{"id":"https://openalex.org/W3124829985","doi":"https://doi.org/10.1055/s-0040-1722283","title":"Merlin-Deficient Schwann Cells Are More Susceptible to Radiation Injury than Normal Schwann Cells In Vitro","display_name":"Merlin-Deficient Schwann Cells Are More Susceptible to Radiation Injury than Normal Schwann Cells In Vitro","publication_year":2021,"publication_date":"2021-01-19","ids":{"openalex":"https://openalex.org/W3124829985","doi":"https://doi.org/10.1055/s-0040-1722283","mag":"3124829985","pmid":"https://pubmed.ncbi.nlm.nih.gov/35769808","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236706"},"language":"en","primary_location":{"id":"doi:10.1055/s-0040-1722283","doi":"https://doi.org/10.1055/s-0040-1722283","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0040-1722283","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052274304","display_name":"Erin R. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Cohen","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008579910","display_name":"Stefanie Pe\u00f1a","orcid":"https://orcid.org/0000-0001-5891-5762","observed_orcids":["https://orcid.org/0000-0001-5891-5762"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefanie Pena","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":"https://orcid.org/0000-0001-5891-5762","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040917569","display_name":"Christine Mei","orcid":"https://orcid.org/0000-0003-3990-5686","observed_orcids":["https://orcid.org/0000-0003-3990-5686"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Mei","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011081270","display_name":"Olena R. Bracho","orcid":"https://orcid.org/0009-0002-2848-8450","observed_orcids":["https://orcid.org/0009-0002-2848-8450"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olena Bracho","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074559844","display_name":"Brian Marples","orcid":"https://orcid.org/0000-0002-8684-4372","observed_orcids":["https://orcid.org/0000-0002-8684-4372"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Marples","raw_affiliation_strings":["Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069399364","display_name":"Nagy Elsayyad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nagy Elsayyad","raw_affiliation_strings":["Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022198589","display_name":"Stefania Goncalves","orcid":"https://orcid.org/0000-0003-3330-0918","observed_orcids":["https://orcid.org/0000-0003-3330-0918"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefania Goncalves","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065665254","display_name":"Michael E. Ivan","orcid":"https://orcid.org/0000-0002-4798-4989","observed_orcids":["https://orcid.org/0000-0002-4798-4989"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ivan","raw_affiliation_strings":["Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047365511","display_name":"Paula V. Monje","orcid":"https://orcid.org/0000-0002-5274-9238","observed_orcids":["https://orcid.org/0000-0002-5274-9238"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula V. Monje","raw_affiliation_strings":["Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States","Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101033542","display_name":"Xue-Zhong Liu","orcid":"https://orcid.org/0000-0002-4758-6470","observed_orcids":["https://orcid.org/0000-0002-4758-6470"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue-Zhong Liu","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072602710","display_name":"Cristina Fern\u00e1ndez\u2010Valle","orcid":"https://orcid.org/0000-0002-6718-1243","observed_orcids":["https://orcid.org/0000-0002-6718-1243"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Fernandez-Valle","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091826521","display_name":"Fred F. Telischi","orcid":"https://orcid.org/0000-0002-2596-6341","observed_orcids":["https://orcid.org/0000-0002-2596-6341"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Telischi","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014026286","display_name":"Christine Thuyvan Dinh","orcid":"https://orcid.org/0000-0001-8138-1770","observed_orcids":["https://orcid.org/0000-0001-8138-1770"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christine T. Dinh","raw_affiliation_strings":["Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014026286"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":0.5284,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58919319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"83","issue":"03","first_page":"228","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vestibular-schwannoma","display_name":"vestibular schwannoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/merlin","display_name":"Merlin","score":0.7009999752044678},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/radiation-injury","display_name":"radiation injury","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stereotactic-radiosurgery","display_name":"stereotactic radiosurgery","score":0.8330000042915344},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.593999981880188},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.746999979019165},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.796999990940094},{"id":"https://openalex.org/keywords/radiobiology","display_name":"radiation biology","score":0.6899999976158142},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.6432098150253296},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6267836093902588},{"id":"https://openalex.org/C178628643","wikidata":"https://www.wikidata.org/wiki/Q410233","display_name":"Merlin (protein)","level":4,"score":0.5929932594299316},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5701245069503784},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5381798148155212},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.5017364025115967},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.469745934009552},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46687549352645874},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4664216637611389},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.45647957921028137},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.4390132427215576},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.4285753071308136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4171801209449768},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4110392928123474},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.38725146651268005},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3362254798412323},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33186429738998413},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.2830703854560852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2817293405532837},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2629181742668152},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1657520830631256},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11454859375953674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10555568337440491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1050383448600769},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08967894315719604},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1055/s-0040-1722283","doi":"https://doi.org/10.1055/s-0040-1722283","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0040-1722283","pdf_url":null,"source":{"id":"https://openalex.org/S4210197100","display_name":"Journal of Neurological Surgery Part B Skull Base","issn_l":"2193-6331","issn":["2193-6331","2193-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurological Surgery Part B: Skull Base","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9236706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Surg B Skull Base","raw_type":"Text"},{"id":"pmid:35769808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35769808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurological surgery. Part B, Skull base","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/34399","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/34399","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9236706","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Surg B Skull Base","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6650716993","display_name":"Identification of Novel Drug Targets For Use in Preventing Deafness Caused by NF2","funder_award_id":"R01DC010189","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W105668805","https://openalex.org/W1561724352","https://openalex.org/W1608714724","https://openalex.org/W1694492712","https://openalex.org/W1752089945","https://openalex.org/W1783508367","https://openalex.org/W1790916114","https://openalex.org/W1977658535","https://openalex.org/W1997729527","https://openalex.org/W1998129814","https://openalex.org/W2003826324","https://openalex.org/W2006835890","https://openalex.org/W2011139344","https://openalex.org/W2015181794","https://openalex.org/W2016927451","https://openalex.org/W2022811243","https://openalex.org/W2028585531","https://openalex.org/W2042119456","https://openalex.org/W2042567095","https://openalex.org/W2050088647","https://openalex.org/W2058433782","https://openalex.org/W2058800908","https://openalex.org/W2077814905","https://openalex.org/W2108745864","https://openalex.org/W2126404651","https://openalex.org/W2130351327","https://openalex.org/W2142911989","https://openalex.org/W2150149139","https://openalex.org/W2164995160","https://openalex.org/W2168211519","https://openalex.org/W2169637630","https://openalex.org/W2170008898","https://openalex.org/W2172819759","https://openalex.org/W2513632767","https://openalex.org/W2549827258","https://openalex.org/W2560817401","https://openalex.org/W2592315804","https://openalex.org/W2610280068","https://openalex.org/W2735833182","https://openalex.org/W2782642594","https://openalex.org/W2801349908","https://openalex.org/W2890128237","https://openalex.org/W2914292124","https://openalex.org/W3000438404","https://openalex.org/W3032448933","https://openalex.org/W6684715665"],"related_works":["https://openalex.org/W4214753926","https://openalex.org/W3196005740","https://openalex.org/W3142857796","https://openalex.org/W3201452814","https://openalex.org/W6889826310","https://openalex.org/W2885310342","https://openalex.org/W2168211519","https://openalex.org/W2715718815","https://openalex.org/W2011811112","https://openalex.org/W6997864694"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"Vestibular":[2],"schwannomas":[3],"(VS)":[4],"are":[5,9,227],"intracranial":[6],"tumors,":[7],"which":[8,158,191],"caused":[10],"by":[11],"NF2":[12],"gene":[13],"mutations":[14],"that":[15,213],"lead":[16],"to":[17,43,195,219,230,258],"loss":[18],"of":[19,31,38,53,79,141,153,176,185,240,247],"merlin":[20],"protein.":[21],"A":[22,150],"treatment":[23],"for":[24,254],"VS":[25,39,267],"is":[26,95,103,252],"stereotactic":[27],"radiosurgery,":[28],"a":[29,96,106],"form":[30],"radiation.":[32],"To":[33],"better":[34],"understand":[35],"the":[36,161,174,245],"radiobiology":[37,246],"and":[40,61,68,75,85,124,133,138,145,168,242,249],"radiation":[41,57,186,231,256,264],"toxicity":[42,265],"adjacent":[44],"structures,":[45],"our":[46],"main":[47],"objectives":[48],"were":[49,179,200],"(1)":[50,130],"investigate":[51],"effects":[52],"single":[54],"fraction":[55],"(SF)":[56],"on":[58,147],"viability,":[59,131],"cytotoxicity,":[60,132],"apoptosis":[62,134],"in":[63,73,105,114,164,166,204,206,235,266],"normal":[64,122,177,233,250],"Schwann":[65,70],"cells":[66,71,142],"(SCs)":[67],"merlin-deficient":[69],"(MD-SCs)":[72],"vitro,":[74],"(2)":[76,139],"analyze":[77],"expression":[78,239],"double":[80],"strand":[81],"DNA":[82,86],"breaks":[83],"(\u03b3-H2AX)":[84],"repair":[87],"protein":[88],"Rad51":[89,146,197],"following":[90],"irradiation.":[91],"Study":[92],"Design":[93],"This":[94,101],"basic":[97],"science":[98],"study.":[99,116],"Setting":[100],"study":[102],"conducted":[104],"research":[107],"laboratory.":[108],"Participants":[109],"Patients":[110],"did":[111],"not":[112],"participate":[113],"this":[115],"Main":[117],"Outcome":[118],"Measures":[119],"In":[120,172],"irradiated":[121,154],"SCs":[123,178,251],"MD-SCs":[125,155,208,226,248],"(0\u201318":[126],"Gy),":[127],"we":[128],"measured":[129],"using":[135],"cell-based":[136],"assays,":[137],"percentage":[140,152],"with":[143],"\u03b3-H2AX":[144,241],"immunofluorescence.":[148],"Results":[149],"high":[151],"expressed":[156],"\u03b3-H2AX,":[157],"may":[159,192,216],"explain":[160],"dose-dependent":[162],"losses":[163],"viability":[165,205],"rodent":[167],"human":[169,189,207],"cell":[170],"lines.":[171],"comparison,":[173],"viabilities":[175],"only":[180],"compromised":[181],"at":[182],"higher":[183],"doses":[184],"(>12":[187],"Gy,":[188,211],"SCs),":[190],"be":[193,217],"related":[194],"less":[196],"repair.":[198],"There":[199],"no":[201],"further":[202],"reductions":[203],"beyond":[209],"9":[210],"suggesting":[212],"<9":[214],"Gy":[215],"insufficient":[218],"initiate":[220],"maximal":[221],"tumor":[222,260],"control.":[223],"Conclusion":[224],"The":[225],"more":[228],"susceptible":[229],"than":[232],"SCs,":[234],"part":[236],"through":[237],"differential":[238],"Rad51.":[243],"Understanding":[244],"important":[253],"optimizing":[255],"protocols":[257],"maximize":[259],"control":[261],"while":[262],"limiting":[263],"patients.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-02-01T00:00:00"}