{"id":"https://openalex.org/W3124061202","doi":"https://doi.org/10.1001/jamanetworkopen.2020.34569","title":"Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival","display_name":"Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival","publication_year":2021,"publication_date":"2021-01-27","ids":{"openalex":"https://openalex.org/W3124061202","doi":"https://doi.org/10.1001/jamanetworkopen.2020.34569","mag":"3124061202","pmid":"https://pubmed.ncbi.nlm.nih.gov/33502483","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7841460"},"language":"en","primary_location":{"id":"doi:10.1001/jamanetworkopen.2020.34569","doi":"https://doi.org/10.1001/jamanetworkopen.2020.34569","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2020.34569","pdf_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2775639/wei_2021_oi_201047_1611112251.48406.pdf","source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2775639/wei_2021_oi_201047_1611112251.48406.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081352122","display_name":"Yongyue Wei","orcid":"https://orcid.org/0000-0002-1132-1796","observed_orcids":["https://orcid.org/0000-0002-1132-1796","https://orcid.org/0009-0003-2547-4528"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyue Wei","raw_affiliation_strings":["China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101855954","display_name":"Hui Huang","orcid":"https://orcid.org/0000-0001-8583-8299","observed_orcids":["https://orcid.org/0000-0001-8583-8299"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Huang","raw_affiliation_strings":["Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027061852","display_name":"Ruyang Zhang","orcid":"https://orcid.org/0000-0003-3861-4297","observed_orcids":["https://orcid.org/0000-0003-3861-4297"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruyang Zhang","raw_affiliation_strings":["China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087827600","display_name":"Zhaozhong Zhu","orcid":"https://orcid.org/0000-0001-5662-1541","observed_orcids":["https://orcid.org/0000-0001-5662-1541"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaozhong Zhu","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090261081","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0001-9880-5330","observed_orcids":["https://orcid.org/0000-0001-9880-5330"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028249243","display_name":"Lijuan Lin","orcid":"https://orcid.org/0000-0002-8305-0294","observed_orcids":["https://orcid.org/0000-0002-8305-0294"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Lin","raw_affiliation_strings":["Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084851606","display_name":"Xuesi Dong","orcid":"https://orcid.org/0000-0003-2986-7866","observed_orcids":["https://orcid.org/0000-0003-2986-7866"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuesi Dong","raw_affiliation_strings":["Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022823961","display_name":"Liangmin Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangmin Wei","raw_affiliation_strings":["Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745238","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-7786-1701","observed_orcids":["https://orcid.org/0000-0002-7786-1701"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413271","display_name":"Zhonghua Liu","orcid":"https://orcid.org/0000-0003-3048-9823","observed_orcids":["https://orcid.org/0000-0003-3048-9823","https://orcid.org/0009-0001-0313-2506"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhonghua Liu","raw_affiliation_strings":["Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100653859","display_name":"Yang Zhao","orcid":"https://orcid.org/0000-0001-9318-5371","observed_orcids":["https://orcid.org/0000-0001-9318-5371"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhao","raw_affiliation_strings":["China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374888","display_name":"Li Su","orcid":"https://orcid.org/0000-0002-6453-199X","observed_orcids":["https://orcid.org/0000-0002-6453-199X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Su","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352695","display_name":"Feng Chen","orcid":"https://orcid.org/0000-0002-2699-7190","observed_orcids":["https://orcid.org/0000-0002-2699-7190"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Chen","raw_affiliation_strings":["China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Biostatistics, Nanjing Medical University School of Public Health, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091331939","display_name":"David C. Christiani","orcid":"https://orcid.org/0000-0002-0301-0242","observed_orcids":["https://orcid.org/0000-0002-0301-0242"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C. Christiani","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","Department of Medicine, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091331939","https://openalex.org/A5100352695"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I83519826"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.5845,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82346349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"e2034569","last_page":"e2034569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.8830000162124634},{"id":"https://openalex.org/keywords/blood-metabolites","display_name":"blood metabolites","score":0.828000009059906},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6510000228881836},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.8790000081062317},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.38100001215934753},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.7039999961853027},{"id":"https://openalex.org/keywords/28-day-mortality","display_name":"28-day mortality","score":0.7710000276565552},{"id":"https://openalex.org/keywords/90-day-mortality","display_name":"90-day mortality","score":0.574999988079071},{"id":"https://openalex.org/keywords/functional-validation","display_name":"functional validation","score":0.4259999990463257},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.45399999618530273},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.30799999833106995},{"id":"https://openalex.org/keywords/berlin-criteria","display_name":"Berlin criteria","score":0.6629999876022339},{"id":"https://openalex.org/keywords/invasive-mechanical-ventilation","display_name":"invasive mechanical ventilation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.6753124594688416},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.6024917364120483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5312843918800354},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.49977540969848633},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.48946964740753174},{"id":"https://openalex.org/C189413060","wikidata":"https://www.wikidata.org/wiki/Q415443","display_name":"Mannan-binding lectin","level":3,"score":0.4825681746006012},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4660094380378723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42796605825424194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3642498254776001},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2566986083984375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.161012202501297},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.11428815126419067},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08117181062698364},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010343","descriptor_name":"Patient Admission","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/jamanetworkopen.2020.34569","doi":"https://doi.org/10.1001/jamanetworkopen.2020.34569","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2020.34569","pdf_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2775639/wei_2021_oi_201047_1611112251.48406.pdf","source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6765374","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7841460","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7841460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7841460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Netw Open","raw_type":"Text"},{"id":"pmid:33502483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33502483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA network open","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1001/jamanetworkopen.2020.34569","doi":"https://doi.org/10.1001/jamanetworkopen.2020.34569","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2020.34569","pdf_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2775639/wei_2021_oi_201047_1611112251.48406.pdf","source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2363433774","display_name":"Molecular and Genetic Analysis of Lung Cancer Survival","funder_award_id":"R01CA092824","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4769690452","display_name":"Harvard Chan School NIEHS Center for Environmental Health","funder_award_id":"P30ES000002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6037131243","display_name":"Molecular Epidemiology of ARDS","funder_award_id":"R01HL060710","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124061202.pdf","grobid_xml":"https://content.openalex.org/works/W3124061202.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W182658290","https://openalex.org/W1184073519","https://openalex.org/W1803784511","https://openalex.org/W1905058580","https://openalex.org/W1970302919","https://openalex.org/W1986607120","https://openalex.org/W1989568128","https://openalex.org/W1995736675","https://openalex.org/W2001315007","https://openalex.org/W2033925475","https://openalex.org/W2037459166","https://openalex.org/W2056593575","https://openalex.org/W2062090250","https://openalex.org/W2078711199","https://openalex.org/W2087857119","https://openalex.org/W2097072789","https://openalex.org/W2106036991","https://openalex.org/W2112390338","https://openalex.org/W2120156715","https://openalex.org/W2148432963","https://openalex.org/W2151355802","https://openalex.org/W2203536584","https://openalex.org/W2213195397","https://openalex.org/W2264585211","https://openalex.org/W2286228001","https://openalex.org/W2301389244","https://openalex.org/W2324862792","https://openalex.org/W2488281607","https://openalex.org/W2613603864","https://openalex.org/W2620241325","https://openalex.org/W2765349573","https://openalex.org/W2803072880","https://openalex.org/W2810178364","https://openalex.org/W2949543964","https://openalex.org/W2956730167","https://openalex.org/W3012186724","https://openalex.org/W3026716332","https://openalex.org/W3034823740","https://openalex.org/W4236982127","https://openalex.org/W4239508938","https://openalex.org/W4243950387","https://openalex.org/W4252933731","https://openalex.org/W6845503085","https://openalex.org/W6979096277"],"related_works":["https://openalex.org/W4388127673","https://openalex.org/W7140222913","https://openalex.org/W4402204578","https://openalex.org/W4404747383","https://openalex.org/W6903327952","https://openalex.org/W4388289437","https://openalex.org/W4414968207","https://openalex.org/W4311367431","https://openalex.org/W4401119452","https://openalex.org/W4392004726"],"abstract_inverted_index":{"Importance:":[0],"Acute":[1],"respiratory":[2],"distress":[3],"syndrome":[4],"(ARDS)":[5],"confers":[6],"high":[7],"mortality":[8,308],"risk":[9,20,38,160,223,268,352,366],"among":[10],"critically":[11],"ill":[12],"patients.":[13],"Identification":[14],"of":[15,33,54,61,132,264,387],"biomarkers":[16],"associated":[17,157,220,283,349,362],"with":[18,36,64,158,181,221,248,266,284,350,363,384],"ARDS":[19,37,55,65,124,159,182,201,222,249,267,351,365,379],"may":[21],"guide":[22],"clinical":[23,376],"diagnosis":[24],"and":[25,39,43,66,84,116,135,161,192,250,296,309,322,337,353,355,367,375],"prognosis.":[26],"Objective:":[27],"To":[28],"systematically":[29],"evaluate":[30],"the":[31,51,139,165,174,237,241,255,259,261,385,388],"association":[32,263],"blood":[34],"metabolites":[35,156],"survival.":[40,162,335,369],"Design,":[41],"Setting,":[42],"Participants:":[44],"In":[45,240,339],"this":[46,340],"cohort":[47,60],"study,":[48,57,341],"data":[49],"from":[50,94,106,168,258],"Molecular":[52],"Epidemiology":[53],"(MEARDS)":[56],"a":[58],"prospective":[59],"403":[62,177],"patients":[63],"1227":[67,193],"non-ARDS":[68],"controls,":[69],"were":[70,73,119,171,179,195],"analyzed.":[71],"Patients":[72],"recruited":[74],"in":[75,91,236,254,378],"intensive":[76],"care":[77],"units":[78],"(ICUs)":[79],"at":[80,359],"Massachusetts":[81],"General":[82],"Hospital":[83],"Beth":[85],"Israel":[86],"Deaconess":[87],"Medical":[88],"Center,":[89],"both":[90],"Boston,":[92],"Massachusetts,":[93],"January":[95,111],"1,":[96],"1998,":[97],"to":[98,110,153,173,347],"December":[99,107],"31,":[100],"2014.":[101],"Data":[102],"analysis":[103],"was":[104,151,219,269,282,361],"performed":[105],"9,":[108],"2018,":[109],"4,":[112],"2019.":[113],"Main":[114],"Outcomes":[115],"Measures:":[117],"Participants":[118],"followed":[120],"up":[121],"daily":[122],"for":[123],"development":[125],"defined":[126],"by":[127],"Berlin":[128],"criteria,":[129],"requiring":[130],"fulfillment":[131],"chest":[133],"radiograph":[134],"oxygenation":[136],"criteria":[137],"on":[138],"same":[140],"calendar":[141],"day":[142],"during":[143],"invasive":[144],"ventilatory":[145],"assistance.":[146],"A":[147],"2-stage":[148],"study":[149],"design":[150],"used":[152],"explore":[154],"novel":[155],"Results:":[163],"Of":[164],"1630":[166],"participants":[167,247,253],"MEARDS":[169],"who":[170],"admitted":[172],"ICU":[175],",":[176],"(24.7%)":[178],"diagnosed":[180],"(mean":[183,202],"[SD]":[184,203],"age,":[185,204],"63.0":[186],"[17.0]":[187],"years;":[188,207],"251":[189],"[62.3%]":[190],"male)":[191],"(75.3%)":[194],"at-risk":[196,252],"but":[197],"did":[198],"not":[199],"have":[200,382],"62.3":[205],"[16.9]":[206],"753":[208],"[61.4%]":[209],"male).":[210],"Mendelian":[211],"randomization":[212],"suggested":[213],"that":[214],"genetically":[215,342],"regulated":[216,343],"serum":[217,280,344,357],"mannose":[218,265,281,345,358],"(odds":[224],"ratio":[225],"[OR],":[226],"0.64;":[227],"95%":[228,273,288,300,314,327],"CI,":[229,274,289,301,315,328],"0.53-0.78;":[230],"P":[231,276,291,303,317,330],"=":[232,277,292,304,318,331],"7.46":[233],"\u00d7":[234,294,306,320,333],"10-6)":[235],"discovery":[238],"stage.":[239],"functional":[242],"validation":[243],"stage":[244],"incorporating":[245],"83":[246],"matched":[251],"control":[256],"group":[257],"ICU,":[260],"protective":[262],"validated":[270],"(OR,":[271,286,298],"0.67;":[272],"0.46-0.97;":[275],".03).":[278],"Furthermore,":[279],"28-day":[285,310],"0.25;":[287],"0.11-0.56;":[290],"6.95":[293],"10-4)":[295,321],"60-day":[297,323],"0.36;":[299],"0.19-0.71;":[302],"3.12":[305],"10-3)":[307,334],"(hazard":[311,324],"ratio,":[312,325],"0.49;":[313],"0.32-0.74;":[316],"6.41":[319],"0.55;":[326],"0.37-0.80;":[329],"2.11":[332],"Conclusions":[336],"Relevance:":[338],"appeared":[346],"be":[348],"outcome,":[354],"increased":[356,383],"admission":[360],"reduced":[364],"better":[368],"These":[370],"findings":[371],"could":[372],"inform":[373],"prevention":[374],"intervention":[377],"cases,":[380],"which":[381],"expansion":[386],"coronavirus":[389],"disease":[390],"2019":[391],"pandemic.":[392]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-01T00:00:00"}
