{"id":"https://openalex.org/W3123647115","doi":"https://doi.org/10.4314/tjpr.v19i9.11","title":"LncRNA MALAT1: A potential therapeutic target in DSSinduced ulcerative colitis progression in vitro","display_name":"LncRNA MALAT1: A potential therapeutic target in DSSinduced ulcerative colitis progression in vitro","publication_year":2020,"publication_date":"2020-11-23","ids":{"openalex":"https://openalex.org/W3123647115","doi":"https://doi.org/10.4314/tjpr.v19i9.11","mag":"3123647115"},"language":"en","primary_location":{"id":"doi:10.4314/tjpr.v19i9.11","doi":"https://doi.org/10.4314/tjpr.v19i9.11","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v19i9.11","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/201767/190272","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-9827","issn":["1596-9827","1596-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3123647115"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ajol.info/index.php/tjpr/article/download/201767/190272","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021859056","display_name":"Baoqin Zhang","orcid":"https://orcid.org/0000-0003-0790-5219","observed_orcids":["https://orcid.org/0000-0003-0790-5219"]},"institutions":[{"id":"https://openalex.org/I4210101913","display_name":"Fifth Tianjin Central Hospital","ror":"https://ror.org/01924nm42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101913"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Baoqin Zhang","raw_affiliation_strings":["Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","institution_ids":["https://openalex.org/I4210101913"]},{"raw_affiliation_string":"of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393748","display_name":"Tiantian Li","orcid":"https://orcid.org/0009-0004-6212-1729","observed_orcids":["https://orcid.org/0009-0004-6212-1729","https://orcid.org/0000-0003-0689-6541"]},"institutions":[{"id":"https://openalex.org/I4210101913","display_name":"Fifth Tianjin Central Hospital","ror":"https://ror.org/01924nm42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101913"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Tiantian Li","raw_affiliation_strings":["Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","institution_ids":["https://openalex.org/I4210101913"]},{"raw_affiliation_string":"of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406906","display_name":"Chao Wang","orcid":"https://orcid.org/0000-0001-8452-1214","observed_orcids":["https://orcid.org/0000-0001-8452-1214"]},"institutions":[{"id":"https://openalex.org/I4210101913","display_name":"Fifth Tianjin Central Hospital","ror":"https://ror.org/01924nm42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101913"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Chao Wang","raw_affiliation_strings":["Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","institution_ids":["https://openalex.org/I4210101913"]},{"raw_affiliation_string":"of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103146625","display_name":"Jing Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101913","display_name":"Fifth Tianjin Central Hospital","ror":"https://ror.org/01924nm42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101913"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Jing Han","raw_affiliation_strings":["Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","institution_ids":["https://openalex.org/I4210101913"]},{"raw_affiliation_string":"of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Baiqing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101913","display_name":"Fifth Tianjin Central Hospital","ror":"https://ror.org/01924nm42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101913"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Baiqing Wang","raw_affiliation_strings":[", Benin City , 300001 Nigeria","Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Benin City , 300001 Nigeria","institution_ids":[]},{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","institution_ids":["https://openalex.org/I4210101913"]},{"raw_affiliation_string":"of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102017519","display_name":"Guang\u2010Bin Sun","orcid":"https://orcid.org/0000-0001-8465-5175","observed_orcids":["https://orcid.org/0000-0001-8465-5175"]},"institutions":[{"id":"https://openalex.org/I4210101913","display_name":"Fifth Tianjin Central Hospital","ror":"https://ror.org/01924nm42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101913"]},{"id":"https://openalex.org/I6406202","display_name":"University of Benin","ror":"https://ror.org/04mznrw11","country_code":"NG","type":"education","lineage":["https://openalex.org/I6406202"]}],"countries":["CN","NG"],"is_corresponding":false,"raw_author_name":"Guangbin Sun","raw_affiliation_strings":["Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","of Pharmacy, University of Benin, Benin City, 300001 Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tianjin Fifth Central Hospital, Tianjin 300450, China","institution_ids":["https://openalex.org/I4210101913"]},{"raw_affiliation_string":"of Pharmacy, University of Benin, Benin City, 300001 Nigeria","institution_ids":["https://openalex.org/I6406202"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.1742,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45211275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"19","issue":"9","first_page":"1871","last_page":"1877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mir-30c-5p","display_name":"miR-30c-5p","score":0.9890000224113464},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.7749999761581421},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7480000257492065},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lncrna-mirna-interaction","display_name":"lncRNA-miRNA interaction","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.8359189629554749},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7276121377944946},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6237236261367798},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5833806991577148},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5679225921630859},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5591892004013062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.548089861869812},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5360499024391174},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5056729316711426},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4682769775390625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46063077449798584},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.45278143882751465},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4135645925998688},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36085718870162964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2845928966999054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23273172974586487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20181584358215332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1955849528312683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1343391239643097},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08331331610679626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08089208602905273},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.05840447545051575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05467939376831055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4314/tjpr.v19i9.11","doi":"https://doi.org/10.4314/tjpr.v19i9.11","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v19i9.11","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/201767/190272","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-9827","issn":["1596-9827","1596-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4314/tjpr.v19i9.11","doi":"https://doi.org/10.4314/tjpr.v19i9.11","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v19i9.11","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/201767/190272","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-9827","issn":["1596-9827","1596-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3123647115.pdf","grobid_xml":"https://content.openalex.org/works/W3123647115.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1506507986","https://openalex.org/W1556309137","https://openalex.org/W1965319009","https://openalex.org/W1978967539","https://openalex.org/W1979895292","https://openalex.org/W1986079650","https://openalex.org/W1986146810","https://openalex.org/W2006556963","https://openalex.org/W2011556145","https://openalex.org/W2014776577","https://openalex.org/W2016430576","https://openalex.org/W2027876496","https://openalex.org/W2029569738","https://openalex.org/W2041838266","https://openalex.org/W2095164057","https://openalex.org/W2108229642","https://openalex.org/W2111688179","https://openalex.org/W2133090587","https://openalex.org/W2136550485","https://openalex.org/W2147287621","https://openalex.org/W2188248802","https://openalex.org/W2620756707","https://openalex.org/W3004854037"],"related_works":["https://openalex.org/W3004854037","https://openalex.org/W3102154959","https://openalex.org/W3169837826","https://openalex.org/W4295422472","https://openalex.org/W3013228258","https://openalex.org/W3092282074","https://openalex.org/W3133861441","https://openalex.org/W1984666548","https://openalex.org/W4290652761","https://openalex.org/W4386796067"],"abstract_inverted_index":{"Purpose:":[0],"Ulcerative":[1],"colitis":[2,32,54,76],"is":[3,33],"a":[4,18,287],"severe":[5],"disease":[6],"affecting":[7],"human":[8],"health":[9],"worldwide.":[10],"Studies":[11],"have":[12],"shown":[13],"that":[14,223,237],"lncRNA":[15,45,89],"MALAT1":[16,46,90,140,160,186,198,253,262,285],"has":[17],"significant":[19],"correlation":[20],"with":[21,66,168],"breast,":[22],"pancreatic,":[23],"colon":[24],"and":[25,47,113,141,199,228,254,271],"liver":[26],"cancers,":[27],"but":[28],"its":[29,191,201],"effects":[30],"on":[31],"yet":[34],"to":[35,71,82,134,149,173,264],"be":[36,246],"discovered.":[37],"In":[38,178],"this":[39],"study,":[40],"the":[41,48,86,136,151,155,162,174,179,218,229,238],"potential":[42],"role":[43],"of":[44,88,122,159,185,208,220,224,231,240,261,266],"underlying":[49],"molecular":[50,137],"mechanism":[51],"in":[52,57,74,93,110,161,203],"DSS-induced":[53,114,163,180],"were":[55,98,125,273],"investigated":[56],"vitro.Methods:":[58],"Colorectal":[59],"mucosal":[60],"cell":[61,116,170,188,211,267],"line":[62],"FHC":[63,94,112,115,164,176,182,205],"was":[64,80,104,132,147,166,215,226],"induced":[65],"dextran":[67],"sulphate":[68],"sodium":[69],"(DSS)":[70],"form":[72],"an":[73],"vitro":[75],"model.":[77],"Transfection":[78],"procedure":[79],"employed":[81],"up-":[83],"or":[84,91],"down-regulate":[85],"expressions":[87,109],"miR-30c-5p":[92,209,232,255,277],"cells.":[95,177,206],"Cell":[96],"viabilities":[97],"detected":[99],"by":[100,127,217,243,248,275],"CCK-8":[101],"assay.":[102],"RT-qPCR":[103],"applied":[105],"for":[106,290],"evaluating":[107],"gene":[108],"normal":[111,175],"lines,":[117],"while":[118,143,190,222,269],"protein":[119],"expression":[120,202,214],"levels":[121],"target":[123,289],"genes":[124],"examined":[126],"Western":[128],"blot":[129],"analysis.":[130],"Starbase":[131],"used":[133],"predict":[135],"interaction":[138,251],"between":[139,154,252],"miR-30c-5p,":[142,296],"luciferase":[144],"reporter":[145],"assay":[146],"utilized":[148],"verify":[150],"binding":[152],"sites":[153],"two":[156],"genes.Results:":[157],"Expression":[158],"cells":[165],"high":[167],"low":[169],"viabilities,":[171,189],"compared":[172],"colitis-like":[181],"cells,":[183],"overexpression":[184],"inhibited":[187,200,216,247],"downregulation":[192],"promoted":[193,242,274],"it.":[194],"MiR-30c-5p":[195],"directly":[196],"targets":[197],"DSS-treated":[204],"Upregulation":[207],"increased":[210],"viabilities.":[212],"Bcl-xL":[213],"up-regulation":[219],"MALAT1,":[221,295],"Bax":[225],"enhanced":[227],"mimics":[230],"reversed":[233],"these":[234],"observations,":[235],"suggesting":[236],"enhancement":[239],"apoptosis":[241,270],"oe-MALAT1":[244],"could":[245],"miR-30c-5p.":[249],"The":[250],"regulated":[256],"NF-\u03baB/TGF-\u03b2/Wnt-\u03b2-catenin":[257,279,297],"signaling":[258,280],"pathway.Conclusion:":[259],"Overexpression":[260],"led":[263],"inhibition":[265],"viability,":[268],"inflammation":[272],"targeting":[276],"via":[278],"pathway.":[281],"These":[282],"findings":[283],"suggest":[284],"as":[286],"therapeutic":[288],"treating":[291],"colitis.":[292],"Keywords:":[293],"Colitis,":[294]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2021-02-01T00:00:00"}