{"id":"https://openalex.org/W3122810489","doi":"https://doi.org/10.3389/fimmu.2020.620166","title":"CU06-1004-Induced Vascular Normalization Improves Immunotherapy by Modulating Tumor Microenvironment via Cytotoxic T Cells","display_name":"CU06-1004-Induced Vascular Normalization Improves Immunotherapy by Modulating Tumor Microenvironment via Cytotoxic T Cells","publication_year":2021,"publication_date":"2021-01-26","ids":{"openalex":"https://openalex.org/W3122810489","doi":"https://doi.org/10.3389/fimmu.2020.620166","mag":"3122810489","pmid":"https://pubmed.ncbi.nlm.nih.gov/33584714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7874050"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2020.620166","doi":"https://doi.org/10.3389/fimmu.2020.620166","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.620166","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.620166/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.620166/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072309505","display_name":"Songyi Park","orcid":"https://orcid.org/0000-0001-5817-4845","observed_orcids":["https://orcid.org/0000-0001-5817-4845"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Songyi Park","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037480612","display_name":"Ji Hoon Oh","orcid":"https://orcid.org/0000-0002-0824-6131","observed_orcids":["https://orcid.org/0000-0002-0824-6131"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Hoon Oh","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101415571","display_name":"Dong Jin Park","orcid":"https://orcid.org/0000-0002-2412-5292","observed_orcids":["https://orcid.org/0000-0002-2412-5292"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Jin Park","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haiying Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haiying Zhang","raw_affiliation_strings":["R&D Department, Curacle Co. Ltd, Seongnam-si, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Department, Curacle Co. Ltd, Seongnam-si, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051113988","display_name":"Minyoung Noh","orcid":"https://orcid.org/0000-0002-0750-1460","observed_orcids":["https://orcid.org/0000-0002-0750-1460"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minyoung Noh","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016451717","display_name":"Yeomyung Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeomyung Kim","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","Vascular System Research Center, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Vascular System Research Center, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039821968","display_name":"Ye-Seul Kim","orcid":"https://orcid.org/0000-0002-1542-2367","observed_orcids":["https://orcid.org/0000-0002-1542-2367"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ye-Seul Kim","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","Vascular System Research Center, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Vascular System Research Center, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101672968","display_name":"Hyejeong Kim","orcid":"https://orcid.org/0000-0002-6334-4033","observed_orcids":["https://orcid.org/0000-0002-6334-4033"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyejeong Kim","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054964892","display_name":"Young\u2010Myeong Kim","orcid":"https://orcid.org/0000-0002-8326-7768","observed_orcids":["https://orcid.org/0000-0002-8326-7768"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Myeong Kim","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","Vascular System Research Center, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Vascular System Research Center, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003546968","display_name":"Sang\u2010Jun Ha","orcid":"https://orcid.org/0000-0002-1192-6031","observed_orcids":["https://orcid.org/0000-0002-1192-6031"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang-Jun Ha","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113916322","display_name":"Young-Guen Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young-Guen Kwon","raw_affiliation_strings":["Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003546968","https://openalex.org/A5113916322"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.0018,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.90176703,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"620166","last_page":"620166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-normalization","display_name":"vascular normalization","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7440000176429749},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9179999828338623},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.847000002861023},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8265505433082581},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6288426518440247},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5995023250579834},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5427106022834778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40397000312805176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39244234561920166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3677699565887451},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.21812370419502258},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1907830536365509},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11468729376792908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04673069715499878}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2020.620166","doi":"https://doi.org/10.3389/fimmu.2020.620166","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.620166","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.620166/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7874050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7874050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:33584714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33584714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a19fcc0d013a438dab9858227b38bf59","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a19fcc0d013a438dab9858227b38bf59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 11 (2021)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/13544384","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/media/CU06-1004-induced_vascular_normalization_improves_immunotherapy_by_modulating_tumor_microenvironment_via_cytotoxic_T_cells/13544384","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.13544384.v2","doi":"https://doi.org/10.6084/m9.figshare.13544384.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.13544384.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Audiovisual"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2020.620166","doi":"https://doi.org/10.3389/fimmu.2020.620166","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.620166","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.620166/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1251031942","display_name":null,"funder_award_id":"BK 21 four","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G30685149","display_name":null,"funder_award_id":"BK21 FOUR","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G3865813888","display_name":null,"funder_award_id":"2019R1A2C3007142","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G494592887","display_name":null,"funder_award_id":"NRF-2015M3A9B6066835","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5255373243","display_name":null,"funder_award_id":"2015M3A9B6066835","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6335846770","display_name":null,"funder_award_id":"2018R1A2A1A05076997","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G643442212","display_name":null,"funder_award_id":"2019R1A2C3007142, 2018R1A2A1A05076997, 2015M3A9B6066835","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3122810489.pdf","grobid_xml":"https://content.openalex.org/works/W3122810489.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1510735640","https://openalex.org/W1943173994","https://openalex.org/W1965596101","https://openalex.org/W1980363723","https://openalex.org/W1990489521","https://openalex.org/W2008070008","https://openalex.org/W2033278321","https://openalex.org/W2033518843","https://openalex.org/W2054967851","https://openalex.org/W2055242813","https://openalex.org/W2089914460","https://openalex.org/W2098600061","https://openalex.org/W2115852392","https://openalex.org/W2131783235","https://openalex.org/W2156106286","https://openalex.org/W2158303916","https://openalex.org/W2171157655","https://openalex.org/W2212142291","https://openalex.org/W2402433991","https://openalex.org/W2523223625","https://openalex.org/W2557573814","https://openalex.org/W2606939149","https://openalex.org/W2702840193","https://openalex.org/W2730714254","https://openalex.org/W2790067792","https://openalex.org/W2793869682","https://openalex.org/W2794408630","https://openalex.org/W2800799386","https://openalex.org/W2802731336","https://openalex.org/W2803061034","https://openalex.org/W2890296921","https://openalex.org/W2891616394","https://openalex.org/W2895357007","https://openalex.org/W2901513648","https://openalex.org/W2913062750","https://openalex.org/W2914098003","https://openalex.org/W2915370072","https://openalex.org/W2915904495","https://openalex.org/W2918589641","https://openalex.org/W2925307360","https://openalex.org/W2939112943","https://openalex.org/W2945338097","https://openalex.org/W2947917787","https://openalex.org/W2964300303","https://openalex.org/W2981494293","https://openalex.org/W2987284967","https://openalex.org/W3000339487","https://openalex.org/W3003714437","https://openalex.org/W3080773873","https://openalex.org/W6759147739"],"related_works":["https://openalex.org/W4327694387","https://openalex.org/W4400729649","https://openalex.org/W4283523776","https://openalex.org/W4241957851","https://openalex.org/W4321596822","https://openalex.org/W4394935133","https://openalex.org/W3003714437","https://openalex.org/W7208257635","https://openalex.org/W3083529074","https://openalex.org/W4389147543"],"abstract_inverted_index":{"Blocking":[0],"the":[1,17,58,77,96,111,124,127,137,157,161,200],"immune":[2,71],"evasion":[3],"mechanism":[4],"of":[5,19,43,49,85,113,126,160,170,190,194],"tumor":[6,78,86,118,138],"cells":[7,69],"has":[8],"become":[9],"an":[10],"attractive":[11],"means":[12],"for":[13],"treating":[14],"cancers.":[15],"However,":[16],"usage":[18],"a":[20,185],"drug":[21,188],"such":[22],"as":[23],"nivolumab":[24],"(\u03b1PD-1),":[25],"which":[26,50,94],"blocks":[27],"programmed":[28],"cell":[29,134],"death":[30],"protein":[31],"1":[32],"(PD-1),":[33],"turned":[34],"out":[35],"to":[36,63,67],"be":[37,64],"only":[38],"effective":[39],"against":[40],"certain":[41],"types":[42],"cancer.":[44],"Especially,":[45],"vascular":[46],"abnormal":[47],"structures":[48],"deter":[51],"delivery":[52,75],"route":[53],"by":[54,89,116],"leakage":[55],"and":[56,70,98,152,173],"cause":[57],"poor":[59],"perfusion":[60],"were":[61],"considered":[62],"environment":[65],"unfavorable":[66],"T":[68,133],"checkpoint":[72],"blockade":[73],"(ICB)":[74],"within":[76,136],"microenvironment":[79],"(TME).":[80],"Herein,":[81],"we":[82],"report":[83],"stabilization":[84],"blood":[87],"vessels":[88],"endothelial":[90],"dysfunctional":[91],"blocker":[92],"CU06-1004,":[93],"modified":[95],"TME":[97],"showed":[99],"synergistic":[100],"effects":[101,164],"with":[102,130,142,149,167],"immunotherapy":[103],"anti-PD-1":[104,143,195],"antibody.":[105],"CU06-1004":[106,183],"combination":[107,128],"therapy":[108],"consistently":[109],"prolonged":[110],"survival":[112],"tumor-bearing":[114],"mice":[115],"decreasing":[117],"growth.":[119],"T-cell":[120],"infiltration":[121],"increased":[122],"in":[123,156,175,199],"tumors":[125],"group,":[129],"cytotoxic":[131],"CD8+":[132],"activity":[135],"parenchyma":[139],"upregulated":[140],"compared":[141],"monotherapy.":[144],"Tumor":[145],"inhibition":[146],"was":[147],"associated":[148],"reduced":[150,153],"hypoxia":[151],"vessel":[154],"density":[155],"central":[158],"region":[159],"tumor.":[162],"These":[163],"correlated":[165],"significantly":[166],"enhanced":[168],"expression":[169],"IFN":[171],"gamma":[172],"PD-L1":[174],"tumors.":[176],"Taken":[177],"together,":[178],"our":[179],"findings":[180],"suggest":[181],"that":[182],"is":[184],"potential":[186],"candidate":[187],"capable":[189],"improving":[191],"therapeutic":[192],"efficacy":[193],"through":[196],"beneficial":[197],"changes":[198],"TME.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-02-01T00:00:00"}
