{"id":"https://openalex.org/W3124548741","doi":"https://doi.org/10.3390/pharmaceutics13010126","title":"Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery","display_name":"Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery","publication_year":2021,"publication_date":"2021-01-19","ids":{"openalex":"https://openalex.org/W3124548741","doi":"https://doi.org/10.3390/pharmaceutics13010126","mag":"3124548741","pmid":"https://pubmed.ncbi.nlm.nih.gov/33478077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7835867"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics13010126","doi":"https://doi.org/10.3390/pharmaceutics13010126","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13010126","pdf_url":"https://www.mdpi.com/1999-4923/13/1/126/pdf?version=1611111704","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/13/1/126/pdf?version=1611111704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108594764","display_name":"Eri Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Hamada","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072372982","display_name":"Tomoaki Kurosaki","orcid":"https://orcid.org/0000-0003-4234-6934","observed_orcids":["https://orcid.org/0000-0003-4234-6934"]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Kurosaki","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4234-6934","affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]},{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077086031","display_name":"Junya Hashizume","orcid":"https://orcid.org/0009-0000-4588-2500","observed_orcids":["https://orcid.org/0009-0000-4588-2500"]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junya Hashizume","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076086534","display_name":"Hitomi Harasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitomi Harasawa","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112876786","display_name":"Hiroo Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroo Nakagawa","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110004430","display_name":"Tadahiro Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadahiro Nakamura","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110333089","display_name":"Yukinobu Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukinobu Kodama","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110001027","display_name":"Hitoshi Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hitoshi Sasaki","raw_affiliation_strings":["Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan","institution_ids":["https://openalex.org/I4210165237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110001027"],"corresponding_institution_ids":["https://openalex.org/I4210165237"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":1.4716,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82195681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"126","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-delivery","display_name":"mRNA delivery","score":0.996999979019165},{"id":"https://openalex.org/keywords/polyethylenimine","display_name":"polyethyleneimine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/poly-gamma-glutamic-acid","display_name":"poly-\u03b3-glutamic acid","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anionic-complexes","display_name":"anionic complexes","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cationic-complexes","display_name":"cationic complexes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/charge-ratio","display_name":"charge ratio","score":0.6520000100135803},{"id":"https://openalex.org/keywords/firefly-luciferase","display_name":"firefly luciferase","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.593999981880188},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7643818259239197},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7328176498413086},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6303707361221313},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6078273057937622},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5845836400985718},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5505663156509399},{"id":"https://openalex.org/C2775925850","wikidata":"https://www.wikidata.org/wiki/Q418697","display_name":"Polyethylenimine","level":4,"score":0.535617470741272},{"id":"https://openalex.org/C2776207055","wikidata":"https://www.wikidata.org/wiki/Q187980","display_name":"Polyglutamic acid","level":2,"score":0.5221000909805298},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5030404925346375},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4340822100639343},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.41737329959869385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3760935366153717},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3742813467979431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2843877077102661},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1261194944381714},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics13010126","doi":"https://doi.org/10.3390/pharmaceutics13010126","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13010126","pdf_url":"https://www.mdpi.com/1999-4923/13/1/126/pdf?version=1611111704","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7835867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7835867","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:33478077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33478077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004774003","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/26317","pdf_url":"https://nagasaki-u.repo.nii.ac.jp/record/26317/files/Pharmaceutics13_126.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmaceutics","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:c3a9ead85c6e4ecdba2438dae4bf38bf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c3a9ead85c6e4ecdba2438dae4bf38bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 13, Iss 1, p 126 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics13010126","doi":"https://doi.org/10.3390/pharmaceutics13010126","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics13010126","pdf_url":"https://www.mdpi.com/1999-4923/13/1/126/pdf?version=1611111704","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4456520817","display_name":"Development of new nucleic acid medicines for intractable respiratory diseases","funder_award_id":"18H02589","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5223944382","display_name":"Development of a novel therapeutic method for liver fibrosis by introducing siRNA using a liver-targeted ternary complex","funder_award_id":"20K12649","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5389892984","display_name":null,"funder_award_id":"JP18H02589, JP20K12649, and 20K07156","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6908588942","display_name":null,"funder_award_id":"and 20K07156","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8045947644","display_name":"Development of gene and nucleic acid medicines for lung cancer based on the multifunctional pulmonary nanoparticles","funder_award_id":"20K07156","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124548741.pdf","grobid_xml":"https://content.openalex.org/works/W3124548741.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1420726270","https://openalex.org/W1968296419","https://openalex.org/W1983417399","https://openalex.org/W1995997091","https://openalex.org/W1998148025","https://openalex.org/W2007713229","https://openalex.org/W2010655741","https://openalex.org/W2013053787","https://openalex.org/W2019026359","https://openalex.org/W2025108978","https://openalex.org/W2030556927","https://openalex.org/W2039422212","https://openalex.org/W2048881858","https://openalex.org/W2050221254","https://openalex.org/W2056560999","https://openalex.org/W2063668324","https://openalex.org/W2065792250","https://openalex.org/W2070009190","https://openalex.org/W2076344185","https://openalex.org/W2087405702","https://openalex.org/W2093630572","https://openalex.org/W2093685827","https://openalex.org/W2095268526","https://openalex.org/W2099400970","https://openalex.org/W2114624491","https://openalex.org/W2120692644","https://openalex.org/W2145768602","https://openalex.org/W2150490625","https://openalex.org/W2330469398","https://openalex.org/W2483007317","https://openalex.org/W2568524810","https://openalex.org/W2573033399","https://openalex.org/W2801954993","https://openalex.org/W2808372952","https://openalex.org/W3112157028"],"related_works":["https://openalex.org/W4391718513","https://openalex.org/W2013053787","https://openalex.org/W7164882438","https://openalex.org/W3164023688","https://openalex.org/W4381251218","https://openalex.org/W2999411982","https://openalex.org/W7130641437","https://openalex.org/W4380422740","https://openalex.org/W2205103606","https://openalex.org/W4283204565"],"abstract_inverted_index":{"We":[0],"previously":[1],"found":[2],"that":[3],"a":[4,42,117,188],"complex":[5,98,110,115,157,186],"comprising":[6],"plasmid":[7],"DNA":[8],"(pDNA),":[9],"polyethylenimine":[10],"(PEI),":[11],"and":[12,24,44,54,63,71,80,84,88,135,143,168,170,190],"\u03b3-polyglutamic":[13],"acid":[14],"(\u03b3-PGA)":[15],"had":[16],"high":[17,100,145,160],"transgene":[18],"efficiency":[19],"without":[20,150],"cytotoxicity":[21],"in":[22,25,86,89,101,146,165,175],"vitro":[23,87,102,147],"vivo.":[26],"However,":[27],"messenger":[28],"RNA":[29],"(mRNA)":[30],"remains":[31],"an":[32,72],"attractive":[33],"alternative":[34],"to":[35,50,158],"pDNA.":[36],"In":[37],"this":[38],"study,":[39],"we":[40],"developed":[41],"safe":[43,189],"effective":[45,191],"delivery":[46,195],"system":[47],"for":[48,193],"mRNA":[49,73],"prevent":[51],"its":[52],"degradation":[53],"efficiently":[55],"deliver":[56],"it":[57],"into":[58],"target":[59],"cells.":[60],"Various":[61],"cationic":[62,96],"anionic":[64,109],"complexes":[65],"were":[66,82,93],"produced":[67],"containing":[68],"PEI,":[69,134],"\u03b3-PGA,":[70],"encoding":[74],"firefly":[75],"luciferase.":[76],"Their":[77],"physicochemical":[78],"properties":[79],"cytotoxicities":[81],"analyzed":[83],"the":[85,125,129,166,176,182,194],"vivo":[90],"protein":[91,103,148,161],"expression":[92,104,149,162,172],"determined.":[94],"The":[95,108],"mRNA/PEI":[97],"showed":[99,144],"with":[105,116],"strong":[106],"cytotoxicity.":[107,151],"was":[111,141,163,173],"constructed":[112,184],"as":[113],"mRNA/PEI8/\u03b3-PGA12":[114,156,185],"theoretical":[118],"charge":[119],"ratio":[120],"of":[121,128,133,138,155,196],"1:8:12":[122],"based":[123],"on":[124],"phosphate":[126],"groups":[127,132,137],"mRNA,":[130],"nitrogen":[131],"carboxylate":[136],"\u03b3-PGA.":[139],"It":[140],"stable":[142],"After":[152],"intravenous":[153],"administration":[154],"mice,":[159],"observed":[164,174],"spleen":[167],"liver":[169],"slight":[171],"lung":[177],"over":[178],"24":[179],"h.":[180],"Thus,":[181],"newly":[183],"provides":[187],"strategy":[192],"mRNA.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-01T00:00:00"}