{"id":"https://openalex.org/W3122561446","doi":"https://doi.org/10.21037/qims-20-895","title":"Feasibility study for ex vivo fluorescence confocal microscopy (FCM) on diagnostic prostate biopsies","display_name":"Feasibility study for ex vivo fluorescence confocal microscopy (FCM) on diagnostic prostate biopsies","publication_year":2021,"publication_date":"2021-01-27","ids":{"openalex":"https://openalex.org/W3122561446","doi":"https://doi.org/10.21037/qims-20-895","mag":"3122561446","pmid":"https://pubmed.ncbi.nlm.nih.gov/33816171","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7930678"},"language":"en","primary_location":{"id":"doi:10.21037/qims-20-895","doi":"https://doi.org/10.21037/qims-20-895","is_oa":true,"landing_page_url":"https://doi.org/10.21037/qims-20-895","pdf_url":"https://qims.amegroups.com/article/viewFile/60123/pdf","source":{"id":"https://openalex.org/S2764457454","display_name":"Quantitative Imaging in Medicine and Surgery","issn_l":"2223-4306","issn":["2223-4306","2223-4292"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Imaging in Medicine and Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://qims.amegroups.com/article/viewFile/60123/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005708049","display_name":"Ulf Titze","orcid":"https://orcid.org/0000-0002-3791-8929","observed_orcids":["https://orcid.org/0000-0002-3791-8929"]},"institutions":[{"id":"https://openalex.org/I4210129627","display_name":"Klinikum Lippe","ror":"https://ror.org/02pbsk254","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210129627"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ulf Titze","raw_affiliation_strings":["Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany","institution_ids":["https://openalex.org/I4210129627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034104832","display_name":"Torsten Hansen","orcid":"https://orcid.org/0000-0001-7885-0580","observed_orcids":["https://orcid.org/0000-0001-7885-0580"]},"institutions":[{"id":"https://openalex.org/I4210129627","display_name":"Klinikum Lippe","ror":"https://ror.org/02pbsk254","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210129627"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Hansen","raw_affiliation_strings":["Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany","institution_ids":["https://openalex.org/I4210129627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083607335","display_name":"Barbara Titze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129627","display_name":"Klinikum Lippe","ror":"https://ror.org/02pbsk254","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210129627"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Titze","raw_affiliation_strings":["Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany","institution_ids":["https://openalex.org/I4210129627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027567490","display_name":"Birte Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129627","display_name":"Klinikum Lippe","ror":"https://ror.org/02pbsk254","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210129627"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birte Schulz","raw_affiliation_strings":["Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Klinikum Lippe GmbH, Detmold, Germany","institution_ids":["https://openalex.org/I4210129627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059818348","display_name":"Alfons Gunnemann","orcid":"https://orcid.org/0000-0002-0793-5111","observed_orcids":["https://orcid.org/0000-0002-0793-5111"]},"institutions":[{"id":"https://openalex.org/I4210129627","display_name":"Klinikum Lippe","ror":"https://ror.org/02pbsk254","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210129627"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alfons Gunnemann","raw_affiliation_strings":["Department of Urology, Klinikum Lippe GmbH, Detmold, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Klinikum Lippe GmbH, Detmold, Germany","institution_ids":["https://openalex.org/I4210129627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034920748","display_name":"Bernardo Maria Cesare Rocco","orcid":"https://orcid.org/0000-0002-9135-0035","observed_orcids":["https://orcid.org/0000-0002-9135-0035"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bernardo Rocco","raw_affiliation_strings":["Department of Urology, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044885343","display_name":"Karl\u2010Dietrich Sievert","orcid":"https://orcid.org/0000-0003-4814-214X","observed_orcids":["https://orcid.org/0000-0003-4814-214X"]},"institutions":[{"id":"https://openalex.org/I4210129627","display_name":"Klinikum Lippe","ror":"https://ror.org/02pbsk254","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210129627"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl-Dietrich Sievert","raw_affiliation_strings":["Department of Urology, Klinikum Lippe GmbH, Detmold, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Klinikum Lippe GmbH, Detmold, Germany","institution_ids":["https://openalex.org/I4210129627"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005708049"],"corresponding_institution_ids":["https://openalex.org/I4210129627"],"apc_list":null,"apc_paid":null,"fwci":1.6395,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.80983232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"11","issue":"4","first_page":"1322","last_page":"1332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/confocal-fluorescence-microscopy","display_name":"confocal fluorescence microscopy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/prostate-biopsy","display_name":"prostate biopsy","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mri-targeted-biopsy","display_name":"MRI-guided biopsy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ex-vivo-tissue-imaging","display_name":"ex vivo tissue imaging","score":0.6480000019073486},{"id":"https://openalex.org/keywords/histopathological-diagnosis","display_name":"histopathological diagnosis","score":0.5180000066757202},{"id":"https://openalex.org/keywords/acridine-orange-staining","display_name":"acridine orange staining","score":0.796999990940094},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.6775598526000977},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.6478234529495239},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.637631893157959},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6305931806564331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6048049330711365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5857475996017456},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5797073841094971},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5443938374519348},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5208430886268616},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4375871419906616},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.42652615904808044},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.42199838161468506},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.351408451795578},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2890668511390686},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.20977336168289185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19796407222747803},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.12601491808891296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07089585065841675},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.21037/qims-20-895","doi":"https://doi.org/10.21037/qims-20-895","is_oa":true,"landing_page_url":"https://doi.org/10.21037/qims-20-895","pdf_url":"https://qims.amegroups.com/article/viewFile/60123/pdf","source":{"id":"https://openalex.org/S2764457454","display_name":"Quantitative Imaging in Medicine and Surgery","issn_l":"2223-4306","issn":["2223-4306","2223-4292"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Imaging in Medicine and Surgery","raw_type":"journal-article"},{"id":"pmid:33816171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33816171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative imaging in medicine and surgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7930678","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7930678/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quant Imaging Med Surg","raw_type":"Text"},{"id":"pmh:oai:publicatt.unicatt.it:10807/346781","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10807/346781","pdf_url":"https://publicatt.unicatt.it/bitstream/10807/346781/1/feasib.pdf","source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:air.unimi.it:2434/876861","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/876861","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.21037/qims-20-895","doi":"https://doi.org/10.21037/qims-20-895","is_oa":true,"landing_page_url":"https://doi.org/10.21037/qims-20-895","pdf_url":"https://qims.amegroups.com/article/viewFile/60123/pdf","source":{"id":"https://openalex.org/S2764457454","display_name":"Quantitative Imaging in Medicine and Surgery","issn_l":"2223-4306","issn":["2223-4306","2223-4292"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Imaging in Medicine and Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3122561446.pdf","grobid_xml":"https://content.openalex.org/works/W3122561446.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1236347705","https://openalex.org/W1757407923","https://openalex.org/W1975536785","https://openalex.org/W1978085863","https://openalex.org/W2024166934","https://openalex.org/W2034024919","https://openalex.org/W2075480836","https://openalex.org/W2083043726","https://openalex.org/W2120965994","https://openalex.org/W2133012565","https://openalex.org/W2151494814","https://openalex.org/W2160047073","https://openalex.org/W2164777277","https://openalex.org/W2321809877","https://openalex.org/W2337356559","https://openalex.org/W2340422569","https://openalex.org/W2377806452","https://openalex.org/W2511949746","https://openalex.org/W2782542351","https://openalex.org/W2922457219","https://openalex.org/W2922760520","https://openalex.org/W2937997180","https://openalex.org/W2940304572","https://openalex.org/W2953583330","https://openalex.org/W2997396471","https://openalex.org/W3000987722","https://openalex.org/W4234547368","https://openalex.org/W4237957904","https://openalex.org/W4244724791"],"related_works":["https://openalex.org/W2940304572","https://openalex.org/W3212932134","https://openalex.org/W7142114277","https://openalex.org/W4392103301","https://openalex.org/W3143309477","https://openalex.org/W4229457574","https://openalex.org/W7131381540","https://openalex.org/W3083935410","https://openalex.org/W4385186328","https://openalex.org/W4409171089"],"abstract_inverted_index":{"BACKGROUND:":[0],"Fluorescence":[1],"confocal":[2],"microscopy":[3],"(FCM)":[4],"is":[5,244],"a":[6,225,245],"novel":[7],"micro-imaging":[8],"technique":[9,37,243],"providing":[10],"optical":[11],"sections":[12],"of":[13,25,52,65,79,114,119,128,133,168,180,192,208,234],"examined":[14],"tissue.":[15],"The":[16],"method":[17,247],"has":[18],"been":[19],"well":[20,85],"established":[21],"for":[22,149,198,213,228,255],"the":[23,50,71,80,88,117,126,129,193,229,250],"diagnosis":[24,231],"tumours":[26],"in":[27,54,87,138,165,200,232,236],"dermatological":[28],"specimens.":[29,45],"Preliminary":[30],"results":[31,72,118],"found":[32],"good":[33,100],"feasibility":[34,197],"when":[35],"this":[36,242],"was":[38,97],"used":[39],"to":[40,73,92,170,177,223],"examine":[41],"prostate":[42,59],"cancer":[43],"(PCa)":[44],"METHODS:":[46],"We":[47],"report":[48],"on":[49,125],"application":[51],"FCM":[53,89,221],"magnet":[55],"resonance":[56],"imaging":[57],"(MRI)-fused":[58],"biopsies":[60,251],"(10":[61],"patients,":[62],"total":[63],"number":[64],"biopsy":[66],"specimens:":[67],"n=121)":[68],"and":[69,103,136,205],"compare":[70],"conventional":[74,93,120],"histology.":[75,94],"RESULTS:":[76],"Specific":[77],"structures":[78],"prostatic":[81],"tissue":[82,194],"were":[83,140,145,163],"very":[84],"represented":[86],"images":[90],"comparable":[91],"Prostate":[95],"carcinoma":[96],"diagnosed":[98],"with":[99,110,116,184],"sensitivity":[101],"(79/68%)":[102],"high":[104],"specificity":[105],"(100%)":[106],"by":[107],"two":[108],"pathologists":[109],"substantial/almost":[111],"perfect":[112],"levels":[113],"agreement":[115],"histology":[121],"(kappa":[122],"0.79/0.86).":[123],"Depending":[124],"quality":[127],"scans,":[130],"malignant":[131],"lesions":[132,144],"1.8":[134],"mm":[135],"more":[137],"diameter":[139],"reliably":[141],"diagnosed.":[142],"Smaller":[143],"rated":[146],"as":[147,252,259],"suspect":[148],"malignancy,":[150],"but":[151],"could":[152,210],"not":[153,189],"be":[154,211,224],"consistently":[155],"differentiated":[156],"from":[157],"reactive":[158],"changes.":[159],"Optimal":[160],"image":[161],"qualities":[162],"achieved":[164],"focus":[166],"depths":[167],"up":[169],"50":[171],"\u00b5m,":[172],"whereas":[173],"deeper":[174],"scans":[175],"led":[176],"insufficient":[178],"representation":[179],"cytological":[181],"features.":[182],"Pre-treatment":[183],"acridine":[185],"orange":[186],"(AO)":[187],"did":[188],"alter":[190],"immunoreactivity":[191],"or":[195],"its":[196],"fluorescence":[199],"situ":[201],"hybridization":[202],"(FISH)":[203],"analyses":[204],"adequate":[206],"amounts":[207],"DNA":[209],"extracted":[212],"further":[214,256],"polymerase":[215],"chain":[216],"reaction":[217],"(PCR)-based":[218],"examinations.":[219],"CONCLUSIONS:":[220],"seems":[222],"promising":[226],"tool":[227],"timely":[230],"cases":[233],"PCa":[235],"patients":[237],"requiring":[238],"therapy.":[239],"In":[240],"particular,":[241],"material-sparing":[246],"that":[248],"conserves":[249],"unfixed":[253],"material":[254],"analysis":[257],"such":[258],"molecular":[260],"tumour":[261],"companion":[262],"diagnosis.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-02-01T00:00:00"}