{"id":"https://openalex.org/W3123656254","doi":"https://doi.org/10.1186/s13287-021-02161-8","title":"Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models","display_name":"Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models","publication_year":2021,"publication_date":"2021-01-25","ids":{"openalex":"https://openalex.org/W3123656254","doi":"https://doi.org/10.1186/s13287-021-02161-8","mag":"3123656254","pmid":"https://pubmed.ncbi.nlm.nih.gov/33494812"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-021-02161-8","doi":"https://doi.org/10.1186/s13287-021-02161-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02161-8","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-021-02161-8","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-021-02161-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100625184","display_name":"Li Liang","orcid":"https://orcid.org/0000-0002-1694-380X","observed_orcids":["https://orcid.org/0000-0002-1694-380X","https://orcid.org/0000-0003-2424-4926"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liang","raw_affiliation_strings":["Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Respiratory Medicine, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074808690","display_name":"Dachao Zheng","orcid":"https://orcid.org/0000-0001-5705-792X","observed_orcids":["https://orcid.org/0000-0001-5705-792X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dachao Zheng","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764416","display_name":"Chao Lu","orcid":"https://orcid.org/0000-0001-5517-3812","observed_orcids":["https://orcid.org/0000-0001-5517-3812"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Lu","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083240431","display_name":"Qinghong Xi","orcid":"https://orcid.org/0009-0006-8701-7551","observed_orcids":["https://orcid.org/0009-0006-8701-7551","https://orcid.org/0000-0001-5726-2077"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghong Xi","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103247499","display_name":"Bao Hua","orcid":"https://orcid.org/0000-0002-0636-7474","observed_orcids":["https://orcid.org/0000-0002-0636-7474"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Bao","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027080813","display_name":"Wengfeng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wengfeng Li","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112697489","display_name":"Yufei Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufei Gu","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060932450","display_name":"Yuanshen Mao","orcid":"https://orcid.org/0000-0003-4120-415X","observed_orcids":["https://orcid.org/0000-0003-4120-415X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanshen Mao","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018008882","display_name":"Bin Xu","orcid":"https://orcid.org/0000-0001-7998-9314","observed_orcids":["https://orcid.org/0000-0001-7998-9314","https://orcid.org/0000-0003-4881-9229"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Xu","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China. chxb2004@126.com","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China. chxb2004@126.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091814370","display_name":"Xin Gu","orcid":"https://orcid.org/0000-0001-5328-3719","observed_orcids":["https://orcid.org/0000-0001-5328-3719"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Gu","raw_affiliation_strings":["Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China. guxin111@163.com","Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China"],"raw_orcid":"https://orcid.org/0000-0001-5328-3719","affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China. guxin111@163.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018008882","https://openalex.org/A5091814370"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":2.7523,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.92528728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"87","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.75},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/mir-301a-3p","display_name":"miR-301a-3p","score":0.9980000257492065},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.8899999856948853},{"id":"https://openalex.org/keywords/chronic-intermittent-hypoxia","display_name":"chronic intermittent hypoxia","score":0.972000002861023},{"id":"https://openalex.org/keywords/corpus-cavernosum-smooth-muscle-cells","display_name":"corpus cavernosum smooth muscle cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hif-1alpha-signaling","display_name":"HIF-1\u03b1 signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/microrna-therapeutic-target","display_name":"microRNA therapeutic target","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.7818061709403992},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6942480206489563},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.672743558883667},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.49387556314468384},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.48827123641967773},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4846563935279846},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4807598292827606},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.47283679246902466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45293760299682617},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4423760771751404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4297771155834198},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.42106494307518005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37380439043045044},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.36934196949005127},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34802839159965515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33292901515960693},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3056568503379822},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22493642568588257},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.186316579580307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13438227772712708},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13287-021-02161-8","doi":"https://doi.org/10.1186/s13287-021-02161-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02161-8","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-021-02161-8","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-51339/v1","doi":"https://doi.org/10.21203/rs.3.rs-51339/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-51339/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-51339/v2","doi":"https://doi.org/10.21203/rs.3.rs-51339/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-51339/v2","pdf_url":"https://www.researchsquare.com/article/rs-51339/v2.pdf?c=1607150142000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-51339/v3","doi":"https://doi.org/10.21203/rs.3.rs-51339/v3","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-51339/v3","pdf_url":"https://www.researchsquare.com/article/rs-51339/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33494812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33494812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7836493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7836493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4530458a16ca44aa8db567ca751faa9b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4530458a16ca44aa8db567ca751faa9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-021-02161-8","doi":"https://doi.org/10.1186/s13287-021-02161-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02161-8","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-021-02161-8","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3881225510","display_name":null,"funder_award_id":"JYZZ021","funder_id":"https://openalex.org/F4320335305","funder_display_name":"School of Medicine, Shanghai Jiao Tong University"}],"funders":[{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320335305","display_name":"School of Medicine, Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3123656254.pdf","grobid_xml":"https://content.openalex.org/works/W3123656254.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W16192970","https://openalex.org/W193592933","https://openalex.org/W1574497513","https://openalex.org/W1879320023","https://openalex.org/W1963758979","https://openalex.org/W1990419270","https://openalex.org/W2002347168","https://openalex.org/W2014946489","https://openalex.org/W2048367126","https://openalex.org/W2057851530","https://openalex.org/W2058173935","https://openalex.org/W2058180357","https://openalex.org/W2058314056","https://openalex.org/W2065460430","https://openalex.org/W2076357493","https://openalex.org/W2108033280","https://openalex.org/W2125819930","https://openalex.org/W2130845194","https://openalex.org/W2169912922","https://openalex.org/W2184437113","https://openalex.org/W2206080624","https://openalex.org/W2290891464","https://openalex.org/W2419675476","https://openalex.org/W2502274362","https://openalex.org/W2507730280","https://openalex.org/W2526691032","https://openalex.org/W2588757737","https://openalex.org/W2744871379","https://openalex.org/W2766250570","https://openalex.org/W2770270415","https://openalex.org/W2771701352","https://openalex.org/W2787162061","https://openalex.org/W2795468221","https://openalex.org/W2804549383","https://openalex.org/W2804934005","https://openalex.org/W2806340351","https://openalex.org/W2811212358","https://openalex.org/W2867037497","https://openalex.org/W2883760436","https://openalex.org/W2889312210","https://openalex.org/W2894481501","https://openalex.org/W2902320442","https://openalex.org/W2965010617","https://openalex.org/W2975937950","https://openalex.org/W3003899977","https://openalex.org/W3108094084","https://openalex.org/W3109349661","https://openalex.org/W4234679221","https://openalex.org/W4245193855","https://openalex.org/W4249523014"],"related_works":["https://openalex.org/W2352568601","https://openalex.org/W2374272643","https://openalex.org/W2186965932","https://openalex.org/W2046077454","https://openalex.org/W4390452441","https://openalex.org/W2357679775","https://openalex.org/W2059248219","https://openalex.org/W1964912188","https://openalex.org/W4298172496","https://openalex.org/W2407165303"],"abstract_inverted_index":{"BACKGROUND:":[0],"Erectile":[1],"dysfunction":[2],"(ED)":[3],"has":[4,23],"often":[5],"been":[6],"observed":[7],"in":[8,31,43,59,79,102,141,156,163],"patients":[9],"with":[10,180],"obstructive":[11],"sleep":[12],"apnea":[13],"(OSA).":[14],"Research":[15],"on":[16],"adipose-derived":[17],"mesenchymal":[18],"stem":[19],"cell":[20],"(ADSC)-derived":[21],"exosomes":[22],"shown":[24],"that":[25,71,108,128,144,167],"they":[26],"have":[27],"significant":[28],"therapeutic":[29,136,174],"effects":[30,137],"many":[32],"diseases":[33],"including":[34],"ED.":[35,160],"METHODS:":[36],"In":[37],"this":[38,164],"study,":[39],"ED":[40,178],"was":[41],"induced":[42],"Sprague":[44],"Dawley":[45],"(SD)":[46],"rats":[47,80,103],"using":[48],"chronic":[49],"intermittent":[50],"hypoxia":[51],"(CIH)":[52],"exposure.":[53],"CIH-mediated":[54],"influences":[55],"were":[56],"then":[57],"measured":[58],"the":[60,94,135,157],"corpus":[61],"cavernous":[62],"smooth":[63,98],"muscle":[64,99],"cells":[65],"(CCSMCs).":[66],"RESULTS:":[67],"Our":[68,125],"data":[69],"showed":[70],"miR-301a-3p-enriched":[72],"exosome":[73],"treatment":[74,90],"significantly":[75,92],"recovered":[76,93],"erectile":[77],"function":[78],"and":[81,86,104,110,114,149],"CCSMCs":[82,142],"by":[83,139],"promoting":[84],"autophagy":[85],"inhibiting":[87],"apoptosis.":[88],"The":[89,161],"also":[91],"level":[95],"of":[96,122,159],"alpha":[97,147],"actin":[100],"(\u03b1-SMA)":[101],"CCSMCs.":[105],"Bioinformatics":[106],"predicted":[107],"phosphatase":[109],"tensin":[111],"homolog":[112],"(PTEN)":[113],"Toll-like":[115],"receptor":[116],"4":[117],"(TLR4)":[118],"might":[119],"be":[120,170],"targets":[121],"miR-301a-3p.":[123],"CONCLUSIONS:":[124],"results":[126],"indicate":[127],"PTEN-overexpression":[129],"vectors":[130,133],"or":[131],"TLR4-overexpression":[132],"reverse":[134],"achieved":[138],"miR-301a-3p":[140,168],"indicating":[143],"PTEN/hypoxia-inducible":[145],"factor-1":[146],"(HIF-1\u03b1)":[148],"TLR4":[150],"signaling":[151],"pathways":[152],"play":[153],"key":[154],"roles":[155],"progression":[158],"findings":[162],"study":[165],"suggest":[166],"should":[169],"considered":[171],"a":[172],"new":[173],"target":[175],"for":[176],"treating":[177],"associated":[179],"OSA.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}