{"id":"https://openalex.org/W3124209488","doi":"https://doi.org/10.1039/d0ay02043e","title":"Dry storage of multiple reagent types within a paper microfluidic device for phenylalanine monitoring","display_name":"Dry storage of multiple reagent types within a paper microfluidic device for phenylalanine monitoring","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3124209488","doi":"https://doi.org/10.1039/d0ay02043e","mag":"3124209488","pmid":"https://pubmed.ncbi.nlm.nih.gov/33463631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8855637"},"language":"en","primary_location":{"id":"doi:10.1039/d0ay02043e","doi":"https://doi.org/10.1039/d0ay02043e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d0ay02043e","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8855637","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016687807","display_name":"Lael Wentland","orcid":"https://orcid.org/0000-0003-4155-8812","observed_orcids":["https://orcid.org/0000-0003-4155-8812"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lael Wentland","raw_affiliation_strings":["Corvallis","Oregon State University","School of Chemical, Biological, and Environmental Engineering","USA","School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":"https://orcid.org/0000-0003-4155-8812","affiliations":[{"raw_affiliation_string":"Corvallis","institution_ids":[]},{"raw_affiliation_string":"Oregon State University","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081009599","display_name":"Rachel Polaski","orcid":"https://orcid.org/0000-0001-6004-9162","observed_orcids":["https://orcid.org/0000-0001-6004-9162"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Polaski","raw_affiliation_strings":["Corvallis","Oregon State University","School of Chemical, Biological, and Environmental Engineering","USA","School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":"https://orcid.org/0000-0001-6004-9162","affiliations":[{"raw_affiliation_string":"Corvallis","institution_ids":[]},{"raw_affiliation_string":"Oregon State University","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044609990","display_name":"Elain S. Fu","orcid":"https://orcid.org/0000-0001-7675-1677","observed_orcids":["https://orcid.org/0000-0001-7675-1677"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elain Fu","raw_affiliation_strings":["Corvallis","Oregon State University","School of Chemical, Biological, and Environmental Engineering","USA","School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":"https://orcid.org/0000-0001-7675-1677","affiliations":[{"raw_affiliation_string":"Corvallis","institution_ids":[]},{"raw_affiliation_string":"Oregon State University","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044609990"],"corresponding_institution_ids":["https://openalex.org/I131249849"],"apc_list":null,"apc_paid":null,"fwci":0.6828,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59947957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":"5","first_page":"660","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-storage","display_name":"dry storage","score":0.6399999856948853},{"id":"https://openalex.org/keywords/reagent-stability","display_name":"reagent stability","score":0.9430000185966492},{"id":"https://openalex.org/keywords/paper-based-microfluidics","display_name":"paper-based microfluidics","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nitroblue-tetrazolium","display_name":"nitroblue tetrazolium","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phenylalanine-dehydrogenase","display_name":"phenylalanine dehydrogenase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.8180000185966492},{"id":"https://openalex.org/keywords/colorimetric-reagent","display_name":"colorimetric reagent","score":0.8050000071525574},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.754986047744751},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.7300559282302856},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6694268584251404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5797505974769592},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4605481028556824},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.308734655380249},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2215876281261444},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16892024874687195},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1371801793575287},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09735873341560364}],"mesh":[{"descriptor_ui":"D003890","descriptor_name":"Desiccation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/d0ay02043e","doi":"https://doi.org/10.1039/d0ay02043e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d0ay02043e","pdf_url":null,"source":{"id":"https://openalex.org/S170358085","display_name":"Analytical Methods","issn_l":"1759-9660","issn":["1759-9660","1759-9679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Methods","raw_type":"journal-article"},{"id":"pmid:33463631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33463631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical methods : advancing methods and applications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8855637","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8855637","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Methods","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8855637","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8855637","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Methods","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1329443836","display_name":null,"funder_award_id":"R01 HD091175","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4219697411","display_name":null,"funder_award_id":"1R01HD091175","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7205555301","display_name":"Creating a paper-based phenylalanine test for personalized therapy monitoring by patients with phenylketonuria","funder_award_id":"5r01hd091175-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1578275753","https://openalex.org/W1749144760","https://openalex.org/W1915707355","https://openalex.org/W1994072127","https://openalex.org/W1998361394","https://openalex.org/W2008580257","https://openalex.org/W2013134165","https://openalex.org/W2022628242","https://openalex.org/W2032311551","https://openalex.org/W2048531234","https://openalex.org/W2092261704","https://openalex.org/W2110312890","https://openalex.org/W2112654810","https://openalex.org/W2285112408","https://openalex.org/W2321911242","https://openalex.org/W2336069139","https://openalex.org/W2411311813","https://openalex.org/W2555459264","https://openalex.org/W2587584959","https://openalex.org/W2589891587","https://openalex.org/W2611617503","https://openalex.org/W2986161152","https://openalex.org/W3000786889","https://openalex.org/W3056842677","https://openalex.org/W4213167025","https://openalex.org/W4231583251"],"related_works":["https://openalex.org/W2189284887","https://openalex.org/W2048531234","https://openalex.org/W3154063080","https://openalex.org/W2587015991","https://openalex.org/W7096040913","https://openalex.org/W2011147969","https://openalex.org/W2502856457","https://openalex.org/W2146330474","https://openalex.org/W2337257378","https://openalex.org/W2394070817"],"abstract_inverted_index":{"The":[0],"degradation":[1,110],"of":[2,8,15,27,39,44,47,74,85,87,94,114],"biochemical":[3],"reagents":[4,52,101,159],"on":[5,36],"the":[6,13,37,40,50,59,65,72,88,91,99,112,118],"timescale":[7],"weeks":[9],"can":[10],"severely":[11],"limit":[12],"utility":[14],"microfluidic":[16,28],"assays":[17],"intended":[18],"for":[19,127,149],"field":[20],"use,":[21],"and":[22,55,63,111,120,147],"is":[23],"a":[24,75,128,161],"challenging":[25],"aspect":[26],"device":[29],"development":[30],"in":[31],"general.":[32],"Our":[33],"study":[34],"focuses":[35],"evaluation":[38],"dry":[41,83,126],"storage":[42,84],"stability":[43],"three":[45,142],"types":[46,144],"reagents:":[48],"(i)":[49],"colorimetric":[51,100],"nitroblue":[53],"tetrazolium":[54],"1-methoxy-5-methylphenazinium":[56],"methylsulfate,":[57],"(ii)":[58],"enzyme":[60,119],"phenylalanine":[61,76,137],"dehydrogenase,":[62],"(iii)":[64],"coenzyme":[66,121],"\u03b2-nicotinamide":[67],"adenine":[68],"dinucleotide":[69],"hydrate,":[70],"within":[71],"context":[73],"monitoring":[77,138],"device.":[78],"We":[79],"have":[80],"demonstrated":[81],"stable":[82],"each":[86],"reagents,":[89],"over":[90],"time":[92],"span":[93],"approximately":[95],"one":[96],"month.":[97],"Drying":[98],"under":[102],"nitrogen":[103],"was":[104],"found":[105],"to":[106,155,164],"largely":[107],"suppress":[108],"reagent":[109,143],"appearance":[113],"nonspecific":[115],"signal,":[116],"while":[117],"retained":[122],"activity":[123],"when":[124],"stored":[125,148],"month":[129],"without":[130],"additional":[131],"processing":[132],"or":[133],"chemical":[134],"additives.":[135],"Finally,":[136],"devices":[139,156],"with":[140],"all":[141],"dried":[145],"down":[146],"15":[150],"days":[151],"showed":[152],"comparable":[153],"functionality":[154],"containing":[157],"freshly-dried":[158],"-":[160],"key":[162],"milestone":[163],"enable":[165],"future":[166],"clinical":[167],"testing.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-02-01T00:00:00"}