{"id":"https://openalex.org/W3119615461","doi":"https://doi.org/10.3389/fonc.2020.585551","title":"MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma","display_name":"MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma","publication_year":2021,"publication_date":"2021-01-08","ids":{"openalex":"https://openalex.org/W3119615461","doi":"https://doi.org/10.3389/fonc.2020.585551","mag":"3119615461","pmid":"https://pubmed.ncbi.nlm.nih.gov/33489883","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7821388"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2020.585551","doi":"https://doi.org/10.3389/fonc.2020.585551","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.585551","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.585551/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.585551/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006866409","display_name":"Benjamin B. Morris","orcid":"https://orcid.org/0000-0001-7415-7703","observed_orcids":["https://orcid.org/0000-0001-7415-7703"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin B. Morris","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States","Department of Pathology, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Pathology, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003605313","display_name":"Nolan A. Wages","orcid":"https://orcid.org/0000-0002-2190-4864","observed_orcids":["https://orcid.org/0000-0002-2190-4864"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nolan A. Wages","raw_affiliation_strings":["Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110685486","display_name":"Patrick A. Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Grant","raw_affiliation_strings":["Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, United States","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072633316","display_name":"P. Todd Stukenberg","orcid":"https://orcid.org/0000-0002-6788-2111","observed_orcids":["https://orcid.org/0000-0002-6788-2111"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Todd Stukenberg","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021713453","display_name":"Ryan D. Gentzler","orcid":"https://orcid.org/0000-0002-8983-6677","observed_orcids":["https://orcid.org/0000-0002-8983-6677"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Gentzler","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Hematology/Oncology, University of Virginia Health System, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Hematology/Oncology, University of Virginia Health System, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073338844","display_name":"Richard Delmar Hall","orcid":"https://orcid.org/0000-0001-5812-8857","observed_orcids":["https://orcid.org/0000-0001-5812-8857"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Hall","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Hematology/Oncology, University of Virginia Health System, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Hematology/Oncology, University of Virginia Health System, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016686763","display_name":"Wallace Akerley","orcid":"https://orcid.org/0000-0002-3090-4778","observed_orcids":["https://orcid.org/0000-0002-3090-4778"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace L. Akerley","raw_affiliation_strings":["Department of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034600767","display_name":"Thomas K. Varghese","orcid":"https://orcid.org/0000-0001-5867-6538","observed_orcids":["https://orcid.org/0000-0001-5867-6538"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas K. Varghese","raw_affiliation_strings":["Division of Thoracic Surgery, Department of Surgery, University of Utah, Salt Lake City, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Thoracic Surgery, Department of Surgery, University of Utah, Salt Lake City, UT, United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030064179","display_name":"Susanne M. Arnold","orcid":"https://orcid.org/0000-0001-6542-9551","observed_orcids":["https://orcid.org/0000-0001-6542-9551"]},"institutions":[{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne M. Arnold","raw_affiliation_strings":["Department of Internal Medicine, Division of Medical Oncology, Markey Cancer Center, Lexington, KY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Medical Oncology, Markey Cancer Center, Lexington, KY, United States","institution_ids":["https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040079785","display_name":"Terence Marques Williams","orcid":"https://orcid.org/0000-0002-1020-0845","observed_orcids":["https://orcid.org/0000-0002-1020-0845"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terence M. Williams","raw_affiliation_strings":["Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046342653","display_name":"Vincenzo Coppola","orcid":"https://orcid.org/0000-0001-6163-1779","observed_orcids":["https://orcid.org/0000-0001-6163-1779"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincenzo Coppola","raw_affiliation_strings":["Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559369","display_name":"David R. Jones","orcid":"https://orcid.org/0000-0002-3001-2841","observed_orcids":["https://orcid.org/0000-0002-3001-2841"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Jones","raw_affiliation_strings":["Department of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, United States","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045456108","display_name":"David Auble","orcid":"https://orcid.org/0000-0002-9999-728X","observed_orcids":["https://orcid.org/0000-0002-9999-728X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Auble","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024089512","display_name":"Marty W. Mayo","orcid":"https://orcid.org/0000-0001-9443-5926","observed_orcids":["https://orcid.org/0000-0001-9443-5926"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marty W. Mayo","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5024089512"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.7053,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.63341843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"585551","last_page":"585551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mybl2","display_name":"MYBL2","score":1.0},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9670000076293945},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/error-prone-dna-repair","display_name":"error-prone DNA repair","score":0.9459999799728394},{"id":"https://openalex.org/keywords/single-strand-break-repair","display_name":"single-strand break repair","score":0.9100000262260437},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8849999904632568},{"id":"https://openalex.org/keywords/rb1","display_name":"RB1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chk1-inhibitor","display_name":"CHK1 inhibitor","score":0.7409999966621399},{"id":"https://openalex.org/keywords/transcriptional-programs","display_name":"transcriptional programs","score":0.8650000095367432},{"id":"https://openalex.org/keywords/somatic-mutation-burden","display_name":"somatic mutation burden","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7179999947547913},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.492000013589859},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.797466516494751},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6788746118545532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.560060441493988},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.44436579942703247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43009498715400696},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42081180214881897},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3989515006542206},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3675493597984314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.326985239982605},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2569798231124878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20616358518600464},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12698686122894287}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2020.585551","doi":"https://doi.org/10.3389/fonc.2020.585551","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.585551","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.585551/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6729788","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7821388","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7821388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7821388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:33489883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33489883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1a759e60bfaf402dba58cabda12ab76f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1a759e60bfaf402dba58cabda12ab76f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 10 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2020.585551","doi":"https://doi.org/10.3389/fonc.2020.585551","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2020.585551","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2020.585551/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1080307856","display_name":null,"funder_award_id":"P30 CA044579","funder_id":"https://openalex.org/F4320317351","funder_display_name":"UVA Cancer Center"},{"id":"https://openalex.org/G1126685252","display_name":"Regulation of a novel epigenome of protein biosynthesis genes","funder_award_id":"R01GM111911","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1771440111","display_name":null,"funder_award_id":"NIH R01 GN118798","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2437524378","display_name":null,"funder_award_id":"NCI R01 CA192399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3198129303","display_name":"Molecular Mechanisms of Mitotic Regulation","funder_award_id":"R01GM118798","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3899782701","display_name":"Targeting SNP BRMS1v2 A273V/A273V to reduce metastases in lung adenocarcinoma","funder_award_id":"R01CA240472","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3968307327","display_name":"Mechanisms to move and steer chromosomes","funder_award_id":"R01GM124042","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4178841932","display_name":"Identifying tumor suppressor targets of SIRT6 in lung cancer","funder_award_id":"R01CA192399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4658171129","display_name":null,"funder_award_id":"NCI R01 CA217169","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G474385781","display_name":null,"funder_award_id":"NCI T32 CA009109-42","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5239122752","display_name":null,"funder_award_id":"R01 CA234617","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5451066789","display_name":null,"funder_award_id":"P30 CA0044579-26","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7929864112","display_name":null,"funder_award_id":"CA009109","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8578065397","display_name":null,"funder_award_id":"NCI T32 CA009109-43","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8775476746","display_name":"BRMS1-mediated suppression of metastases in p53 mutant lung adenocarcinoma","funder_award_id":"R01CA217169","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G879433487","display_name":null,"funder_award_id":"NCI R01 CA234617","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000134899","display_name":"University of Kentucky Markey Cancer Center \u2013 Cancer Center Support Grant","funder_award_id":"P30CA177558","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000890047","display_name":"Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies","funder_award_id":"T32CA009109","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000901327","display_name":"University of Virginia Cancer Center Support Grant","funder_award_id":"P30CA044579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306497","display_name":"Roswell Park Cancer Institute","ror":"https://ror.org/0499dwk57"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320309886","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/05vt9qd57"},{"id":"https://openalex.org/F4320310408","display_name":"Comprehensive Cancer Center, City of Hope","ror":"https://ror.org/00w6g5w60"},{"id":"https://openalex.org/F4320312218","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966"},{"id":"https://openalex.org/F4320317194","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60"},{"id":"https://openalex.org/F4320317351","display_name":"UVA Cancer Center","ror":"https://ror.org/04w75nz84"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333204","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961"},{"id":"https://openalex.org/F4320333552","display_name":"Cancer Center, University of Colorado","ror":"https://ror.org/04cqn7d42"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3119615461.pdf","grobid_xml":"https://content.openalex.org/works/W3119615461.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1523531555","https://openalex.org/W1968931043","https://openalex.org/W1982957001","https://openalex.org/W2040113180","https://openalex.org/W2054621069","https://openalex.org/W2057132693","https://openalex.org/W2062739292","https://openalex.org/W2082447947","https://openalex.org/W2104003823","https://openalex.org/W2114843025","https://openalex.org/W2117131162","https://openalex.org/W2117692326","https://openalex.org/W2120897875","https://openalex.org/W2122115679","https://openalex.org/W2137279574","https://openalex.org/W2148110430","https://openalex.org/W2157009395","https://openalex.org/W2168396953","https://openalex.org/W2283197001","https://openalex.org/W2315243978","https://openalex.org/W2338722087","https://openalex.org/W2397003243","https://openalex.org/W2406250479","https://openalex.org/W2416423710","https://openalex.org/W2466033276","https://openalex.org/W2609243345","https://openalex.org/W2612774985","https://openalex.org/W2652345243","https://openalex.org/W2718870674","https://openalex.org/W2765400887","https://openalex.org/W2767972229","https://openalex.org/W2769859791","https://openalex.org/W2770178180","https://openalex.org/W2770647635","https://openalex.org/W2783667606","https://openalex.org/W2783907570","https://openalex.org/W2785792383","https://openalex.org/W2795993993","https://openalex.org/W2803843511","https://openalex.org/W2805730761","https://openalex.org/W2886565599","https://openalex.org/W2898088739","https://openalex.org/W2898789672","https://openalex.org/W2908842729","https://openalex.org/W2911188335","https://openalex.org/W2911653212","https://openalex.org/W2946173685","https://openalex.org/W2946448900","https://openalex.org/W2965681656","https://openalex.org/W3019551824","https://openalex.org/W3042430778","https://openalex.org/W4211006558","https://openalex.org/W4298324324"],"related_works":["https://openalex.org/W3188630833","https://openalex.org/W4304585053","https://openalex.org/W7163124340","https://openalex.org/W3045119100","https://openalex.org/W4409094361","https://openalex.org/W4307350396","https://openalex.org/W6939774476","https://openalex.org/W6920906571","https://openalex.org/W2018115010","https://openalex.org/W3082743025"],"abstract_inverted_index":{"It":[0],"has":[1],"long":[2],"been":[3],"recognized":[4],"that":[5,33,62,135,162,200],"defects":[6],"in":[7,38,150,227],"cell":[8,172],"cycle":[9,173],"checkpoint":[10,221],"and":[11,22,36,45,73,100,123,148,176,209],"DNA":[12,46,76,152,207],"repair":[13,154],"pathways":[14],"give":[15,178],"rise":[16,179],"to":[17,180,197,237],"genomic":[18,131,193],"instability,":[19],"tumor":[20],"heterogeneity,":[21],"metastasis.":[23],"Despite":[24],"this":[25,157],"knowledge,":[26],"the":[27,39,75,218],"transcription":[28,79],"factor-mediated":[29],"gene":[30],"expression":[31,91,111],"programs":[32],"enable":[34],"survival":[35,99,102],"proliferation":[37],"face":[40],"of":[41,66,96,105,126,130,171,220],"enormous":[42],"replication":[43,202],"stress":[44,203],"damage":[47,77],"have":[48],"remained":[49],"elusive.":[50],"Using":[51],"robust":[52,94],"omics":[53],"data":[54,133,185],"from":[55],"two":[56,87],"independent":[57],"studies,":[58,88],"we":[59,159],"provide":[60,160],"evidence":[61,161],"a":[63,93,169,187,234],"large":[64],"cohort":[65],"lung":[67,138,239],"adenocarcinomas":[68,139],"exhibit":[69],"significant":[70,192],"genome":[71],"instability":[72,194],"overexpress":[74],"responsive":[78],"factor":[80],"MYB":[81],"proto-oncogene":[82],"like":[83],"2":[84],"(MYBL2).":[85],"Across":[86],"elevated":[89,109,141],"MYBL2":[90,110,136,196,229],"was":[92],"marker":[95],"poor":[97],"overall":[98],"disease-free":[101],"outcomes,":[103],"regardless":[104],"disease":[106],"stage.":[107],"Clinically,":[108],"identified":[112],"patients":[113],"with":[114,168,191],"aggressive":[115],"early":[116],"onset":[117],"disease,":[118],"increased":[119,124],"lymph":[120],"node":[121],"involvement,":[122],"incidence":[125],"distant":[127],"metastases.":[128],"Analysis":[129],"sequencing":[132],"demonstrated":[134],"High":[137,230],"had":[140],"somatic":[142],"mutation":[143],"burden,":[144],"widespread":[145],"chromosomal":[146],"alterations,":[147],"alterations":[149],"single-strand":[151,164],"break":[153,165],"pathways.":[155],"In":[156],"study,":[158],"impaired":[163],"repair,":[166,208],"combined":[167],"loss":[170],"regulators":[174],"TP53":[175],"RB1,":[177],"MYBL2-mediated":[181],"transcriptional":[182],"programs.":[183],"Omics":[184],"supports":[186,217],"model":[188],"wherein":[189],"tumors":[190],"upregulate":[195],"drive":[198],"genes":[199],"control":[201],"responses,":[204],"promote":[205],"error-prone":[206],"antagonize":[210],"faithful":[211],"homologous":[212],"recombination":[213],"repair.":[214],"Our":[215],"study":[216],"use":[219],"kinase":[222],"1":[223],"(CHK1)":[224],"pharmacological":[225],"inhibitors,":[226],"targeted":[228],"patient":[231,241],"cohorts,":[232],"as":[233],"future":[235],"therapy":[236],"improve":[238],"adenocarcinoma":[240],"outcomes.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-01-18T00:00:00"}