{"id":"https://openalex.org/W3127030334","doi":"https://doi.org/10.1155/2021/8811236","title":"Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines","display_name":"Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines","publication_year":2021,"publication_date":"2021-01-30","ids":{"openalex":"https://openalex.org/W3127030334","doi":"https://doi.org/10.1155/2021/8811236","mag":"3127030334","pmid":"https://pubmed.ncbi.nlm.nih.gov/33603822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7868152"},"language":"en","primary_location":{"id":"doi:10.1155/2021/8811236","doi":"https://doi.org/10.1155/2021/8811236","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/8811236","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/2021/8811236","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/2021/8811236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078091835","display_name":"Lusia Barek Moses","orcid":"https://orcid.org/0000-0002-4625-8854","observed_orcids":["https://orcid.org/0000-0002-4625-8854"]},"institutions":[{"id":"https://openalex.org/I161371597","display_name":"Universiti of Malaysia Sabah","ror":"https://ror.org/040v70252","country_code":"MY","type":"education","lineage":["https://openalex.org/I161371597"]},{"id":"https://openalex.org/I930072361","display_name":"Tun Hussein Onn University of Malaysia","ror":"https://ror.org/01c5wha71","country_code":"MY","type":"education","lineage":["https://openalex.org/I930072361"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Lusia Barek Moses","raw_affiliation_strings":["Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Pagoh Campus, Hub Pendidikan Tinggi Pagoh, KM1, Jalan Panchor, 84600, Muar, Johor, Malaysia","Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-4625-8854","affiliations":[{"raw_affiliation_string":"Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Pagoh Campus, Hub Pendidikan Tinggi Pagoh, KM1, Jalan Panchor, 84600, Muar, Johor, Malaysia","institution_ids":["https://openalex.org/I930072361"]},{"raw_affiliation_string":"Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia","institution_ids":["https://openalex.org/I161371597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013335944","display_name":"Mohd Fadzelly Abu Bakar","orcid":"https://orcid.org/0000-0002-3589-9533","observed_orcids":["https://orcid.org/0000-0002-3589-9533"]},"institutions":[{"id":"https://openalex.org/I930072361","display_name":"Tun Hussein Onn University of Malaysia","ror":"https://ror.org/01c5wha71","country_code":"MY","type":"education","lineage":["https://openalex.org/I930072361"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Mohd Fadzelly Abu Bakar","raw_affiliation_strings":["Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Pagoh Campus, Hub Pendidikan Tinggi Pagoh, KM1, Jalan Panchor, 84600, Muar, Johor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-3589-9533","affiliations":[{"raw_affiliation_string":"Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Pagoh Campus, Hub Pendidikan Tinggi Pagoh, KM1, Jalan Panchor, 84600, Muar, Johor, Malaysia","institution_ids":["https://openalex.org/I930072361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022492374","display_name":"Hasmadi Mamat","orcid":"https://orcid.org/0000-0001-8637-5257","observed_orcids":["https://orcid.org/0000-0001-8637-5257"]},"institutions":[{"id":"https://openalex.org/I161371597","display_name":"Universiti of Malaysia Sabah","ror":"https://ror.org/040v70252","country_code":"MY","type":"education","lineage":["https://openalex.org/I161371597"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hasmadi Mamat","raw_affiliation_strings":["Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia"],"raw_orcid":"https://orcid.org/0000-0001-8637-5257","affiliations":[{"raw_affiliation_string":"Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia","institution_ids":["https://openalex.org/I161371597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032344225","display_name":"Zaleha Abdul Aziz","orcid":"https://orcid.org/0000-0002-1971-1254","observed_orcids":["https://orcid.org/0000-0002-1971-1254"]},"institutions":[{"id":"https://openalex.org/I161371597","display_name":"Universiti of Malaysia Sabah","ror":"https://ror.org/040v70252","country_code":"MY","type":"education","lineage":["https://openalex.org/I161371597"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Zaleha Abdul Aziz","raw_affiliation_strings":["Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-1971-1254","affiliations":[{"raw_affiliation_string":"Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia","institution_ids":["https://openalex.org/I161371597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013335944","https://openalex.org/A5032344225"],"corresponding_institution_ids":["https://openalex.org/I161371597","https://openalex.org/I930072361"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.7682,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.59838425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.3059000074863434,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eurycoma-longifolia","display_name":"Eurycoma longifolia","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7400000095367432},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9399999976158142},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.7900000214576721},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.8479999899864197},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7839999794960022},{"id":"https://openalex.org/keywords/microwave-drying","display_name":"microwave drying","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8169108629226685},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.7199215888977051},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.7097675800323486},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6447827219963074},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5309618711471558},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.5222650170326233},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.5211146473884583},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5106056332588196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5034326910972595},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48828816413879395},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4441308081150055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4432344436645508},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.42983531951904297},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.41519638895988464},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41029587388038635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.330142080783844},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2961099445819855},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12853923439979553},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10918596386909485},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.09148171544075012},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0768156349658966},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2021/8811236","doi":"https://doi.org/10.1155/2021/8811236","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/8811236","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/2021/8811236","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmid:33603822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33603822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7868152","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7868152/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmh:oai:eprints.uthm.edu.my:1800","doi":null,"is_oa":false,"landing_page_url":"http://eprints.uthm.edu.my/1800/1/J12050_40f2b034231307a74af4dab99b1695d6.pdf","pdf_url":"http://eprints.uthm.edu.my/1800/1/J12050_40f2b034231307a74af4dab99b1695d6.pdf","source":{"id":"https://openalex.org/S4306400770","display_name":"UTHM Institutional Repository (Universiti Tun Hussein Onn Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I930072361","host_organization_name":"Tun Hussein Onn University of Malaysia","host_organization_lineage":["https://openalex.org/I930072361"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.ums.edu.my:26983","doi":null,"is_oa":true,"landing_page_url":"http://eprints.ums.edu.my/26983/1/Unfermented%20freeze-dried%20leaf%20extract%20of%20Tongkat%20Ali%20%28Eurycoma%20longifolia%20Jack.%29%20induced%20cytotoxicity%20and%20apoptosis%20in%20MDA-MB-231%20and%20MCF-7%20breast%20cancer%20cell%20lines%20FULL%20TEXT.pdf","pdf_url":"https://eprints.ums.edu.my/id/eprint/26983/3/Unfermented%20freeze-dried%20leaf%20extract%20of%20Tongkat%20Ali%20%28Eurycoma%20longifolia%20Jack.%29%20induced%20cytotoxicity%20and%20apoptosis%20in%20MDA-MB-231%20and%20MCF-7%20breast%20cancer%20cell%20lines%20ABSTRACT.pdf","source":{"id":"https://openalex.org/S4306400331","display_name":"UMS Institutional Repository (Universiti Malaysia Sabah)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161371597","host_organization_name":"Universiti of Malaysia Sabah","host_organization_lineage":["https://openalex.org/I161371597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1155/2021/8811236","doi":"https://doi.org/10.1155/2021/8811236","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/8811236","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/2021/8811236","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3622561438","display_name":null,"funder_award_id":"1560 (FRGS/1/2015/WAB01UTHM/02/1)","funder_id":"https://openalex.org/F4320321709","funder_display_name":"Ministry of Higher Education, Malaysia"}],"funders":[{"id":"https://openalex.org/F4320310112","display_name":"Universiti Tun Hussein Onn Malaysia","ror":"https://ror.org/01c5wha71"},{"id":"https://openalex.org/F4320321709","display_name":"Ministry of Higher Education, Malaysia","ror":"https://ror.org/05mcs2t73"},{"id":"https://openalex.org/F4320322714","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64"},{"id":"https://openalex.org/F4320323704","display_name":"Universiti Malaysia Sabah","ror":"https://ror.org/040v70252"},{"id":"https://openalex.org/F4320335206","display_name":"Fakulti Perubatan dan Sains Kesihatan, Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64"},{"id":"https://openalex.org/F4320337083","display_name":"Faculty of Medicine and Health, University of Sydney","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3127030334.pdf","grobid_xml":"https://content.openalex.org/works/W3127030334.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W29902740","https://openalex.org/W279208640","https://openalex.org/W1543006546","https://openalex.org/W1554966088","https://openalex.org/W1968077233","https://openalex.org/W1970786395","https://openalex.org/W1983719750","https://openalex.org/W1991360752","https://openalex.org/W1993814623","https://openalex.org/W1994186100","https://openalex.org/W2071831285","https://openalex.org/W2076841501","https://openalex.org/W2078274906","https://openalex.org/W2090340479","https://openalex.org/W2128450526","https://openalex.org/W2140894399","https://openalex.org/W2152149333","https://openalex.org/W2161610573","https://openalex.org/W2171909916","https://openalex.org/W2188775946","https://openalex.org/W2232369444","https://openalex.org/W2294515230","https://openalex.org/W2408954743","https://openalex.org/W2461593894","https://openalex.org/W2590341808","https://openalex.org/W2596486793","https://openalex.org/W2738738407","https://openalex.org/W2781000208","https://openalex.org/W2789754526","https://openalex.org/W2793972506","https://openalex.org/W2889646458","https://openalex.org/W2897651816","https://openalex.org/W2948680670","https://openalex.org/W2969032330","https://openalex.org/W3006161317","https://openalex.org/W3032757310","https://openalex.org/W4234245904"],"related_works":["https://openalex.org/W2099663739","https://openalex.org/W7218002656","https://openalex.org/W2051469101","https://openalex.org/W2157107686","https://openalex.org/W7197177710","https://openalex.org/W3155723138","https://openalex.org/W2761857465","https://openalex.org/W3174229019","https://openalex.org/W2184938990","https://openalex.org/W7095115119"],"abstract_inverted_index":{"The":[0,34,70,107,143,170],"present":[1],"study":[2],"was":[3,74,99,116,146,155,177,182],"conducted":[4],"to":[5,187,251],"determine":[6],"the":[7,85,111,117,132,158,180,241],"cytotoxicity":[8,59,271],"effect":[9,60,268],"of":[10,22,36,87,97,135,172,210,243,248],"Eurycoma":[11],"longifolia":[12,38,250],"(Jack.)":[13],"leaf":[14,114,246],"extracts":[15,55],"and":[16,31,43,50,64,84,89,122,141,164,215,234,258],"also":[17],"its":[18,77,270],"possible":[19],"anticancer":[20],"mechanism":[21],"action":[23],"against":[24],"breast":[25],"cancer":[26],"cell":[27,79,81,150,153,254],"lines:":[28],"non-hormone-dependent":[29],"MDA-MB-231":[30,121,168,176,220,257],"hormone-dependent":[32],"MCF-7.":[33],"leaves":[35],"E.":[37,249],"were":[39,56,207],"processed":[40],"into":[41],"unfermented":[42,112,244],"fermented":[44],"batches":[45],"before":[46],"drying":[47,52],"using":[48,61,67,92,101],"freeze":[49],"microwave-oven":[51],"techniques.":[53],"Obtained":[54],"tested":[57,100],"for":[58,76,175,228],"MTT":[62],"assay":[63],"phenolic":[65],"determination":[66],"HPLC-DAD":[68],"technique.":[69,95],"most":[71,118],"toxic":[72,119],"sample":[73,266],"analyzed":[75],"apoptotic":[78,90,173,217,236],"quantification,":[80],"cycle":[82,154],"distribution,":[83],"expression":[86],"caspases":[88],"protein":[91,218],"flow":[93],"cytometry":[94],"Fragmentation":[96],"DNA":[98,144],"an":[102],"agarose":[103],"gel":[104],"electrophoresis":[105],"system.":[106],"results":[108,239],"determined":[109],"that":[110],"freeze-dried":[113,245],"extract":[115,130,247],"towards":[120,269],"MCF-7":[123,162,199,223],"cells,":[124,221],"in":[125,148,161,167,198,202,219],"a":[126,203],"dose-dependent":[127],"manner.":[128,205],"This":[129],"contains":[131],"highest":[133],"phenolics":[134],"gallic":[136],"acid,":[137,139],"chlorogenic":[138],"ECG,":[140],"EGCG.":[142],"fragmentation":[145],"observed":[147],"both":[149],"lines,":[151],"where":[152],"arrested":[156],"at":[157,193],"G2/M":[159],"phase":[160,166],"cells":[163,174,200,224],"S":[165],"cells.":[169],"number":[171],"increased":[178],"when":[179],"treatment":[181],"prolonged":[183],"from":[184],"24":[185],"h":[186,189],"48":[188],"but":[190],"slightly":[191],"decreased":[192],"72":[194],"h,":[195],"whereas":[196,222],"apoptosis":[197,253],"occurred":[201],"time-dependent":[204],"There":[206],"significant":[208,226],"activities":[209,227],"cytochrome":[211,230],"c,":[212,231],"caspase-3,":[213],"Bax,":[214,232],"Bcl-2":[216,235],"showed":[225],"caspase-8,":[229],"p53,":[233],"protein.":[237],"These":[238],"indicate":[240],"ability":[242],"induce":[252],"death":[255],"on":[256,265],"MCF-7,":[259],"as":[260,262],"well":[261],"real":[263],"evidence":[264],"preparation":[267],"level.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-02-15T00:00:00"}