{"id":"https://openalex.org/W3124768024","doi":"https://doi.org/10.3390/jcm10030375","title":"Differential microRNA Expression in USP8-Mutated and Wild-Type Corticotroph Pituitary Tumors Reflect the Difference in Protein Ubiquitination Processes","display_name":"Differential microRNA Expression in USP8-Mutated and Wild-Type Corticotroph Pituitary Tumors Reflect the Difference in Protein Ubiquitination Processes","publication_year":2021,"publication_date":"2021-01-20","ids":{"openalex":"https://openalex.org/W3124768024","doi":"https://doi.org/10.3390/jcm10030375","mag":"3124768024","pmid":"https://pubmed.ncbi.nlm.nih.gov/33498176","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7863919"},"language":"en","primary_location":{"id":"doi:10.3390/jcm10030375","doi":"https://doi.org/10.3390/jcm10030375","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm10030375","pdf_url":"https://www.mdpi.com/2077-0383/10/3/375/pdf?version=1611815175","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/10/3/375/pdf?version=1611815175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073243622","display_name":"Mateusz Bujko","orcid":"https://orcid.org/0000-0001-5826-8446","observed_orcids":["https://orcid.org/0000-0001-5826-8446"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mateusz Bujko","raw_affiliation_strings":["Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0001-5826-8446","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021615209","display_name":"Paulina Kober","orcid":"https://orcid.org/0000-0002-7735-8137","observed_orcids":["https://orcid.org/0000-0002-7735-8137"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Paulina Kober","raw_affiliation_strings":["Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062248387","display_name":"Joanna Boresowicz","orcid":"https://orcid.org/0000-0002-6299-4931","observed_orcids":["https://orcid.org/0000-0002-6299-4931"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Boresowicz","raw_affiliation_strings":["Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070305258","display_name":"Natalia Rusetska","orcid":"https://orcid.org/0000-0001-7496-2489","observed_orcids":["https://orcid.org/0000-0001-7496-2489"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Natalia Rusetska","raw_affiliation_strings":["Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066324624","display_name":"Natalia \u017beber\u2010Lubecka","orcid":"https://orcid.org/0000-0003-4036-3191","observed_orcids":["https://orcid.org/0000-0003-4036-3191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Zeber-Lubecka","raw_affiliation_strings":["Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, 01-813 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, 01-813 Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000571424","display_name":"Agnieszka Paziewska","orcid":"https://orcid.org/0000-0002-6644-1509","observed_orcids":["https://orcid.org/0000-0002-6644-1509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Paziewska","raw_affiliation_strings":["Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroendocrinology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032597328","display_name":"Monika P\u0119kul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Pekul","raw_affiliation_strings":["Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057679172","display_name":"Grzegorz Zieli\u0144ski","orcid":"https://orcid.org/0000-0001-6980-5614","observed_orcids":["https://orcid.org/0000-0001-6980-5614"]},"institutions":[{"id":"https://openalex.org/I4210146974","display_name":"Wojskowy Instytut Medyczny","ror":"https://ror.org/04zvqhj72","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210146974"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Grzegorz Zielinski","raw_affiliation_strings":["Department of Neurosurgery, Military Institute of Medicine, 04-141 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Military Institute of Medicine, 04-141 Warsaw, Poland","institution_ids":["https://openalex.org/I4210146974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087773022","display_name":"Andrzej Styk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146974","display_name":"Wojskowy Instytut Medyczny","ror":"https://ror.org/04zvqhj72","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210146974"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Styk","raw_affiliation_strings":["Department of Neurosurgery, Military Institute of Medicine, 04-141 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Military Institute of Medicine, 04-141 Warsaw, Poland","institution_ids":["https://openalex.org/I4210146974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080856557","display_name":"Jacek Kunicki","orcid":"https://orcid.org/0000-0002-2304-7974","observed_orcids":["https://orcid.org/0000-0002-2304-7974"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek Kunicki","raw_affiliation_strings":["Department of Neurosurgery, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007944267","display_name":"Jerzy Ostrowski","orcid":"https://orcid.org/0000-0003-1363-3766","observed_orcids":["https://orcid.org/0000-0003-1363-3766"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jerzy Ostrowski","raw_affiliation_strings":["Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, 01-813 Warsaw, Poland","Department of Genetics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, 01-813 Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067277538","display_name":"JANUSZ ALEKSANDER SIEDLECKI","orcid":"https://orcid.org/0000-0003-4889-5416","observed_orcids":["https://orcid.org/0000-0003-4889-5416"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Janusz A Siedlecki","raw_affiliation_strings":["Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073696409","display_name":"Maria Maksymowicz","orcid":"https://orcid.org/0000-0002-6806-6079","observed_orcids":["https://orcid.org/0000-0002-6806-6079"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Maria Maksymowicz","raw_affiliation_strings":["Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, 02-781 Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073696409"],"corresponding_institution_ids":["https://openalex.org/I4210150880"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":2.6132,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89934453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"375","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usp8-mutations","display_name":"USP8 mutations","score":0.9309999942779541},{"id":"https://openalex.org/keywords/corticotropinoma","display_name":"corticotropinoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9800000190734863},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7749059200286865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5419411063194275},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.5203901529312134},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4790416955947876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47837916016578674},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4538085460662842},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.426771342754364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3324016332626343},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.30232369899749756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2690798342227936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14752206206321716}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/jcm10030375","doi":"https://doi.org/10.3390/jcm10030375","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm10030375","pdf_url":"https://www.mdpi.com/2077-0383/10/3/375/pdf?version=1611815175","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6770651","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7863919","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7863919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7863919","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:33498176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33498176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8318467a77f94f04b30ec1f8820a0370","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8318467a77f94f04b30ec1f8820a0370","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Medicine, Vol 10, Iss 375, p 375 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcm10030375","doi":"https://doi.org/10.3390/jcm10030375","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm10030375","pdf_url":"https://www.mdpi.com/2077-0383/10/3/375/pdf?version=1611815175","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124768024.pdf","grobid_xml":"https://content.openalex.org/works/W3124768024.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1572701675","https://openalex.org/W1925935443","https://openalex.org/W1974254202","https://openalex.org/W1975715657","https://openalex.org/W2026098321","https://openalex.org/W2051766033","https://openalex.org/W2100301546","https://openalex.org/W2252521414","https://openalex.org/W2465675210","https://openalex.org/W2474530751","https://openalex.org/W2497188434","https://openalex.org/W2519986025","https://openalex.org/W2587517604","https://openalex.org/W2612828221","https://openalex.org/W2750729558","https://openalex.org/W2768781242","https://openalex.org/W2774699268","https://openalex.org/W2791332828","https://openalex.org/W2792308364","https://openalex.org/W2809742082","https://openalex.org/W2887049666","https://openalex.org/W2897881602","https://openalex.org/W2921757966","https://openalex.org/W2948560532","https://openalex.org/W2951391897","https://openalex.org/W2953153127","https://openalex.org/W2954757312","https://openalex.org/W2978162365","https://openalex.org/W2980671115","https://openalex.org/W2980831600","https://openalex.org/W2989832464","https://openalex.org/W2994699197","https://openalex.org/W2996928569","https://openalex.org/W3006608415","https://openalex.org/W3006782573","https://openalex.org/W3014640582","https://openalex.org/W3034125256","https://openalex.org/W3089783481","https://openalex.org/W6753668158"],"related_works":["https://openalex.org/W2978162365","https://openalex.org/W3153196728","https://openalex.org/W4399242690","https://openalex.org/W4392292256","https://openalex.org/W4309461068","https://openalex.org/W7164402925","https://openalex.org/W2972046122","https://openalex.org/W7120398727","https://openalex.org/W4297993284","https://openalex.org/W4212775792"],"abstract_inverted_index":{"Background:":[0],"USP8":[1,77,185],"mutations":[2,78],"are":[3,154],"the":[4,47,149,164],"most":[5,150],"common":[6],"driver":[7],"changes":[8],"in":[9,40,134,156,177,180,197],"corticotroph":[10,70],"pituitary":[11],"tumors.":[12,174,202],"They":[13],"have":[14],"direct":[15],"effect":[16],"on":[17],"cells\u2019":[18],"proteome":[19],"through":[20],"disturbance":[21],"of":[22,32,50,102,115,118,144,166],"ubiquitination":[23,189],"process":[24],"and":[25,42,45,57,68,85,105,120,137,172],"also":[26],"influence":[27,163],"gene":[28,86,198],"expression.":[29],"The":[30],"aim":[31],"this":[33],"study":[34],"was":[35,88],"to":[36,184,195],"compare":[37],"microRNA":[38,52,56,116,178],"profiles":[39,117],"USP8-mutated":[41,94,119,171],"wild-type":[43,112,121,173],"tumors":[44,71,122],"determine":[46],"probable":[48],"role":[49],"differential":[51],"expression":[53,87,165,179,199],"by":[54,133],"integrative":[55],"mRNA":[58],"analysis.":[59,140],"Methods:":[60],"Patients":[61],"with":[62,81,90,96],"Cushing\u2019s":[63,97],"disease":[64,98],"(n":[65,72],"=":[66,73],"28)":[67],"silent":[69],"20)":[74],"were":[75,79,131],"included.":[76],"identified":[80],"Sanger":[82],"sequencing.":[83,92],"MicroRNA":[84],"determined":[89,132],"next-generation":[91],"Results:":[93],"patients":[95],"showed":[99,147],"higher":[100],"rate":[101],"clinical":[103],"remission":[104],"trend":[106],"towards":[107],"lower":[108],"tumor":[109],"volume":[110],"than":[111],"patients.":[113],"Comparison":[114],"revealed":[123],"68":[124],"differentially":[125,168],"expressed":[126,169],"microRNAs.":[127],"Their":[128],"target":[129],"genes":[130,153,167],"silico":[135],"prediction":[136],"microRNA/mRNA":[138],"correlation":[139],"GeneSet":[141],"Enrichment":[142],"analysis":[143],"putative":[145],"targets":[146],"that":[148],"significantly":[151],"overrepresented":[152],"involved":[155],"protein":[157],"ubiquitination-related":[158],"processes.":[159],"Only":[160],"few":[161],"microRNAs":[162],"between":[170,200],"Conclusions:":[175],"Differences":[176],"corticotropinomas":[181],"stratified":[182],"according":[183],"status":[186],"reflect":[187],"disturbed":[188],"processes,":[190],"but":[191],"do":[192],"not":[193],"correspond":[194],"differences":[196],"these":[201]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-02-01T00:00:00"}