{"id":"https://openalex.org/W3122392363","doi":"https://doi.org/10.1177/1535759721990042","title":"Cells That \u201cFire Together, Wire Together\u201d, but Do They Transcribe Together in Epilepsy?","display_name":"Cells That \u201cFire Together, Wire Together\u201d, but Do They Transcribe Together in Epilepsy?","publication_year":2021,"publication_date":"2021-01-29","ids":{"openalex":"https://openalex.org/W3122392363","doi":"https://doi.org/10.1177/1535759721990042","mag":"3122392363","pmid":"https://pubmed.ncbi.nlm.nih.gov/33508978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8010875"},"language":"en","primary_location":{"id":"doi:10.1177/1535759721990042","doi":"https://doi.org/10.1177/1535759721990042","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1535759721990042","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1535759721990042","source":{"id":"https://openalex.org/S76379409","display_name":"Epiliepsy currents/Epilepsy currents","issn_l":"1535-7511","issn":["1535-7511","1535-7597"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy Currents","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1535759721990042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061167168","display_name":"Sadi Qui\u00f1ones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadi Qui\u00f1ones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039346693","display_name":"Chris G. Dulla","orcid":"https://orcid.org/0000-0002-6560-6535","observed_orcids":["https://orcid.org/0000-0002-6560-6535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Dulla","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6560-6535","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"2","first_page":"124","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neuron-types","display_name":"neuronal cell types","score":0.8650000095367432},{"id":"https://openalex.org/keywords/single-nucleus-transcriptomics","display_name":"single-nucleus transcriptomics","score":0.9539999961853027},{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/principal-neurons","display_name":"principal neurons","score":0.6930000185966492},{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glutamate-signaling","display_name":"glutamate signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.746999979019165},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3630000054836273},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7423543930053711},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3620918393135071},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.32160043716430664},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3032532334327698}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1177/1535759721990042","doi":"https://doi.org/10.1177/1535759721990042","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1535759721990042","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1535759721990042","source":{"id":"https://openalex.org/S76379409","display_name":"Epiliepsy currents/Epilepsy currents","issn_l":"1535-7511","issn":["1535-7511","1535-7597"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy Currents","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8010875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8010875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy Curr","raw_type":"Text"},{"id":"pmid:33508978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33508978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy currents","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/1535759721990042","doi":"https://doi.org/10.1177/1535759721990042","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1535759721990042","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1535759721990042","source":{"id":"https://openalex.org/S76379409","display_name":"Epiliepsy currents/Epilepsy currents","issn_l":"1535-7511","issn":["1535-7511","1535-7597"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy Currents","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3122392363.pdf"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1487443352","https://openalex.org/W1975440733","https://openalex.org/W2085228451","https://openalex.org/W2129974095","https://openalex.org/W2341328588","https://openalex.org/W2803194497","https://openalex.org/W2950976066","https://openalex.org/W2969948459","https://openalex.org/W3011286936","https://openalex.org/W3092259116"],"related_works":["https://openalex.org/W2907222344","https://openalex.org/W2770064001","https://openalex.org/W204914600","https://openalex.org/W2567478882","https://openalex.org/W7079311901","https://openalex.org/W4390745350","https://openalex.org/W2070323117","https://openalex.org/W2074047036","https://openalex.org/W4310223471","https://openalex.org/W2027066452"],"abstract_inverted_index":{"Identification":[0],"of":[1,56,73,95,105,128,178,197,214],"Epilepsy-Associated":[2],"Neuronal":[3],"Subtypes":[4],"and":[5,110,132,134,138,194],"Gene":[6],"Expression":[7],"Underlying":[8],"Epileptogenesis":[9],"Pfisterer":[10],"U,":[11],"Petukhov":[12],"V,":[13],"Demharter":[14],"S,":[15],"Meichsner":[16],"J,":[17,29,38],"Thompson":[18],"JJ,":[19],"Batiuk":[20],"MY,":[21],"Asenjo-Martinez":[22],"A,":[23,27],"Vasistha":[24],"NA,":[25],"Thakur":[26],"Mikkelsen":[28],"Adorjan":[30],"I,":[31],"Pinborg":[32],"LH,":[33],"Pers":[34],"TH,":[35],"von":[36],"Engelhardt":[37],"Kharchenko":[39],"PV,":[40],"Khodosevich":[41],"K.":[42],"Nat":[43,51],"Commun.":[44,52],"2020;11(1):5038.":[45],"doi:10.1038/s41467-020-18752-7":[46],"[published":[47],"correction":[48],"appears":[49],"in":[50,85,121,143,182,189],"2020;11(1):5988]Epilepsy":[53],"is":[54,65],"one":[55,177],"the":[57,70,86,116,144,151,154,162,179],"most":[58],"common":[59],"neurological":[60],"disorders,":[61],"yet":[62],"its":[63],"pathophysiology":[64],"poorly":[66],"understood":[67],"due":[68],"to":[69,161],"high":[71],"complexity":[72],"affected":[74],"neuronal":[75,80,98,123,210],"circuits.":[76],"To":[77],"identify":[78],"dysfunctional":[79],"subtypes":[81,124,142,152],"underlying":[82],"seizure":[83],"activity":[84],"human":[87],"brain,":[88],"we":[89,166],"have":[90],"performed":[91],"single-nucleus":[92],"transcriptomics":[93],"analysis":[94],">110":[96],"000":[97],"transcriptomes":[99],"derived":[100],"from":[101,125],"temporal":[102,107],"cortex":[103],"samples":[104],"multiple":[106,190],"lobe":[108],"epilepsy":[109],"nonepileptic":[111],"subjects.":[112],"We":[113],"found":[114],"that":[115],"largest":[117,155],"transcriptomic":[118,157,169],"changes":[119,158,188],"occur":[120],"distinct":[122],"several":[126],"families":[127,146],"principal":[129],"neurons":[130],"(L5-6_Fezf2":[131],"L2-3_Cux2)":[133],"GABAergic":[135],"interneurons":[136],"(Sst":[137],"Pvalb),":[139],"whereas":[140],"other":[141],"same":[145,163],"were":[147],"less":[148],"affected.":[149],"Furthermore,":[150],"with":[153],"epilepsy-related":[156],"may":[159],"belong":[160],"circuit,":[164],"since":[165],"observed":[167],"coordinated":[168],"shifts":[170],"across":[171],"these":[172],"subtypes.":[173],"Glutamate":[174],"signaling":[175],"exhibited":[176],"strongest":[180],"dysregulations":[181],"epilepsy,":[183],"highlighted":[184],"by":[185],"layer-wise":[186],"transcriptional":[187],"glutamate":[191],"receptor":[192,202],"genes":[193,198],"strong":[195],"upregulation":[196],"coding":[199],"for":[200],"AMPA":[201],"auxiliary":[203],"subunits.":[204],"Overall,":[205],"our":[206],"data":[207],"reveal":[208],"a":[209],"subtype-specific":[211],"molecular":[212],"phenotype":[213],"epilepsy.":[215]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-02-01T00:00:00"}
