{"id":"https://openalex.org/W3127024016","doi":"https://doi.org/10.3389/fimmu.2020.589048","title":"JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages","display_name":"JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages","publication_year":2021,"publication_date":"2021-02-08","ids":{"openalex":"https://openalex.org/W3127024016","doi":"https://doi.org/10.3389/fimmu.2020.589048","mag":"3127024016","pmid":"https://pubmed.ncbi.nlm.nih.gov/33628203","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7897702"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2020.589048","doi":"https://doi.org/10.3389/fimmu.2020.589048","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.589048","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.589048/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.589048/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103040078","display_name":"Rongqing Li","orcid":"https://orcid.org/0009-0003-6202-9407","observed_orcids":["https://orcid.org/0009-0003-6202-9407","https://orcid.org/0000-0003-1501-6171"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Rongqing Li","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Na Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN","JP"],"is_corresponding":false,"raw_author_name":"Na Sun","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363115","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0003-1871-4477","observed_orcids":["https://orcid.org/0000-0003-1871-4477"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609751","display_name":"Xueqin Li","orcid":"https://orcid.org/0000-0001-5270-4825","observed_orcids":["https://orcid.org/0000-0001-5270-4825","https://orcid.org/0009-0001-7671-5403"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueqin Li","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008845532","display_name":"Jie Zhao","orcid":"https://orcid.org/0000-0002-0096-637X","observed_orcids":["https://orcid.org/0000-0002-0096-637X","https://orcid.org/0000-0002-8795-2770"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhao","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027106575","display_name":"Wanpeng Cheng","orcid":"https://orcid.org/0000-0003-2471-5273","observed_orcids":["https://orcid.org/0000-0003-2471-5273"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanpeng Cheng","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101406880","display_name":"Hui Hua","orcid":"https://orcid.org/0000-0002-8229-5492","observed_orcids":["https://orcid.org/0000-0002-8229-5492"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Hua","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065422079","display_name":"Masahiko Fukatsu","orcid":"https://orcid.org/0000-0002-7957-0000","observed_orcids":["https://orcid.org/0000-0002-7957-0000"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Fukatsu","raw_affiliation_strings":["The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110742139","display_name":"Hirotaka Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Mori","raw_affiliation_strings":["The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633838","display_name":"Hiroshi Takahashi","orcid":"https://orcid.org/0000-0002-6563-7729","observed_orcids":["https://orcid.org/0000-0002-6563-7729"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takahashi","raw_affiliation_strings":["The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024928427","display_name":"Hiroshi Ohkawara","orcid":"https://orcid.org/0000-0002-3129-1977","observed_orcids":["https://orcid.org/0000-0002-3129-1977"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ohkawara","raw_affiliation_strings":["The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051504544","display_name":"Miwa Fukami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miwa Fukami","raw_affiliation_strings":["The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793448","display_name":"Masatoshi Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257969","display_name":"Jusendo Hospital","ror":"https://ror.org/05wg82p98","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405257969"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masatoshi Okamoto","raw_affiliation_strings":["Department of Hematology, YUASA Foundation Jusendo General Hospital, Koriyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, YUASA Foundation Jusendo General Hospital, Koriyama, Japan","institution_ids":["https://openalex.org/I4405257969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592962","display_name":"Yoichi Hamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256039","display_name":"Iwaki City Medical Center","ror":"https://ror.org/03psq8c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256039"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Hamazaki","raw_affiliation_strings":["Department of Hematology, Iwaki City Medical Center, Iwaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Iwaki City Medical Center, Iwaki, Japan","institution_ids":["https://openalex.org/I4405256039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115595768","display_name":"Kuiyang Zheng","orcid":"https://orcid.org/0009-0003-4568-3888","observed_orcids":["https://orcid.org/0009-0003-4568-3888"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kuiyang Zheng","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101780983","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0003-2002-2947","observed_orcids":["https://orcid.org/0000-0003-2002-2947"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051889915","display_name":"Takayuki Ikezoe","orcid":"https://orcid.org/0000-0002-7858-278X","observed_orcids":["https://orcid.org/0000-0002-7858-278X"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takayuki Ikezoe","raw_affiliation_strings":["The Department of Hematology, Fukushima Medical University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hematology, Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051889915","https://openalex.org/A5101780983"],"corresponding_institution_ids":["https://openalex.org/I130830085","https://openalex.org/I177388780"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.7804,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84754843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"589048","last_page":"589048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7480000257492065},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.906000018119812},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/pkm1","display_name":"PKM1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/chaperone-mediated-autophagy","display_name":"chaperone-mediated autophagy","score":0.972000002861023},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5100534558296204},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5085865259170532},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4953659772872925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4899841845035553},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4893190562725067},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4752224087715149},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4157397150993347},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37746134400367737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33118313550949097},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32094788551330566},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20653235912322998},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.18003711104393005},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15959811210632324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15139314532279968},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09328493475914001},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08983081579208374}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2020.589048","doi":"https://doi.org/10.3389/fimmu.2020.589048","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.589048","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.589048/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:33628203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33628203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7897702","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7897702/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f2e7910c66fd46ee91f514e64761a9e6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2e7910c66fd46ee91f514e64761a9e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2020.589048","doi":"https://doi.org/10.3389/fimmu.2020.589048","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.589048","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.589048/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2553764879","display_name":"Development of a novel treatment strategy to protect vascular endothelial cells with TM mutant","funder_award_id":"18H02844","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3127024016.pdf","grobid_xml":"https://content.openalex.org/works/W3127024016.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1544249031","https://openalex.org/W1965543435","https://openalex.org/W1977932388","https://openalex.org/W2015207840","https://openalex.org/W2021426948","https://openalex.org/W2026621967","https://openalex.org/W2028966742","https://openalex.org/W2029255902","https://openalex.org/W2077084538","https://openalex.org/W2077231697","https://openalex.org/W2078608203","https://openalex.org/W2089551665","https://openalex.org/W2094457899","https://openalex.org/W2135551354","https://openalex.org/W2150107812","https://openalex.org/W2153586956","https://openalex.org/W2296002833","https://openalex.org/W2339682850","https://openalex.org/W2466769121","https://openalex.org/W2621661262","https://openalex.org/W2767705208","https://openalex.org/W2769004457","https://openalex.org/W2891613655","https://openalex.org/W2904599501","https://openalex.org/W2909022970","https://openalex.org/W2911435756","https://openalex.org/W2920838111","https://openalex.org/W2962017319","https://openalex.org/W2973311260","https://openalex.org/W3000217587","https://openalex.org/W3005678720","https://openalex.org/W3011817128","https://openalex.org/W3041438918"],"related_works":["https://openalex.org/W4313374516","https://openalex.org/W4415051765","https://openalex.org/W7099388786","https://openalex.org/W1852968885","https://openalex.org/W4413107006","https://openalex.org/W2092971614","https://openalex.org/W2533144509","https://openalex.org/W2110210855","https://openalex.org/W2076145355","https://openalex.org/W2070330288"],"abstract_inverted_index":{"A":[0],"substitution":[1],"mutation":[2,46,96,138,157],"of":[3,12,26,32,65,83,91,109,113,127,146,167],"valine":[4],"to":[5,140,165],"phenylalanine":[6],"at":[7],"codon":[8],"encoding":[9],"position":[10],"617":[11],"the":[13,41,63,89,94,136,155],"Janus":[14],"kinase":[15],"2":[16],"(JAK2)":[17],"gene":[18],"(JAK2V617F)":[19],"has":[20],"been":[21],"detected":[22],"in":[23,70,73,78,104,117],"myeloid":[24],"cells":[25],"some":[27],"individuals":[28],"with":[29,75,99,106,119],"higher":[30],"levels":[31,64],"proinflammatory":[33],"cytokine":[34],"production":[35,90,131],"such":[36],"as":[37],"interleukin":[38],"(IL)-6.":[39],"However,":[40,81],"mechanisms":[42],"by":[43,85],"which":[44],"JAK2V617F":[45,71,95,137,156],"mediating":[47],"those":[48],"cytokines":[49],"remain":[50],"unclear.":[51],"We,":[52],"therefore,":[53],"established":[54],"JAK2V617F-expressing":[55],"murine":[56],"macrophages":[57,72,98],"(JAK2V617F":[58],"macrophages)":[59],"and":[60,169],"found":[61],"that":[62,154],"p-STAT3":[66],"were":[67],"markedly":[68],"elevated":[69,101,129],"association":[74],"an":[76,100],"increase":[77],"IL-6":[79,121,130,171],"production.":[80,122,172],"inhibition":[82],"STAT3":[84,116,133,168],"C188-9":[86],"significantly":[87],"decreased":[88],"IL-6.":[92],"Furthermore,":[93],"endowed":[97],"glycolytic":[102],"phenotype":[103],"parallel":[105,118],"aberrant":[107],"expression":[108,126],"PKM1.":[110],"Interestingly,":[111],"silencing":[112],"PKM1":[114,128,141,160],"inactivated":[115],"reduced":[120],"In":[123],"contrast,":[124],"ectopic":[125],"via":[132,144,149],"activation.":[134],"Importantly,":[135],"contributed":[139],"protein":[142],"stabilization":[143],"blockade":[145],"lysosomal-dependent":[147],"degradation":[148],"chaperone-mediated":[150],"autophagy":[151],"(CMA),":[152],"indicating":[153],"could":[158],"protect":[159],"from":[161],"CMA-mediated":[162],"degradation,":[163],"leading":[164],"activation":[166],"promoting":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-02-15T00:00:00"}