{"id":"https://openalex.org/W3120553017","doi":null,"title":"Time-resolved Structural and Mechanistic Studies of Water Oxidation in Photosystem II : water here, water there, water everywhere","display_name":"Time-resolved Structural and Mechanistic Studies of Water Oxidation in Photosystem II : water here, water there, water everywhere","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3120553017","mag":"3120553017"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-174116","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072596718","display_name":"Casper de Lichtenberg","orcid":"https://orcid.org/0000-0003-2975-8395","observed_orcids":["https://orcid.org/0000-0003-2975-8395"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Casper de Lichtenberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2975-8395","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072596718"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photosystem-ii","display_name":"photosystem II","score":0.9670000076293945},{"id":"https://openalex.org/keywords/water-oxidation","display_name":"water oxidation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/s-state-cycle","display_name":"S-state cycle","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mn4ca-cluster","display_name":"Mn4Ca cluster","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oxygen-evolving-complex","display_name":"oxygen-evolving complex","score":0.7260000109672546},{"id":"https://openalex.org/keywords/kok-cycle","display_name":"Kok cycle","score":0.5860000252723694},{"id":"https://openalex.org/keywords/high-spin-and-low-spin-states","display_name":"high-spin and low-spin states","score":0.5609999895095825},{"id":"https://openalex.org/keywords/electron-magnetic-resonance","display_name":"electron magnetic resonance","score":0.5600000023841858},{"id":"https://openalex.org/keywords/isotopic-equilibration","display_name":"isotopic equilibration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/photosynthetic-water-splitting","display_name":"photosynthetic water splitting","score":0.5680000185966492},{"id":"https://openalex.org/keywords/thylakoids","display_name":"thylakoids","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C183688256","wikidata":"https://www.wikidata.org/wiki/Q11982","display_name":"Photosynthesis","level":2,"score":0.7516006231307983},{"id":"https://openalex.org/C80298142","wikidata":"https://www.wikidata.org/wiki/Q22327014","display_name":"Photosystem II","level":3,"score":0.6984244585037231},{"id":"https://openalex.org/C65440619","wikidata":"https://www.wikidata.org/wiki/Q177974","display_name":"Atmosphere (unit)","level":2,"score":0.6557499170303345},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.556394636631012},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4885150194168091},{"id":"https://openalex.org/C26148502","wikidata":"https://www.wikidata.org/wiki/Q2488752","display_name":"Earth (classical element)","level":2,"score":0.4880203306674957},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.44928622245788574},{"id":"https://openalex.org/C135473242","wikidata":"https://www.wikidata.org/wiki/Q4147614","display_name":"Oxygen evolution","level":4,"score":0.4457220137119293},{"id":"https://openalex.org/C56990077","wikidata":"https://www.wikidata.org/wiki/Q2628457","display_name":"Oxygen-evolving complex","level":4,"score":0.4253273606300354},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.418399840593338},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.41077566146850586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1689372956752777},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.14375397562980652},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.1068306565284729},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.08107253909111023},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07960483431816101},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07118991017341614},{"id":"https://openalex.org/C37914503","wikidata":"https://www.wikidata.org/wiki/Q156495","display_name":"Mathematical physics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-174116","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3120553017","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A1458877","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-174116","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":181,"referenced_works":["https://openalex.org/W39478705","https://openalex.org/W1210608600","https://openalex.org/W1420450493","https://openalex.org/W1632274414","https://openalex.org/W1653383623","https://openalex.org/W1916839240","https://openalex.org/W1961714136","https://openalex.org/W1963482869","https://openalex.org/W1963757625","https://openalex.org/W1964738515","https://openalex.org/W1965209520","https://openalex.org/W1966640444","https://openalex.org/W1967250117","https://openalex.org/W1968571307","https://openalex.org/W1970240925","https://openalex.org/W1973721002","https://openalex.org/W1974045653","https://openalex.org/W1974631004","https://openalex.org/W1975709387","https://openalex.org/W1975878413","https://openalex.org/W1976477575","https://openalex.org/W1977535375","https://openalex.org/W1977808628","https://openalex.org/W1980319436","https://openalex.org/W1981349118","https://openalex.org/W1982351418","https://openalex.org/W1983270134","https://openalex.org/W1986829915","https://openalex.org/W1987946602","https://openalex.org/W1989585864","https://openalex.org/W1990326465","https://openalex.org/W1990589424","https://openalex.org/W1993690743","https://openalex.org/W1994600616","https://openalex.org/W1995263137","https://openalex.org/W1996917852","https://openalex.org/W2000037965","https://openalex.org/W2000046331","https://openalex.org/W2003808104","https://openalex.org/W2005594958","https://openalex.org/W2007312008","https://openalex.org/W2009439819","https://openalex.org/W2009778355","https://openalex.org/W2010278274","https://openalex.org/W2011999890","https://openalex.org/W2012015338","https://openalex.org/W2013526703","https://openalex.org/W2014308971","https://openalex.org/W2016035644","https://openalex.org/W2016436079","https://openalex.org/W2018211671","https://openalex.org/W2018808877","https://openalex.org/W2022085399","https://openalex.org/W2024281414","https://openalex.org/W2025192406","https://openalex.org/W2026276520","https://openalex.org/W2028954835","https://openalex.org/W2030822242","https://openalex.org/W2031996140","https://openalex.org/W2033285121","https://openalex.org/W2036585503","https://openalex.org/W2037514313","https://openalex.org/W2041049135","https://openalex.org/W2041540545","https://openalex.org/W2043298415","https://openalex.org/W2047178453","https://openalex.org/W2048725349","https://openalex.org/W2050982148","https://openalex.org/W2051335657","https://openalex.org/W2052084976","https://openalex.org/W2052231206","https://openalex.org/W2054154737","https://openalex.org/W2055843587","https://openalex.org/W2057833130","https://openalex.org/W2057863409","https://openalex.org/W2060166296","https://openalex.org/W2060459491","https://openalex.org/W2062190671","https://openalex.org/W2062704019","https://openalex.org/W2065164261","https://openalex.org/W2065439398","https://openalex.org/W2066652100","https://openalex.org/W2068048246","https://openalex.org/W2068219766","https://openalex.org/W2073317899","https://openalex.org/W2073433036","https://openalex.org/W2075310223","https://openalex.org/W2075403935","https://openalex.org/W2078605416","https://openalex.org/W2080301483","https://openalex.org/W2081987930","https://openalex.org/W2083027598","https://openalex.org/W2083907491","https://openalex.org/W2084395989","https://openalex.org/W2084586294","https://openalex.org/W2086794964","https://openalex.org/W2087432921","https://openalex.org/W2089155511","https://openalex.org/W2090027771","https://openalex.org/W2094399323","https://openalex.org/W2095533694","https://openalex.org/W2096781815","https://openalex.org/W2099149919","https://openalex.org/W2101470980","https://openalex.org/W2103118098","https://openalex.org/W2104158871","https://openalex.org/W2105125469","https://openalex.org/W2105216660","https://openalex.org/W2108959691","https://openalex.org/W2109055242","https://openalex.org/W2117225984","https://openalex.org/W2119477002","https://openalex.org/W2120906539","https://openalex.org/W2121741259","https://openalex.org/W2133308690","https://openalex.org/W2135206804","https://openalex.org/W2135531978","https://openalex.org/W2142184469","https://openalex.org/W2150170500","https://openalex.org/W2151559704","https://openalex.org/W2154018565","https://openalex.org/W2154680016","https://openalex.org/W2154798762","https://openalex.org/W2156554354","https://openalex.org/W2156555675","https://openalex.org/W2162930642","https://openalex.org/W2163275303","https://openalex.org/W2165896332","https://openalex.org/W2171085687","https://openalex.org/W2181046927","https://openalex.org/W2205413804","https://openalex.org/W2207200725","https://openalex.org/W2234131943","https://openalex.org/W2274299351","https://openalex.org/W2275483672","https://openalex.org/W2288482780","https://openalex.org/W2288739910","https://openalex.org/W2312948346","https://openalex.org/W2313944297","https://openalex.org/W2314215565","https://openalex.org/W2315512063","https://openalex.org/W2316116292","https://openalex.org/W2331676917","https://openalex.org/W2345995128","https://openalex.org/W2404357619","https://openalex.org/W2468642025","https://openalex.org/W2480233451","https://openalex.org/W2551990020","https://openalex.org/W2552491981","https://openalex.org/W2572846769","https://openalex.org/W2588411561","https://openalex.org/W2593502667","https://openalex.org/W2604437060","https://openalex.org/W2610889696","https://openalex.org/W2743461873","https://openalex.org/W2755666871","https://openalex.org/W2766995515","https://openalex.org/W2770053020","https://openalex.org/W2783411755","https://openalex.org/W2786135659","https://openalex.org/W2791310162","https://openalex.org/W2794515220","https://openalex.org/W2808140278","https://openalex.org/W2833363893","https://openalex.org/W2885453840","https://openalex.org/W2896852927","https://openalex.org/W2899973458","https://openalex.org/W2913361701","https://openalex.org/W2942715885","https://openalex.org/W2950452190","https://openalex.org/W2964594504","https://openalex.org/W2968153311","https://openalex.org/W2981053739","https://openalex.org/W2986618850","https://openalex.org/W3004558197","https://openalex.org/W3009168642","https://openalex.org/W3016859480","https://openalex.org/W3026535819","https://openalex.org/W3033831040","https://openalex.org/W3144422471","https://openalex.org/W4281382652"],"related_works":["https://openalex.org/W1964738515","https://openalex.org/W2101470980","https://openalex.org/W411477781","https://openalex.org/W7032935167","https://openalex.org/W2932316988","https://openalex.org/W2055916436","https://openalex.org/W39478705","https://openalex.org/W3004946223","https://openalex.org/W2966622","https://openalex.org/W1221855245"],"abstract_inverted_index":{"Oxygenic":[0],"photosynthesis":[1],"is":[2,39,46,77,91,104,121,186,299,355,549,593],"undisputedly":[3],"one":[4],"of":[5,36,53,86,97,115,125,168,175,215,236,242,252,264,268,292,336,347,360,374,382,391,411,449,472,488,509,541,555,570,579,638],"the":[6,21,24,34,84,94,112,116,129,133,140,159,164,169,176,182,187,191,217,223,234,248,253,265,269,273,290,293,308,315,321,327,334,337,345,358,367,372,389,392,409,417,426,435,447,450,453,460,470,473,478,486,489,498,506,510,515,522,534,553,559,562,580,584,589,604,634,639],"most":[7,613],"important":[8,551],"chemical":[9,193],"processes":[10],"for":[11,132,333,344,405,552],"human":[12],"life":[13],"on":[14,212,326],"earth":[15],"as":[16,43,56,66],"it":[17,103,147,351],"not":[18,40,550],"only":[19,41],"fills":[20],"atmosphere":[22],"with":[23,201,272,482,573,595],"oxygen":[25,591],"that":[26,127,178,238,277,289,310,399,419,446,459,524,546,582,588,606],"we":[27,232,496],"need":[28],"to":[29,69,158,163,189,240,313,402,424,442,544,586,600],"breathe,":[30],"but":[31,45],"also":[32,47,378],"sustains":[33],"accumulation":[35],"biomass,":[37],"which":[38,90],"used":[42,180],"nourishment":[44],"present":[48,287],"in":[49,60,93,111,137,181,221,247,275,307,357,366,388,434,477,485,502,533,558],"almost":[50],"every":[51],"aspect":[52],"our":[54],"lives":[55],"building":[57],"material,":[58],"textiles":[59],"clothes":[61],"and":[62,100,118,161,207,330,349,396,413,527,531,575,619],"furniture,":[63],"or":[64,320,529,561],"even":[65],"living":[67],"decorations":[68],"name":[70,85],"a":[71,80,302,380,503,568,596],"few.":[72],"The":[73,628],"photosynthetic":[74],"water-splitting":[75],"mechanism":[76],"catalyzed":[78],"by":[79,83,106,123,301,420,539],"water:plastoquinone":[81],"oxido-reductase":[82],"photosystem":[87],"II":[88],"(PSII),":[89],"embedded":[92],"thylakoid":[95],"membranes":[96],"plants,":[98],"algae":[99],"cyanobacteria.":[101],"As":[102],"excited":[105],"light,":[107],"charge":[108],"separation":[109],"occurs":[110,615],"reaction":[113,136,185],"center":[114],"protein":[117],"an":[119,149,243,623],"electron":[120,280],"extracted":[122],"oxidation":[124,166,226,364],"Mn4Ca-cluster,":[126],"constitutes":[128],"active":[130,218],"site":[131,219],"water":[134,154,183,245,297,427,507,631,637],"splitting":[135,184],"PSII.":[138],"When":[139],"Mn4Ca-cluster":[141,160,585],"has":[142],"been":[143],"oxidized":[144],"4":[145],"times,":[146],"forms":[148],"oxygen-oxygen":[150],"bond":[151,518,611],"between":[152,305,452,462,521,616],"two":[153],"derived":[155],"ligands":[156,174],"bound":[157,428],"returns":[162],"lowest":[165],"state":[167,250,339],"catalytic":[170,254],"cycle.":[171,255,369,642],"Understanding":[172],"what":[173],"cluster":[177],"are":[179],"key":[188],"unlocking":[190],"underlying":[192],"mechanism.":[194,627],"In":[195,537,608],"this":[196,375,494,547],"thesis":[197],"I":[198,229,286,377,415,444,566],"describe":[199,230],"investigations,":[200],"room":[202,467],"temperature":[203],"X-ray":[204,208],"diffraction":[205],"(XRD)":[206],"emission":[209],"spectroscopy":[210],"(XES)":[211],"PSII":[213],"microcrystals,":[214],"how":[216,231,350],"looks":[220],"all":[222,361],"stable":[224],"intermediate":[225,363],"states.":[227,564],"Furthermore":[228],"uncovered":[233],"sequence":[235],"events":[237],"lead":[239],"insertion":[241,508],"additional":[244],"ligand":[246],"S2-S3":[249,511],"transition":[251,512],"Furthermore,":[256],"through":[257],"time-resolved":[258],"membrane-inlet":[259],"mass":[260],"spectrometry":[261],"(TR-MIMS)":[262],"measurements":[263],"isotopic":[266],"equilibration":[267],"substrate":[270,296,406,474,556,571],"waters":[271,523,557,581],"bulk":[274],"conditions":[276],"induce":[278],"different":[279,340,393],"magnetic":[281],"resonance":[282],"(EPR)":[283],"spectroscopic":[284],"signatures,":[285],"evidence":[288],"exchange":[291,475,554],"slowly":[294],"exchanging":[295,454,491,594,636],"Ws":[298,348],"controlled":[300],"dynamic":[303],"equilibrium":[304,451],"conformations":[306,455],"S2-state":[309],"give":[311],"rise":[312],"either":[314],"low-spin":[316],"multiline":[317],"(LS-ML)":[318],"signal":[319],"high-spin":[322],"(HS)":[323],"signal.":[324],"Based":[325],"crystal":[328],"structures":[329],"litterature":[331],"suggestions":[332],"conformation":[335,430],"HS":[338],"scenarios":[341],"were":[342,400,525],"presented":[343],"assignment":[346,605],"exchanges.":[352],"This":[353],"analysis":[354],"discussed":[356],"context":[359],"semi-stable":[362],"states":[365],"Kok":[368],"To":[370],"further":[371,602],"understanding":[373],"equilibrium,":[376],"studied":[379],"selection":[381],"mutants":[383],"positioned":[384],"at":[385,397,466],"strategic":[386],"places":[387],"vicinity":[390,487],"proposed":[394],"substrates":[395],"points":[398],"suggested":[401],"be":[403],"critical":[404],"entry.":[407],"With":[408,493],"combination":[410,569],"TR-MIMS":[412,574],"EPR,":[414],"reached":[416],"conclusion":[418],"mutating":[421],"valine":[422],"185":[423],"asparagine,":[425],"A-type":[429],"was":[431,440,456,464,513],"stabilized,":[432],"meanwhile":[433],"mutant":[436],"where":[437,505],"aspartate":[438],"61":[439],"mutated":[441],"alanine":[443],"observed":[445],"barrier":[448],"so":[457],"high":[458],"interchange":[461],"them":[463],"arrested":[465],"temperature.":[468],"Additionally":[469],"retardation":[471],"rates":[476],"S3-states":[479],"fit":[480],"best":[481,500],"D61":[483],"being":[484],"fast":[490],"water.":[492],"information":[495],"found":[497],"data":[499],"explained":[501],"scenario":[504],"determining":[514],"if":[516],"O-O":[517,610],"formation":[519,612],"occurred":[520],"W2":[526,530,617],"W3":[528],"O5":[532,592,620],"S2":[535,560],"state.":[536],"addition,":[538],"mutation":[540],"glutamate":[542],"189":[543],"glutamine":[545],"residue":[548],"S3":[563],"Finally":[565],"use":[567],"labelling":[572,578],"time":[576],"resolved":[577],"ligate":[583],"show":[587],"briding":[590],"near":[597],"identical":[598],"rate":[599],"Ws,":[601],"supporting":[603],"Ws=O5.":[607],"conclusion,":[609],"likely":[614],"(Wf)":[618],"(Ws)":[621],"via":[622],"oxo-oxyl":[624],"radical":[625],"coupling":[626],"newly":[629],"inserted":[630],"thus":[632],"represents":[633],"slow":[635],"following":[640],"S-state":[641]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-01-18T00:00:00"}