{"id":"https://openalex.org/W3120577796","doi":null,"title":"Effects of mGluII Receptor Antagonist LY341495 on Nicotine-Sensitized Rats","display_name":"Effects of mGluII Receptor Antagonist LY341495 on Nicotine-Sensitized Rats","publication_year":2011,"publication_date":"2011-08-26","ids":{"openalex":"https://openalex.org/W3120577796","mag":"3120577796"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-1424","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/mqp-all/425","pdf_url":"https://digitalcommons.wpi.edu/mqp-all/425","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wpi.edu/mqp-all/425","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033547796","display_name":"Kelly Tam","orcid":"https://orcid.org/0000-0002-4560-7952","observed_orcids":["https://orcid.org/0000-0002-4560-7952"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kelly Tam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4560-7952","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033547796"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.32690000534057617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.32690000534057617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.257099986076355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.20800000429153442,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mglu2-receptor","display_name":"mGlu2 receptor","score":0.6320000290870667},{"id":"https://openalex.org/keywords/ly341495","display_name":"LY341495","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nicotine-sensitization","display_name":"nicotine sensitization","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.9110000133514404},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8059999942779541},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptor-antagonists","display_name":"metabotropic glutamate receptor antagonists","score":0.777999997138977},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reward-pathways","display_name":"reward pathways","score":0.8029999732971191},{"id":"https://openalex.org/keywords/fmri","display_name":"functional MRI","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5841692686080933},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5204006433486938},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.4797326624393463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4452058672904968},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3603360652923584},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3266088366508484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2719365358352661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26506203413009644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1885526478290558}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-1424","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/mqp-all/425","pdf_url":"https://digitalcommons.wpi.edu/mqp-all/425","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},{"id":"mag:3120577796","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1424&context=mqp-all","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-1424","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/mqp-all/425","pdf_url":"https://digitalcommons.wpi.edu/mqp-all/425","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120577796.pdf","grobid_xml":"https://content.openalex.org/works/W3120577796.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1485231747","https://openalex.org/W1571140265","https://openalex.org/W1833341014","https://openalex.org/W1974687066","https://openalex.org/W1975153891","https://openalex.org/W1978947725","https://openalex.org/W1980321165","https://openalex.org/W1983869923","https://openalex.org/W1996157865","https://openalex.org/W1997113206","https://openalex.org/W1997245512","https://openalex.org/W1998886599","https://openalex.org/W2000363595","https://openalex.org/W2003873821","https://openalex.org/W2005292858","https://openalex.org/W2006368686","https://openalex.org/W2010451491","https://openalex.org/W2011373325","https://openalex.org/W2011596780","https://openalex.org/W2016375502","https://openalex.org/W2018436424","https://openalex.org/W2018659080","https://openalex.org/W2022856147","https://openalex.org/W2023740284","https://openalex.org/W2024380338","https://openalex.org/W2025284542","https://openalex.org/W2045185962","https://openalex.org/W2054668681","https://openalex.org/W2055500587","https://openalex.org/W2057046889","https://openalex.org/W2061506085","https://openalex.org/W2066951615","https://openalex.org/W2070995312","https://openalex.org/W2071583576","https://openalex.org/W2074307342","https://openalex.org/W2075741245","https://openalex.org/W2078420847","https://openalex.org/W2085955270","https://openalex.org/W2090782551","https://openalex.org/W2093639447","https://openalex.org/W2096702554","https://openalex.org/W2103263170","https://openalex.org/W2104094850","https://openalex.org/W2106042714","https://openalex.org/W2107370783","https://openalex.org/W2121962606","https://openalex.org/W2122921281","https://openalex.org/W2123802262","https://openalex.org/W2126701055","https://openalex.org/W2131422183","https://openalex.org/W2159242539","https://openalex.org/W2160527423","https://openalex.org/W2168801837","https://openalex.org/W2226370386"],"related_works":["https://openalex.org/W2104460183","https://openalex.org/W2101085697","https://openalex.org/W2023415006","https://openalex.org/W2106252038","https://openalex.org/W2007765042","https://openalex.org/W2084634246","https://openalex.org/W2093194745","https://openalex.org/W7096821683","https://openalex.org/W1977190239","https://openalex.org/W1993175254"],"abstract_inverted_index":{"Cigarette":[0],"smoking":[1],"has":[2],"become":[3],"a":[4],"worldwide":[5],"problem":[6],"leading":[7],"to":[8,54,72],"millions":[9],"of":[10,29,78,95,109],"fatalities":[11],"annually.":[12],"Research":[13],"is":[14],"focused":[15],"on":[16],"unraveling":[17],"the":[18,27,45,55,79,87,93,99,110],"neurobiology":[19],"behind":[20],"nicotine":[21,32],"dependence.":[22],"The":[23],"present":[24,100],"study":[25,101],"evaluated":[26],"role":[28],"glutamate":[30,49,96],"in":[31,41,66,76,86],"sensitization":[33],"by":[34],"measuring":[35],"both":[36],"locomotor":[37,67],"and":[38,97,112],"brain":[39],"activities":[40],"nicotine-sensitized":[42],"rats":[43,57],"given":[44],"Group":[46],"II":[47],"metabotropic":[48],"receptor":[50],"antagonist":[51],"LY341495.":[52],"Contrary":[53],"hypothesis,":[56],"treated":[58],"with":[59,105],"LY341495":[60],"did":[61],"not":[62],"show":[63,73],"an":[64,106],"increase":[65],"activity.":[68],"fMRI":[69],"results":[70],"appeared":[71],"slight":[74],"activation":[75],"parts":[77],"reward":[80],"pathway":[81],"but":[82],"no":[83],"apparent":[84],"activity":[85],"motor":[88],"loop.":[89],"To":[90],"better":[91],"understand":[92],"effects":[94],"LY341495,":[98],"should":[102],"be":[103],"repeated":[104],"increased":[107],"dosage":[108],"drug":[111],"greater":[113],"sample":[114],"size":[115],"for":[116],"imaging.":[117]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2021-01-18T00:00:00"}