{"id":"https://openalex.org/W3119085705","doi":"https://doi.org/10.3390/cancers13020198","title":"Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma","display_name":"Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma","publication_year":2021,"publication_date":"2021-01-08","ids":{"openalex":"https://openalex.org/W3119085705","doi":"https://doi.org/10.3390/cancers13020198","mag":"3119085705","pmid":"https://pubmed.ncbi.nlm.nih.gov/33429865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7827324"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13020198","doi":"https://doi.org/10.3390/cancers13020198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13020198","pdf_url":"https://www.mdpi.com/2072-6694/13/2/198/pdf?version=1610084938","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/2/198/pdf?version=1610084938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089796322","display_name":"Elena Fountzilas","orcid":"https://orcid.org/0000-0002-4884-2544","observed_orcids":["https://orcid.org/0000-0002-4884-2544"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]},{"id":"https://openalex.org/I4210101191","display_name":"Euromedica","ror":"https://ror.org/015aet155","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210101191"]}],"countries":["CY","GR"],"is_corresponding":false,"raw_author_name":"Elena Fountzilas","raw_affiliation_strings":["European University Cyprus, 1516 Engomi, Cyprus","Second Department of Medical Oncology, Euromedica General Clinic of Thessaloniki, 54645 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European University Cyprus, 1516 Engomi, Cyprus","institution_ids":["https://openalex.org/I201118511"]},{"raw_affiliation_string":"Second Department of Medical Oncology, Euromedica General Clinic of Thessaloniki, 54645 Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210101191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081271665","display_name":"Alexia Eliades","orcid":"https://orcid.org/0000-0001-8459-7163","observed_orcids":["https://orcid.org/0000-0001-8459-7163"]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Alexia Eliades","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":"https://orcid.org/0000-0001-8459-7163","affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030109945","display_name":"Georgia-Angeliki Koliou","orcid":"https://orcid.org/0000-0002-4205-5080","observed_orcids":["https://orcid.org/0000-0002-4205-5080"]},"institutions":[{"id":"https://openalex.org/I4210115932","display_name":"Hellenic Cooperative Oncology Group","ror":"https://ror.org/02bxsvn11","country_code":"GR","type":"company","lineage":["https://openalex.org/I4210115932"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgia-Angeliki Koliou","raw_affiliation_strings":["Section of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, 11526 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, 11526 Athens, Greece","institution_ids":["https://openalex.org/I4210115932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633640","display_name":"Achilleas Achilleos","orcid":"https://orcid.org/0000-0001-7157-8991","observed_orcids":["https://orcid.org/0000-0001-7157-8991"]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Achilleas Achilleos","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063212748","display_name":"Charalambos Loizides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Charalambos Loizides","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067080871","display_name":"Kyriakos Tsangaras","orcid":"https://orcid.org/0000-0001-7454-0454","observed_orcids":["https://orcid.org/0000-0001-7454-0454"]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Kyriakos Tsangaras","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":"https://orcid.org/0000-0001-7454-0454","affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012112204","display_name":"Dimitrios G. Pectasides","orcid":"https://orcid.org/0000-0002-2102-2167","observed_orcids":["https://orcid.org/0000-0002-2102-2167"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Pectasides","raw_affiliation_strings":["Oncology Section, Second Department of Internal Medicine, Hippokration Hospital, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Section, Second Department of Internal Medicine, Hippokration Hospital, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002813173","display_name":"Joseph Sgouros","orcid":"https://orcid.org/0000-0001-5537-3611","observed_orcids":["https://orcid.org/0000-0001-5537-3611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Sgouros","raw_affiliation_strings":["Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026269698","display_name":"Pavlos Papakostas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Pavlos Papakostas","raw_affiliation_strings":["Oncology Unit, Hippokration Hospital, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Hippokration Hospital, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053006338","display_name":"Grigorios Rallis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Grigorios Rallis","raw_affiliation_strings":["Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, 56429 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, 56429 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063134810","display_name":"Amanda K. Psyrri","orcid":"https://orcid.org/0000-0002-4321-766X","observed_orcids":["https://orcid.org/0000-0002-4321-766X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Amanda Psyrri","raw_affiliation_strings":["Section of Medical Oncology, Department of Internal Medicine, Attikon University Hospital, Faculty of Medicine, National and Kapodistrian University of Athens School of Medicine, 12462 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medical Oncology, Department of Internal Medicine, Attikon University Hospital, Faculty of Medicine, National and Kapodistrian University of Athens School of Medicine, 12462 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056643910","display_name":"CHRISTOS A. PAPADIMITRIOU","orcid":"https://orcid.org/0000-0001-8084-0445","observed_orcids":["https://orcid.org/0000-0001-8084-0445"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210119545","display_name":"Aretaeio Hospital","ror":"https://ror.org/02qvqb543","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210119545"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Papadimitriou","raw_affiliation_strings":["Oncology Unit, Aretaieion Hospital, National and Kapodistrian University of Athens School of Medicine, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Aretaieion Hospital, National and Kapodistrian University of Athens School of Medicine, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210119545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005489735","display_name":"Georgios Oikonomopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150697","display_name":"Metropolitan Hospital","ror":"https://ror.org/05a3efx98","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210150697"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Oikonomopoulos","raw_affiliation_strings":["Second Department of Medical Oncology, Metropolitan Hospital, 18547 Piraeus, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Metropolitan Hospital, 18547 Piraeus, Greece","institution_ids":["https://openalex.org/I4210150697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102782310","display_name":"Konstantinos Ferentinos","orcid":"https://orcid.org/0000-0003-1391-6600","observed_orcids":["https://orcid.org/0000-0003-1391-6600"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Konstantinos Ferentinos","raw_affiliation_strings":["Department of Radiation Oncology, German Oncology Center, European University Cyprus, 4108 Limassol, Cyprus"],"raw_orcid":"https://orcid.org/0000-0003-1391-6600","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, German Oncology Center, European University Cyprus, 4108 Limassol, Cyprus","institution_ids":["https://openalex.org/I201118511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086594420","display_name":"Anna A. Koumarianou","orcid":"https://orcid.org/0000-0002-4159-2511","observed_orcids":["https://orcid.org/0000-0002-4159-2511"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anna Koumarianou","raw_affiliation_strings":["Fourth Department of Internal Medicine, Hematology-Oncology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-4159-2511","affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Hematology-Oncology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060334897","display_name":"George Zarkavelis","orcid":"https://orcid.org/0000-0001-5961-2237","observed_orcids":["https://orcid.org/0000-0001-5961-2237"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Zarkavelis","raw_affiliation_strings":["Department of Medical Oncology, University Hospital of Ioannina, Medical School, 45500 Ioannina, Greece"],"raw_orcid":"https://orcid.org/0000-0001-5961-2237","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital of Ioannina, Medical School, 45500 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108218933","display_name":"Christos Dervenis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154864","display_name":"Agia Olga Hospital","ror":"https://ror.org/050zvc738","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210154864"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Dervenis","raw_affiliation_strings":["First Department of Surgery, General Hospital Konstantopouleio Agia Olga, 14233 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, General Hospital Konstantopouleio Agia Olga, 14233 Athens, Greece","institution_ids":["https://openalex.org/I4210154864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039349296","display_name":"Gerasimos Aravantinos","orcid":"https://orcid.org/0000-0002-2106-1713","observed_orcids":["https://orcid.org/0000-0002-2106-1713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerasimos Aravantinos","raw_affiliation_strings":["Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0002-2106-1713","affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108427383","display_name":"Dimitrios I. Bafaloukos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150697","display_name":"Metropolitan Hospital","ror":"https://ror.org/05a3efx98","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210150697"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Bafaloukos","raw_affiliation_strings":["First Department of Medical Oncology, Metropolitan Hospital, 18547 Piraeus, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medical Oncology, Metropolitan Hospital, 18547 Piraeus, Greece","institution_ids":["https://openalex.org/I4210150697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108599039","display_name":"P. Kosmidis","orcid":"https://orcid.org/0009-0003-1478-0087","observed_orcids":["https://orcid.org/0009-0003-1478-0087"]},"institutions":[{"id":"https://openalex.org/I4210122009","display_name":"Hygeia Hospital","ror":"https://ror.org/03qv5tx95","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210122009"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Paris Kosmidis","raw_affiliation_strings":["Second Department of Medical Oncology, Hygeia Hospital, 15123 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Hygeia Hospital, 15123 Athens, Greece","institution_ids":["https://openalex.org/I4210122009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070188844","display_name":"George Papaxoinis","orcid":"https://orcid.org/0000-0001-6900-784X","observed_orcids":["https://orcid.org/0000-0001-6900-784X"]},"institutions":[{"id":"https://openalex.org/I4210121914","display_name":"St Savas Hospital","ror":"https://ror.org/036h9st94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210121914"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Papaxoinis","raw_affiliation_strings":["Second Department of Internal Medicine, Agios Savvas Cancer Hospital, 11522 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Agios Savvas Cancer Hospital, 11522 Athens, Greece","institution_ids":["https://openalex.org/I4210121914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074458672","display_name":"Maria Theochari","orcid":"https://orcid.org/0000-0001-8107-5108","observed_orcids":["https://orcid.org/0000-0001-8107-5108"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Theochari","raw_affiliation_strings":["First Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, 11528 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, 11528 Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087834972","display_name":"Ioannis I. Varthalitis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131513","display_name":"Chania General Hospital \u201dSt. George\u201d","ror":"https://ror.org/03tte1d07","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210131513"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Varthalitis","raw_affiliation_strings":["Oncology Department, General Hospital of Chania, 73300 Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, General Hospital of Chania, 73300 Crete, Greece","institution_ids":["https://openalex.org/I4210131513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087963010","display_name":"Nikolaos K. Kentepozidis","orcid":"https://orcid.org/0000-0002-6037-5707","observed_orcids":["https://orcid.org/0000-0002-6037-5707"]},"institutions":[{"id":"https://openalex.org/I4210102619","display_name":"Hellenic Airforce General Hospital","ror":"https://ror.org/0169n7f49","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210102619"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Kentepozidis","raw_affiliation_strings":["Department of Medical Oncology, 251 Airforce General Hospital, 11525 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, 251 Airforce General Hospital, 11525 Athens, Greece","institution_ids":["https://openalex.org/I4210102619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034182778","display_name":"Georgios Rigakos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122009","display_name":"Hygeia Hospital","ror":"https://ror.org/03qv5tx95","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210122009"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Rigakos","raw_affiliation_strings":["Third Department of Medical Oncology, Hygeia Hospital, 15123 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Medical Oncology, Hygeia Hospital, 15123 Athens, Greece","institution_ids":["https://openalex.org/I4210122009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012832857","display_name":"Zacharenia Saridaki","orcid":"https://orcid.org/0000-0003-2931-5797","observed_orcids":["https://orcid.org/0000-0003-2931-5797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zacharenia Saridaki","raw_affiliation_strings":["Asklepios Oncology Department, 71303 Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asklepios Oncology Department, 71303 Heraklion, Crete, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021315519","display_name":"Adamantia Nikolaidi","orcid":"https://orcid.org/0000-0003-2057-9585","observed_orcids":["https://orcid.org/0000-0003-2057-9585"]},"institutions":[{"id":"https://openalex.org/I4210132022","display_name":"Mitera Hospital","ror":"https://ror.org/02mgwph26","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210132022"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Adamantia Nikolaidi","raw_affiliation_strings":["Oncology Clinic, Mitera Hospital, 15123 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Clinic, Mitera Hospital, 15123 Athens, Greece","institution_ids":["https://openalex.org/I4210132022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064636994","display_name":"Athina N. Christopoulou","orcid":"https://orcid.org/0000-0002-9402-2045","observed_orcids":["https://orcid.org/0000-0002-9402-2045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Athina Christopoulou","raw_affiliation_strings":["Medical Oncology Unit, S. Andrew Hospital, 26335 Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, S. Andrew Hospital, 26335 Patras, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005087419","display_name":"Florentia Fostira","orcid":"https://orcid.org/0000-0003-2751-2332","observed_orcids":["https://orcid.org/0000-0003-2751-2332"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Florentia Fostira","raw_affiliation_strings":["Molecular Diagnostics Laboratory, InRASTES, National Centre for Scientific Research \u201cDemokritos\u201d, 15341 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0003-2751-2332","affiliations":[{"raw_affiliation_string":"Molecular Diagnostics Laboratory, InRASTES, National Centre for Scientific Research \u201cDemokritos\u201d, 15341 Athens, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047656028","display_name":"Epaminontas Samantas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Epaminontas Samantas","raw_affiliation_strings":["Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, 14564 Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014605303","display_name":"Elena Kypri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Elena Kypri","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107467173","display_name":"Marios Ioannides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Marios Ioannides","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049900739","display_name":"George Koumbaris","orcid":"https://orcid.org/0000-0002-5670-8329","observed_orcids":["https://orcid.org/0000-0002-5670-8329"]},"institutions":[{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"George Koumbaris","raw_affiliation_strings":["NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041575636","display_name":"George Fountzilas","orcid":"https://orcid.org/0000-0001-8045-2186","observed_orcids":["https://orcid.org/0000-0001-8045-2186"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]},{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["CY","GR"],"is_corresponding":false,"raw_author_name":"George Fountzilas","raw_affiliation_strings":["Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","Department of Radiation Oncology, German Oncology Center, European University Cyprus, 4108 Limassol, Cyprus","Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Department of Radiation Oncology, German Oncology Center, European University Cyprus, 4108 Limassol, Cyprus","institution_ids":["https://openalex.org/I201118511"]},{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019758131","display_name":"Philippos C. Patsalis","orcid":"https://orcid.org/0000-0003-0662-460X","observed_orcids":["https://orcid.org/0000-0003-0662-460X"]},"institutions":[{"id":"https://openalex.org/I17389662","display_name":"University of Nicosia","ror":"https://ror.org/04v18t651","country_code":"CY","type":"education","lineage":["https://openalex.org/I17389662"]},{"id":"https://openalex.org/I4392738209","display_name":"Medicover Genetics (Cyprus)","ror":"https://ror.org/01hx2yw16","country_code":"CY","type":"company","lineage":["https://openalex.org/I4392738209"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Philippos C. Patsalis","raw_affiliation_strings":["Medical School, University of Nicosia, 2417 Nicosia, Cyprus","NIPD Genetics Limited, 2409 Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, University of Nicosia, 2417 Nicosia, Cyprus","institution_ids":["https://openalex.org/I17389662"]},{"raw_affiliation_string":"NIPD Genetics Limited, 2409 Nicosia, Cyprus","institution_ids":["https://openalex.org/I4392738209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5019758131"],"corresponding_institution_ids":["https://openalex.org/I17389662","https://openalex.org/I4392738209"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":1.2741,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82741822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":"2","first_page":"198","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/germline-pathogenic-variants","display_name":"germline pathogenic variants","score":0.921999990940094},{"id":"https://openalex.org/keywords/cancer-susceptibility-genes","display_name":"cancer susceptibility genes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/homologous-recombination-repair-genes","display_name":"homologous recombination repair genes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.6949999928474426},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mutyh","display_name":"MUTYH","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chek2","display_name":"CHEK2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.906000018119812},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.593999981880188},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7963481545448303},{"id":"https://openalex.org/C141496672","wikidata":"https://www.wikidata.org/wiki/Q14883437","display_name":"MUTYH","level":5,"score":0.7383210062980652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6405457854270935},{"id":"https://openalex.org/C2776071976","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"CHEK2","level":5,"score":0.6226421594619751},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.6140414476394653},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5481059551239014},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4535948634147644},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43776577711105347},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4228460192680359},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3635253310203552},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33894091844558716},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.2616121470928192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13124677538871765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11763134598731995},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0930626392364502}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers13020198","doi":"https://doi.org/10.3390/cancers13020198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13020198","pdf_url":"https://www.mdpi.com/2072-6694/13/2/198/pdf?version=1610084938","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6733388","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7827324","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7827324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7827324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:33429865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33429865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c2dd7d5a58a84b5cad336331ca59a65e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c2dd7d5a58a84b5cad336331ca59a65e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 198, p 198 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers13020198","doi":"https://doi.org/10.3390/cancers13020198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13020198","pdf_url":"https://www.mdpi.com/2072-6694/13/2/198/pdf?version=1610084938","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309021","display_name":"Ariad Pharmaceuticals","ror":"https://ror.org/01dwtyk53"},{"id":"https://openalex.org/F4320323363","display_name":"Genesis Pharma","ror":"https://ror.org/04f1ha654"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3119085705.pdf","grobid_xml":"https://content.openalex.org/works/W3119085705.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1838826168","https://openalex.org/W1844119416","https://openalex.org/W1926715094","https://openalex.org/W1980125751","https://openalex.org/W2035801850","https://openalex.org/W2051978340","https://openalex.org/W2092259915","https://openalex.org/W2119180969","https://openalex.org/W2146542392","https://openalex.org/W2147918436","https://openalex.org/W2154866190","https://openalex.org/W2161479848","https://openalex.org/W2726331924","https://openalex.org/W2738571634","https://openalex.org/W2741937391","https://openalex.org/W2791631640","https://openalex.org/W2792327545","https://openalex.org/W2805031648","https://openalex.org/W2809494794","https://openalex.org/W2810883871","https://openalex.org/W2883600652","https://openalex.org/W2886054665","https://openalex.org/W2911550830","https://openalex.org/W2913041225","https://openalex.org/W2947826965","https://openalex.org/W2981674199","https://openalex.org/W2984359187","https://openalex.org/W2989421973","https://openalex.org/W2989955432","https://openalex.org/W2998609748","https://openalex.org/W3001713806","https://openalex.org/W3008479902","https://openalex.org/W3015069968","https://openalex.org/W3030206881","https://openalex.org/W3091797030","https://openalex.org/W3095107109"],"related_works":["https://openalex.org/W4362584158","https://openalex.org/W3212777167","https://openalex.org/W3198621181","https://openalex.org/W4406229780","https://openalex.org/W3178475513","https://openalex.org/W7125426942","https://openalex.org/W2886054665","https://openalex.org/W4327967140","https://openalex.org/W4296747775","https://openalex.org/W4411516084"],"abstract_inverted_index":{"Our":[0],"aim":[1],"was":[2,35,139,163],"to":[3,43,126,197],"determine":[4],"the":[5,114],"prevalence,":[6],"prognostic":[7],"and":[8,62,69,80,97,110,157],"predictive":[9,190],"role":[10,191],"of":[11,30,60,83,160,172,182,192],"germline":[12,179],"pathogenic/likely":[13],"pathogenic":[14],"variants":[15],"(P/LPVs)":[16],"in":[17,21,67,77,90,145],"cancer":[18,32],"predisposing":[19],"genes":[20,34,74,162],"patients":[22,39,103,173],"with":[23,45,174],"pancreatic":[24],"ductal":[25],"adenocarcinoma":[26],"(PDAC).":[27],"Germline":[28],"testing":[29],"62":[31],"susceptibility":[33],"performed":[36],"on":[37],"unselected":[38],"diagnosed":[40],"from":[41],"02/2003":[42],"01/2020":[44],"PDAC,":[46],"treated":[47],"at":[48],"Hellenic":[49],"Cooperative":[50],"Oncology":[51],"Group":[52],"(HeCOG)-affiliated":[53],"Centers.":[54],"The":[55,151,189],"main":[56],"endpoints":[57],"were":[58,75,88,105],"prevalence":[59],"P/LPVs":[61,66,87,109,121,194],"overall":[63],"survival":[64],"(OS).":[65],"PDAC-associated":[68],"homologous":[70],"recombination":[71],"repair":[72],"(HRR)":[73],"identified":[76,89],"22":[78],"(4.0%)":[79],"42":[81],"(7.7%)":[82],"549":[84],"patients,":[85],"respectively.":[86],"16":[91],"genes,":[92],"including":[93],"ATM":[94],"(11,":[95],"2.0%)":[96],"BRCA2":[98],"(6,":[99],"1.1%),":[100],"while":[101],"19":[102],"(3.5%)":[104],"heterozygotes":[106],"for":[107,142],"MUTYH":[108],"9":[111],"(1.6%)":[112],"carried":[113],"low-risk":[115],"allele,":[116],"CHEK2":[117],"p.(Ile157Thr).":[118],"Patients":[119],"carrying":[120],"had":[122],"improved":[123,143],"OS":[124,144],"compared":[125],"non-carriers":[127],"(22.6":[128],"vs.":[129],"13.9":[130],"months,":[131],"p":[132],"=":[133,149,167],"0.006).":[134],"In":[135],"multivariate":[136],"analysis,":[137],"there":[138],"a":[140],"trend":[141],"P/LPV":[146],"carriers":[147],"(p":[148],"0.063).":[150],"interaction":[152],"term":[153],"between":[154],"platinum":[155],"exposure":[156],"mutational":[158],"status":[159],"HRR":[161],"not":[164],"significant":[165,170],"(p-value":[166],"0.35).":[168],"A":[169],"proportion":[171],"PDAC":[175],"carries":[176],"clinically":[177],"relevant":[178],"P/LPVs,":[180],"irrespectively":[181],"age,":[183],"family":[184],"history":[185],"or":[186],"disease":[187],"stage.":[188],"these":[193],"has":[195],"yet":[196],"be":[198],"defined.":[199],"ClinicalTrials.gov":[200],"Identifier:":[201],"NCT03982446.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-01-18T00:00:00"}