{"id":"https://openalex.org/W3119084804","doi":"https://doi.org/10.3390/antiox10010103","title":"Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review","display_name":"Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review","publication_year":2021,"publication_date":"2021-01-12","ids":{"openalex":"https://openalex.org/W3119084804","doi":"https://doi.org/10.3390/antiox10010103","mag":"3119084804","pmid":"https://pubmed.ncbi.nlm.nih.gov/33445767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7828223"},"language":"en","primary_location":{"id":"doi:10.3390/antiox10010103","doi":"https://doi.org/10.3390/antiox10010103","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10010103","pdf_url":"https://www.mdpi.com/2076-3921/10/1/103/pdf?version=1611234090","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3119084804"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/10/1/103/pdf?version=1611234090","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049071275","display_name":"Paula Fern\u00e1ndez\u2010Palanca","orcid":"https://orcid.org/0000-0001-9765-9562","observed_orcids":["https://orcid.org/0000-0001-9765-9562"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Fern\u00e1ndez-Palanca","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9765-9562","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031653173","display_name":"Carolina M\u00e9ndez\u2010Blanco","orcid":"https://orcid.org/0000-0001-6378-2554","observed_orcids":["https://orcid.org/0000-0001-6378-2554"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carolina M\u00e9ndez-Blanco","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079560768","display_name":"Flavia Fondevila","orcid":"https://orcid.org/0000-0003-2881-704X","observed_orcids":["https://orcid.org/0000-0003-2881-704X"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Flavia Fondevila","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2881-704X","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042870785","display_name":"Mar\u00eda Jes\u00fas Tu\u00f1\u00f3n","orcid":"https://orcid.org/0000-0001-7827-5918","observed_orcids":["https://orcid.org/0000-0001-7827-5918"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda J. Tu\u00f1\u00f3n","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7827-5918","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063159500","display_name":"Russel Joseph Reiter","orcid":"https://orcid.org/0000-0001-6763-4225","observed_orcids":["https://orcid.org/0000-0001-6763-4225"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russel J. Reiter","raw_affiliation_strings":["Department of Cell Systems & Anatomy, UT Health San Antonio Long School of Medicine, San Antonio, TX 78229, USA"],"raw_orcid":"https://orcid.org/0000-0001-6763-4225","affiliations":[{"raw_affiliation_string":"Department of Cell Systems & Anatomy, UT Health San Antonio Long School of Medicine, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035398172","display_name":"Jose Luis Mauriz","orcid":"https://orcid.org/0000-0003-3160-8599","observed_orcids":["https://orcid.org/0000-0003-3160-8599"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 L. Mauriz","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3160-8599","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084567869","display_name":"Javier Gonz\u00e1lez\u2010Gallego","orcid":"https://orcid.org/0000-0002-4386-9342","observed_orcids":["https://orcid.org/0000-0002-4386-9342"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I8833935","display_name":"Universidad de Le\u00f3n","ror":"https://ror.org/02tzt0b78","country_code":"ES","type":"education","lineage":["https://openalex.org/I8833935"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Gonz\u00e1lez-Gallego","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4386-9342","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Campus of Vegazana s/n, 24071 Le\u00f3n, Spain","institution_ids":["https://openalex.org/I8833935"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035398172"],"corresponding_institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431","https://openalex.org/I8833935"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.1756,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.76785714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"103","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8339999914169312},{"id":"https://openalex.org/keywords/carcinogenesis-prevention","display_name":"carcinogenesis prevention","score":0.7649999856948853},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9639999866485596},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.5730000138282776},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.8069999814033508},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8820000290870667},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5120000243186951},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9241782426834106},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5863896012306213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5472753047943115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5403895378112793},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5330537557601929},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4889022409915924},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.46886780858039856},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4628120958805084},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4625991880893707},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45226943492889404},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.43454426527023315},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4164923131465912},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39147886633872986},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3818240165710449},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3790775537490845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35536736249923706},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3508341908454895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.342673122882843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/antiox10010103","doi":"https://doi.org/10.3390/antiox10010103","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10010103","pdf_url":"https://www.mdpi.com/2076-3921/10/1/103/pdf?version=1611234090","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6734211","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7828223","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:33445767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33445767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7828223","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7828223/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmh:oai:buleria.unileon.es:10612/23566","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10612/23566","pdf_url":null,"source":{"id":"https://openalex.org/S4306401642","display_name":"Buleria (Universidad de Le\u00f3n)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169046204","host_organization_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","host_organization_lineage":["https://openalex.org/I169046204"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:cbcfde9a1adc4233b1b1259c2b22e1a3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cbcfde9a1adc4233b1b1259c2b22e1a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 10, Iss 1, p 103 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antiox10010103","doi":"https://doi.org/10.3390/antiox10010103","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10010103","pdf_url":"https://www.mdpi.com/2076-3921/10/1/103/pdf?version=1611234090","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3119084804.pdf","grobid_xml":"https://content.openalex.org/works/W3119084804.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1583010521","https://openalex.org/W1583940256","https://openalex.org/W1956142364","https://openalex.org/W1966604963","https://openalex.org/W1989239469","https://openalex.org/W2000502706","https://openalex.org/W2008244839","https://openalex.org/W2009579436","https://openalex.org/W2013838468","https://openalex.org/W2024226207","https://openalex.org/W2032425910","https://openalex.org/W2047740187","https://openalex.org/W2048517423","https://openalex.org/W2053243600","https://openalex.org/W2053462924","https://openalex.org/W2064932230","https://openalex.org/W2070955337","https://openalex.org/W2078823089","https://openalex.org/W2083834339","https://openalex.org/W2084482878","https://openalex.org/W2088988390","https://openalex.org/W2093060455","https://openalex.org/W2093557429","https://openalex.org/W2095407436","https://openalex.org/W2096498477","https://openalex.org/W2101025849","https://openalex.org/W2123373938","https://openalex.org/W2133054989","https://openalex.org/W2137278952","https://openalex.org/W2138918717","https://openalex.org/W2142490215","https://openalex.org/W2143187760","https://openalex.org/W2156098321","https://openalex.org/W2159437534","https://openalex.org/W2162346811","https://openalex.org/W2183986908","https://openalex.org/W2205425710","https://openalex.org/W2407351686","https://openalex.org/W2412783057","https://openalex.org/W2504816780","https://openalex.org/W2529856835","https://openalex.org/W2583667332","https://openalex.org/W2586682700","https://openalex.org/W2587302795","https://openalex.org/W2597174991","https://openalex.org/W2606778500","https://openalex.org/W2606820045","https://openalex.org/W2618876418","https://openalex.org/W2736693285","https://openalex.org/W2738694063","https://openalex.org/W2753496952","https://openalex.org/W2785545673","https://openalex.org/W2789881042","https://openalex.org/W2793972506","https://openalex.org/W2800668750","https://openalex.org/W2804432927","https://openalex.org/W2805766913","https://openalex.org/W2889646458","https://openalex.org/W2890554786","https://openalex.org/W2891198237","https://openalex.org/W2892757136","https://openalex.org/W2897214576","https://openalex.org/W2924855259","https://openalex.org/W2930873894","https://openalex.org/W2963099938","https://openalex.org/W2967835500","https://openalex.org/W2976156847","https://openalex.org/W2980663941","https://openalex.org/W2989326381","https://openalex.org/W2989629572","https://openalex.org/W2991029237","https://openalex.org/W2992186857","https://openalex.org/W3011670387","https://openalex.org/W3022387787","https://openalex.org/W3029690703","https://openalex.org/W3036137214","https://openalex.org/W3039266078","https://openalex.org/W3042759466","https://openalex.org/W3045887819","https://openalex.org/W3082943564","https://openalex.org/W4249224946","https://openalex.org/W4294215472","https://openalex.org/W6604262532","https://openalex.org/W6683587420","https://openalex.org/W6732892865","https://openalex.org/W7214086991"],"related_works":["https://openalex.org/W2368382223","https://openalex.org/W2802992700","https://openalex.org/W2968010375","https://openalex.org/W3037641282","https://openalex.org/W2597174991","https://openalex.org/W2891198237","https://openalex.org/W2949634646","https://openalex.org/W4220770314","https://openalex.org/W7110656523","https://openalex.org/W2133054989"],"abstract_inverted_index":{"-acetyl-5-methoxytryptamine)":[0],"is":[1],"an":[2],"indoleamine":[3],"with":[4,17,130],"antioxidant,":[5],"chronobiotic":[6],"and":[7,63,81,108,122,148,158,167],"anti-inflammatory":[8],"properties;":[9],"reduced":[10],"levels":[11],"of":[12,20,25,34,47,57,71,83,103,143,151,164,184,190],"this":[13,40],"hormone":[14],"are":[15],"associated":[16],"higher":[18],"risk":[19],"cancer.":[21],"Several":[22],"beneficial":[23],"effects":[24],"melatonin":[26,58,104,185],"have":[27],"been":[28],"described":[29],"in":[30,68,105,128,186],"a":[31,110],"broad":[32],"number":[33],"tumors,":[35],"including":[36],"liver":[37,61,117,191],"cancers.":[38],"In":[39],"work":[41],"we":[42],"systematically":[43],"reviewed":[44],"the":[45,48,54,69,96,100,115,138,172,177,181,188],"publications":[46],"last":[49],"15":[50],"years":[51],"that":[52,179],"assessed":[53],"underlying":[55],"mechanisms":[56],"activities":[59],"against":[60],"cancers,":[62],"its":[64],"role":[65,183],"as":[66,109,141,160,162],"coadjuvant":[67],"treatment":[70,112],"these":[72],"tumors.":[73],"Literature":[74],"research":[75],"was":[76],"performed":[77],"employing":[78],"PubMed,":[79],"Scopus":[80],"Web":[82],"Science":[84],"(WOS)":[85],"databases":[86],"and,":[87],"after":[88],"screening,":[89],"51":[90],"articles":[91],"were":[92,135],"included.":[93],"Results":[94],"from":[95],"selected":[97],"studies":[98],"denoted":[99],"useful":[101],"actions":[102],"preventing":[106],"carcinogenesis":[107],"promising":[111],"option":[113],"for":[114],"primary":[116],"tumors":[118],"hepatocellular":[119],"carcinoma":[120],"(HCC)":[121],"cholangiocarcinoma":[123],"(CCA),":[124],"either":[125],"alone":[126],"or":[127],"combination":[129],"other":[131],"compounds.":[132],"Different":[133],"processes":[134],"modulated":[136],"by":[137],"indole,":[139],"such":[140],"inhibition":[142],"oxidative":[144],"stress,":[145],"proliferation,":[146],"angiogenesis":[147],"invasion,":[149],"promotion":[150],"immune":[152],"system":[153],"response,":[154],"cell":[155],"cycle":[156],"arrest":[157],"apoptosis,":[159],"well":[161],"recovery":[163],"circadian":[165],"rhythms":[166],"autophagy":[168],"modulation.":[169],"Taken":[170],"together,":[171],"present":[173],"systematic":[174],"review":[175],"highlights":[176],"evidence":[178],"document":[180],"potential":[182],"improving":[187],"landscape":[189],"tumor":[192],"treatment.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-01-18T00:00:00"}
