{"id":"https://openalex.org/W3122437113","doi":"https://doi.org/10.3390/ph14020095","title":"Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease","display_name":"Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease","publication_year":2021,"publication_date":"2021-01-27","ids":{"openalex":"https://openalex.org/W3122437113","doi":"https://doi.org/10.3390/ph14020095","mag":"3122437113","pmid":"https://pubmed.ncbi.nlm.nih.gov/33513737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7911954"},"language":"en","primary_location":{"id":"doi:10.3390/ph14020095","doi":"https://doi.org/10.3390/ph14020095","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14020095","pdf_url":"https://www.mdpi.com/1424-8247/14/2/95/pdf?version=1611736027","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/14/2/95/pdf?version=1611736027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077593043","display_name":"Jacob Kosyakovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Kosyakovsky","raw_affiliation_strings":["HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA","School of Medicine, University of Virginia, 200 Jeanette Lancaster Way, Charlottesville, VA 22903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA","institution_ids":["https://openalex.org/I52792670"]},{"raw_affiliation_string":"School of Medicine, University of Virginia, 200 Jeanette Lancaster Way, Charlottesville, VA 22903, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075759855","display_name":"Jared M. Fine","orcid":"https://orcid.org/0000-0002-0271-9065","observed_orcids":["https://orcid.org/0000-0002-0271-9065"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jared Fine","raw_affiliation_strings":["HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA"],"raw_orcid":"https://orcid.org/0000-0002-0271-9065","affiliations":[{"raw_affiliation_string":"HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046805860","display_name":"William H. Frey","orcid":"https://orcid.org/0000-0002-6373-0794","observed_orcids":["https://orcid.org/0000-0002-6373-0794"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Frey","raw_affiliation_strings":["HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA","institution_ids":["https://openalex.org/I52792670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021352245","display_name":"Leah R. Hanson","orcid":"https://orcid.org/0000-0002-2847-7949","observed_orcids":["https://orcid.org/0000-0002-2847-7949"]},"institutions":[{"id":"https://openalex.org/I52792670","display_name":"HealthPartners","ror":"https://ror.org/03s9ada67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I52792670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Hanson","raw_affiliation_strings":["HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA"],"raw_orcid":"https://orcid.org/0000-0002-2847-7949","affiliations":[{"raw_affiliation_string":"HealthPartners Neuroscience Center, HealthPartners Institute, Saint Paul, MN 55130, USA","institution_ids":["https://openalex.org/I52792670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075759855"],"corresponding_institution_ids":["https://openalex.org/I52792670"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1944},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1944},"fwci":1.6289,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.84257426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"2","first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.3353999853134155,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9629999995231628},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neurovascular-disease","display_name":"neurovascular disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.7200000286102295},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.7506396770477295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6897304654121399},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.6308836936950684},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5877408981323242},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5548111200332642},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45108091831207275},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34228357672691345},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2855445146560669},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25198227167129517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1459466814994812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14115500450134277}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ph14020095","doi":"https://doi.org/10.3390/ph14020095","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14020095","pdf_url":"https://www.mdpi.com/1424-8247/14/2/95/pdf?version=1611736027","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7911954","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7911954","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmid:33513737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33513737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a26d39a7966e4d1ca7cac70db418906b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a26d39a7966e4d1ca7cac70db418906b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 14, Iss 2, p 95 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph14020095","doi":"https://doi.org/10.3390/ph14020095","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14020095","pdf_url":"https://www.mdpi.com/1424-8247/14/2/95/pdf?version=1611736027","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3122437113.pdf","grobid_xml":"https://content.openalex.org/works/W3122437113.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W1088862126","https://openalex.org/W1489844805","https://openalex.org/W1508884137","https://openalex.org/W1510941488","https://openalex.org/W1514932744","https://openalex.org/W1517528796","https://openalex.org/W1592937389","https://openalex.org/W1963945544","https://openalex.org/W1964271667","https://openalex.org/W1970779072","https://openalex.org/W1973304468","https://openalex.org/W1983877968","https://openalex.org/W1993023011","https://openalex.org/W1995797290","https://openalex.org/W1997183854","https://openalex.org/W1998111067","https://openalex.org/W1999116330","https://openalex.org/W2001525797","https://openalex.org/W2004959154","https://openalex.org/W2006221702","https://openalex.org/W2008516570","https://openalex.org/W2008946188","https://openalex.org/W2009012892","https://openalex.org/W2009978681","https://openalex.org/W2012933242","https://openalex.org/W2013322977","https://openalex.org/W2020415247","https://openalex.org/W2022730808","https://openalex.org/W2026956101","https://openalex.org/W2032694823","https://openalex.org/W2037426713","https://openalex.org/W2044138536","https://openalex.org/W2044682044","https://openalex.org/W2048228128","https://openalex.org/W2049888915","https://openalex.org/W2050030843","https://openalex.org/W2054113864","https://openalex.org/W2056477869","https://openalex.org/W2056789677","https://openalex.org/W2057770297","https://openalex.org/W2062851065","https://openalex.org/W2066734010","https://openalex.org/W2069972562","https://openalex.org/W2071117904","https://openalex.org/W2072788211","https://openalex.org/W2076458228","https://openalex.org/W2077216169","https://openalex.org/W2077680189","https://openalex.org/W2077756131","https://openalex.org/W2079935694","https://openalex.org/W2082149083","https://openalex.org/W2083337622","https://openalex.org/W2084272059","https://openalex.org/W2086096852","https://openalex.org/W2087390633","https://openalex.org/W2088017190","https://openalex.org/W2089034809","https://openalex.org/W2089920521","https://openalex.org/W2107405263","https://openalex.org/W2111200377","https://openalex.org/W2112867510","https://openalex.org/W2117674127","https://openalex.org/W2123301364","https://openalex.org/W2123882607","https://openalex.org/W2127455950","https://openalex.org/W2127960694","https://openalex.org/W2133159465","https://openalex.org/W2135009525","https://openalex.org/W2141814662","https://openalex.org/W2143959688","https://openalex.org/W2145577892","https://openalex.org/W2151625241","https://openalex.org/W2154881330","https://openalex.org/W2158232673","https://openalex.org/W2168936681","https://openalex.org/W2171559922","https://openalex.org/W2219854607","https://openalex.org/W2265799967","https://openalex.org/W2299808451","https://openalex.org/W2306119705","https://openalex.org/W2324465359","https://openalex.org/W2329336071","https://openalex.org/W2402476390","https://openalex.org/W2418654089","https://openalex.org/W2520046828","https://openalex.org/W2531401390","https://openalex.org/W2600568015","https://openalex.org/W2609085690","https://openalex.org/W2652858501","https://openalex.org/W2736398109","https://openalex.org/W2754967293","https://openalex.org/W2757642952","https://openalex.org/W2758951655","https://openalex.org/W2762087180","https://openalex.org/W2763403209","https://openalex.org/W2769853159","https://openalex.org/W2774369241","https://openalex.org/W2780739174","https://openalex.org/W2786962139","https://openalex.org/W2794361626","https://openalex.org/W2801187948","https://openalex.org/W2804592477","https://openalex.org/W2894231856","https://openalex.org/W2894357926","https://openalex.org/W2895004036","https://openalex.org/W2896418665","https://openalex.org/W2903517662","https://openalex.org/W2903957639","https://openalex.org/W2908632279","https://openalex.org/W2913876336","https://openalex.org/W2919368574","https://openalex.org/W2921259698","https://openalex.org/W2950920754","https://openalex.org/W2971180542","https://openalex.org/W2976163884","https://openalex.org/W2977337099","https://openalex.org/W2980394465","https://openalex.org/W2980471106","https://openalex.org/W2989846484","https://openalex.org/W3001604987","https://openalex.org/W3015042576","https://openalex.org/W3048109944","https://openalex.org/W3081664061","https://openalex.org/W3084656137","https://openalex.org/W4210440929","https://openalex.org/W4241875855"],"related_works":["https://openalex.org/W3084656137","https://openalex.org/W4417449079","https://openalex.org/W2977337099","https://openalex.org/W2009978681","https://openalex.org/W3001604987","https://openalex.org/W2062851065","https://openalex.org/W4406338095","https://openalex.org/W1996910944","https://openalex.org/W2736398109","https://openalex.org/W1963945544"],"abstract_inverted_index":{"Identifying":[0],"disease-modifying":[1,92],"therapies":[2],"for":[3,20,34,176],"neurological":[4,69,172],"diseases":[5,121],"remains":[6],"one":[7],"of":[8,24,56,65,68,74,112,118,127,179],"the":[9,18,63,109,174],"greatest":[10],"gaps":[11],"in":[12,62,94,140],"modern":[13],"medicine.":[14],"Herein,":[15],"we":[16],"present":[17],"rationale":[19],"intranasal":[21],"(IN)":[22],"delivery":[23,160],"deferoxamine":[25],"(DFO),":[26],"a":[27,32,40,53,66],"high-affinity":[28],"iron":[29,47,50,88,113],"chelator,":[30],"as":[31],"treatment":[33],"neurodegenerative":[35,149],"and":[36,59,77,86,103,151,167],"neurovascular":[37],"disease":[38,96,99],"with":[39,49],"focus":[41],"on":[42],"its":[43,155],"novel":[44],"mechanisms.":[45,124],"Brain":[46],"dyshomeostasis":[48],"accumulation":[51],"is":[52,60,182],"known":[54,156],"feature":[55],"brain":[57,146],"aging":[58],"implicated":[61],"pathogenesis":[64],"number":[67],"diseases.":[70],"A":[71],"substantial":[72],"body":[73],"preclinical":[75,163],"evidence":[76,128],"early":[78],"clinical":[79],"data":[80],"has":[81],"demonstrated":[82],"that":[83],"IN":[84,134,180],"DFO":[85,115,135,181],"other":[87,148],"chelators":[89],"have":[90],"strong":[91],"impacts":[93],"Alzheimer's":[95],"(AD),":[97],"Parkinson's":[98],"(PD),":[100],"ischemic":[101],"stroke,":[102],"intracranial":[104],"hemorrhage":[105],"(ICH).":[106],"Acting":[107],"by":[108,132],"disease-nonspecific":[110],"pathway":[111],"chelation,":[114],"targets":[116],"each":[117],"these":[119],"complex":[120],"via":[122],"multifactorial":[123],"Accumulating":[125],"lines":[126],"suggest":[129],"further":[130,177],"mechanisms":[131],"which":[133],"may":[136],"also":[137],"be":[138],"beneficial":[139],"cognitive":[141],"aging,":[142],"multiple":[143,165],"sclerosis,":[144],"traumatic":[145],"injury,":[147],"diseases,":[150,173],"vascular":[152],"dementia.":[153],"Considering":[154],"safety":[157],"profile,":[158],"targeted":[159],"method,":[161],"robust":[162],"efficacy,":[164],"mechanisms,":[166],"potential":[168],"applicability":[169],"across":[170],"many":[171],"case":[175],"development":[178],"considerable.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-01T00:00:00"}
