{"id":"https://openalex.org/W3127020148","doi":"https://doi.org/10.1039/d0cy02426k","title":"Engineering the large pocket of an ( S )-selective transaminase for asymmetric synthesis of ( S )-1-amino-1-phenylpropane","display_name":"Engineering the large pocket of an ( S )-selective transaminase for asymmetric synthesis of ( S )-1-amino-1-phenylpropane","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3127020148","doi":"https://doi.org/10.1039/d0cy02426k","mag":"3127020148"},"language":"en","primary_location":{"id":"doi:10.1039/d0cy02426k","doi":"https://doi.org/10.1039/d0cy02426k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d0cy02426k","pdf_url":null,"source":{"id":"https://openalex.org/S2482773761","display_name":"Catalysis Science & Technology","issn_l":"2044-4753","issn":["2044-4753","2044-4761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Catalysis Science &amp; Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000560957","display_name":"Youyu Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4391768089","display_name":"State Key Laboratory of Bioreactor Engineering","ror":"https://ror.org/02hqczw19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youyu Xie","raw_affiliation_strings":["East China University of Science and Technology","New World Institute of Biotechnology","People's Republic of China","Shanghai 200237","State Key Laboratory of Bioreactor Engineering","State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"New World Institute of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Shanghai 200237","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering","institution_ids":["https://openalex.org/I4391768089"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China","institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018896568","display_name":"Feng Xu","orcid":"https://orcid.org/0000-0002-9168-561X","observed_orcids":["https://orcid.org/0000-0002-9168-561X"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4391768089","display_name":"State Key Laboratory of Bioreactor Engineering","ror":"https://ror.org/02hqczw19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Xu","raw_affiliation_strings":["East China University of Science and Technology","New World Institute of Biotechnology","People's Republic of China","Shanghai 200237","State Key Laboratory of Bioreactor Engineering","State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"New World Institute of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Shanghai 200237","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering","institution_ids":["https://openalex.org/I4391768089"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China","institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101560429","display_name":"Lin Yang","orcid":"https://orcid.org/0009-0007-5352-3058","observed_orcids":["https://orcid.org/0009-0007-5352-3058"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4391768089","display_name":"State Key Laboratory of Bioreactor Engineering","ror":"https://ror.org/02hqczw19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["East China University of Science and Technology","New World Institute of Biotechnology","People's Republic of China","Shanghai 200237","State Key Laboratory of Bioreactor Engineering","State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"New World Institute of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Shanghai 200237","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering","institution_ids":["https://openalex.org/I4391768089"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China","institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}]},{"author_position":"middle","author":{"id":null,"display_name":"He Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4391768089","display_name":"State Key Laboratory of Bioreactor Engineering","ror":"https://ror.org/02hqczw19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He Liu","raw_affiliation_strings":["East China University of Science and Technology","New World Institute of Biotechnology","People's Republic of China","Shanghai 200237","State Key Laboratory of Bioreactor Engineering","State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"New World Institute of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Shanghai 200237","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering","institution_ids":["https://openalex.org/I4391768089"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China","institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075750829","display_name":"Xiangyang Xu","orcid":"https://orcid.org/0000-0002-1364-7941","observed_orcids":["https://orcid.org/0000-0002-1364-7941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangyang Xu","raw_affiliation_strings":["PR China","Zaozhuang Jienuo Enzyme Co., Ltd","Zaozhuang Jienuo Enzyme Co., Ltd., Shandong Province 277116, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PR China","institution_ids":[]},{"raw_affiliation_string":"Zaozhuang Jienuo Enzyme Co., Ltd","institution_ids":[]},{"raw_affiliation_string":"Zaozhuang Jienuo Enzyme Co., Ltd., Shandong Province 277116, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007689920","display_name":"Hualei Wang","orcid":"https://orcid.org/0000-0002-0111-753X","observed_orcids":["https://orcid.org/0000-0002-0111-753X"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4391768089","display_name":"State Key Laboratory of Bioreactor Engineering","ror":"https://ror.org/02hqczw19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hualei Wang","raw_affiliation_strings":["East China University of Science and Technology","New World Institute of Biotechnology","People's Republic of China","Shanghai 200237","State Key Laboratory of Bioreactor Engineering","State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-0111-753X","affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"New World Institute of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Shanghai 200237","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering","institution_ids":["https://openalex.org/I4391768089"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China","institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046398218","display_name":"Dongzhi Wei","orcid":"https://orcid.org/0000-0003-3655-3937","observed_orcids":["https://orcid.org/0000-0003-3655-3937"]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4391768089","display_name":"State Key Laboratory of Bioreactor Engineering","ror":"https://ror.org/02hqczw19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongzhi Wei","raw_affiliation_strings":["East China University of Science and Technology","New World Institute of Biotechnology","People's Republic of China","Shanghai 200237","State Key Laboratory of Bioreactor Engineering","State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-3655-3937","affiliations":[{"raw_affiliation_string":"East China University of Science and Technology","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"New World Institute of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Shanghai 200237","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering","institution_ids":["https://openalex.org/I4391768089"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China","institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007689920","https://openalex.org/A5046398218"],"corresponding_institution_ids":["https://openalex.org/I143593769","https://openalex.org/I4391768089"],"apc_list":null,"apc_paid":null,"fwci":0.6307,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.59743297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"11","issue":"7","first_page":"2461","last_page":"2470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amine-transaminase","display_name":"amine transaminase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/enzyme-engineering","display_name":"enzyme engineering","score":0.6420000195503235},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chiral-amines","display_name":"chiral amines","score":0.9480000138282776},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.8487061262130737},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.7734329700469971},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5926942229270935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.581858217716217},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.5747672915458679},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4555354118347168},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38964295387268066},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3518208861351013},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.33424365520477295},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10162666440010071}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/d0cy02426k","doi":"https://doi.org/10.1039/d0cy02426k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d0cy02426k","pdf_url":null,"source":{"id":"https://openalex.org/S2482773761","display_name":"Catalysis Science & Technology","issn_l":"2044-4753","issn":["2044-4753","2044-4761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Catalysis Science &amp; Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3969276354","display_name":"\u77ed\u94fe\u8131\u6c22\u9176\u5e95\u7269\u8bc6\u522b\u7684\u5206\u5b50\u57fa\u7840\u53ca\u5176\u7acb\u4f53\u9009\u62e9\u6027\u5f62\u6210\u673a\u5236\u7814\u7a76","funder_award_id":"21776084","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4212725738","display_name":null,"funder_award_id":"22078097","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1662068511","https://openalex.org/W1932985359","https://openalex.org/W1937735508","https://openalex.org/W1975304761","https://openalex.org/W1975801495","https://openalex.org/W1986056153","https://openalex.org/W1993266050","https://openalex.org/W1998899760","https://openalex.org/W2004269755","https://openalex.org/W2024851405","https://openalex.org/W2029142249","https://openalex.org/W2054979333","https://openalex.org/W2056183134","https://openalex.org/W2060809301","https://openalex.org/W2086149891","https://openalex.org/W2090774371","https://openalex.org/W2107677212","https://openalex.org/W2111817148","https://openalex.org/W2125469569","https://openalex.org/W2128635872","https://openalex.org/W2133919510","https://openalex.org/W2153433577","https://openalex.org/W2157858198","https://openalex.org/W2168974130","https://openalex.org/W2496645452","https://openalex.org/W2524638452","https://openalex.org/W2528127298","https://openalex.org/W2528204036","https://openalex.org/W2600356273","https://openalex.org/W2605966849","https://openalex.org/W2610922899","https://openalex.org/W2751746672","https://openalex.org/W2767029048","https://openalex.org/W2778939204","https://openalex.org/W2809826342","https://openalex.org/W2892995761","https://openalex.org/W2898223435","https://openalex.org/W2954921771","https://openalex.org/W2967405228","https://openalex.org/W2989273215","https://openalex.org/W3039234454"],"related_works":["https://openalex.org/W2528204036","https://openalex.org/W2496645452","https://openalex.org/W2783968834","https://openalex.org/W2782078732","https://openalex.org/W7064466043","https://openalex.org/W4363650041","https://openalex.org/W2947194549","https://openalex.org/W2950160441","https://openalex.org/W4393147898","https://openalex.org/W7167102879"],"abstract_inverted_index":{"Amine":[0],"transaminases":[1],"offer":[2],"an":[3],"environmentally":[4],"benign":[5],"chiral":[6],"amine":[7],"asymmetric":[8],"synthesis":[9],"route.":[10]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-15T00:00:00"}
