{"id":"https://openalex.org/W3124680305","doi":"https://doi.org/10.1038/s41467-021-20940-y","title":"H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions","display_name":"H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions","publication_year":2021,"publication_date":"2021-01-29","ids":{"openalex":"https://openalex.org/W3124680305","doi":"https://doi.org/10.1038/s41467-021-20940-y","mag":"3124680305","pmid":"https://pubmed.ncbi.nlm.nih.gov/33514712","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7846766"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-20940-y","doi":"https://doi.org/10.1038/s41467-021-20940-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-20940-y","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41467-021-20940-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089122416","display_name":"Yichao Cai","orcid":"https://orcid.org/0000-0002-5142-4167","observed_orcids":["https://orcid.org/0000-0002-5142-4167"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yichao Cai","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","Department of Biological Sciences, National University of Singapore, Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-5142-4167","affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004938926","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0001-8674-7970","observed_orcids":["https://orcid.org/0000-0001-8674-7970"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062126680","display_name":"Yan Ping Loh","orcid":"https://orcid.org/0000-0002-2517-0458","observed_orcids":["https://orcid.org/0000-0002-2517-0458"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yan Ping Loh","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048249682","display_name":"Jia Qi Tng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jia Qi Tng","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041675725","display_name":"Mei Chee Lim","orcid":"https://orcid.org/0000-0002-8338-9554","observed_orcids":["https://orcid.org/0000-0002-8338-9554"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mei Chee Lim","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-8338-9554","affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040385101","display_name":"Zhendong Cao","orcid":"https://orcid.org/0000-0002-8189-0169","observed_orcids":["https://orcid.org/0000-0002-8189-0169"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Zhendong Cao","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112618187","display_name":"Anandhkumar Raju","orcid":"https://orcid.org/0009-0002-0389-9384","observed_orcids":["https://orcid.org/0009-0002-0389-9384"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anandhkumar Raju","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004683234","display_name":"Erez Lieberman Aiden","orcid":"https://orcid.org/0000-0003-0634-6486","observed_orcids":["https://orcid.org/0000-0003-0634-6486"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erez Lieberman Aiden","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100735520","display_name":"Shang Li","orcid":"https://orcid.org/0000-0002-6226-3362","observed_orcids":["https://orcid.org/0000-0002-6226-3362"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shang Li","raw_affiliation_strings":["Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore","Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062127857","display_name":"Manikandan Lakshmanan","orcid":"https://orcid.org/0000-0001-5103-3054","observed_orcids":["https://orcid.org/0000-0001-5103-3054"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lakshmanan Manikandan","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051799874","display_name":"Vinay Tergaonkar","orcid":"https://orcid.org/0000-0001-9009-0844","observed_orcids":["https://orcid.org/0000-0001-9009-0844"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Vinay Tergaonkar","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064577241","display_name":"Greg Tucker\u2010Kellogg","orcid":"https://orcid.org/0000-0001-8407-9251","observed_orcids":["https://orcid.org/0000-0001-8407-9251"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Greg Tucker-Kellogg","raw_affiliation_strings":["Computational Biology Programme, National University of Singapore, Singapore, Singapore. dbsgtk@nus.edu.sg","Department of Biological Sciences, National University of Singapore, Singapore, Singapore. dbsgtk@nus.edu.sg","Department of Biological Sciences, National University of Singapore, Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-8407-9251","affiliations":[{"raw_affiliation_string":"Computational Biology Programme, National University of Singapore, Singapore, Singapore. dbsgtk@nus.edu.sg","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore. dbsgtk@nus.edu.sg","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087492673","display_name":"Melissa J. Fullwood","orcid":"https://orcid.org/0000-0003-0321-7865","observed_orcids":["https://orcid.org/0000-0003-0321-7865","https://orcid.org/0000-0003-2355-7277"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Melissa Jane Fullwood","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore. mfullwood@ntu.edu.sg","School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-0321-7865","affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore. mfullwood@ntu.edu.sg","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064577241","https://openalex.org/A5087492673"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I4405277804","https://openalex.org/I75573869"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":5560,"currency":"USD","value_usd":5560},"fwci":14.3041,"has_fulltext":true,"cited_by_count":314,"citation_normalized_percentile":{"value":0.99679929,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"719","last_page":"719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.06419999897480011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.652999997138977},{"id":"https://openalex.org/keywords/chromatin-interactions","display_name":"chromatin interactions","score":0.7639999985694885},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cell-identity","display_name":"cell identity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.8679999709129333},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7645295262336731},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5640656352043152},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5378913283348083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4938364624977112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4907153844833374},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4742290675640106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46818649768829346},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.42968666553497314},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.402287095785141}],"mesh":[{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037941","descriptor_name":"Silencer Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063185","descriptor_name":"Epigenetic Repression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-021-20940-y","doi":"https://doi.org/10.1038/s41467-021-20940-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-20940-y","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6773122","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7846766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7846766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7846766","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:33514712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33514712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/231970","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/231970","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus OA2021","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:d3b2681ce73046bd90d6e3a3c6cb6762","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d3b2681ce73046bd90d6e3a3c6cb6762","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-20940-y","doi":"https://doi.org/10.1038/s41467-021-20940-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-20940-y","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G234101554","display_name":null,"funder_award_id":"NRFF2012-054","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G3425638656","display_name":null,"funder_award_id":"NRF-CRP17-2017","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G3691621637","display_name":null,"funder_award_id":"NRF-CRP17-2017-02","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G4150216259","display_name":null,"funder_award_id":"NRF-NRFF2012\u2013054","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G428618706","display_name":null,"funder_award_id":"NRF-NRFF2012-054","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"},{"id":"https://openalex.org/G589201317","display_name":null,"funder_award_id":"NRF-CRP17-2017-02","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G7016736585","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320336974","funder_display_name":"Cancer Science Institute of Singapore, National University of Singapore"},{"id":"https://openalex.org/G7844527391","display_name":null,"funder_award_id":"MOE2014-T3-1-006","funder_id":"https://openalex.org/F4320320709","funder_display_name":"National Research Foundation Singapore"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320336974","display_name":"Cancer Science Institute of Singapore, National University of Singapore","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1523117612","https://openalex.org/W1605145036","https://openalex.org/W1652691961","https://openalex.org/W1968746842","https://openalex.org/W1968931043","https://openalex.org/W1971578941","https://openalex.org/W1973062929","https://openalex.org/W1976852696","https://openalex.org/W1977709885","https://openalex.org/W1979513200","https://openalex.org/W1986030515","https://openalex.org/W1987908519","https://openalex.org/W1990194472","https://openalex.org/W2004966039","https://openalex.org/W2009157415","https://openalex.org/W2010187447","https://openalex.org/W2011463791","https://openalex.org/W2015845481","https://openalex.org/W2016625153","https://openalex.org/W2022508345","https://openalex.org/W2029284014","https://openalex.org/W2035618305","https://openalex.org/W2035783958","https://openalex.org/W2043822218","https://openalex.org/W2059673309","https://openalex.org/W2059699217","https://openalex.org/W2060608189","https://openalex.org/W2066017487","https://openalex.org/W2070172761","https://openalex.org/W2076154138","https://openalex.org/W2088822192","https://openalex.org/W2090562510","https://openalex.org/W2092668546","https://openalex.org/W2094136494","https://openalex.org/W2098651180","https://openalex.org/W2100867243","https://openalex.org/W2107277218","https://openalex.org/W2108797218","https://openalex.org/W2110951885","https://openalex.org/W2116147219","https://openalex.org/W2118334191","https://openalex.org/W2123705545","https://openalex.org/W2128151873","https://openalex.org/W2131116802","https://openalex.org/W2131271579","https://openalex.org/W2137199638","https://openalex.org/W2147493038","https://openalex.org/W2147947827","https://openalex.org/W2153424791","https://openalex.org/W2156647225","https://openalex.org/W2158789637","https://openalex.org/W2159164310","https://openalex.org/W2162641630","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2172557341","https://openalex.org/W2233101569","https://openalex.org/W2243544746","https://openalex.org/W2259938310","https://openalex.org/W2323326409","https://openalex.org/W2324997809","https://openalex.org/W2411397641","https://openalex.org/W2466171108","https://openalex.org/W2507209892","https://openalex.org/W2523690171","https://openalex.org/W2529765639","https://openalex.org/W2557288658","https://openalex.org/W2585920126","https://openalex.org/W2586373162","https://openalex.org/W2604177551","https://openalex.org/W2614185636","https://openalex.org/W2620721366","https://openalex.org/W2761133874","https://openalex.org/W2761553829","https://openalex.org/W2765083951","https://openalex.org/W2765567136","https://openalex.org/W2807496313","https://openalex.org/W2901209536","https://openalex.org/W2904230974","https://openalex.org/W2914809873","https://openalex.org/W2922109697","https://openalex.org/W2944727022","https://openalex.org/W2951956418","https://openalex.org/W2952336494","https://openalex.org/W2953007287","https://openalex.org/W2980597982","https://openalex.org/W2987062778","https://openalex.org/W3007150393","https://openalex.org/W3008725968","https://openalex.org/W3008828407"],"related_works":["https://openalex.org/W4366144084","https://openalex.org/W2922109697","https://openalex.org/W4386558478","https://openalex.org/W2783512198","https://openalex.org/W6901909988","https://openalex.org/W2131116802","https://openalex.org/W3163970006","https://openalex.org/W4280612859","https://openalex.org/W7111663730","https://openalex.org/W2419037911"],"abstract_inverted_index":{"The":[0],"mechanisms":[1,152],"underlying":[2],"gene":[3,36],"repression":[4],"and":[5,52,76,82,101,124,136,150],"silencers":[6,32],"are":[7,47,140],"poorly":[8],"understood.":[9],"Here":[10],"we":[11,130],"investigate":[12],"the":[13,19],"hypothesis":[14],"that":[15,33,44,132],"H3K27me3-rich":[16,45,58,112,133,148],"regions":[17,46,59,92,97,113,149],"of":[18,24,70,153],"genome,":[20],"defined":[21],"from":[22],"clusters":[23],"H3K27me3":[25,75,100,143],"peaks,":[26],"may":[27],"be":[28],"used":[29],"to":[30,68,142],"identify":[31],"can":[34],"regulate":[35],"expression":[37],"via":[38,155],"proximity":[39],"or":[40],"looping.":[41,156],"We":[42],"find":[43],"associated":[48,120],"with":[49,55,93,98,111,121],"chromatin":[50,84,108,138],"interactions":[51,87,139],"interact":[53],"preferentially":[54],"each":[56],"other.":[57],"component":[60],"removal":[61],"at":[62,79,91],"interaction":[63],"anchors":[64],"by":[65],"CRISPR":[66],"leads":[67],"upregulation":[69],"interacting":[71,80],"target":[72],"genes,":[73],"altered":[74,83,125],"H3K27ac":[77,103],"levels":[78,104],"regions,":[81],"interactions.":[85,109],"Chromatin":[86],"did":[88],"not":[89],"change":[90],"high":[94,102],"H3K27me3,":[95],"but":[96],"low":[99],"showed":[105],"changes":[106,117],"in":[107,118],"Cells":[110],"knockout":[114],"also":[115],"show":[116],"phenotype":[119],"cell":[122],"identity,":[123],"xenograft":[126],"tumor":[127],"growth.":[128],"Finally,":[129],"observe":[131],"regions-associated":[134],"genes":[135],"long-range":[137],"susceptible":[141],"depletion.":[144],"Our":[145],"results":[146],"characterize":[147],"their":[151],"functioning":[154]},"counts_by_year":[{"year":2026,"cited_by_count":53},{"year":2025,"cited_by_count":65},{"year":2024,"cited_by_count":75},{"year":2023,"cited_by_count":57},{"year":2022,"cited_by_count":48},{"year":2021,"cited_by_count":15}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-02-01T00:00:00"}
