{"id":"https://openalex.org/W3120597036","doi":"https://doi.org/10.1007/s10637-020-01035-9","title":"Characterization and management of ERK inhibitor associated dermatologic adverse events: analysis from a nonrandomized trial of ulixertinib for advanced cancers","display_name":"Characterization and management of ERK inhibitor associated dermatologic adverse events: analysis from a nonrandomized trial of ulixertinib for advanced cancers","publication_year":2021,"publication_date":"2021-01-03","ids":{"openalex":"https://openalex.org/W3120597036","doi":"https://doi.org/10.1007/s10637-020-01035-9","mag":"3120597036","pmid":"https://pubmed.ncbi.nlm.nih.gov/33389388","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282166"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-020-01035-9","doi":"https://doi.org/10.1007/s10637-020-01035-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-020-01035-9","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282166","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101471774","display_name":"Jennifer Wu","orcid":"https://orcid.org/0000-0002-7874-2720","observed_orcids":["https://orcid.org/0000-0002-7874-2720"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"J. Wu","raw_affiliation_strings":["College of Medicine, Chang Gung University, Taoyuan, Taiwan","Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, Taiwan","Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Keelung, Linkou, Taipei, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108712011","display_name":"D. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Liu","raw_affiliation_strings":["Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006697352","display_name":"Michael David Offin","orcid":"https://orcid.org/0000-0002-7959-3018","observed_orcids":["https://orcid.org/0000-0002-7959-3018"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Offin","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Lezcano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Lezcano","raw_affiliation_strings":["Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009070223","display_name":"Jean M. Torrisi","orcid":"https://orcid.org/0009-0003-4455-6529","observed_orcids":["https://orcid.org/0009-0003-4455-6529"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Torrisi","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Brownstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Brownstein","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068193017","display_name":"David Michael Hyman","orcid":"https://orcid.org/0000-0001-8150-9762","observed_orcids":["https://orcid.org/0000-0001-8150-9762"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. M. Hyman","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034595315","display_name":"Mrinal M. Gounder","orcid":"https://orcid.org/0000-0001-8468-0119","observed_orcids":["https://orcid.org/0000-0001-8468-0119"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. M. Gounder","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062426672","display_name":"Wassim M. Abida","orcid":"https://orcid.org/0000-0002-9006-7043","observed_orcids":["https://orcid.org/0000-0002-9006-7043"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Abida","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063199354","display_name":"Alexander Edward Dela Cruz Drilon","orcid":"https://orcid.org/0000-0001-6806-9061","observed_orcids":["https://orcid.org/0000-0001-6806-9061"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Drilon","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","Thoracic Oncology and Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, 530 East 74th Street, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Thoracic Oncology and Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, 530 East 74th Street, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065435809","display_name":"James J. Harding","orcid":"https://orcid.org/0000-0002-7029-4310","observed_orcids":["https://orcid.org/0000-0002-7029-4310","https://orcid.org/0000-0003-0766-9965"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. J. Harding","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008479799","display_name":"Ryan Joseph Sullivan","orcid":"https://orcid.org/0000-0001-5344-6645","observed_orcids":["https://orcid.org/0000-0001-5344-6645"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Sullivan","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071800834","display_name":"Filip Jank\u00fa","orcid":"https://orcid.org/0000-0002-8123-4065","observed_orcids":["https://orcid.org/0000-0002-8123-4065"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Janku","raw_affiliation_strings":["MD Anderson Cancer Center, The University of Texas, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, The University of Texas, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111189291","display_name":"D. Welsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Welsch","raw_affiliation_strings":["BioMed Valley Discoveries, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed Valley Discoveries, Kansas City, MO, 64111, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040158883","display_name":"Mary Laura Varterasian","orcid":"https://orcid.org/0009-0007-5921-0984","observed_orcids":["https://orcid.org/0009-0007-5921-0984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Varterasian","raw_affiliation_strings":["BioMed Valley Discoveries, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed Valley Discoveries, Kansas City, MO, 64111, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055780077","display_name":"Anna L. Groover","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Groover","raw_affiliation_strings":["BioMed Valley Discoveries, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed Valley Discoveries, Kansas City, MO, 64111, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080998623","display_name":"Bingyu Li","orcid":"https://orcid.org/0000-0002-9222-951X","observed_orcids":["https://orcid.org/0000-0002-9222-951X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. T. Li","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lib1@mskcc.org","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA. lib1@mskcc.org","Thoracic Oncology and Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, 530 East 74th Street, New York, NY, 10021, USA. lib1@mskcc.org","Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lib1@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA. lib1@mskcc.org","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Thoracic Oncology and Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, 530 East 74th Street, New York, NY, 10021, USA. lib1@mskcc.org","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002599922","display_name":"Mario E. Lacouture","orcid":"https://orcid.org/0000-0002-4818-3710","observed_orcids":["https://orcid.org/0000-0002-4818-3710"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. E. Lacouture","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lacoutum@mskcc.org","Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lacoutum@mskcc.org","Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, 530 East 74th Street, New York, NY, 10021, USA. lacoutum@mskcc.org","Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lacoutum@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lacoutum@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medicine, 530 East 74th Street, New York, NY, 10021, USA. lacoutum@mskcc.org","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5002599922","https://openalex.org/A5080998623"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":3.8344,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93832755,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"39","issue":"3","first_page":"785","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulixertinib","display_name":"ulixertinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dermatologic-adverse-events","display_name":"dermatologic adverse events","score":0.9860000014305115},{"id":"https://openalex.org/keywords/acneiform-rash","display_name":"acneiform rash","score":0.9300000071525574},{"id":"https://openalex.org/keywords/maculopapular-rash","display_name":"maculopapular rash","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/braf-mutant-cancers","display_name":"BRAF-mutant cancers","score":0.7400000095367432},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/treatment-algorithm","display_name":"treatment algorithm","score":0.4020000100135803},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5199999809265137},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7303078770637512},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7154601216316223},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.4862560033798218},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.47295019030570984},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4336535334587097},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3668748140335083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3252352476119995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3044995665550232},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.08601391315460205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10637-020-01035-9","doi":"https://doi.org/10.1007/s10637-020-01035-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-020-01035-9","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:33389388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33389388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:pubmedcentral.nih.gov:9282166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282166","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Invest New Drugs","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9282166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282166","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Invest New Drugs","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1491720556","https://openalex.org/W1596719598","https://openalex.org/W1805895843","https://openalex.org/W1827097565","https://openalex.org/W1840105071","https://openalex.org/W1979501715","https://openalex.org/W1984047229","https://openalex.org/W1986803564","https://openalex.org/W1991837616","https://openalex.org/W1993668182","https://openalex.org/W1994711522","https://openalex.org/W1997605441","https://openalex.org/W1998085563","https://openalex.org/W2004191314","https://openalex.org/W2009991604","https://openalex.org/W2012766798","https://openalex.org/W2020300829","https://openalex.org/W2045391651","https://openalex.org/W2054151334","https://openalex.org/W2062860758","https://openalex.org/W2068736424","https://openalex.org/W2077950012","https://openalex.org/W2080013502","https://openalex.org/W2081267461","https://openalex.org/W2083122926","https://openalex.org/W2097762752","https://openalex.org/W2104016108","https://openalex.org/W2114578638","https://openalex.org/W2114646009","https://openalex.org/W2117927681","https://openalex.org/W2134758896","https://openalex.org/W2138635576","https://openalex.org/W2144648936","https://openalex.org/W2147513363","https://openalex.org/W2151979638","https://openalex.org/W2160344439","https://openalex.org/W2172909145","https://openalex.org/W2216171368","https://openalex.org/W2216253840","https://openalex.org/W2233721184","https://openalex.org/W2274811855","https://openalex.org/W2289337746","https://openalex.org/W2329871425","https://openalex.org/W2330036981","https://openalex.org/W2408782013","https://openalex.org/W2409547711","https://openalex.org/W2471998636","https://openalex.org/W2504049772","https://openalex.org/W2527801059","https://openalex.org/W2560367415","https://openalex.org/W2561347874","https://openalex.org/W2595398870","https://openalex.org/W2605630889","https://openalex.org/W2619622310","https://openalex.org/W2742574328","https://openalex.org/W2756647112","https://openalex.org/W2759091821","https://openalex.org/W2762842128","https://openalex.org/W2766879274","https://openalex.org/W2774483419","https://openalex.org/W2916967884"],"related_works":["https://openalex.org/W2048008796","https://openalex.org/W2381661869","https://openalex.org/W2673262484","https://openalex.org/W2117676712","https://openalex.org/W2797760005","https://openalex.org/W2158414440","https://openalex.org/W2774483419","https://openalex.org/W2016506204","https://openalex.org/W1998085563","https://openalex.org/W2399727503"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-01-18T00:00:00"}