{"id":"https://openalex.org/W3124569148","doi":"https://doi.org/10.18632/oncoscience.522","title":"Dysregulated PJA1-TGF-\u03b2 signaling in cancer stem cell-associated liver cancers","display_name":"Dysregulated PJA1-TGF-\u03b2 signaling in cancer stem cell-associated liver cancers","publication_year":2020,"publication_date":"2020-11-30","ids":{"openalex":"https://openalex.org/W3124569148","doi":"https://doi.org/10.18632/oncoscience.522","mag":"3124569148","pmid":"https://pubmed.ncbi.nlm.nih.gov/33457451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7781490"},"language":"en","primary_location":{"id":"doi:10.18632/oncoscience.522","doi":"https://doi.org/10.18632/oncoscience.522","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncoscience.522","pdf_url":"https://doi.org/10.18632/oncoscience.522","source":{"id":"https://openalex.org/S4210206977","display_name":"Oncoscience","issn_l":"2331-4737","issn":["2331-4737"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncoscience.522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100727841","display_name":"Jian Chen","orcid":"https://orcid.org/0000-0003-1090-5586","observed_orcids":["https://orcid.org/0000-0003-1090-5586","https://orcid.org/0000-0001-5230-7141","https://orcid.org/0000-0001-8105-3670"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian Chen","raw_affiliation_strings":["Department of Gastroenterology, Hepatology, & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","Sandhill Therapeutics, Inc., Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology, & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Sandhill Therapeutics, Inc., Dallas, TX, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045456666","display_name":"Julian A. Gingold","orcid":"https://orcid.org/0000-0002-0354-5933","observed_orcids":["https://orcid.org/0000-0002-0354-5933"]},"institutions":[{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian A. Gingold","raw_affiliation_strings":["Montefiore Medical Center, OB/GYN and Women's Health, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Medical Center, OB/GYN and Women's Health, Bronx, NY, USA","institution_ids":["https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100727841"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.7209,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65451919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"11-12","first_page":"88","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sptbn1","display_name":"SPTBN1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.9240000247955322},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/liver-cancer-progression","display_name":"liver cancer progression","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6762807369232178},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6421647071838379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6344174742698669},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5846250653266907},{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.5837624073028564},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5693749785423279},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4593338072299957},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4566463828086853},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.4560004770755768},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45236724615097046},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40726709365844727},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.38083407282829285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3655179738998413},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.30197662115097046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12057393789291382},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.076128751039505},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18632/oncoscience.522","doi":"https://doi.org/10.18632/oncoscience.522","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncoscience.522","pdf_url":"https://doi.org/10.18632/oncoscience.522","source":{"id":"https://openalex.org/S4210206977","display_name":"Oncoscience","issn_l":"2331-4737","issn":["2331-4737"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6717117","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7781490","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7781490","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7781490","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"Text"},{"id":"pmid:33457451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33457451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/oncoscience.522","doi":"https://doi.org/10.18632/oncoscience.522","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncoscience.522","pdf_url":"https://doi.org/10.18632/oncoscience.522","source":{"id":"https://openalex.org/S4210206977","display_name":"Oncoscience","issn_l":"2331-4737","issn":["2331-4737"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308400","display_name":"American Association for the Study of Liver Diseases","ror":"https://ror.org/005tjs461"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124569148.pdf","grobid_xml":"https://content.openalex.org/works/W3124569148.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1519258930","https://openalex.org/W1523071718","https://openalex.org/W1828456061","https://openalex.org/W1971837077","https://openalex.org/W1977918192","https://openalex.org/W1988523074","https://openalex.org/W1993434123","https://openalex.org/W1999132074","https://openalex.org/W2002195359","https://openalex.org/W2002850554","https://openalex.org/W2003526568","https://openalex.org/W2009212819","https://openalex.org/W2009396278","https://openalex.org/W2009629707","https://openalex.org/W2014415467","https://openalex.org/W2018851752","https://openalex.org/W2031709894","https://openalex.org/W2034514059","https://openalex.org/W2040929679","https://openalex.org/W2048177238","https://openalex.org/W2060043441","https://openalex.org/W2071946531","https://openalex.org/W2072688355","https://openalex.org/W2086711528","https://openalex.org/W2096998441","https://openalex.org/W2099361912","https://openalex.org/W2100801124","https://openalex.org/W2102983928","https://openalex.org/W2107144403","https://openalex.org/W2128239138","https://openalex.org/W2140946995","https://openalex.org/W2144578935","https://openalex.org/W2158378236","https://openalex.org/W2170665235","https://openalex.org/W2171262765","https://openalex.org/W2256023856","https://openalex.org/W2552243272","https://openalex.org/W2560499218","https://openalex.org/W2569474304","https://openalex.org/W2625559053","https://openalex.org/W2756331708","https://openalex.org/W2774591024","https://openalex.org/W2787358630","https://openalex.org/W2789966375","https://openalex.org/W2795867722","https://openalex.org/W2809889937","https://openalex.org/W2883204623","https://openalex.org/W2894166779","https://openalex.org/W2898314774","https://openalex.org/W2908573150","https://openalex.org/W2953822009","https://openalex.org/W2971671150","https://openalex.org/W3009596272","https://openalex.org/W3040737854","https://openalex.org/W4288076435","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W3009596272","https://openalex.org/W4245486417","https://openalex.org/W2563371803","https://openalex.org/W1989340278","https://openalex.org/W2077948074","https://openalex.org/W2738171429","https://openalex.org/W1908276267","https://openalex.org/W2769165607","https://openalex.org/W2885982493","https://openalex.org/W2980143344"],"abstract_inverted_index":{"The":[0],"transforming":[1],"growth":[2],"factor":[3,96],"beta":[4],"(TGF-\u03b2)":[5],"signaling":[6,23,85,179,221],"pathway":[7,41,57],"plays":[8],"important":[9],"roles":[10],"in":[11,109,113,127,135,138,160,186,226],"cell":[12,15],"differentiation,":[13],"stem":[14,124,224],"modulation,":[16],"organ":[17],"lineage,":[18],"and":[19,79,99,107,112,132,162,168,183,205],"immune":[20],"suppression.":[21],"TGF-\u03b2":[22,40,56,75,84,154,170,202],"is":[24,62,148,158,163],"negatively":[25],"regulated":[26],"by":[27,52,195],"the":[28,44,49,81,92,119],"ubiquitin-proteasome":[29],"pathway.":[30],"Although":[31],"mouse":[32,140],"models":[33],"of":[34,47,83,118,153,193],"cancer":[35,60,208,223],"arising":[36],"from":[37,70],"a":[38,54,139,143,149],"defective":[39,55],"clearly":[42],"demonstrate":[43],"tumor-suppressive":[45],"role":[46],"TGF-\u03b2,":[48,89],"underlying":[50],"mechanism":[51],"which":[53],"triggers":[58],"liver":[59,115,188,207,227],"development":[61],"poorly":[63],"understood.":[64],"This":[65],"review":[66],"summarizes":[67],"key":[68,150],"findings":[69,212],"our":[71],"recent":[72],"studies":[73],"connecting":[74],"to":[76,86,165],"hepatic":[77],"oncogenesis":[78],"highlights":[80],"vulnerability":[82],"PJA1-mediated":[87],"ubiquitination.":[88],"together":[90],"with":[91,197],"chromatin":[93],"insulator":[94],"CCCTC-binding":[95],"(CTCF),":[97],"epigenetically":[98],"transcriptionally":[100],"regulate":[101],"tumor":[102,171],"promoter":[103],"genes,":[104],"including":[105],"IGF2":[106],"TERT,":[108],"TGF-\u03b2-defective":[110],"mice":[111],"human":[114,187],"cancers.":[116,189,228],"Dysfunction":[117],"TGF-\u03b2-regulated":[120],"SPTBN1/SMAD3/CTCF":[121],"complex":[122],"increases":[123],"cell-like":[125],"properties":[126],"hepatocellular":[128],"carcinoma":[129],"(HCC)":[130],"cells":[131,137,225],"enhances":[133],"tumorigenesis":[134,185],"tumor-initiating":[136],"model.":[141],"PJA1,":[142],"novel":[144],"E3":[145,198],"ubiquitin":[146],"ligase,":[147],"negative":[151],"regulator":[152],"signaling.":[155],"PJA1":[156,194],"overexpression":[157],"detected":[159],"HCCs":[161],"sufficient":[164],"suppress":[166],"SMAD3-":[167],"SPTBN1-mediated":[169],"suppressor":[172],"signaling,":[173],"promoting":[174],"HCC":[175],"proliferation.":[176],"Dysregulated":[177],"PJA1-TGF-\u03b2":[178,220],"activates":[180],"oncogenic":[181],"genes":[182],"promotes":[184],"In":[190],"addition,":[191],"inhibition":[192],"treatment":[196],"ligase":[199],"inhibitors":[200],"restores":[201],"tumor-suppressor":[203],"function":[204],"suppresses":[206],"progression.":[209],"These":[210],"new":[211],"suggest":[213],"potential":[214],"therapeutic":[215],"avenues":[216],"for":[217],"targeting":[218],"dysregulated":[219],"via":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-01T00:00:00"}
