{"id":"https://openalex.org/W3124154166","doi":"https://doi.org/10.1073/pnas.2015931118","title":"Structure and assembly of the diiron cofactor in the heme-oxygenase\u2013like domain of the N -nitrosourea\u2013producing enzyme SznF","display_name":"Structure and assembly of the diiron cofactor in the heme-oxygenase\u2013like domain of the N -nitrosourea\u2013producing enzyme SznF","publication_year":2021,"publication_date":"2021-01-19","ids":{"openalex":"https://openalex.org/W3124154166","doi":"https://doi.org/10.1073/pnas.2015931118","mag":"3124154166","pmid":"https://pubmed.ncbi.nlm.nih.gov/33468680","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7848743"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2015931118","doi":"https://doi.org/10.1073/pnas.2015931118","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2015931118","pdf_url":"https://www.pnas.org/content/pnas/118/4/e2015931118.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/content/pnas/118/4/e2015931118.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082210207","display_name":"Molly J. McBride","orcid":"https://orcid.org/0000-0003-3832-1355","observed_orcids":["https://orcid.org/0000-0003-3832-1355"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly J. McBride","raw_affiliation_strings":["Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021909347","display_name":"Sarah R. Pope","orcid":"https://orcid.org/0000-0002-2756-4530","observed_orcids":["https://orcid.org/0000-0002-2756-4530"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah R. Pope","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014782194","display_name":"Kai Hu","orcid":"https://orcid.org/0000-0002-6555-2581","observed_orcids":["https://orcid.org/0000-0002-6555-2581"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Hu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029471963","display_name":"Jeffrey W. Slater","orcid":"https://orcid.org/0000-0002-1126-8905","observed_orcids":["https://orcid.org/0000-0002-1126-8905"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Slater","raw_affiliation_strings":["Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157884568","display_name":"C. Denise Okafor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Denise Okafor","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071740181","display_name":"Emily P. Balskus","orcid":"https://orcid.org/0000-0001-5985-5714","observed_orcids":["https://orcid.org/0000-0001-5985-5714"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily P. Balskus","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States","Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076704150","display_name":"Joseph Martin Bollinger Jr.","orcid":"https://orcid.org/0000-0003-0751-8585","observed_orcids":["https://orcid.org/0000-0003-0751-8585"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Martin Bollinger","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039479636","display_name":"Amie K. Boal","orcid":"https://orcid.org/0000-0002-1234-8472","observed_orcids":["https://orcid.org/0000-0002-1234-8472"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amie K. Boal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039479636","https://openalex.org/A5071740181","https://openalex.org/A5076704150","https://openalex.org/A5157884568"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":3.6249,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.94411921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"118","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cofactor-assembly","display_name":"cofactor assembly","score":0.7400000095367432},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.7369433641433716},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.702417254447937},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6317864656448364},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.629116415977478},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6144755482673645},{"id":"https://openalex.org/C165474305","wikidata":"https://www.wikidata.org/wiki/Q419615","display_name":"Oxygenase","level":3,"score":0.6073898077011108},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5827739834785461},{"id":"https://openalex.org/C2776946711","wikidata":"https://www.wikidata.org/wiki/Q418311","display_name":"Nitrosourea","level":3,"score":0.5281821489334106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41463518142700195},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3917122185230255},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18200957775115967},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07894814014434814},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009607","descriptor_name":"Nitrosourea Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019159","descriptor_name":"Nonheme Iron Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D019159","descriptor_name":"Nonheme Iron Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.2015931118","doi":"https://doi.org/10.1073/pnas.2015931118","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2015931118","pdf_url":"https://www.pnas.org/content/pnas/118/4/e2015931118.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2020.07.29.227702","doi":"https://doi.org/10.1101/2020.07.29.227702","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.29.227702","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/07/30/2020.07.29.227702.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:6775289","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7848743","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7848743","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7848743","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:33468680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33468680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1771389","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1771389","pdf_url":"https://www.osti.gov/servlets/purl/1771389","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1772784","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1772784","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1073/pnas.2015931118","doi":"https://doi.org/10.1073/pnas.2015931118","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2015931118","pdf_url":"https://www.pnas.org/content/pnas/118/4/e2015931118.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G102163711","display_name":null,"funder_award_id":"DE\u2010 AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G107546177","display_name":null,"funder_award_id":"DE- AC02-06-CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1313983767","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1664757510","display_name":null,"funder_award_id":"AC02\u201306CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G170736304","display_name":null,"funder_award_id":"GM119707","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1752970295","display_name":"Structures and Mechanisms of \u201cHeme-oxygenase-like\u201d Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C\u2013C-Fragmentation Reactions","funder_award_id":"R01GM138580","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1947107004","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G2287611682","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G262962599","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3039663548","display_name":null,"funder_award_id":"S10 OD012289","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3075337988","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G3127483976","display_name":null,"funder_award_id":"ACB-12002","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3152346458","display_name":null,"funder_award_id":"DE-AC02-06CH11357","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3329398301","display_name":null,"funder_award_id":"DE-AC02-06CH11357","funder_id":"https://openalex.org/F4320334038","funder_display_name":"Michigan Technology Tri-Corridor"},{"id":"https://openalex.org/G3424175725","display_name":null,"funder_award_id":"S10 OD012289","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G3897991018","display_name":"High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APS","funder_award_id":"1s10od012289-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3913106684","display_name":null,"funder_award_id":"ACB12002","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G409777406","display_name":null,"funder_award_id":"DE-AC02-06CH11357","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G416541740","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320334038","funder_display_name":"Michigan Technology Tri-Corridor"},{"id":"https://openalex.org/G4356617607","display_name":null,"funder_award_id":"AGM-12006","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4773269573","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G560641806","display_name":null,"funder_award_id":"GM138580","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5607048534","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5906309288","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G6072549038","display_name":null,"funder_award_id":"ACB-12002","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6848031779","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6918803902","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G7147508703","display_name":null,"funder_award_id":"085P1000817","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8392946372","display_name":"The biosynthesis of N-N bond-containing natural products","funder_award_id":"R01GM132564","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8473838722","display_name":null,"funder_award_id":"AGM-12006","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000014584","display_name":null,"funder_award_id":"AGM-12006","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907598","display_name":"Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies","funder_award_id":"R35GM119707","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G993149817","display_name":null,"funder_award_id":"DE-AC02-06CH11357 ","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320334038","display_name":"Michigan Technology Tri-Corridor","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124154166.pdf","grobid_xml":"https://content.openalex.org/works/W3124154166.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1482589774","https://openalex.org/W1513876647","https://openalex.org/W1973456990","https://openalex.org/W1981704948","https://openalex.org/W1982554906","https://openalex.org/W1990134274","https://openalex.org/W1997254796","https://openalex.org/W1998000782","https://openalex.org/W2001285904","https://openalex.org/W2006279626","https://openalex.org/W2010785482","https://openalex.org/W2015055975","https://openalex.org/W2017256508","https://openalex.org/W2018786362","https://openalex.org/W2027560458","https://openalex.org/W2032882299","https://openalex.org/W2037913221","https://openalex.org/W2042545763","https://openalex.org/W2044173651","https://openalex.org/W2044218686","https://openalex.org/W2053009800","https://openalex.org/W2059430774","https://openalex.org/W2085584322","https://openalex.org/W2087027286","https://openalex.org/W2091913250","https://openalex.org/W2114761992","https://openalex.org/W2131777290","https://openalex.org/W2144631571","https://openalex.org/W2149859312","https://openalex.org/W2153839710","https://openalex.org/W2163657152","https://openalex.org/W2171395457","https://openalex.org/W2317873538","https://openalex.org/W2403869332","https://openalex.org/W2601157778","https://openalex.org/W2610659133","https://openalex.org/W2729971436","https://openalex.org/W2748821064","https://openalex.org/W2787805923","https://openalex.org/W2792584246","https://openalex.org/W2793464565","https://openalex.org/W2794533949","https://openalex.org/W2884048872","https://openalex.org/W2885110609","https://openalex.org/W2910454002","https://openalex.org/W2911469917","https://openalex.org/W2912191120","https://openalex.org/W2921634767","https://openalex.org/W2945221789","https://openalex.org/W2954489918","https://openalex.org/W2955067587","https://openalex.org/W2961654060","https://openalex.org/W2971437052","https://openalex.org/W2976704092","https://openalex.org/W3011189660","https://openalex.org/W3033414899","https://openalex.org/W4230660447","https://openalex.org/W4233040395","https://openalex.org/W4237115204","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3033414899","https://openalex.org/W3211004627","https://openalex.org/W4296793611","https://openalex.org/W4365449932","https://openalex.org/W4390794536","https://openalex.org/W4364352035","https://openalex.org/W7125966260","https://openalex.org/W7221569898","https://openalex.org/W3011189660","https://openalex.org/W3162784599"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"biosynthesis":[2],"of":[3,21,68,87,107,150,282,300,316,337,356,368,379,393],"the":[4,9,28,33,44,48,55,66,69,74,96,108,112,144,154,167,173,182,252,278,283,317,334,354,369],"pancreatic":[5],"cancer":[6],"drug":[7,284],"streptozotocin,":[8],"tri-domain":[10],"nonheme-iron":[11],"oxygenase,":[12],"SznF,":[13],"hydroxylates":[14],"N":[15,18,22,34,36,234,270,279,288],"\u03b4":[16],"and":[17,61,101,115,147,162,181,199,220,264,294,326,328,353,390],"\u03c9":[19,23],"\u2019":[20],"-methyl-L-arginine":[24],"before":[25],"oxidatively":[26],"rearranging":[27],"triply":[29],"modified":[30],"guanidine":[31],"to":[32,104,116,171,251,296,332],"-methyl-":[35],"-nitrosourea":[37,280],"pharmacophore.":[38],"A":[39],"previously":[40],"published":[41],"structure":[42,336],"visualized":[43],"mono-iron":[45],"cofactor":[46,72,110,186,202,348],"in":[47,65,73,111,215,229,238,364],"enzyme\u2019s":[49],"C-terminal":[50],"cupin":[51],"domain,":[52],"which":[53,137],"effects":[54],"final":[56],"rearrangement,":[57],"but":[58,236],"exhibited":[59],"disorder":[60],"minimal":[62],"metal":[63,197],"occupancy":[64],"site":[67],"proposed":[70],"diiron":[71,109,129,242,255,302,321],"N-":[75],"hydroxylating":[76],"heme-oxygenase-like":[77],"(HO-like)":[78],"central":[79,287],"domain.":[80],"Here":[81],"we":[82],"leverage":[83],"our":[84],"recent":[85],"report":[86],"an":[88,205,211,297,357],"intensely":[89],"absorbing":[90],"\u00b5":[91],"-peroxodiiron(III/III)":[92],"intermediate":[93],"formed":[94],"from":[95,323],"Fe":[97,155,177],"2":[98,103,152,156,175,178,319],"(II/II)":[99,157,179],"complex":[100,180,322],"O":[102,151,174,318],"understand":[105],"assembly":[106,315],"HO-like":[113,233,241,254,301],"domain":[114,290],"obtain":[117,333],"structures":[118,164],"with":[119,133,305,342],"both":[120,166],"SznF":[121,276,325],"iron":[122],"cofactors":[123],"bound.":[124],"Tight":[125],"binding":[126,142,217],"at":[127,143],"one":[128],"subsite":[130,146],"is":[131,138,227,362],"associated":[132],"a":[134,190,338,366,373,386],"conformational":[135,168],"change,":[136],"followed":[139],"by":[140,153,210,218],"weak":[141],"second":[145],"rapid":[148],"capture":[149],"complex.":[158],"Differences":[159],"between":[160],"iron-deficient":[161],"iron-replete":[163],"reveal":[165],"change":[169],"required":[170],"form":[172],"-reactive":[176,320],"structural":[183,311,389],"basis":[184,375],"for":[185,376,388],"instability,":[187,352],"showing":[188],"that":[189,308,361],"ligand-harboring":[191],"core":[192],"helix":[193,213],"dynamically":[194],"refolds":[195],"during":[196],"acquisition":[198,349],"release.":[200],"The":[201,224,274],"also":[203],"coordinates":[204],"unanticipated":[206,358],"Glu":[207],"ligand":[208,226,360],"contributed":[209],"auxiliary":[212],"implicated":[214],"substrate":[216],"docking":[219],"molecular":[221],"dynamics":[222],"simulation.":[223],"additional":[225],"conserved":[228,363],"another":[230],"experimentally":[231],"validated":[232],"-oxygenase":[235,289],"not":[237],"two":[239],"known":[240],"desaturases.":[243],"Among":[244],"\u223c9600":[245],"sequences":[246,371],"identified":[247],"bioinformatically":[248],"as":[249,269],"belonging":[250],"emerging":[253,298],"protein":[256],"(HDO)":[257],"superfamily,":[258],"\u223c25%":[259],"have":[260,309],"this":[261,330],"carboxylate":[262],"residue":[263],"are":[265],"thus":[266,384],"tentatively":[267],"assigned":[268,340],"-oxygenases.":[271],"Significance":[272],"statement":[273],"enzyme":[275],"assembles":[277],"pharmacophore":[281],"streptozotocin.":[285],"Its":[286],"resembles":[291],"heme-oxygenase":[292],"(HO)":[293],"belongs":[295],"superfamily":[299],"enzymes":[303],"(HDOs)":[304],"unstable":[306],"metallocofactors":[307],"resisted":[310],"characterization.":[312],"We":[313],"investigated":[314],"metal-free":[324],"Fe(II)":[327],"leveraged":[329],"insight":[331],"first":[335],"functionally":[339],"HDO":[341,370],"intact":[343],"cofactor.":[344],"Conformational":[345],"changes":[346],"accompanying":[347],"explain":[350],"its":[351],"observation":[355],"glutamate":[359],"only":[365],"subset":[367],"provides":[372],"potential":[374],"top-level":[377],"assignment":[378],"enzymatic":[380],"function.":[381],"Our":[382],"results":[383],"provide":[385],"roadmap":[387],"functional":[391],"characterization":[392],"novel":[394],"HDOs.":[395]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-01T00:00:00"}
