[87],"and":[90,118,139,144,156,192,205,212,223,230],"determined":[91],"miR-186":[92,107,117,162,172,181,201,217],"expression":[93,184,196],"polymerase":[97],"chain":[98],"reaction.":[99],"Using":[100],"loss-of-function":[102],"approach,":[103],"examined":[105],"how":[106],"delivered":[108,173,218],"affected":[111,136],"The":[113],"putative":[114],"relationship":[115],"between":[116],"SRY-related":[119],"HMG":[120],"box":[121],"transcription":[122],"factor":[123],"4":[124],"(SOX4)":[125],"was":[126,163],"tested":[127],"using":[128],"luciferase":[129],"assay.":[130],"Next,":[131],"investigated":[133],"EV-miR-186":[135],"fibroblast":[137,154,178,203,228],"targeting":[142],"SOX4":[143,211,222],"its":[145],"downstream":[146],"gene,":[147],"Dickkopf-1":[148],"(DKK1).":[149],"RESULTS:":[150],"suppressed":[152,194,221],"lung":[153],"delayed":[157],"mice.":[161],"but":[167],"enriched":[168],"BMSC-EVs.":[171],"suppress":[177],"activation.":[179],"Furthermore,":[180],"reduced":[182],"SOX4,":[186],"target":[188,238],"gene":[189],"miR-186,":[191],"hence":[193],"DKK1.":[198,213],"Finally,":[199],"EV-delivered":[200],"impaired":[202],"alleviated":[206],"via":[208],"downregulation":[209],"CONCLUSION:":[214],"conclusion,":[216],"DKK1":[224],"expression,":[225],"thereby":[226],"blocking":[227],"ameliorating":[231],"thus":[233],"presenting":[234],"novel":[236],"IPF.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-02-15T00:00:00"}
