{"id":"https://openalex.org/W3119200743","doi":"https://doi.org/10.2174/1871525719666210112154340","title":"Antihyperglycemic and Antidyslipidemic Activities of the Aqueous Salvia hispanica Extract in Diabetic Rat","display_name":"Antihyperglycemic and Antidyslipidemic Activities of the Aqueous Salvia hispanica Extract in Diabetic Rat","publication_year":2021,"publication_date":"2021-01-13","ids":{"openalex":"https://openalex.org/W3119200743","doi":"https://doi.org/10.2174/1871525719666210112154340","mag":"3119200743","pmid":"https://pubmed.ncbi.nlm.nih.gov/33438569"},"language":"en","primary_location":{"id":"doi:10.2174/1871525719666210112154340","doi":"https://doi.org/10.2174/1871525719666210112154340","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871525719666210112154340","pdf_url":null,"source":{"id":"https://openalex.org/S2764933655","display_name":"Cardiovascular & Hematological Agents in Medicinal Chemistry","issn_l":"1871-5257","issn":["1871-5257","1875-6182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular & Hematological Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090561255","display_name":"Fadwa El-Ouady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153608","display_name":"Universit\u00e9 Moulay Ismail de Meknes","ror":"https://ror.org/04cnscd67","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210153608"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"El-ouady Fadwa","raw_affiliation_strings":["Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia,\nMoulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia,\nMoulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco","institution_ids":["https://openalex.org/I4210153608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063815758","display_name":"Ayoub Amssayef","orcid":"https://orcid.org/0000-0003-1052-1419","observed_orcids":["https://orcid.org/0000-0003-1052-1419"]},"institutions":[{"id":"https://openalex.org/I4210153608","display_name":"Universit\u00e9 Moulay Ismail de Meknes","ror":"https://ror.org/04cnscd67","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210153608"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ayoub Amssayef","raw_affiliation_strings":["Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia,\nMoulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia,\nMoulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco","institution_ids":["https://openalex.org/I4210153608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068960016","display_name":"Mohamed Eddouks","orcid":"https://orcid.org/0000-0001-6462-489X","observed_orcids":["https://orcid.org/0000-0001-6462-489X"]},"institutions":[{"id":"https://openalex.org/I4210153608","display_name":"Universit\u00e9 Moulay Ismail de Meknes","ror":"https://ror.org/04cnscd67","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210153608"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Mohamed Eddouks","raw_affiliation_strings":["Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia,\nMoulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia,\nMoulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco","institution_ids":["https://openalex.org/I4210153608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068960016"],"corresponding_institution_ids":["https://openalex.org/I4210153608"],"apc_list":null,"apc_paid":null,"fwci":1.3734,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78774932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"20","issue":"1","first_page":"60","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chia-seeds","display_name":"Salvia hispanica","score":1.0},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.824999988079071},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6150000095367432},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8109999895095825},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plant-aqueous-extracts","display_name":"aqueous plant extract","score":0.8169999718666077},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6851235628128052},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.6411281824111938},{"id":"https://openalex.org/C2776473397","wikidata":"https://www.wikidata.org/wiki/Q157151","display_name":"Salvia","level":2,"score":0.6163880228996277},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.4204980432987213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27250152826309204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23277565836906433},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089945","descriptor_name":"Salvia hispanica","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1871525719666210112154340","doi":"https://doi.org/10.2174/1871525719666210112154340","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871525719666210112154340","pdf_url":null,"source":{"id":"https://openalex.org/S2764933655","display_name":"Cardiovascular & Hematological Agents in Medicinal Chemistry","issn_l":"1871-5257","issn":["1871-5257","1875-6182"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular & Hematological Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:33438569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33438569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular & hematological agents in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5107707060","display_name":null,"funder_award_id":"PPR/2015/35/","funder_id":"https://openalex.org/F4320323771","funder_display_name":"Centre National pour la Recherche Scientifique et Technique"}],"funders":[{"id":"https://openalex.org/F4320323771","display_name":"Centre National pour la Recherche Scientifique et Technique","ror":"https://ror.org/00675rp98"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1992603691","https://openalex.org/W2013881426","https://openalex.org/W2019076819","https://openalex.org/W2022666405","https://openalex.org/W2023313228","https://openalex.org/W2026555343","https://openalex.org/W2028765375","https://openalex.org/W2031596649","https://openalex.org/W2035360369","https://openalex.org/W2044532358","https://openalex.org/W2045256521","https://openalex.org/W2051076602","https://openalex.org/W2060891384","https://openalex.org/W2075226625","https://openalex.org/W2083535249","https://openalex.org/W2088012387","https://openalex.org/W2092977773","https://openalex.org/W2108268914","https://openalex.org/W2120704605","https://openalex.org/W2150387584","https://openalex.org/W2161462309","https://openalex.org/W2167543749","https://openalex.org/W2195729708","https://openalex.org/W2344257391","https://openalex.org/W2365177684","https://openalex.org/W2460530547","https://openalex.org/W2467042885","https://openalex.org/W2547189656","https://openalex.org/W2809892914","https://openalex.org/W2895456134","https://openalex.org/W2898844307","https://openalex.org/W2913105102","https://openalex.org/W2917310524","https://openalex.org/W2950783575","https://openalex.org/W2953943730","https://openalex.org/W2971554685","https://openalex.org/W3006973817"],"related_works":["https://openalex.org/W4292466444","https://openalex.org/W1744605756","https://openalex.org/W2045828212","https://openalex.org/W7218954061","https://openalex.org/W2810326603","https://openalex.org/W2582017512","https://openalex.org/W2950133851","https://openalex.org/W2030968482","https://openalex.org/W4414981573","https://openalex.org/W4407290070"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,66,88,111,120,129,150],"study":[2,33,196],"targeted":[3],"to":[4,35,53,177],"evaluate":[5],"the":[6,32,37,41,136,139,144,198],"antihyperglycemic":[7,38,199],"activity":[8,122],"of":[9,31,40,44,70,77,90,123,131,138,152,203],"Salvia":[10,13,45],"hispanica.":[11],"BACKGROUND:":[12],"hispanica":[14,46,72,154],"L.":[15],"(Lamiaceae)":[16],"is":[17],"a":[18,75,159,186],"medicinal":[19],"plant":[20,140],"with":[21,158],"many":[22],"beneficial":[23],"properties":[24],"on":[25,94,163,170],"human":[26],"health.":[27],"OBJECTIVE:":[28],"This":[29],"objective":[30],"was":[34,80,103,117,125,174],"investigate":[36],"effect":[39,89,157,162,189],"aqueous":[42,68],"extract":[43,69,141,146,151],"(S.":[47],"hispanica)":[48],"seeds":[49],"and":[50,59,85,97,107,168,200],"its":[51],"capacity":[52],"improve":[54],"lipid":[55,98],"profile":[56],"in":[57,83,105,133,190,205],"normal":[58,84,106],"STZ-induced":[60],"diabetic":[61,86,109],"rats.":[62,87,110,206],"MATERIAL":[63],"AND":[64],"METHODS:":[65],"seed":[67],"S.":[71,153],"(SHSAE)":[73],"at":[74],"dose":[76],"100":[78],"mg/kg":[79],"administered":[81],"orally":[82],"oral":[91,112],"SHSAE":[92,124,173,184,204],"treatment":[93],"blood":[95],"glucose":[96,113,179],"levels":[99,167],"during":[100],"15":[101],"days":[102],"assessed":[104],"streptozotocin-induced":[108],"tolerance":[114,180],"test":[115],"(OGTT)":[116],"carried":[118],"out.":[119],"antioxidant":[121,188],"also":[126,175],"examined.":[127],"RESULTS:":[128],"decrease":[130],"glycemia":[132],"rats":[134],"following":[135],"administration":[137],"suggested":[142],"that":[143],"studied":[145],"possesses":[147,185],"antidiabetic":[148],"effect.":[149],"produced":[155],"hypolipidemic":[156],"significant":[160],"lowering":[161],"plasma":[164],"total":[165],"cholesterol":[166],"increased":[169],"HDL-cholesterol":[171],"levels.":[172],"able":[176],"enhance":[178],"using":[181],"OGTT.":[182],"Moreover,":[183],"potential":[187],"vitro.":[191],"CONCLUSION:":[192],"In":[193],"conclusion,":[194],"this":[195],"demonstrates":[197],"antilipidemic":[201],"effects":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-01-18T00:00:00"}