{"id":"https://openalex.org/W3127036141","doi":"https://doi.org/10.1016/j.heliyon.2021.e06221","title":"Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease","display_name":"Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3127036141","doi":"https://doi.org/10.1016/j.heliyon.2021.e06221","mag":"3127036141","pmid":"https://pubmed.ncbi.nlm.nih.gov/33659745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7892929"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2021.e06221","doi":"https://doi.org/10.1016/j.heliyon.2021.e06221","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2021.e06221","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2021.e06221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061646917","display_name":"Kimio Watanabe","orcid":"https://orcid.org/0000-0002-8773-0967","observed_orcids":["https://orcid.org/0000-0002-8773-0967"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210087594","display_name":"St. Luke's International Hospital","ror":"https://ror.org/002wydw38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087594"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kimio Watanabe","raw_affiliation_strings":["Department of Blood Purification, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan","Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan","Division of Kidney Center, St Luke's International Hospital, Tokyo, 104-8560, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Purification, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Division of Kidney Center, St Luke's International Hospital, Tokyo, 104-8560, Japan","institution_ids":["https://openalex.org/I4210087594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059710641","display_name":"Emiko Sato","orcid":"https://orcid.org/0000-0002-6998-2909","observed_orcids":["https://orcid.org/0000-0002-6998-2909"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Emiko Sato","raw_affiliation_strings":["Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan","Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075020655","display_name":"Eikan Mishima","orcid":"https://orcid.org/0000-0002-3706-2745","observed_orcids":["https://orcid.org/0000-0002-3706-2745"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eikan Mishima","raw_affiliation_strings":["Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035121457","display_name":"Mayu Watanabe","orcid":"https://orcid.org/0000-0003-4253-3465","observed_orcids":["https://orcid.org/0000-0003-4253-3465"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayu Watanabe","raw_affiliation_strings":["Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061369169","display_name":"Takaaki Abe","orcid":"https://orcid.org/0000-0003-3170-4660","observed_orcids":["https://orcid.org/0000-0003-3170-4660"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Abe","raw_affiliation_strings":["Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065937535","display_name":"Nobuyuki Takahashi","orcid":"https://orcid.org/0000-0002-9816-6185","observed_orcids":["https://orcid.org/0000-0002-9816-6185"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Takahashi","raw_affiliation_strings":["Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan","Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052525882","display_name":"Masaaki Nakayama","orcid":"https://orcid.org/0000-0002-6052-6202","observed_orcids":["https://orcid.org/0000-0002-6052-6202"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I4210087594","display_name":"St. Luke's International Hospital","ror":"https://ror.org/002wydw38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087594"]},{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Nakayama","raw_affiliation_strings":["Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan","Division of Kidney Center, St Luke's International Hospital, Tokyo, 104-8560, Japan","Research Division of Dialysis Treatment and Chronic Kidney Disease, Tohoku University Hospital, Sendai, 980-8574, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Division of Kidney Center, St Luke's International Hospital, Tokyo, 104-8560, Japan","institution_ids":["https://openalex.org/I4210087594"]},{"raw_affiliation_string":"Research Division of Dialysis Treatment and Chronic Kidney Disease, Tohoku University Hospital, Sendai, 980-8574, Japan","institution_ids":["https://openalex.org/I4210093896"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059710641","https://openalex.org/A5061646917"],"corresponding_institution_ids":["https://openalex.org/I130830085","https://openalex.org/I201537933","https://openalex.org/I4210087594"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":3.6876,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.94052531,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"e06221","last_page":"e06221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hippocampal-neuronal-injury","display_name":"hippocampal neuronal damage","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7210000157356262},{"id":"https://openalex.org/keywords/indoxyl-sulfate","display_name":"indoxyl sulfate","score":0.9330000281333923},{"id":"https://openalex.org/keywords/indole-3-acetic-acid","display_name":"indole-3-acetic acid","score":0.9079999923706055},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.9549999833106995},{"id":"https://openalex.org/keywords/indole","display_name":"indole","score":0.6370000243186951},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9459999799728394},{"id":"https://openalex.org/keywords/learning-disabilities","display_name":"learning disabilities","score":0.6809999942779541},{"id":"https://openalex.org/keywords/adenine-induced-ckd","display_name":"adenine-induced CKD","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6879119873046875},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6850486993789673},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6735241413116455},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6409846544265747},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.586565375328064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5849425196647644},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5055782794952393},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4962659478187561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4330924153327942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3832494616508484},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36863893270492554},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2547707259654999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2155209481716156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06947079300880432}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2021.e06221","doi":"https://doi.org/10.1016/j.heliyon.2021.e06221","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2021.e06221","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7892929","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7892929/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7892929/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:33659745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33659745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5330c65049034a07931215956d19f7b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5330c65049034a07931215956d19f7b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 7, Iss 2, Pp e06221- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2021.e06221","doi":"https://doi.org/10.1016/j.heliyon.2021.e06221","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2021.e06221","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G143716541","display_name":"Pathological involvement of carbonyl stress for development of cognitive impairment in CKD","funder_award_id":"23591196","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3352101402","display_name":"Elucidating the pathogenic mechanism of CKD-associated cognitive dysfunction and muscle wasting as revealed by metabolic changes in organs","funder_award_id":"19K08669","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5344601884","display_name":null,"funder_award_id":"2013-1","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6909242982","display_name":"Chronic kidney disease (CKD) and Cognitive impairment: Possible mechanisms of Cerebro-renal interaction","funder_award_id":"15K19461","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8987833187","display_name":"Gut-renal axis: microbiota and chronic kidney disease","funder_award_id":"18K08198","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3127036141.pdf","grobid_xml":"https://content.openalex.org/works/W3127036141.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1593907193","https://openalex.org/W1594154614","https://openalex.org/W1707133078","https://openalex.org/W1937321483","https://openalex.org/W1964706382","https://openalex.org/W1967061503","https://openalex.org/W1968731447","https://openalex.org/W1971944843","https://openalex.org/W1976780633","https://openalex.org/W1987672637","https://openalex.org/W1992184827","https://openalex.org/W1999731922","https://openalex.org/W2002847222","https://openalex.org/W2006379860","https://openalex.org/W2017169966","https://openalex.org/W2029733118","https://openalex.org/W2031948766","https://openalex.org/W2057050776","https://openalex.org/W2092555768","https://openalex.org/W2120453226","https://openalex.org/W2122231873","https://openalex.org/W2124097908","https://openalex.org/W2124651748","https://openalex.org/W2133299072","https://openalex.org/W2152289383","https://openalex.org/W2170369453","https://openalex.org/W2171614571","https://openalex.org/W2263989649","https://openalex.org/W2297901344","https://openalex.org/W2761931108","https://openalex.org/W2777538610","https://openalex.org/W2794246608","https://openalex.org/W2883939750","https://openalex.org/W2886256829","https://openalex.org/W2914437754","https://openalex.org/W2920283819","https://openalex.org/W2943665263","https://openalex.org/W2968211876","https://openalex.org/W2984529289","https://openalex.org/W2997285271","https://openalex.org/W3034400121","https://openalex.org/W3034602289","https://openalex.org/W3044451018","https://openalex.org/W4233809339"],"related_works":["https://openalex.org/W3205890231","https://openalex.org/W2006379860","https://openalex.org/W3034103458","https://openalex.org/W4285010501","https://openalex.org/W3034602289","https://openalex.org/W4225401843","https://openalex.org/W4407954114","https://openalex.org/W4394843044","https://openalex.org/W4389452757","https://openalex.org/W3200590828"],"abstract_inverted_index":{"One":[0],"third":[1],"of":[2,26,39,50,86,115],"the":[3,23,37,47,51,65,133],"patients":[4],"with":[5,123],"chronic":[6],"kidney":[7],"disease":[8],"(CKD)":[9],"develop":[10],"cognitive":[11],"impairment,":[12],"which":[13],"is":[14],"also":[15,90],"an":[16],"independent":[17],"risk":[18],"factor":[19],"for":[20],"mortality.":[21],"However,":[22],"concise":[24],"mechanism":[25],"cerebro-renal":[27],"interaction":[28],"has":[29],"not":[30],"been":[31],"clarified.":[32],"The":[33,84],"present":[34],"study":[35],"examines":[36],"effects":[38],"uremic":[40,66,88,142,153],"toxins":[41,67,89,143],"on":[42,148],"neuronal":[43,56,117,150],"cells":[44,58,118,151],"and":[45,59,73,78,93,112,152],"analyzes":[46],"pathological":[48],"condition":[49],"brain":[52],"using":[53,132],"mouse":[54],"hippocampal":[55,149],"HT-22":[57,82],"adenine-induced":[60],"CKD":[61,101,121,154],"model":[62],"rats.":[63],"Among":[64],"analyzed,":[68],"indoxyl":[69],"sulfate,":[70],"indole,":[71],"3-indoleacetate,":[72],"methylglyoxal":[74],"significantly":[75],"decreased":[76,91],"viability":[77,92],"glutathione":[79,94],"level":[80,95],"in":[81,119,158],"cells.":[83],"mixture":[85],"these":[87],"at":[96],"a":[97,145],"lower":[98],"dose.":[99],"Adenine-induced":[100],"rat":[102],"showed":[103],"marked":[104],"renal":[105],"damage,":[106],"increased":[107,113],"urinary":[108],"oxidative":[109],"stress":[110],"markers,":[111],"numbers":[114],"pyknotic":[116],"hippocampus.":[120,159],"rats":[122,155],"damaged":[124],"hippocampus":[125],"demonstrated":[126],"poor":[127],"learning":[128],"process":[129],"when":[130],"tested":[131],"Morris":[134],"water":[135],"maze":[136],"test.":[137],"Our":[138],"results":[139],"suggest":[140],"that":[141],"have":[144],"toxic":[146],"effect":[147],"shows":[156],"pyknosis":[157]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-02-15T00:00:00"}
