{"id":"https://openalex.org/W3120448317","doi":"https://doi.org/10.1039/d0ra09320c","title":"Pharmacophore modeling and virtual screening studies for discovery of novel farnesoid X receptor (FXR) agonists","display_name":"Pharmacophore modeling and virtual screening studies for discovery of novel farnesoid X receptor (FXR) agonists","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3120448317","doi":"https://doi.org/10.1039/d0ra09320c","mag":"3120448317","pmid":"https://pubmed.ncbi.nlm.nih.gov/35424145","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8693749"},"language":"en","primary_location":{"id":"doi:10.1039/d0ra09320c","doi":"https://doi.org/10.1039/d0ra09320c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0ra09320c","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d0ra09320c","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d0ra09320c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088149259","display_name":"Shizhen Zhao","orcid":"https://orcid.org/0000-0003-0633-4821","observed_orcids":["https://orcid.org/0000-0003-0633-4821"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shizhen Zhao","raw_affiliation_strings":["China","Henan University","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","People's Hospital of Hebi","School of Medicine","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China"],"raw_orcid":"https://orcid.org/0000-0003-0633-4821","affiliations":[{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"People's Hospital of Hebi","institution_ids":[]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008767578","display_name":"Wenjing Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Peng","raw_affiliation_strings":["China","Henan University","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","People's Hospital of Hebi","School of Medicine","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"People's Hospital of Hebi","institution_ids":[]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636176","display_name":"Xinping Li","orcid":"https://orcid.org/0000-0002-8477-6783","observed_orcids":["https://orcid.org/0000-0002-8477-6783"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinping Li","raw_affiliation_strings":["China","Henan University","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","People's Hospital of Hebi","School of Medicine","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"People's Hospital of Hebi","institution_ids":[]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039154845","display_name":"Le Wang","orcid":"https://orcid.org/0000-0002-7899-5613","observed_orcids":["https://orcid.org/0000-0002-7899-5613"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Wang","raw_affiliation_strings":["China","Henan University","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","People's Hospital of Hebi","School of Medicine","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"People's Hospital of Hebi","institution_ids":[]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035894823","display_name":"Wenbo Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Yin","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery","Ministry of Education","School of Pharmaceutical Engineering","Shenyang 110016","Shenyang Pharmaceutical University","Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery","institution_ids":[]},{"raw_affiliation_string":"Ministry of Education","institution_ids":[]},{"raw_affiliation_string":"School of Pharmaceutical Engineering","institution_ids":[]},{"raw_affiliation_string":"Shenyang 110016","institution_ids":[]},{"raw_affiliation_string":"Shenyang Pharmaceutical University","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696376","display_name":"Yan\u2010Dong Wang","orcid":"https://orcid.org/0000-0003-2293-5854","observed_orcids":["https://orcid.org/0000-0003-2293-5854"]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Dong Wang","raw_affiliation_strings":["Beijing","Beijing University of Chemical Technology","China","College of Life Science and Technology","State Key Laboratory of Chemical Resource Engineering","State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing","institution_ids":[]},{"raw_affiliation_string":"Beijing University of Chemical Technology","institution_ids":["https://openalex.org/I75390827"]},{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"College of Life Science and Technology","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering","institution_ids":["https://openalex.org/I4405271766"]},{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058073008","display_name":"Ruifang Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruifang Hou","raw_affiliation_strings":["China","Henan University","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","People's Hospital of Hebi","School of Medicine","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"People's Hospital of Hebi","institution_ids":[]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100357384","display_name":"Weidong Chen","orcid":"https://orcid.org/0000-0002-7787-2638","observed_orcids":["https://orcid.org/0000-0002-7787-2638"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei-Dong Chen","raw_affiliation_strings":["China","Henan University","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","People's Hospital of Hebi","School of Medicine","Key Laboratory of Molecular Pathology, School of Basic Medical Science, Inner Mongolia Medical University, Hohhot, China","Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China","institution_ids":[]},{"raw_affiliation_string":"Henan University","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery","institution_ids":[]},{"raw_affiliation_string":"People's Hospital of Hebi","institution_ids":[]},{"raw_affiliation_string":"School of Medicine","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Molecular Pathology, School of Basic Medical Science, Inner Mongolia Medical University, Hohhot, China","institution_ids":["https://openalex.org/I44673925"]},{"raw_affiliation_string":"Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, People's Hospital of Hebi, School of Medicine, Henan University, Henan, China","institution_ids":["https://openalex.org/I173899330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5058073008","https://openalex.org/A5100357384"],"corresponding_institution_ids":["https://openalex.org/I173899330","https://openalex.org/I44673925"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.384,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.48272018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"2158","last_page":"2166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fxr-agonists","display_name":"FXR agonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacophore-modeling","display_name":"pharmacophore modeling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"virtual screening","score":0.996999979019165},{"id":"https://openalex.org/keywords/small-heterodimer-partner","display_name":"small heterodimer partner","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cyp7a1","display_name":"CYP7A1","score":0.949999988079071},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.7919999957084656},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.9738855361938477},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.8859190940856934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6446732878684998},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.5209435224533081},{"id":"https://openalex.org/C89673097","wikidata":"https://www.wikidata.org/wiki/Q14907373","display_name":"Cholesterol 7 alpha-hydroxylase","level":3,"score":0.5152142643928528},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5027494430541992},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49411919713020325},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4702818691730499},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4446043372154236},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4354991614818573},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4159370958805084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3716028332710266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2559587061405182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2535383403301239},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20346865057945251},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19298100471496582}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d0ra09320c","doi":"https://doi.org/10.1039/d0ra09320c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0ra09320c","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d0ra09320c","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmid:35424145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35424145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8693749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8693749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1039/d0ra09320c","doi":"https://doi.org/10.1039/d0ra09320c","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d0ra09320c","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2021/ra/d0ra09320c","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1432344615","display_name":null,"funder_award_id":"21A310001","funder_id":"https://openalex.org/F4320325625","funder_display_name":"Education Department of Henan Province"},{"id":"https://openalex.org/G2255038605","display_name":null,"funder_award_id":"2019YLZDYJ19","funder_id":"https://openalex.org/F4320322878","funder_display_name":"Henan University"},{"id":"https://openalex.org/G2745451053","display_name":null,"funder_award_id":"182300410323","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G2926161692","display_name":null,"funder_award_id":"81903444","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3014216404","display_name":null,"funder_award_id":"2018M640674","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G393740804","display_name":null,"funder_award_id":"81472232","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4445088411","display_name":null,"funder_award_id":"81672433","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5205474008","display_name":null,"funder_award_id":"PYBZ1803","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5600847293","display_name":null,"funder_award_id":"81970726","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6234502245","display_name":null,"funder_award_id":"PYBZ1803","funder_id":"https://openalex.org/F4320335783","funder_display_name":"China-Japan Friendship Hospital"},{"id":"https://openalex.org/G6411766591","display_name":null,"funder_award_id":"81970551","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6742339581","display_name":null,"funder_award_id":"Grant No. 81970726","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6884587249","display_name":null,"funder_award_id":"Grant No. 81970551","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322878","display_name":"Henan University","ror":"https://ror.org/003xyzq10"},{"id":"https://openalex.org/F4320323845","display_name":"Natural Science Foundation of Henan Province","ror":null},{"id":"https://openalex.org/F4320325625","display_name":"Education Department of Henan Province","ror":null},{"id":"https://openalex.org/F4320335783","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120448317.pdf","grobid_xml":"https://content.openalex.org/works/W3120448317.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1677336966","https://openalex.org/W1985210677","https://openalex.org/W1997156924","https://openalex.org/W2001908216","https://openalex.org/W2016716035","https://openalex.org/W2017358597","https://openalex.org/W2029730391","https://openalex.org/W2030341720","https://openalex.org/W2049515100","https://openalex.org/W2081218071","https://openalex.org/W2082184791","https://openalex.org/W2082752454","https://openalex.org/W2087577664","https://openalex.org/W2099017410","https://openalex.org/W2108730917","https://openalex.org/W2118406741","https://openalex.org/W2125168178","https://openalex.org/W2171398834","https://openalex.org/W2273379630","https://openalex.org/W2341281514","https://openalex.org/W2523690932","https://openalex.org/W2741204870","https://openalex.org/W2769380893","https://openalex.org/W2774738748","https://openalex.org/W2808908625","https://openalex.org/W2903907874","https://openalex.org/W2913047952","https://openalex.org/W2952800496","https://openalex.org/W2988012250"],"related_works":["https://openalex.org/W1997036098","https://openalex.org/W1159002909","https://openalex.org/W2811079086","https://openalex.org/W2160264029","https://openalex.org/W2025453290","https://openalex.org/W4283805043","https://openalex.org/W4401107801","https://openalex.org/W2047184814","https://openalex.org/W2017358597","https://openalex.org/W3155857567"],"abstract_inverted_index":{"activity":[0],"by":[1],"using":[2],"homogeneous":[3],"time":[4],"resolved":[5],"fluorescence":[6],"(HTRF)":[7],"assay":[8,15,21],"and":[9,34,54],"the":[10,26,69],"full-length":[11],"FXR":[12,29,66],"reporter":[13],"gene":[14],"in":[16,41,68],"HepG2":[17],"cells.":[18],"Real-time":[19],"PCR":[20],"was":[22],"performed":[23],"to":[24],"measure":[25],"expression":[27],"of":[28,46,71],"target":[30],"genes.":[31],"Compounds":[32],"F4":[33,53],"F17":[35,55],"increased":[36],"small":[37],"heterodimer":[38],"partner":[39],"(SHP),":[40],"turn,":[42],"suppress":[43],"mRNA":[44],"levels":[45],"cholesterol":[47],"7-alpha-hydroxylase":[48],"(CYP7A1).":[49],"The":[50],"obtained":[51],"compounds":[52],"from":[56],"this":[57],"study":[58],"may":[59],"be":[60],"potential":[61],"leads":[62],"for":[63],"developing":[64],"novel":[65],"agonists":[67],"treatment":[70],"metabolic":[72],"diseases.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-01-18T00:00:00"}