{"id":"https://openalex.org/W3125594975","doi":"https://doi.org/10.3389/fimmu.2020.579151","title":"Donor-Derived Myeloid Heme Oxygenase-1 Controls the Development of Graft-Versus-Host Disease","display_name":"Donor-Derived Myeloid Heme Oxygenase-1 Controls the Development of Graft-Versus-Host Disease","publication_year":2021,"publication_date":"2021-01-18","ids":{"openalex":"https://openalex.org/W3125594975","doi":"https://doi.org/10.3389/fimmu.2020.579151","mag":"3125594975","pmid":"https://pubmed.ncbi.nlm.nih.gov/33537027","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7849683"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2020.579151","doi":"https://doi.org/10.3389/fimmu.2020.579151","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.579151","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.579151/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.579151/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052916444","display_name":"Chlo\u00e9 Spilleboudt","orcid":"https://orcid.org/0000-0002-8009-403X","observed_orcids":["https://orcid.org/0000-0002-8009-403X"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Chlo\u00e9 Spilleboudt","raw_affiliation_strings":["Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046405694","display_name":"Virginie De Wilde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Virginie De Wilde","raw_affiliation_strings":["Erasme Hospital, Hematology Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasme Hospital, Hematology Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102706406","display_name":"Philippe Lewalle","orcid":"https://orcid.org/0009-0005-6483-9782","observed_orcids":["https://orcid.org/0009-0005-6483-9782"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe Lewalle","raw_affiliation_strings":["Jules Bordet Institute, Hematology Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jules Bordet Institute, Hematology Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063346641","display_name":"Ludovic Cabanne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ludovic Cabanne","raw_affiliation_strings":["AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067800144","display_name":"Mathieu Leclerc","orcid":"https://orcid.org/0000-0001-9426-0257","observed_orcids":["https://orcid.org/0000-0001-9426-0257"]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Leclerc","raw_affiliation_strings":["AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066351481","display_name":"Florence Beckerich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florence Beckerich","raw_affiliation_strings":["AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084671985","display_name":"Dominique Bories","orcid":"https://orcid.org/0000-0003-0444-7056","observed_orcids":["https://orcid.org/0000-0003-0444-7056"]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Bories","raw_affiliation_strings":["AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023694981","display_name":"S\u00edlvia Cardoso","orcid":"https://orcid.org/0000-0003-4639-698X","observed_orcids":["https://orcid.org/0000-0003-4639-698X"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Silvia Cardoso","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067643807","display_name":"Miguel Parreira Soares","orcid":"https://orcid.org/0000-0002-9314-4833","observed_orcids":["https://orcid.org/0000-0002-9314-4833"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel P. Soares","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000964288","display_name":"Beno\u00eet Vokaer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Vokaer","raw_affiliation_strings":["Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025178319","display_name":"Jean\u2010Michel Hougardy","orcid":"https://orcid.org/0000-0002-7769-5360","observed_orcids":["https://orcid.org/0000-0002-7769-5360"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Michel Hougardy","raw_affiliation_strings":["Erasme Hospital, Nephrology and Internal Medicine Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasme Hospital, Nephrology and Internal Medicine Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035759942","display_name":"V\u00e9ronique Flamand","orcid":"https://orcid.org/0000-0002-8906-3758","observed_orcids":["https://orcid.org/0000-0002-8906-3758"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Flamand","raw_affiliation_strings":["Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023072513","display_name":"Judith Racap\u00e9","orcid":"https://orcid.org/0000-0002-1266-0191","observed_orcids":["https://orcid.org/0000-0002-1266-0191"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Judith Racap\u00e9","raw_affiliation_strings":["Centre de Recherche \u00c9pid\u00e9miologie, Biostatistique et Recherche clinique, \u00c9cole de Sant\u00e9 Publique, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","Erasme Hospital, Nephrology and Internal Medicine Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche \u00c9pid\u00e9miologie, Biostatistique et Recherche clinique, \u00c9cole de Sant\u00e9 Publique, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Erasme Hospital, Nephrology and Internal Medicine Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089852959","display_name":"Marc Joel Abramowicz","orcid":"https://orcid.org/0000-0003-0623-8768","observed_orcids":["https://orcid.org/0000-0003-0623-8768"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marc Abramowicz","raw_affiliation_strings":["Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011668592","display_name":"S\u00e9bastien Maury","orcid":"https://orcid.org/0000-0002-1170-8683","observed_orcids":["https://orcid.org/0000-0002-1170-8683"]},"institutions":[{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013","https://openalex.org/I2800365227"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Maury","raw_affiliation_strings":["AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Henri Mondor, Department of Hematology, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]},{"raw_affiliation_string":"University Paris Est Cr\u00e9teil (UPEC), Cr\u00e9teil, France","institution_ids":["https://openalex.org/I197681013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067808520","display_name":"Ala\u00edn Le Moine","orcid":"https://orcid.org/0000-0001-7575-9255","observed_orcids":["https://orcid.org/0000-0001-7575-9255"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Alain Le Moine","raw_affiliation_strings":["Erasme Hospital, Nephrology and Internal Medicine Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erasme Hospital, Nephrology and Internal Medicine Department, Universit\u00e9 libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]},{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5052916444","https://openalex.org/A5067808520"],"corresponding_institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.8146,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69806243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"11","issue":null,"first_page":"579151","last_page":"579151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/t-cell-alloreactivity","display_name":"T cell alloreactivity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/heme-degradation","display_name":"heme degradation","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2779730776","wikidata":"https://www.wikidata.org/wiki/Q5631153","display_name":"HMOX1","level":5,"score":0.7709465026855469},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.6860030889511108},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6053113341331482},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5864999294281006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5791094303131104},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5412601232528687},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.5316551327705383},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5191256403923035},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5126621127128601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4970746338367462},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.49624544382095337},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.35693028569221497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.325480580329895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23889285326004028},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1087496280670166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10808950662612915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2020.579151","doi":"https://doi.org/10.3389/fimmu.2020.579151","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.579151","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.579151/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7849683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7849683","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:33537027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33537027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/320366","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/320366","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in immunology, 11","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/320480","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/320480","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in immunology, 11","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:bf844a85d1ce4939bdde8c6a1163b84d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bf844a85d1ce4939bdde8c6a1163b84d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2020.579151","doi":"https://doi.org/10.3389/fimmu.2020.579151","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.579151","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.579151/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315775","display_name":"Fonds Erasme","ror":"https://ror.org/01mdyh744"},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3125594975.pdf","grobid_xml":"https://content.openalex.org/works/W3125594975.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W193514409","https://openalex.org/W953222022","https://openalex.org/W1600690434","https://openalex.org/W1905243364","https://openalex.org/W1921451985","https://openalex.org/W1967207824","https://openalex.org/W1967894154","https://openalex.org/W1969061377","https://openalex.org/W1970068943","https://openalex.org/W1971080924","https://openalex.org/W1975281156","https://openalex.org/W1988906407","https://openalex.org/W1991565364","https://openalex.org/W1992754142","https://openalex.org/W1998226797","https://openalex.org/W1999569754","https://openalex.org/W2001382332","https://openalex.org/W2006626672","https://openalex.org/W2009521826","https://openalex.org/W2013496788","https://openalex.org/W2014941431","https://openalex.org/W2017467835","https://openalex.org/W2021369287","https://openalex.org/W2022380404","https://openalex.org/W2023332062","https://openalex.org/W2027424250","https://openalex.org/W2027427419","https://openalex.org/W2028502712","https://openalex.org/W2032159980","https://openalex.org/W2044916014","https://openalex.org/W2045254759","https://openalex.org/W2050231750","https://openalex.org/W2053713912","https://openalex.org/W2059625939","https://openalex.org/W2060672294","https://openalex.org/W2065210647","https://openalex.org/W2070855360","https://openalex.org/W2071015953","https://openalex.org/W2083415995","https://openalex.org/W2084332691","https://openalex.org/W2090132467","https://openalex.org/W2102446851","https://openalex.org/W2108217572","https://openalex.org/W2109360536","https://openalex.org/W2116705704","https://openalex.org/W2124919802","https://openalex.org/W2128312300","https://openalex.org/W2135917418","https://openalex.org/W2139754464","https://openalex.org/W2144630241","https://openalex.org/W2145005876","https://openalex.org/W2152561959","https://openalex.org/W2157325100","https://openalex.org/W2158281895","https://openalex.org/W2159602242","https://openalex.org/W2162853795","https://openalex.org/W2166803343","https://openalex.org/W2219486185","https://openalex.org/W2298261633","https://openalex.org/W2403145592","https://openalex.org/W2412247228","https://openalex.org/W2471500324","https://openalex.org/W2565288403","https://openalex.org/W2565310583","https://openalex.org/W2585558237","https://openalex.org/W2769990542","https://openalex.org/W2792681620","https://openalex.org/W2802982213","https://openalex.org/W2810724782","https://openalex.org/W2895369816","https://openalex.org/W2897442673","https://openalex.org/W2902983626","https://openalex.org/W3005956088","https://openalex.org/W3015250769","https://openalex.org/W3023823988","https://openalex.org/W3044828702"],"related_works":["https://openalex.org/W4408403782","https://openalex.org/W2403145592","https://openalex.org/W4250063202","https://openalex.org/W2978146824","https://openalex.org/W2565310583","https://openalex.org/W2563181505","https://openalex.org/W6966705623","https://openalex.org/W2291303648","https://openalex.org/W2009814627","https://openalex.org/W2050231750"],"abstract_inverted_index":{"Graft-versus-host":[0],"disease":[1],"(GVHD)":[2],"remains":[3],"a":[4,119,151,215],"major":[5],"clinical":[6,96],"drawback":[7],"of":[8,49,58,66,98,107,141,172,179,201],"allogeneic":[9,36,70,80],"hematopoietic":[10,37,113],"stem":[11,38,114],"cell":[12,39,93],"transplantation":[13,40],"(HSCT).":[14],"Here,":[15],"we":[16,167,184],"investigated":[17],"how":[18],"the":[19,50,55,64,87,127,169,177,190,199,233],"stress":[20],"responsive":[21],"heme":[22,25],"catabolizing":[23],"enzyme":[24],"oxygenase-1":[26],"(HO-1,":[27],"encoded":[28],"by":[29,188],"HMOX1)":[30],"regulates":[31],"GVHD":[32,68,75,145,182,204],"in":[33,41,54,76,86,103,126,176,205,226],"response":[34],"to":[35,148,231],"mice":[42,77],"and":[43,183,198,222],"humans.":[44],"We":[45],"found":[46],"that":[47],"deletion":[48],"Hmox1":[51],"allele,":[52],"specifically":[53],"myeloid":[56,88,174,212],"compartment":[57,89],"mouse":[59],"donor":[60],"bone":[61,81],"marrow,":[62],"promotes":[63],"development":[65],"aggressive":[67],"after":[69],"transplantation.":[71],"The":[72,95],"mechanism":[73],"driving":[74],"transplanted":[78,111],"with":[79,112,133,160],"marrow":[82],"lacking":[83],"HO-1":[84,135,162,175,213,234],"expression":[85],"involves":[90],"enhanced":[91],"T":[92],"alloreactivity.":[94],"relevance":[97],"these":[99],"observations":[100],"was":[101],"validated":[102],"two":[104,206],"independent":[105,207,239],"cohorts":[106],"HSCT":[108,208,220,227],"patients.":[109],"Individuals":[110],"cells":[115],"from":[116],"donors":[117,149],"carrying":[118,150],"long":[120],"homozygous":[121],"(GT)n":[122,153,195],"repeat":[123,154],"polymorphism":[124,158],"(L/L)":[125],"HMOX1":[128,194],"promoter,":[129],"which":[130],"is":[131],"associated":[132,159],"lower":[134],"expression,":[136],"were":[137],"at":[138],"higher":[139,161],"risk":[140,240],"developing":[142,243],"severe":[143,202,244],"acute":[144,203,245],"as":[146,237],"compared":[147],"short":[152],"(S/L":[155],"or":[156],"S/S)":[157],"expression.":[163],"In":[164],"this":[165,186],"study,":[166],"showed":[168],"unique":[170],"importance":[171],"donor-derived":[173],"prevention":[178],"lethal":[180],"experimental":[181],"corroborated":[185],"observation":[187],"demonstrating":[189],"association":[191],"between":[192],"human":[193],"microsatellite":[196],"polymorphisms":[197],"incidence":[200],"patient":[209],"cohorts.":[210],"Donor-derived":[211],"constitutes":[214],"potential":[216],"therapeutic":[217],"target":[218],"for":[219,242],"patients":[221,228],"large-scale":[223],"prospective":[224],"studies":[225],"are":[229],"necessary":[230],"validate":[232],"L/L":[235],"genotype":[236],"an":[238],"factor":[241],"GVHD.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-02-01T00:00:00"}