{"id":"https://openalex.org/W3124099345","doi":"https://doi.org/10.1080/1120009x.2021.1873632","title":"Proinflammatory circulating markers: new players for evaluating asymptomatic acute cardiovascular toxicity in breast cancer treatment","display_name":"Proinflammatory circulating markers: new players for evaluating asymptomatic acute cardiovascular toxicity in breast cancer treatment","publication_year":2021,"publication_date":"2021-01-22","ids":{"openalex":"https://openalex.org/W3124099345","doi":"https://doi.org/10.1080/1120009x.2021.1873632","mag":"3124099345","pmid":"https://pubmed.ncbi.nlm.nih.gov/33480330"},"language":"en","primary_location":{"id":"doi:10.1080/1120009x.2021.1873632","doi":"https://doi.org/10.1080/1120009x.2021.1873632","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1120009x.2021.1873632","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3124099345"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053603861","display_name":"P\u00e2mella Lonardoni Micheletti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"P. L. Micheletti","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Estadual de Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Estadual de Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091050132","display_name":"Jana\u00edna Carla da Silva","orcid":"https://orcid.org/0000-0001-9910-4413","observed_orcids":["https://orcid.org/0000-0001-9910-4413"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. Carla-da-Silva","raw_affiliation_strings":["Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9910-4413","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053475497","display_name":"Thalita Basso Scandolara","orcid":"https://orcid.org/0000-0003-4709-9207","observed_orcids":["https://orcid.org/0000-0003-4709-9207"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T. B. Scandolara","raw_affiliation_strings":["Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006511477","display_name":"Rodrigo Kern","orcid":"https://orcid.org/0000-0003-3154-0088","observed_orcids":["https://orcid.org/0000-0003-3154-0088"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R. Kern","raw_affiliation_strings":["Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048144084","display_name":"Vin\u00edcius Dias Alves","orcid":"https://orcid.org/0000-0003-1228-1746","observed_orcids":["https://orcid.org/0000-0003-1228-1746"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"V. D. Alves","raw_affiliation_strings":["Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004617457","display_name":"J\u00e9ssica Malanowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J. Malanowski","raw_affiliation_strings":["Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069258338","display_name":"Vanessa Jacob Victorino","orcid":"https://orcid.org/0000-0001-9339-2653","observed_orcids":["https://orcid.org/0000-0001-9339-2653"]},"institutions":[{"id":"https://openalex.org/I270441400","display_name":"Instituto Federal do Rio de Janeiro","ror":"https://ror.org/007qd1t98","country_code":"BR","type":"government","lineage":["https://openalex.org/I270441400"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"V. J. Victorino","raw_affiliation_strings":["Instituto Federal do Rio de Janeiro, Campus Engenheiro Paulo de Frontin, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Federal do Rio de Janeiro, Campus Engenheiro Paulo de Frontin, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I270441400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110504629","display_name":"A. C. S. A. Herrera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. C. S. A. Herrera","raw_affiliation_strings":["Pontif\u00edcia Universidade Cat\u00f3lica de Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontif\u00edcia Universidade Cat\u00f3lica de Londrina, Paran\u00e1, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048458694","display_name":"Daniel Rech","orcid":"https://orcid.org/0000-0002-2654-4562","observed_orcids":["https://orcid.org/0000-0002-2654-4562"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D. Rech","raw_affiliation_strings":["Hospital de C\u00e2ncer de Francisco Beltr\u00e3o, Ceonc, Paran\u00e1, Brazil","Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Francisco Beltr\u00e3o, Ceonc, Paran\u00e1, Brazil","institution_ids":[]},{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103950493","display_name":"J. A. O. Souza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. O. Souza","raw_affiliation_strings":["Hospital de C\u00e2ncer de Francisco Beltr\u00e3o, Ceonc, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Francisco Beltr\u00e3o, Ceonc, Paran\u00e1, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059608236","display_name":"A. N. C. Sim\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. N. C. Sim\u00e3o","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Estadual de Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Estadual de Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008237870","display_name":"Carolina Panis","orcid":"https://orcid.org/0000-0002-0104-4369","observed_orcids":["https://orcid.org/0000-0002-0104-4369"]},"institutions":[{"id":"https://openalex.org/I193876067","display_name":"Universidade Estadual do Oeste do Paran\u00e1","ror":"https://ror.org/05ne20t07","country_code":"BR","type":"education","lineage":["https://openalex.org/I193876067"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"C. Panis","raw_affiliation_strings":["Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0104-4369","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia de Tumores, Universidade Estadual do Oeste do Paran\u00e1, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I193876067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076632354","display_name":"Isa\u00edas Dichi","orcid":"https://orcid.org/0000-0002-9127-8264","observed_orcids":["https://orcid.org/0000-0002-9127-8264"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"I. Dichi","raw_affiliation_strings":["Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Estadual de Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Estadual de Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008237870"],"corresponding_institution_ids":["https://openalex.org/I193876067"],"apc_list":null,"apc_paid":null,"fwci":1.226,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7887399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"33","issue":"2","first_page":"106","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.765999972820282},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.75},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6840000152587891},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7599999904632568},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/free-iron","display_name":"free iron","score":0.9869999885559082},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.7509999871253967},{"id":"https://openalex.org/keywords/ck-mb","display_name":"CK-MB","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.796999990940094},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5090000033378601},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.7300000190734863},{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiomyopathy","display_name":"chemotherapy-induced cardiomyopathy","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6350436210632324},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6334718465805054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6312971115112305},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6133620738983154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.60548996925354},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5665703415870667},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4887714087963104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44212764501571655},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.41950511932373047},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16889256238937378}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/1120009x.2021.1873632","doi":"https://doi.org/10.1080/1120009x.2021.1873632","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1120009x.2021.1873632","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},{"id":"pmid:33480330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33480330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemotherapy (Florence, Italy)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W176315691","https://openalex.org/W1760708290","https://openalex.org/W1920678049","https://openalex.org/W1968130898","https://openalex.org/W1975217388","https://openalex.org/W1977455486","https://openalex.org/W1990291053","https://openalex.org/W1998554650","https://openalex.org/W1998616721","https://openalex.org/W2015250033","https://openalex.org/W2019430227","https://openalex.org/W2021286927","https://openalex.org/W2027725187","https://openalex.org/W2030387756","https://openalex.org/W2039527479","https://openalex.org/W2047168760","https://openalex.org/W2059769058","https://openalex.org/W2083386761","https://openalex.org/W2089972763","https://openalex.org/W2091739595","https://openalex.org/W2093870248","https://openalex.org/W2104272500","https://openalex.org/W2107304130","https://openalex.org/W2108123383","https://openalex.org/W2108705681","https://openalex.org/W2111241903","https://openalex.org/W2127284954","https://openalex.org/W2137159389","https://openalex.org/W2138135866","https://openalex.org/W2150525368","https://openalex.org/W2181396979","https://openalex.org/W2185082648","https://openalex.org/W2254993519","https://openalex.org/W2330366426","https://openalex.org/W2333047164","https://openalex.org/W2402660168","https://openalex.org/W2530366440","https://openalex.org/W2560560709","https://openalex.org/W2588881638","https://openalex.org/W2591131474","https://openalex.org/W2600519012","https://openalex.org/W2600611552","https://openalex.org/W2606920283","https://openalex.org/W2622405194","https://openalex.org/W2623170270","https://openalex.org/W2625326071","https://openalex.org/W2726870915","https://openalex.org/W2731297640","https://openalex.org/W2735238612","https://openalex.org/W2736563004","https://openalex.org/W2739862359","https://openalex.org/W2742723442","https://openalex.org/W2743231654","https://openalex.org/W2750642298","https://openalex.org/W2773292660","https://openalex.org/W2774166447","https://openalex.org/W2778340298","https://openalex.org/W2783954599","https://openalex.org/W2791340070","https://openalex.org/W2795373908","https://openalex.org/W2805254636","https://openalex.org/W2886652708","https://openalex.org/W2887277557","https://openalex.org/W2909507870","https://openalex.org/W2915976688","https://openalex.org/W2947073256","https://openalex.org/W2948656647","https://openalex.org/W2950071015","https://openalex.org/W2966397735","https://openalex.org/W2976701016","https://openalex.org/W2989718361","https://openalex.org/W2999536665","https://openalex.org/W3006491472","https://openalex.org/W3007935666","https://openalex.org/W4211264672","https://openalex.org/W4323236812"],"related_works":["https://openalex.org/W2767869583","https://openalex.org/W3092580834","https://openalex.org/W2127284954","https://openalex.org/W4402370591","https://openalex.org/W2087534382","https://openalex.org/W2773236325","https://openalex.org/W2111241903","https://openalex.org/W4399424926","https://openalex.org/W3024248839","https://openalex.org/W4406991362"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2,63],"aimed":[3],"to":[4,42,92,109],"evaluate":[5],"markers":[6,16,51],"of":[7,33,55,274,292,301],"cardiac":[8],"damage":[9],"(total":[10],"CK,":[11],"CKMB":[12],"and":[13,20,41,52,69,98,134,198,288,297],"CRP),":[14],"inflammatory":[15],"(free":[17],"iron,":[18],"homocysteine":[19,189,249],"TNF-\u03b1)":[21],"as":[22,24,266,295],"well":[23],"lipidogram":[25],"in":[26,61,150],"breast":[27,66,280],"cancer":[28,67,281],"patients":[29,68],"undergoing":[30],"acute":[31],"cycles":[32],"doxorubicin":[34],"(DOX),":[35],"paclitaxel":[36],"(PTX)":[37],"or":[38],"trastuzumab":[39],"(TZ)":[40],"verify":[43],"if":[44],"there":[45],"is":[46],"an":[47],"association":[48],"between":[49],"these":[50],"the":[53,56,62,81,89,145,272,290,299],"toxicity":[54],"chemotherapeutic":[57],"treatment.":[58],"Methods:":[59],"Included":[60],"were":[64,75],"120":[65],"50":[70],"healthy":[71],"controls.":[72],"All":[73],"analyzes":[74],"performed":[76],"on":[77],"automated":[78],"systems.":[79],"For":[80],"statistical":[82],"analysis,":[83],"each":[84],"group":[85],"was":[86],"compared":[87],"with":[88],"controls":[90],"according":[91],"their":[93],"normality":[94],"by":[95,279],"Student's":[96],"t-test":[97],"Mann-Whitney":[99],"test.":[100],"Results:":[101],"Our":[102,269],"results":[103],"showed":[104],"that":[105,283],"DOX":[106],"treatment":[107],"led":[108],"increased":[110],"hsCRP":[111,159],"(4.80":[112],"\u00b1":[113,121,128,138,153,161,169,176,183,191,202,214,222,230,237,244,251,260],"1.23":[114],"mg/dL,":[115,163,224],"p":[116,123,131,141,156,164,171,178,186,195,206,217,225,232,239,246,254,263],"=":[117,124,132,142,157,165,172,179,187,196,207,226,233,240,247,255,264],"0.0005),":[118],"triglycerides":[119,174,235],"(187.6":[120],"25.06,":[122],"0.0231),":[125],"TNF-\u03b1":[126,181,242],"(42.31":[127],"17.96":[129],"pg/mL,":[130,185],"0.01)":[133],"Fe":[135],"levels":[136],"(138.8":[137],"18.6":[139],"\u03bcg/dL,":[140,205],"0.0193).":[143],"In":[144],"meantime,":[146],"PTX":[147],"induced":[148],"changes":[149],"CK-MB":[151,212,296],"(8.78":[152],"4.2":[154],"U/L,":[155,216],"0.0361),":[158],"(7.12":[160],"1.87":[162],"0.0006),":[166],"cholesterol":[167,228],"(201.7":[168,175],"19.54,":[170,177],"0.05),":[173],"0.0277),":[180],"(38.27":[182],"9.12":[184],"0.023),":[188],"(10.95":[190],"0,":[192],"86":[193],"\u03bcmol/L,":[194,253],"0.005),":[197],"free":[199,257],"iron":[200,258],"(113":[201],"18":[203],"6":[204],"0.045)":[208],"while":[209],"TZ":[210],"augmented":[211],"(6.9":[213],"1.97":[215],"<":[218],"0.00),":[219],"hsPCR":[220],"(3.12":[221],"0.68":[223],"0.095),":[227],"(218.3":[229,236],"16.79,":[231,238],"0.0317),":[234],"0.0127),":[241],"(89.6":[243],"12.11,":[245],"0.032),":[248],"(9.95":[250],"1.15":[252],"0.0396),":[256],"(120.5":[259],"4.64":[261],"\u03bcg/dl,":[262],"0.0058)":[265],"well.":[267],"Conclusions:":[268],"data":[270],"demonstrated":[271],"existence":[273],"a":[275],"proinflammatory":[276],"net":[277],"triggered":[278],"chemotherapy":[282],"could":[284],"increase":[285],"cardiomyocytes":[286],"permeability":[287],"allow":[289],"leakage":[291],"circulating":[293],"proteins":[294],"induce":[298],"production":[300],"hsCRP.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-02-01T00:00:00"}