{"id":"https://openalex.org/W3122321909","doi":"https://doi.org/10.1007/s12035-021-02297-x","title":"Impact of Genetic Risk Factors for Alzheimer\u2019s Disease on Brain Glucose Metabolism","display_name":"Impact of Genetic Risk Factors for Alzheimer\u2019s Disease on Brain Glucose Metabolism","publication_year":2021,"publication_date":"2021-01-21","ids":{"openalex":"https://openalex.org/W3122321909","doi":"https://doi.org/10.1007/s12035-021-02297-x","mag":"3122321909","pmid":"https://pubmed.ncbi.nlm.nih.gov/33479841"},"language":"en","primary_location":{"id":"doi:10.1007/s12035-021-02297-x","doi":"https://doi.org/10.1007/s12035-021-02297-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12035-021-02297-x","pdf_url":null,"source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016801481","display_name":"Sukhee Cho","orcid":"https://orcid.org/0000-0002-2553-6296","observed_orcids":["https://orcid.org/0000-0002-2553-6296"]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sukhee Cho","raw_affiliation_strings":["Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-2553-6296","affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea","institution_ids":["https://openalex.org/I193352282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648768","display_name":"Hyein G. Lee","orcid":"https://orcid.org/0000-0002-1525-2599","observed_orcids":["https://orcid.org/0000-0002-1525-2599","https://orcid.org/0009-0004-3724-0953"]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyein Lee","raw_affiliation_strings":["Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-1525-2599","affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea","institution_ids":["https://openalex.org/I193352282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010137230","display_name":"Jinsoo Seo","orcid":"https://orcid.org/0000-0001-6432-6964","observed_orcids":["https://orcid.org/0000-0001-6432-6964"]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinsoo Seo","raw_affiliation_strings":["Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea. jsseo@dgist.ac.kr","Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea"],"raw_orcid":"https://orcid.org/0000-0001-6432-6964","affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea. jsseo@dgist.ac.kr","institution_ids":["https://openalex.org/I193352282"]},{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, DGIST, Daegu, 42988, South Korea","institution_ids":["https://openalex.org/I193352282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010137230"],"corresponding_institution_ids":["https://openalex.org/I193352282"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":0.4644,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.40446169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"58","issue":"6","first_page":"2608","last_page":"2619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.9909999966621399},{"id":"https://openalex.org/keywords/polygenic-disease","display_name":"polygenic disease","score":0.7260000109672546},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ad-pathogenesis","display_name":"AD pathogenesis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5450000166893005},{"id":"https://openalex.org/keywords/therapeutic-drug-development","display_name":"therapeutic drug development","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7757944464683533},{"id":"https://openalex.org/C27502469","wikidata":"https://www.wikidata.org/wiki/Q906343","display_name":"Dysfunctional family","level":2,"score":0.6012488007545471},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5819941759109497},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5088491439819336},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5036188960075378},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4771822690963745},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.46812334656715393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43739116191864014},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4263848066329956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3529316782951355},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3140209913253784},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17515167593955994},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15479964017868042},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12035-021-02297-x","doi":"https://doi.org/10.1007/s12035-021-02297-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12035-021-02297-x","pdf_url":null,"source":{"id":"https://openalex.org/S194681035","display_name":"Molecular Neurobiology","issn_l":"0893-7648","issn":["0893-7648","1559-1182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurobiology","raw_type":"journal-article"},{"id":"pmid:33479841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33479841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G377579828","display_name":null,"funder_award_id":"2019R1C1C1008591","funder_id":"https://openalex.org/F4320322347","funder_display_name":"Ministry of Science ICT and Future Planning"},{"id":"https://openalex.org/G5878903250","display_name":null,"funder_award_id":"2018M3C7A1056275","funder_id":"https://openalex.org/F4320322347","funder_display_name":"Ministry of Science ICT and Future Planning"}],"funders":[{"id":"https://openalex.org/F4320322347","display_name":"Ministry of Science ICT and Future Planning","ror":"https://ror.org/032e49973"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W126091187","https://openalex.org/W1151405824","https://openalex.org/W1463613178","https://openalex.org/W1521108077","https://openalex.org/W1522806115","https://openalex.org/W1543737421","https://openalex.org/W1718410121","https://openalex.org/W1968933263","https://openalex.org/W1969013845","https://openalex.org/W1970779072","https://openalex.org/W1970858190","https://openalex.org/W1972609075","https://openalex.org/W1974266381","https://openalex.org/W1975250375","https://openalex.org/W1975727000","https://openalex.org/W1978799642","https://openalex.org/W1988821503","https://openalex.org/W1991758365","https://openalex.org/W2000462597","https://openalex.org/W2010550564","https://openalex.org/W2011617651","https://openalex.org/W2014723821","https://openalex.org/W2017033087","https://openalex.org/W2018961056","https://openalex.org/W2032127135","https://openalex.org/W2032885546","https://openalex.org/W2037678016","https://openalex.org/W2041325253","https://openalex.org/W2043768383","https://openalex.org/W2045106215","https://openalex.org/W2046798812","https://openalex.org/W2050226347","https://openalex.org/W2056367893","https://openalex.org/W2058459789","https://openalex.org/W2061519105","https://openalex.org/W2067443877","https://openalex.org/W2067645279","https://openalex.org/W2071305328","https://openalex.org/W2076241970","https://openalex.org/W2076517751","https://openalex.org/W2079580613","https://openalex.org/W2079598623","https://openalex.org/W2085397620","https://openalex.org/W2088148170","https://openalex.org/W2088474892","https://openalex.org/W2089141103","https://openalex.org/W2092635505","https://openalex.org/W2093891993","https://openalex.org/W2095519862","https://openalex.org/W2097157695","https://openalex.org/W2098548022","https://openalex.org/W2101526550","https://openalex.org/W2101991516","https://openalex.org/W2107080306","https://openalex.org/W2111631797","https://openalex.org/W2115021528","https://openalex.org/W2124443688","https://openalex.org/W2124882555","https://openalex.org/W2128348740","https://openalex.org/W2132091452","https://openalex.org/W2133143628","https://openalex.org/W2134630622","https://openalex.org/W2136922708","https://openalex.org/W2137243283","https://openalex.org/W2138369511","https://openalex.org/W2145812954","https://openalex.org/W2146542148","https://openalex.org/W2148516306","https://openalex.org/W2157665412","https://openalex.org/W2166036638","https://openalex.org/W2171758504","https://openalex.org/W2172204522","https://openalex.org/W2261760577","https://openalex.org/W2282741949","https://openalex.org/W2297872912","https://openalex.org/W2403478980","https://openalex.org/W2509538385","https://openalex.org/W2510806376","https://openalex.org/W2556956494","https://openalex.org/W2576833703","https://openalex.org/W2605493286","https://openalex.org/W2611277309","https://openalex.org/W2623976789","https://openalex.org/W2739598026","https://openalex.org/W2743727231","https://openalex.org/W2756852269","https://openalex.org/W2766908402","https://openalex.org/W2767859551","https://openalex.org/W2786962139","https://openalex.org/W2787666045","https://openalex.org/W2789361216","https://openalex.org/W2789730644","https://openalex.org/W2791406808","https://openalex.org/W2791894605","https://openalex.org/W2805798400","https://openalex.org/W2881473390","https://openalex.org/W2883139774","https://openalex.org/W2899239550","https://openalex.org/W2903677140","https://openalex.org/W2903952336","https://openalex.org/W2903973081","https://openalex.org/W2904701356","https://openalex.org/W2905067650","https://openalex.org/W2905302555","https://openalex.org/W2907547898","https://openalex.org/W2911248861","https://openalex.org/W2913638709","https://openalex.org/W2916749909","https://openalex.org/W2918580443","https://openalex.org/W2922380492","https://openalex.org/W2954390789","https://openalex.org/W2965909772","https://openalex.org/W2971770812","https://openalex.org/W2980172305","https://openalex.org/W2989855650","https://openalex.org/W2992102276","https://openalex.org/W2992371953","https://openalex.org/W2995254660","https://openalex.org/W2997545733","https://openalex.org/W2999315469","https://openalex.org/W3004033201","https://openalex.org/W3005977767","https://openalex.org/W3015916968","https://openalex.org/W3035923503","https://openalex.org/W3103041673"],"related_works":["https://openalex.org/W3095894610","https://openalex.org/W3121521613","https://openalex.org/W4293030287","https://openalex.org/W1990293508","https://openalex.org/W2996814867","https://openalex.org/W4387850007","https://openalex.org/W3049483551","https://openalex.org/W2768364584","https://openalex.org/W4414162674","https://openalex.org/W7117892383"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-02-01T00:00:00"}