{"id":"https://openalex.org/W3122202310","doi":"https://doi.org/10.1016/j.biopha.2020.111177","title":"A strategy for component-based Chinese medicines design approach of Polygonum orientale L. against hypoxia/reoxygenation based on uniform design-stepwise regression-simulated annealing","display_name":"A strategy for component-based Chinese medicines design approach of Polygonum orientale L. against hypoxia/reoxygenation based on uniform design-stepwise regression-simulated annealing","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3122202310","doi":"https://doi.org/10.1016/j.biopha.2020.111177","mag":"3122202310","pmid":"https://pubmed.ncbi.nlm.nih.gov/33454585"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2020.111177","doi":"https://doi.org/10.1016/j.biopha.2020.111177","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2020.111177","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332220313706/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0753332220313706/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001890236","display_name":"Siqi Wan","orcid":"https://orcid.org/0009-0009-0739-7091","observed_orcids":["https://orcid.org/0009-0009-0739-7091"]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Wan","raw_affiliation_strings":["School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: wansiqi0607@163.com","School of Pharmacy, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: wansiqi0607@163.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692119","display_name":"Jinfang Zhang","orcid":"https://orcid.org/0000-0001-8487-6007","observed_orcids":["https://orcid.org/0000-0001-8487-6007"]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfang Zhang","raw_affiliation_strings":["School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: zhangjinfang9499@163.com","School of Pharmacy, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: zhangjinfang9499@163.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010225963","display_name":"Rong Hou","orcid":"https://orcid.org/0000-0002-8236-6318","observed_orcids":["https://orcid.org/0000-0002-8236-6318"]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Hou","raw_affiliation_strings":["College of Science, Minzu University of China, Beijing, 100081, China. Electronic address: hr961@163.com","College of Science, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science, Minzu University of China, Beijing, 100081, China. Electronic address: hr961@163.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"College of Science, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074774124","display_name":"Minsi Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minsi Zheng","raw_affiliation_strings":["School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: zhengminsimuc@163.com","School of Pharmacy, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: zhengminsimuc@163.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697077","display_name":"Liya Liu","orcid":"https://orcid.org/0000-0003-4413-9517","observed_orcids":["https://orcid.org/0000-0003-4413-9517"]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liya Liu","raw_affiliation_strings":["College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China. Electronic address: sclar@muc.edu.cn","College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China. Electronic address: sclar@muc.edu.cn","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016138544","display_name":"Mingshuo Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingshuo Zhang","raw_affiliation_strings":["School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: mingshuoZ321@126.com","School of Pharmacy, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: mingshuoZ321@126.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396745","display_name":"Zhiyong Li","orcid":"https://orcid.org/0000-0003-3237-4317","observed_orcids":["https://orcid.org/0000-0003-3237-4317"]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiyong Li","raw_affiliation_strings":["School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: lizhiyong7899@sina.com","School of Pharmacy, Minzu University of China, Beijing, 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: lizhiyong7899@sina.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090532513","display_name":"Xiulan Huang","orcid":"https://orcid.org/0000-0002-7569-1606","observed_orcids":["https://orcid.org/0000-0002-7569-1606"]},"institutions":[{"id":"https://openalex.org/I145897649","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62","country_code":"CN","type":"education","lineage":["https://openalex.org/I145897649"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiulan Huang","raw_affiliation_strings":["School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: hxlcun@126.com","School of Pharmacy, Minzu University of China, Beijing, 100081, China"],"raw_orcid":"https://orcid.org/0000-0002-7569-1606","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China. Electronic address: hxlcun@126.com","institution_ids":["https://openalex.org/I145897649"]},{"raw_affiliation_string":"School of Pharmacy, Minzu University of China, Beijing, 100081, China","institution_ids":["https://openalex.org/I145897649"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090532513","https://openalex.org/A5100396745"],"corresponding_institution_ids":["https://openalex.org/I145897649"],"apc_list":{"value":2660,"currency":"USD","value_usd":2660},"apc_paid":{"value":2660,"currency":"USD","value_usd":2660},"fwci":2.5298,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87211998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"135","issue":null,"first_page":"111177","last_page":"111177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygonum-orientale","display_name":"Polygonum orientale","score":0.9490000009536743},{"id":"https://openalex.org/keywords/orientin","display_name":"orientin","score":0.7879999876022339},{"id":"https://openalex.org/keywords/quercitrin","display_name":"quercitrin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitexin","display_name":"vitexin","score":1.0},{"id":"https://openalex.org/keywords/hypoxia-reoxygenation-injury","display_name":"hypoxia/reoxygenation injury","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9079999923706055},{"id":"https://openalex.org/keywords/h9c2-cells","display_name":"H9c2 cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/multi-objective-optimization","display_name":"multi-objective optimization","score":0.847000002861023},{"id":"https://openalex.org/keywords/uniform-design","display_name":"uniform design","score":0.9810000061988831},{"id":"https://openalex.org/keywords/stepwise-regression","display_name":"stepwise regression","score":0.9229999780654907},{"id":"https://openalex.org/keywords/simulated-annealing","display_name":"simulated annealing","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7839999794960022},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6140000224113464},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2779301978","wikidata":"https://www.wikidata.org/wiki/Q259075","display_name":"Vitexin","level":4,"score":0.512866735458374},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5039693713188171},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4922710955142975},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.4850103557109833},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.42174601554870605},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4118127226829529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40267813205718994},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31418082118034363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2893064022064209},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20438840985298157},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.18067827820777893},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.14872854948043823},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1059059202671051},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D028502","descriptor_name":"Polygonum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopha.2020.111177","doi":"https://doi.org/10.1016/j.biopha.2020.111177","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2020.111177","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332220313706/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:33454585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33454585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b3b3a06e691e45c1940f9cf03a468902","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b3b3a06e691e45c1940f9cf03a468902","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 135, Iss , Pp 111177- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2020.111177","doi":"https://doi.org/10.1016/j.biopha.2020.111177","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2020.111177","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0753332220313706/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6256444366","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G684722277","display_name":null,"funder_award_id":"2020MDJC04","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7143697853","display_name":null,"funder_award_id":"60325704","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8150284781","display_name":null,"funder_award_id":"2020MDJC04","funder_id":"https://openalex.org/F4320328117","funder_display_name":"Minzu University of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328117","display_name":"Minzu University of China","ror":"https://ror.org/0044e2g62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3122202310.pdf","grobid_xml":"https://content.openalex.org/works/W3122202310.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1512471581","https://openalex.org/W1968344802","https://openalex.org/W1970930356","https://openalex.org/W2001284886","https://openalex.org/W2001911649","https://openalex.org/W2027706303","https://openalex.org/W2051395985","https://openalex.org/W2089644936","https://openalex.org/W2090092823","https://openalex.org/W2102689108","https://openalex.org/W2121429373","https://openalex.org/W2122000223","https://openalex.org/W2147794687","https://openalex.org/W2264983316","https://openalex.org/W2361003505","https://openalex.org/W2399140686","https://openalex.org/W2524889084","https://openalex.org/W2607852602","https://openalex.org/W2754999594","https://openalex.org/W2890059392"],"related_works":["https://openalex.org/W2042767959","https://openalex.org/W2180052197","https://openalex.org/W2890059392","https://openalex.org/W2003463986","https://openalex.org/W2735027421","https://openalex.org/W3015274846","https://openalex.org/W2363442318","https://openalex.org/W4248354570","https://openalex.org/W7165879853","https://openalex.org/W2792034293"],"abstract_inverted_index":{"Presently,":[0],"optimal":[1,69],"proportions":[2],"and":[3,31,48,121],"synergistic":[4,41],"mechanisms":[5],"of":[6,43,71,117,124,167,172],"component-based":[7,173],"Chinese":[8,174,189,195],"medicines":[9,175],"are":[10],"critical":[11],"for":[12,162,191],"developing":[13],"novel":[14],"strategies":[15],"to":[16,38,185],"treat":[17],"cardiovascular":[18],"diseases":[19],"(CVDs).":[20],"A":[21],"new":[22,187],"multi-objective":[23],"optimization":[24],"algorithm":[25],"based":[26,193],"on":[27,194],"uniform":[28],"design":[29],"(UD)":[30],"stepwise":[32],"regression":[33],"(SR)":[34],"modeling":[35,156],"is":[36],"proposed":[37],"find":[39,186],"the":[40,51,60,84,103,122,140,147,163,168,183],"effect":[42],"orientin":[44],"(Ori),":[45],"quercitrin":[46],"(Que)":[47],"vitexin":[49],"(Vit),":[50],"three":[52,73],"effective":[53],"components":[54,74],"from":[55,176],"Polygonum":[56],"orientale":[57],"L.,":[58],"using":[59],"H9c2":[61,104],"cells":[62,105],"injury":[63,106],"induced":[64,107],"by":[65,77,108,138],"hypoxia/reoxygenation":[66],"(H/R).":[67],"The":[68],"proportion":[70],"these":[72],"was":[75,150],"calculated":[76],"simulated":[78],"annealing":[79],"(SA).":[80],"In":[81],"this":[82],"research,":[83],"excellent":[85],"combination":[86],"named":[87],"OQV-e":[88,134],"(Ori:":[89],"Que:":[90],"Vit":[91],"=12.55":[92],"\u03bcM:":[93,95],"39.99":[94],"19.99":[96],"\u03bcM)":[97],"could":[98,135],"exert":[99],"significant":[100],"cardioprotection":[101],"against":[102],"H/R":[109],"through":[110],"increasing":[111],"cell":[112],"viability,":[113],"decreasing":[114],"leakage":[115],"rate":[116],"lactate":[118],"dehydrogenase":[119],"(LDH)":[120],"level":[123],"nitric":[125],"oxide":[126],"(NO).":[127],"Moreover,":[128],"western":[129],"blot":[130],"analysis":[131,166],"revealed":[132],"that":[133,146],"activate":[136],"autophagy":[137],"inhibiting":[139],"p-JNK/JNK":[141],"signaling":[142],"pathway,":[143],"which":[144,179],"showed":[145],"method":[148],"(UD-SR-SA)":[149],"a":[151,159],"feasible":[152],"strategy.":[153],"Mathematical":[154],"system":[155],"may":[157],"be":[158],"considerable":[160],"approach":[161],"powerful":[164],"mathematical":[165],"complex":[169],"pharmacological":[170],"effects":[171],"herbal":[177,196],"medicines,":[178],"might":[180],"greatly":[181],"enhance":[182],"efficiency":[184],"modern":[188],"drugs":[190],"CVDs":[192],"medicine":[197],"(CHM)":[198],"with":[199],"affirmative":[200],"therapeutic":[201],"effect.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-02-01T00:00:00"}