{"id":"https://openalex.org/W3120892275","doi":"https://doi.org/10.1186/s12967-020-02572-w","title":"PGM5-AS1 impairs miR-587-mediated GDF10 inhibition and abrogates progression of prostate cancer","display_name":"PGM5-AS1 impairs miR-587-mediated GDF10 inhibition and abrogates progression of prostate cancer","publication_year":2021,"publication_date":"2021-01-06","ids":{"openalex":"https://openalex.org/W3120892275","doi":"https://doi.org/10.1186/s12967-020-02572-w","mag":"3120892275","pmid":"https://pubmed.ncbi.nlm.nih.gov/33407592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7789719"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-020-02572-w","doi":"https://doi.org/10.1186/s12967-020-02572-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-020-02572-w","pdf_url":"https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02572-w","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02572-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101766549","display_name":"Lei Du","orcid":"https://orcid.org/0000-0001-5766-1051","observed_orcids":["https://orcid.org/0000-0001-5766-1051"]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Du","raw_affiliation_strings":["Department of Oncology, Linyi People's Hospital, No. 27, East Section of Jiefang RoadShandong, Linyi, 276000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Linyi People's Hospital, No. 27, East Section of Jiefang RoadShandong, Linyi, 276000, People's Republic of China","institution_ids":["https://openalex.org/I4210097945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018422579","display_name":"Yongli Gao","orcid":"https://orcid.org/0000-0001-8012-7674","observed_orcids":["https://orcid.org/0000-0001-8012-7674"]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongli Gao","raw_affiliation_strings":["Department of Oncology, Linyi People's Hospital, No. 27, East Section of Jiefang RoadShandong, Linyi, 276000, People's Republic of China. gaoyongli1980@163.com","Department of Oncology, Linyi People\u2019s Hospital, No. 27, East Section of Jiefang RoadShandong, Linyi, 276000, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Linyi People's Hospital, No. 27, East Section of Jiefang RoadShandong, Linyi, 276000, People's Republic of China. gaoyongli1980@163.com","institution_ids":["https://openalex.org/I4210097945"]},{"raw_affiliation_string":"Department of Oncology, Linyi People\u2019s Hospital, No. 27, East Section of Jiefang RoadShandong, Linyi, 276000, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210097945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018422579"],"corresponding_institution_ids":["https://openalex.org/I4210097945"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":1.8916,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86349412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gdf10","display_name":"GDF10","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mirna-sponge","display_name":"microRNA sponge","score":0.625},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.6589999794960022},{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"competing endogenous RNA","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6580952405929565},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6469713449478149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5957807898521423},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5743348598480225},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5683056116104126},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5389474630355835},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.48000258207321167},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.4796462655067444},{"id":"https://openalex.org/C202416437","wikidata":"https://www.wikidata.org/wiki/Q423832","display_name":"Antisense RNA","level":4,"score":0.47165241837501526},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45049771666526794},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4329444468021393},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.42844638228416443},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39884448051452637},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36886829137802124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2708996832370758},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06811520457267761}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055413","descriptor_name":"Growth Differentiation Factor 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12967-020-02572-w","doi":"https://doi.org/10.1186/s12967-020-02572-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-020-02572-w","pdf_url":"https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02572-w","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6700945","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7789719","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:33407592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33407592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7789719","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7789719/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f9c1eea91ed645909db525701dd5c8d1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f9c1eea91ed645909db525701dd5c8d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-14 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-020-02572-w","doi":"https://doi.org/10.1186/s12967-020-02572-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-020-02572-w","pdf_url":"https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-020-02572-w","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120892275.pdf","grobid_xml":"https://content.openalex.org/works/W3120892275.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1725513595","https://openalex.org/W1768099230","https://openalex.org/W1972166080","https://openalex.org/W2001407706","https://openalex.org/W2024468954","https://openalex.org/W2034893482","https://openalex.org/W2068376654","https://openalex.org/W2100757676","https://openalex.org/W2157832939","https://openalex.org/W2196532506","https://openalex.org/W2335029242","https://openalex.org/W2800738672","https://openalex.org/W2801440485","https://openalex.org/W2888027311","https://openalex.org/W2900782973","https://openalex.org/W2911188335","https://openalex.org/W2915478882","https://openalex.org/W2919687352","https://openalex.org/W2923639686","https://openalex.org/W2947489533","https://openalex.org/W2952083209","https://openalex.org/W2954535002","https://openalex.org/W2966914517","https://openalex.org/W2970130061","https://openalex.org/W2980603427","https://openalex.org/W2984137583","https://openalex.org/W3047617076","https://openalex.org/W3048591641"],"related_works":["https://openalex.org/W3088911984","https://openalex.org/W2096077415","https://openalex.org/W4285170663","https://openalex.org/W2762311866","https://openalex.org/W2976034693","https://openalex.org/W2948011254","https://openalex.org/W2951424539","https://openalex.org/W2952063235","https://openalex.org/W2982329838","https://openalex.org/W7118616359"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prostate":[1],"cancer":[2],"(PCa)":[3],"is":[4,125],"a":[5],"leading":[6],"cause":[7],"of":[8,15,37,49,56,84,116,136,143,172,187,206],"cancer-related":[9],"death":[10],"in":[11,23,44,106,120,130,147,152,174],"males.":[12],"Aberrant":[13],"expression":[14,83,91,186,194],"long":[16],"non-coding":[17],"RNAs":[18],"(lncRNAs)":[19],"has":[20],"been":[21],"implicated":[22],"various":[24],"human":[25,38],"malignancies,":[26],"including":[27],"PCa.":[28],"This":[29],"study":[30],"aims":[31],"to":[32,159,181,183,198],"clarify":[33],"the":[34,45,82,114,169,185],"inhibitory":[35],"role":[36,171],"PGM5":[39],"antisense":[40],"RNA":[41,76,98],"1":[42],"(PGM5-AS1)":[43],"proliferation":[46,108,139,202],"and":[47,59,75,87,109,140,203],"apoptosis":[48,142,205],"PCa":[50,100,117,131,144,175,207],"cells.":[51,208],"METHODS:":[52],"The":[53],"regulatory":[54],"network":[55],"PGM5-AS1/microRNA-587":[57],"(miR-587)/growth":[58],"differentiation":[60],"factor":[61],"10":[62],"(GDF10)":[63],"axis":[64],"was":[65,177],"examined":[66],"by":[67,89,179,195],"dual-luciferase":[68],"reporter":[69],"gene":[70,193],"assay,":[71],"RNA-binding":[72],"protein":[73],"immunoprecipitation,":[74],"pull":[77],"down":[78],"assay.":[79],"We":[80,165],"manipulated":[81],"PGM5-AS1,":[85],"miR-587":[86,182],"GDF10":[88,192],"transducing":[90],"vectors,":[92],"mimic,":[93],"inhibitor,":[94],"or":[95],"short":[96],"hairpin":[97],"into":[99],"cells,":[101,145],"thus":[102,200],"establishing":[103],"their":[104],"functions":[105],"cell":[107,132],"apoptosis.":[110],"Additionally,":[111],"we":[112],"measured":[113],"tumorigenicity":[115],"cells":[118,176],"xenografted":[119],"nude":[121,153],"mice.":[122,154],"RESULTS:":[123],"PGM5-AS1":[124,137,156,173,190],"expressed":[126],"at":[127],"low":[128],"levels":[129],"lines.":[133],"Forced":[134],"overexpression":[135],"restricted":[138],"facilitated":[141],"manifesting":[146],"suppressed":[148],"xenograft":[149],"tumor":[150],"growth":[151],"Notably,":[155],"competitively":[157,196],"bound":[158],"miR-587,":[160,199],"which":[161],"directly":[162],"targets":[163],"GDF10.":[164,188],"further":[166],"validated":[167],"that":[168],"anti-cancer":[170],"achieved":[178],"binding":[180,197],"promote":[184],"CONCLUSION:":[189],"upregulates":[191],"inhibiting":[201],"accelerating":[204]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-01-18T00:00:00"}
