{"id":"https://openalex.org/W3121152182","doi":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","title":"N-Nitro-L-Arginine-Methyl ester Exerts Neuroprotection byInhibiting Inflammation in Cerebral Injury Induced by Transient Ischemia/Reperfusion in Rats: Pharmaceutical Science-Psychology for Curing Mental Health","display_name":"N-Nitro-L-Arginine-Methyl ester Exerts Neuroprotection byInhibiting Inflammation in Cerebral Injury Induced by Transient Ischemia/Reperfusion in Rats: Pharmaceutical Science-Psychology for Curing Mental Health","publication_year":2021,"publication_date":"2021-01-22","ids":{"openalex":"https://openalex.org/W3121152182","doi":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","mag":"3121152182"},"language":"en","primary_location":{"id":"doi:10.22376/ijpbs/lpr.2021.11.1.p87-93","doi":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","is_oa":true,"landing_page_url":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","pdf_url":"http://ijlpr.com/index.php/journal/article/download/989/795","source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Life Science and Pharma Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://ijlpr.com/index.php/journal/article/download/989/795","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059514848","display_name":"Hiba A. Awooda","orcid":"https://orcid.org/0000-0002-6665-7780","observed_orcids":["https://orcid.org/0000-0002-6665-7780"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hiba A Awooda","raw_affiliation_strings":["Al Maarefa University, College of Applied Sciences, Respiratory Care Department, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Al Maarefa University, College of Applied Sciences, Respiratory Care Department, Riyadh, Saudi Arabia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059514848"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00606447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.984000027179718},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.9670000076293945},{"id":"https://openalex.org/keywords/transient-focal-cerebral-ischemia","display_name":"transient focal cerebral ischemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/carotid-occlusion","display_name":"carotid artery occlusion","score":0.8040000200271606},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8734374642372131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7597065567970276},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7070372104644775},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6963940262794495},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6191679239273071},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5777840614318848},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5664141774177551},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.503574550151825},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48404473066329956},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4811728894710541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30008837580680847}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22376/ijpbs/lpr.2021.11.1.p87-93","doi":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","is_oa":true,"landing_page_url":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","pdf_url":"http://ijlpr.com/index.php/journal/article/download/989/795","source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Life Science and Pharma Research","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.ijlpr.com:article/989","doi":null,"is_oa":true,"landing_page_url":"https://www.ijlpr.com/index.php/journal/article/view/989","pdf_url":"https://www.ijlpr.com/index.php/journal/article/download/989/795","source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2250-0480","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.22376/ijpbs/lpr.2021.11.1.p87-93","doi":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","is_oa":true,"landing_page_url":"https://doi.org/10.22376/ijpbs/lpr.2021.11.1.p87-93","pdf_url":"http://ijlpr.com/index.php/journal/article/download/989/795","source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Life Science and Pharma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318809","display_name":"AlMaarefa University","ror":"https://ror.org/00s3s5518"},{"id":"https://openalex.org/F4320326056","display_name":"Alexandria University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3121152182.pdf","grobid_xml":"https://content.openalex.org/works/W3121152182.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W68751456","https://openalex.org/W1511302815","https://openalex.org/W1978648371","https://openalex.org/W1986347387","https://openalex.org/W1991407090","https://openalex.org/W1991495749","https://openalex.org/W2003627002","https://openalex.org/W2005101685","https://openalex.org/W2015237618","https://openalex.org/W2021792423","https://openalex.org/W2033834764","https://openalex.org/W2054134716","https://openalex.org/W2060903407","https://openalex.org/W2071118631","https://openalex.org/W2084211940","https://openalex.org/W2093203564","https://openalex.org/W2096998441","https://openalex.org/W2128635872","https://openalex.org/W2141210606","https://openalex.org/W2143049104","https://openalex.org/W2167316127","https://openalex.org/W2531529425","https://openalex.org/W2586670300","https://openalex.org/W2802537586","https://openalex.org/W2912046388","https://openalex.org/W2921112006","https://openalex.org/W4210440929","https://openalex.org/W4230666570"],"related_works":["https://openalex.org/W7220602466","https://openalex.org/W2143049104","https://openalex.org/W2902224080","https://openalex.org/W2912425479","https://openalex.org/W130610591","https://openalex.org/W2418929586","https://openalex.org/W2324722381","https://openalex.org/W2071233035","https://openalex.org/W4225369254","https://openalex.org/W2385922645"],"abstract_inverted_index":{"Cerebral":[0],"ischemia-reperfusion":[1,52],"injury":[2],"is":[3,199],"a":[4,38,187,204],"pivotal":[5],"cause":[6],"of":[7,33,56,66,89,95,105,207],"deaths":[8],"due":[9],"to":[10,18,48,60,92,128,136,155],"cerebrovascular":[11],"accidents.":[12],"Further":[13],"research":[14],"efforts":[15],"are":[16],"needed":[17],"reveal":[19],"the":[20,30,117,161,164,170,190],"mechanism":[21],"underlying":[22],"its":[23],"aggravation":[24],"or":[25],"alleviation.":[26],"We":[27],"previously":[28],"reported":[29],"antioxidant":[31],"effect":[32,202],"N-Nitro-L-Arginine-":[34],"Methyl":[35],"Ester":[36],"(L-NAME),":[37],"nonselective":[39],"nitric":[40],"oxide":[41,145],"synthase":[42],"(NOS)":[43],"inhibitor,":[44],"on":[45,203],"rats":[46,75,82,90,183],"subjected":[47,91],"transient":[49,208],"focal":[50,209],"cerebral":[51,210],"(I/R).":[53],"The":[54],"aim":[55],"this":[57],"work":[58],"was":[59],"explore":[61],"further":[62],"neuroprotective":[63],"anti-inflammatory":[64,201],"effects":[65],"L-NAME.":[67],"This":[68],"study":[69],"involved":[70],"30":[71,93],"adult":[72],"male":[73],"Wistar":[74],"divided":[76],"into":[77],"three":[78],"groups":[79],"with":[80,111,160],"ten":[81],"in":[83,180],"each:":[84],"sham-operated":[85],"(control),":[86],"I/R":[87,119,162],"group":[88,109],"minutes":[94,115],"left":[96],"common":[97],"carotid":[98],"artery":[99],"(CCA)":[100],"occlusion":[101],"followed":[102],"by":[103],"24-hour":[104],"reperfusion":[106],"and":[107,143,169,175],"test":[108],"infused":[110],"L-NAME":[112,181,193],"intraperitoneally":[113],"15":[114],"before":[116],"same":[118],"period.":[120],"Neurological":[121],"assessments":[122],"were":[123,147,177],"evaluated,":[124],"Western":[125],"blotting":[126],"used":[127,135],"estimate":[129],"Nuclear":[130],"factor-kappa":[131],"B":[132],"(NF-?B),":[133],"ELISA":[134],"detect":[137],"Tumor":[138],"necrosis":[139],"factor-":[140],"\u03b1":[141],"(TNF-\u03b1),":[142],"Nitric":[144],"metabolites":[146],"measured":[148],"colorimetrically,":[149],"as":[150,152],"well":[151],"H&E":[153],"staining":[154],"assess":[156],"brain":[157],"damage.":[158],"Compared":[159],"group,":[163],"neurological":[165],"score,":[166],"infarction":[167],"area,":[168],"inflammatory":[171],"biomarkers":[172],"NF-?B,":[173],"TNF-\u03b1,":[174],"NO":[176],"significantly":[178],"decreased":[179],"treated":[182],"(P":[184],"=0.001).":[185],"As":[186],"conclusion":[188],"from":[189],"current":[191],"study,":[192],"showed":[194],"potential":[195],"neuroprotection":[196],"through":[197],"it":[198],"an":[200],"rat\u2019s":[205],"model":[206],"ischemia-reperfusion.":[211]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-02-01T00:00:00"}