{"id":"https://openalex.org/W3127025875","doi":"https://doi.org/10.1186/s13256-020-02654-9","title":"A bedridden young lady with hypophosphatemic rickets treated with denosumab: a case report","display_name":"A bedridden young lady with hypophosphatemic rickets treated with denosumab: a case report","publication_year":2021,"publication_date":"2021-02-07","ids":{"openalex":"https://openalex.org/W3127025875","doi":"https://doi.org/10.1186/s13256-020-02654-9","mag":"3127025875","pmid":"https://pubmed.ncbi.nlm.nih.gov/33549117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7868015"},"language":"en","primary_location":{"id":"doi:10.1186/s13256-020-02654-9","doi":"https://doi.org/10.1186/s13256-020-02654-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13256-020-02654-9","pdf_url":"https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/s13256-020-02654-9","source":{"id":"https://openalex.org/S162052592","display_name":"Journal of Medical Case Reports","issn_l":"1752-1947","issn":["1752-1947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Case Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3127025875"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/s13256-020-02654-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048272078","display_name":"Butheinah A. Al-Sharafi","orcid":"https://orcid.org/0000-0002-0520-8164","observed_orcids":["https://orcid.org/0000-0002-0520-8164"]},"institutions":[{"id":"https://openalex.org/I170535673","display_name":"Sana'a University","ror":"https://ror.org/04hcvaf32","country_code":"YE","type":"education","lineage":["https://openalex.org/I170535673"]}],"countries":["YE"],"is_corresponding":true,"raw_author_name":"Butheinah A. Al-Sharafi","raw_affiliation_strings":["Department of Medicine, School of Medicine and Health Sciences, Sana'a University, PO Box 12268, Sana'a, Yemen. balsharafi@hotmail.com","Department of Medicine, School of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine and Health Sciences, Sana'a University, PO Box 12268, Sana'a, Yemen. balsharafi@hotmail.com","institution_ids":["https://openalex.org/I170535673"]},{"raw_affiliation_string":"Department of Medicine, School of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen","institution_ids":["https://openalex.org/I170535673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021654549","display_name":"Nuha A. Al-Yousfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170535673","display_name":"Sana'a University","ror":"https://ror.org/04hcvaf32","country_code":"YE","type":"education","lineage":["https://openalex.org/I170535673"]}],"countries":["YE"],"is_corresponding":false,"raw_author_name":"Nuha A. Al-Yousfi","raw_affiliation_strings":["Department of Medicine, School of Medicine and Health Sciences, Sana'a University, PO Box 12268, Sana'a, Yemen","Department of Medicine, School of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine and Health Sciences, Sana'a University, PO Box 12268, Sana'a, Yemen","institution_ids":["https://openalex.org/I170535673"]},{"raw_affiliation_string":"Department of Medicine, School of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen","institution_ids":["https://openalex.org/I170535673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072661733","display_name":"Said A. Bamashmus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153165","display_name":"University of Science and Technology, Sana\u2019a","ror":"https://ror.org/0520msa48","country_code":"YE","type":"education","lineage":["https://openalex.org/I4387153165"]}],"countries":["YE"],"is_corresponding":false,"raw_author_name":"Said A. Bamashmus","raw_affiliation_strings":["Department of Orthopedic Surgery, University of Science and Technology Hospital, PO Box 13061, Sana'a, Yemen","Department of Orthopedic Surgery, University of Science and Technology Hospital, Sana\u2019a, Yemen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, University of Science and Technology Hospital, PO Box 13061, Sana'a, Yemen","institution_ids":[]},{"raw_affiliation_string":"Department of Orthopedic Surgery, University of Science and Technology Hospital, Sana\u2019a, Yemen","institution_ids":["https://openalex.org/I4387153165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048272078"],"corresponding_institution_ids":["https://openalex.org/I170535673"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypophosphatemic-rickets","display_name":"hypophosphatemic rickets","score":0.9990000128746033},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9959999918937683},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bedridden-patients","display_name":"bedridden patients","score":0.699999988079071},{"id":"https://openalex.org/keywords/walking-recovery","display_name":"walking recovery","score":0.515999972820282},{"id":"https://openalex.org/keywords/bone-deformity","display_name":"bone deformity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/growth-failure","display_name":"growth failure","score":0.7070000171661377},{"id":"https://openalex.org/keywords/phosphate-supplementation","display_name":"phosphorus supplementation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9392063021659851},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.8846355676651001},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.8648671507835388},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.6588281393051147},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6419054269790649},{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.6322563886642456},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.5628432631492615},{"id":"https://openalex.org/C2778049618","wikidata":"https://www.wikidata.org/wiki/Q860395","display_name":"Osteomalacia","level":3,"score":0.518005907535553},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41509705781936646},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4022189974784851},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32563531398773193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2657371759414673}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010018","descriptor_name":"Osteomalacia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063730","descriptor_name":"Rickets, Hypophosphatemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13256-020-02654-9","doi":"https://doi.org/10.1186/s13256-020-02654-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13256-020-02654-9","pdf_url":"https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/s13256-020-02654-9","source":{"id":"https://openalex.org/S162052592","display_name":"Journal of Medical Case Reports","issn_l":"1752-1947","issn":["1752-1947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6774595","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7868015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:33549117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33549117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical case reports","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:7868015","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7868015/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Case Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f466133dc4ad438fbae3fd4965a9916d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f466133dc4ad438fbae3fd4965a9916d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)","raw_type":"article"},{"id":"doi:10.60692/jxpkg-e6t15","doi":"https://doi.org/10.60692/jxpkg-e6t15","is_oa":true,"landing_page_url":"https://doi.org/10.60692/jxpkg-e6t15","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/q3jer-gac64","doi":"https://doi.org/10.60692/q3jer-gac64","is_oa":true,"landing_page_url":"https://doi.org/10.60692/q3jer-gac64","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13256-020-02654-9","doi":"https://doi.org/10.1186/s13256-020-02654-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13256-020-02654-9","pdf_url":"https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/s13256-020-02654-9","source":{"id":"https://openalex.org/S162052592","display_name":"Journal of Medical Case Reports","issn_l":"1752-1947","issn":["1752-1947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3127025875.pdf","grobid_xml":"https://content.openalex.org/works/W3127025875.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2004344897","https://openalex.org/W2061807047","https://openalex.org/W2063407237","https://openalex.org/W2103303116","https://openalex.org/W2140330355","https://openalex.org/W2803769911","https://openalex.org/W2934326527","https://openalex.org/W2939361435","https://openalex.org/W2947770255","https://openalex.org/W2950738816","https://openalex.org/W2974878273"],"related_works":["https://openalex.org/W4308137978","https://openalex.org/W4283584275","https://openalex.org/W2182479647","https://openalex.org/W4402941019","https://openalex.org/W2944498171","https://openalex.org/W4220695833","https://openalex.org/W2998587584","https://openalex.org/W4220924363","https://openalex.org/W4402555665","https://openalex.org/W3081141004"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypophosphatemic":[1],"rickets":[2,48,178],"is":[3,152],"associated":[4],"with":[5,34,46,53,135],"delayed":[6],"walking,":[7],"bone":[8],"deformities,":[9],"growth":[10],"failure":[11],"and":[12,25,56,83,99,119,126,132,140,189],"physical":[13],"dysfunction":[14],"that":[15,31,179],"can":[16],"limit":[17],"daily":[18],"activities.":[19],"Treatment":[20],"consists":[21],"of":[22,78,86,93,102,144],"phosphate":[23],"salts":[24],"calcitriol.":[26],"We":[27],"report":[28],"a":[29,205],"case":[30],"received":[32],"denosumab":[33,114],"marked":[35],"improvement":[36],"in":[37,59,115,161,164,209],"her":[38],"condition.":[39],"CASE":[40],"PRESENTATION:":[41],"A":[42],"24-year-old":[43],"Yemeni":[44],"female":[45],"hypophosphatemic":[47,177],"presented":[49],"to":[50,117,166,174,193,207,216,219],"an":[51,153],"endocrinologist":[52],"severe":[54,57,74,171],"weakness":[55],"pain":[58],"the":[60,67,94,103,109,185,191],"extremities,":[61],"she":[62,122,128,146,169],"had":[63,170,180],"been":[64,182],"bedridden":[65,198],"for":[66,156,199],"last":[68],"4":[69,200],"years.":[70,201],"Bone":[71],"density":[72],"showed":[73],"osteoporosis":[75,172],"(T":[76],"score":[77,85,92,101],"hip":[79,87],"was":[80,88,96,105,111,123,133,147],"-":[81,89,97,106],"5.0":[82],"Z":[84,100],"5.0,":[90],"T":[91],"spine":[95,104],"6.0":[98],"6.1)":[107],"so":[108],"patient":[110,163,186],"started":[112],"on":[113],"addition":[116,165],"calcitriol":[118,167],"after":[120,141,196],"7months":[121],"feeling":[124],"stronger":[125],"felt":[127],"could":[129],"stand":[130],"assisted":[131],"walking":[134,148],"assistance":[136],"within":[137],"9":[138],"months":[139],"1.5":[142],"years":[143],"treatment":[145,155],"unassisted.":[149],"CONCLUSION:":[150],"Denosumab":[151],"effective":[154],"osteoporosis,":[157],"we":[158],"used":[159],"it":[160],"our":[162],"because":[168],"due":[173],"long":[175],"standing":[176],"not":[181],"treated":[183],"properly,":[184],"improved":[187],"markedly":[188],"regained":[190],"ability":[192],"walk":[194],"again":[195],"being":[197],"It":[202],"may":[203],"be":[204,217],"drug":[206],"consider":[208],"such":[210],"cases":[211],"although":[212],"further":[213],"studies":[214],"need":[215],"done":[218],"confirm":[220],"this.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-02-15T00:00:00"}