{"id":"https://openalex.org/W3118330998","doi":"https://doi.org/10.1021/acs.biochem.0c00700","title":"Structural Characterization of the Interaction between the \u03b1MI-Domain of the Integrin Mac-1 (\u03b1M\u03b22) and the Cytokine Pleiotrophin","display_name":"Structural Characterization of the Interaction between the \u03b1MI-Domain of the Integrin Mac-1 (\u03b1M\u03b22) and the Cytokine Pleiotrophin","publication_year":2021,"publication_date":"2021-01-11","ids":{"openalex":"https://openalex.org/W3118330998","doi":"https://doi.org/10.1021/acs.biochem.0c00700","mag":"3118330998","pmid":"https://pubmed.ncbi.nlm.nih.gov/33427449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8641143"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.0c00700","doi":"https://doi.org/10.1021/acs.biochem.0c00700","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.0c00700","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8641143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Feng","raw_affiliation_strings":["From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hoa Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoa Nguyen","raw_affiliation_strings":["From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Di Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Di Shen","raw_affiliation_strings":["From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031989706","display_name":"Hanqing Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanqing Deng","raw_affiliation_strings":["From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076471078","display_name":"Zhoumai Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhoumai Jiang","raw_affiliation_strings":["From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080274586","display_name":"Nataly P. Podolnikova","orcid":"https://orcid.org/0009-0007-8088-0800","observed_orcids":["https://orcid.org/0009-0007-8088-0800"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nataly Podolnikova","raw_affiliation_strings":["School of Life Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042525731","display_name":"Tatiana P. Ugarova","orcid":"https://orcid.org/0000-0003-4449-5140","observed_orcids":["https://orcid.org/0000-0003-4449-5140"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Ugarova","raw_affiliation_strings":["School of Life Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049765140","display_name":"Xu Wang","orcid":"https://orcid.org/0000-0002-7369-677X","observed_orcids":["https://orcid.org/0000-0002-7369-677X"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xu Wang","raw_affiliation_strings":["From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States"],"raw_orcid":"https://orcid.org/0000-0002-7369-677X","affiliations":[{"raw_affiliation_string":"From the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049765140"],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9161,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68317256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"60","issue":"3","first_page":"182","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mac-1","display_name":"Mac-1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pleiotrophin","display_name":"pleiotrophin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/integrin-ligand-binding","display_name":"integrin ligand binding","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.8069999814033508},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ionic-strength-dependence","display_name":"ionic strength dependence","score":0.7889999747276306},{"id":"https://openalex.org/keywords/myeloid-leukocytes","display_name":"myeloid leukocytes","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779822564","wikidata":"https://www.wikidata.org/wiki/Q14916160","display_name":"Pleiotrophin","level":4,"score":0.9362765550613403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7224792242050171},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5587234497070312},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5295876860618591},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.49512186646461487},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.4875430762767792},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.446664422750473},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.43591630458831787},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4211477041244507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.281424880027771},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19426017999649048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14946383237838745},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.biochem.0c00700","doi":"https://doi.org/10.1021/acs.biochem.0c00700","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.0c00700","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:33427449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33427449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8641143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8641143","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8641143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8641143","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2860984507","display_name":"Interactions of pleiotrophin with receptor type protein tyrosine phosphatase","funder_award_id":"R01GM118518","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000859045","display_name":"The role of beta 2 integrins in macrophage fusion","funder_award_id":"R01HL063199","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W80842343","https://openalex.org/W1492715703","https://openalex.org/W1514135676","https://openalex.org/W1514774608","https://openalex.org/W1518078436","https://openalex.org/W1538531198","https://openalex.org/W1584454203","https://openalex.org/W1952634910","https://openalex.org/W1963533463","https://openalex.org/W1967875039","https://openalex.org/W1972470306","https://openalex.org/W1974656135","https://openalex.org/W1981424925","https://openalex.org/W1982415800","https://openalex.org/W1984464853","https://openalex.org/W2003111769","https://openalex.org/W2003398489","https://openalex.org/W2015024443","https://openalex.org/W2019503485","https://openalex.org/W2028575077","https://openalex.org/W2029677015","https://openalex.org/W2030838838","https://openalex.org/W2048918501","https://openalex.org/W2050286820","https://openalex.org/W2054286408","https://openalex.org/W2060149822","https://openalex.org/W2063243999","https://openalex.org/W2063559096","https://openalex.org/W2068707448","https://openalex.org/W2069088190","https://openalex.org/W2087823284","https://openalex.org/W2088848851","https://openalex.org/W2089184841","https://openalex.org/W2089625435","https://openalex.org/W2093400164","https://openalex.org/W2094061973","https://openalex.org/W2094469836","https://openalex.org/W2105624689","https://openalex.org/W2114742587","https://openalex.org/W2120762331","https://openalex.org/W2129098607","https://openalex.org/W2129751113","https://openalex.org/W2136969158","https://openalex.org/W2137578797","https://openalex.org/W2137963069","https://openalex.org/W2138408888","https://openalex.org/W2141089307","https://openalex.org/W2146981926","https://openalex.org/W2148521301","https://openalex.org/W2156472428","https://openalex.org/W2158369873","https://openalex.org/W2163240674","https://openalex.org/W2167861740","https://openalex.org/W2169821755","https://openalex.org/W2285620773","https://openalex.org/W2335432651","https://openalex.org/W2439008136","https://openalex.org/W2473399577","https://openalex.org/W2605519143","https://openalex.org/W2615643960","https://openalex.org/W2756635978","https://openalex.org/W2768023356","https://openalex.org/W2791632360","https://openalex.org/W2943749770","https://openalex.org/W2944670712","https://openalex.org/W2953814967","https://openalex.org/W7140253188"],"related_works":["https://openalex.org/W3172516754","https://openalex.org/W4396769562","https://openalex.org/W4391636634","https://openalex.org/W3033177879","https://openalex.org/W2052258955","https://openalex.org/W2079376981","https://openalex.org/W2136969158","https://openalex.org/W2038310113","https://openalex.org/W2335432651","https://openalex.org/W4313053700"],"abstract_inverted_index":{"Integrin":[0],"Mac-1":[1,121],"(\u03b1":[2],"M":[3,42,94,116,147,174,219],"\u03b2":[4],"2":[5],")":[6],"is":[7,19,44,151],"an":[8,64,101],"adhesion":[9,80],"receptor":[10],"vital":[11],"to":[12,46,71],"many":[13],"functions":[14],"of":[15,25,30,35,60,83,87,100,113,164,172,203,213],"myeloid":[16],"leukocytes.":[17],"It":[18],"also":[20,192],"the":[21,26,56,69,73,77,92,98,107,114,123,142,145,161,169,183,186,198,201,204,214,217],"most":[22],"promiscuous":[23],"member":[24],"integrin":[27],"family":[28],"capable":[29],"recognizing":[31],"a":[32,119,194,211],"broad":[33],"range":[34],"ligands.":[36],"In":[37,106],"particular,":[38],"its":[39],"ligand-binding":[40,58],"\u03b1":[41,93,115,146,173,218],"I-domain":[43,117,148,220],"known":[45],"bind":[47],"cationic":[48,124],"proteins/peptides":[49],"depleted":[50],"in":[51,68,91,168,197],"acidic":[52,65,88],"residues.":[53],"This":[54],"contradicts":[55],"canonical":[57],"mechanism":[59],"\u03b1I-domains,":[61],"which":[62],"requires":[63],"amino":[66,89],"acid":[67],"ligand":[70],"coordinate":[72],"divalent":[74,152],"cation":[75],"within":[76],"metal":[78],"ion-dependent":[79],"site":[81],"(MIDAS)":[82],"\u03b1I-domains.":[84],"The":[85,176],"lack":[86],"acids":[90],"I-domain-binding":[95],"sequences":[96],"suggests":[97],"existence":[99],"as-yet":[102],"uncharacterized":[103],"interaction":[104,143,184,215],"mechanism.":[105],"present":[108],"study,":[109],"we":[110,140,209],"analyzed":[111],"interactions":[112],"with":[118],"representative":[120],"ligand,":[122],"cytokine":[125],"pleiotrophin":[126],"(PTN).":[127],"Through":[128],"NMR":[129],"chemical":[130],"shift":[131],"perturbation":[132],"analysis,":[133],"cross":[134],"saturation,":[135],"NOESY,":[136],"and":[137,149,154,166,221],"mutagenesis":[138],"studies,":[139],"found":[141],"between":[144,160,185,216],"PTN":[150,165],"cation-independent":[153],"mediated":[155],"mostly":[156],"by":[157],"hydrophobic":[158],"contacts":[159],"N-terminal":[162],"domain":[163],"residues":[167],"\u03b15\u2212\u03b25":[170],"loop":[171],"I-domain.":[175],"observation":[177],"that":[178],"increased":[179],"ionic":[180],"strength":[181],"weakens":[182],"proteins":[187],"indicates":[188],"electrostatic":[189],"forces":[190],"may":[191],"play":[193],"significant":[195],"role":[196],"binding.":[199],"On":[200],"basis":[202],"results":[205],"from":[206],"these":[207],"experiments,":[208],"formulated":[210],"model":[212],"PTN.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-01-18T00:00:00"}
