{"id":"https://openalex.org/W3119979477","doi":null,"title":"High-throughput Maturation of Engineered Human Skeletal Muscle Tissue","display_name":"High-throughput Maturation of Engineered Human Skeletal Muscle Tissue","publication_year":2017,"publication_date":"2017-04-26","ids":{"openalex":"https://openalex.org/W3119979477","mag":"3119979477"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-1249","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/mqp-all/250","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1249&context=mqp-all","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1249&context=mqp-all","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055001513","display_name":"Alexander Keith Marry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Keith Marry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068263727","display_name":"Annabella Perolino Goncalves","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annabella Perolino Goncalves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039594159","display_name":"Benjamin James Cossette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin James Cossette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110736191","display_name":"Mina Essam William","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mina Essam William","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44360824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-maturation","display_name":"tissue maturation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.953000009059906},{"id":"https://openalex.org/keywords/biomimetics","display_name":"biomimetics","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6126353740692139},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5381587147712708},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3918694853782654},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3634478449821472},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3330264389514923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3291061520576477},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3216381072998047},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.11332875490188599},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-1249","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/mqp-all/250","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1249&context=mqp-all","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},{"id":"mag:3119979477","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1249&context=mqp-all","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wpi.edu:mqp-all-1249","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/mqp-all/250","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=1249&context=mqp-all","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Major Qualifying Projects (All Years)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3119979477.pdf","grobid_xml":"https://content.openalex.org/works/W3119979477.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W810857154","https://openalex.org/W1976896311","https://openalex.org/W1998646921","https://openalex.org/W2005840935","https://openalex.org/W2017325468","https://openalex.org/W2019691564","https://openalex.org/W2023385232","https://openalex.org/W2044277965","https://openalex.org/W2047090435","https://openalex.org/W2047823030","https://openalex.org/W2057072817","https://openalex.org/W2057478863","https://openalex.org/W2062221551","https://openalex.org/W2070700342","https://openalex.org/W2092915424","https://openalex.org/W2115357041","https://openalex.org/W2118533478","https://openalex.org/W2139725243","https://openalex.org/W2169448756","https://openalex.org/W2170830993","https://openalex.org/W2223742570","https://openalex.org/W2314829387","https://openalex.org/W2465610369"],"related_works":["https://openalex.org/W2969727918","https://openalex.org/W7128948910","https://openalex.org/W3149997414","https://openalex.org/W7079677424","https://openalex.org/W4403300440","https://openalex.org/W2590870153","https://openalex.org/W4231706087","https://openalex.org/W1985617866","https://openalex.org/W2078863581","https://openalex.org/W2192900494"],"abstract_inverted_index":{"As":[0],"pharmaceutical":[1],"spending":[2],"increases,":[3],"the":[4,33],"need":[5],"for":[6,26,42],"predictive":[7],"disease":[8],"models":[9],"is":[10],"ever":[11],"rising.":[12],"Tissue-engineered":[13],"skeletal":[14,23],"muscle":[15,24],"(TESM)":[16],"could":[17],"offer":[18],"functional":[19],"units":[20],"of":[21,36],"human":[22],"tissue":[25],"high-throughput":[27,104],"drug":[28],"screening":[29],"and":[30,51,63,75,85,97],"may":[31],"circumnavigate":[32],"non-predictive":[34],"nature":[35],"most":[37],"traditional":[38],"preclinical":[39],"model":[40],"systems":[41],"musculoskeletal":[43],"diseases.":[44],"However,":[45],"current":[46],"TESM":[47,100],"constructs":[48,101],"are":[49],"immature":[50],"lack":[52],"biomimicry":[53],"to":[54,72,79,95],"native":[55],"tissue.":[56],"Tissue":[57],"maturation":[58],"strategies":[59],"such":[60],"as":[61],"mechanical":[62],"electrical":[64],"stimulation":[65],"have":[66,76],"been":[67,77],"employed":[68],"in":[69,102],"an":[70],"effort":[71],"improve":[73,80],"biomimicry,":[74],"demonstrated":[78],"myofiber":[81],"alignment,":[82],"protein":[83],"expression,":[84],"contractile":[86],"ability.":[87],"In":[88],"this":[89],"MQP,":[90],"a":[91,103],"device":[92],"was":[93],"designed":[94],"mechanically":[96],"electrically":[98],"stimulate":[99],"manner.":[105]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2021-01-18T00:00:00"}