{"id":"https://openalex.org/W3120634278","doi":"https://doi.org/10.1111/jne.12933","title":"Nutritional and developmental programming effects of insulin","display_name":"Nutritional and developmental programming effects of insulin","publication_year":2021,"publication_date":"2021-01-13","ids":{"openalex":"https://openalex.org/W3120634278","doi":"https://doi.org/10.1111/jne.12933","mag":"3120634278","pmid":"https://pubmed.ncbi.nlm.nih.gov/33438814"},"language":"en","primary_location":{"id":"doi:10.1111/jne.12933","doi":"https://doi.org/10.1111/jne.12933","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jne.12933","pdf_url":null,"source":{"id":"https://openalex.org/S100175869","display_name":"Journal of Neuroendocrinology","issn_l":"0953-8194","issn":["0953-8194","1365-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17863/cam.64542","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084067366","display_name":"Laura Dearden","orcid":"https://orcid.org/0000-0002-0804-074X","observed_orcids":["https://orcid.org/0000-0002-0804-074X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4387153067","display_name":"MRC Metabolic Diseases Unit","ror":"https://ror.org/037a8w620","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4387153067","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Dearden","raw_affiliation_strings":["MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4387153067","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060733104","display_name":"S\u00e9bastien G. Bouret","orcid":"https://orcid.org/0000-0002-4174-9769","observed_orcids":["https://orcid.org/0000-0002-4174-9769"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4387155073","display_name":"Lille Neurosciences & Cognition","ror":"https://ror.org/04p94ax69","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155073"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sebastien G. Bouret","raw_affiliation_strings":["Inserm Laboratory of Development and Plasticity of the Neuroendocrine Brain Lille Neuroscience &amp; Cognition Research Center Lille France","University of Lille, Lille, France","Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition Research Center, Lille, France"],"raw_orcid":"https://orcid.org/0000-0002-4174-9769","affiliations":[{"raw_affiliation_string":"Inserm Laboratory of Development and Plasticity of the Neuroendocrine Brain Lille Neuroscience &amp; Cognition Research Center Lille France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]},{"raw_affiliation_string":"University of Lille, Lille, France","institution_ids":["https://openalex.org/I2279609970"]},{"raw_affiliation_string":"Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition Research Center, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054905393","display_name":"Susan Elizabeth Ozanne","orcid":"https://orcid.org/0000-0001-8753-5144","observed_orcids":["https://orcid.org/0000-0001-8753-5144"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4387153067","display_name":"MRC Metabolic Diseases Unit","ror":"https://ror.org/037a8w620","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4387153067","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Susan E. Ozanne","raw_affiliation_strings":["MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4387153067","https://openalex.org/I87048295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5054905393","https://openalex.org/A5060733104"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I241749","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4387153067","https://openalex.org/I4387155073","https://openalex.org/I87048295"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":1.0159,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.66206897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"33","issue":"4","first_page":"e12933","last_page":"e12933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.8610000014305115},{"id":"https://openalex.org/keywords/developmental-programming","display_name":"developmental programming","score":0.9190000295639038},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cardiovascular-development","display_name":"cardiovascular development","score":0.765999972820282},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.9750000238418579},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.703000009059906},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/developmental-defects","display_name":"developmental defects","score":0.4569999873638153},{"id":"https://openalex.org/keywords/intervention-strategies","display_name":"intervention strategies","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.7105074524879456},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6740421056747437},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.6437090635299683},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6339461803436279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6198358535766602},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5960476398468018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5665696859359741},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5279737114906311},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5270747542381287},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5026302337646484},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4735162556171417},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4638286828994751},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.43674543499946594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.243473082780838},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.1931215226650238},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08123716711997986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1111/jne.12933","doi":"https://doi.org/10.1111/jne.12933","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jne.12933","pdf_url":null,"source":{"id":"https://openalex.org/S100175869","display_name":"Journal of Neuroendocrinology","issn_l":"0953-8194","issn":["0953-8194","1365-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:33438814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33438814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroendocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03375761v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03375761","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0953-8194","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:inserm-03204429v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-03204429","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroendocrinology, 2021, 33 (4), pp.e12933. &#x27E8;10.1111/jne.12933&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/317429","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/317429","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.64542","doi":"https://doi.org/10.17863/cam.64542","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.64542","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.17863/cam.64542","doi":"https://doi.org/10.17863/cam.64542","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.64542","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3193349380","display_name":"Early life origins of obesity: developmental programming of hypothalamic development and function.","funder_award_id":"106026/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G474800708","display_name":"Insulin and hypoxia: key determinants in the programming of cardiovascular disease by maternal obesity","funder_award_id":"RG/17/12/33167","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5096235777","display_name":"Epigenetic programming of metabolic health across the life-course","funder_award_id":"MC_UU_00014/4","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W56113180","https://openalex.org/W1531334610","https://openalex.org/W1553488119","https://openalex.org/W1572204961","https://openalex.org/W1592674309","https://openalex.org/W1609815362","https://openalex.org/W1819107323","https://openalex.org/W1898712068","https://openalex.org/W1904623078","https://openalex.org/W1963494401","https://openalex.org/W1966392766","https://openalex.org/W1967865345","https://openalex.org/W1970703362","https://openalex.org/W1972142752","https://openalex.org/W1972275518","https://openalex.org/W1973893657","https://openalex.org/W1974859431","https://openalex.org/W1977128714","https://openalex.org/W1978667553","https://openalex.org/W1981345421","https://openalex.org/W1984655425","https://openalex.org/W1987282198","https://openalex.org/W1987922392","https://openalex.org/W1988106824","https://openalex.org/W1988507644","https://openalex.org/W1989324173","https://openalex.org/W1989651794","https://openalex.org/W1989998126","https://openalex.org/W1996374391","https://openalex.org/W1997723844","https://openalex.org/W1998526261","https://openalex.org/W2002743121","https://openalex.org/W2006126067","https://openalex.org/W2010026151","https://openalex.org/W2018943342","https://openalex.org/W2023599847","https://openalex.org/W2025373081","https://openalex.org/W2029029271","https://openalex.org/W2029761858","https://openalex.org/W2030545115","https://openalex.org/W2030771432","https://openalex.org/W2031904419","https://openalex.org/W2036633211","https://openalex.org/W2037594642","https://openalex.org/W2043840872","https://openalex.org/W2049502800","https://openalex.org/W2050277764","https://openalex.org/W2056750064","https://openalex.org/W2061129895","https://openalex.org/W2062316965","https://openalex.org/W2068220777","https://openalex.org/W2069459842","https://openalex.org/W2070233031","https://openalex.org/W2073074119","https://openalex.org/W2074067666","https://openalex.org/W2075759305","https://openalex.org/W2079577144","https://openalex.org/W2080379121","https://openalex.org/W2082137398","https://openalex.org/W2082760281","https://openalex.org/W2083208640","https://openalex.org/W2084673631","https://openalex.org/W2087813348","https://openalex.org/W2091128918","https://openalex.org/W2093102805","https://openalex.org/W2098557383","https://openalex.org/W2099190065","https://openalex.org/W2106305501","https://openalex.org/W2108707862","https://openalex.org/W2109447492","https://openalex.org/W2112752274","https://openalex.org/W2113307363","https://openalex.org/W2114094464","https://openalex.org/W2119211650","https://openalex.org/W2127619125","https://openalex.org/W2128148566","https://openalex.org/W2130148279","https://openalex.org/W2130259798","https://openalex.org/W2130597092","https://openalex.org/W2132075500","https://openalex.org/W2134162846","https://openalex.org/W2137521058","https://openalex.org/W2143831945","https://openalex.org/W2144747931","https://openalex.org/W2145240577","https://openalex.org/W2146351793","https://openalex.org/W2147984307","https://openalex.org/W2149925967","https://openalex.org/W2153951916","https://openalex.org/W2154970636","https://openalex.org/W2155312901","https://openalex.org/W2159898302","https://openalex.org/W2160261425","https://openalex.org/W2161029842","https://openalex.org/W2165675787","https://openalex.org/W2262338962","https://openalex.org/W2282430430","https://openalex.org/W2304199492","https://openalex.org/W2320506313","https://openalex.org/W2409586042","https://openalex.org/W2564062062","https://openalex.org/W2567282730","https://openalex.org/W2593159782","https://openalex.org/W2605702331","https://openalex.org/W2611371461","https://openalex.org/W2621612369","https://openalex.org/W2784021290","https://openalex.org/W2790552383","https://openalex.org/W2809354242","https://openalex.org/W2895605859","https://openalex.org/W2896223352","https://openalex.org/W2905662715","https://openalex.org/W2913228286","https://openalex.org/W2928260009","https://openalex.org/W2943076970","https://openalex.org/W2946564910","https://openalex.org/W2959248233","https://openalex.org/W2965309120","https://openalex.org/W2970782252","https://openalex.org/W2977722791","https://openalex.org/W3016860006","https://openalex.org/W3027421343","https://openalex.org/W3032539057","https://openalex.org/W3086747701","https://openalex.org/W4233848990","https://openalex.org/W6658222621","https://openalex.org/W6732716831"],"related_works":["https://openalex.org/W2070079360","https://openalex.org/W4221067379","https://openalex.org/W109271438","https://openalex.org/W2905913841","https://openalex.org/W2092542674","https://openalex.org/W2995726684","https://openalex.org/W2074195231","https://openalex.org/W7097059558","https://openalex.org/W4248217285","https://openalex.org/W7117448964"],"abstract_inverted_index":{"The":[0,19],"discovery":[1],"of":[2,25,37,96,99,110,122],"insulin":[3,111],"in":[4,10,15,22,65,112],"1921":[5],"was":[6],"a":[7,88,97],"major":[8,44],"breakthrough":[9],"medicine":[11],"and":[12,27,61,94,117,143,152],"for":[13],"therapy":[14],"patients":[16],"with":[17,150],"diabetes.":[18],"dramatic":[20],"rise":[21],"the":[23,70,92,108,113,146],"prevalence":[24,36],"overweight":[26],"obesity":[28,151],"has":[29,74],"been":[30],"tightly":[31],"linked":[32],"to":[33,49,55,131,141],"an":[34],"increased":[35],"gestational":[38],"diabetes":[39,60],"mellitus":[40],"(GDM),":[41],"which":[42],"poses":[43],"health":[45],"concerns.":[46],"Babies":[47],"born":[48],"GDM":[50],"mothers":[51],"are":[52],"more":[53],"likely":[54],"develop":[56],"obesity,":[57],"type":[58],"2":[59],"cardiovascular":[62,115],"disease":[63],"later":[64],"life.":[66],"Evidence":[67],"accumulated":[68],"during":[69,84,119],"past":[71],"two":[72],"decades":[73],"revealed":[75],"that":[76],"high":[77],"levels":[78],"insulin,":[79],"such":[80],"as":[81,124,126],"those":[82],"observed":[83],"GDM,":[85],"can":[86,129],"have":[87],"widespread":[89],"effect":[90],"on":[91,107],"development":[93],"function":[95],"variety":[98],"organs.":[100],"This":[101],"review":[102],"summarises":[103],"our":[104],"current":[105],"knowledge":[106],"role":[109],"placenta,":[114],"system":[116],"brain":[118],"critical":[120],"periods":[121],"development,":[123],"well":[125],"how":[127],"it":[128],"contribute":[130],"lifelong":[132],"metabolic":[133],"regulation.":[134],"We":[135],"also":[136],"discuss":[137],"possible":[138],"intervention":[139],"strategies":[140],"ameliorate":[142],"hopefully":[144],"reverse":[145],"developmental":[147],"defects":[148],"associated":[149],"GDM.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-01-18T00:00:00"}
