{"id":"https://openalex.org/W3115716635","doi":null,"title":"Genome-wide profiling of chromosomal aberrations in renal cell carcinoma using high-density single nucleotide polymorphism arrays","display_name":"Genome-wide profiling of chromosomal aberrations in renal cell carcinoma using high-density single nucleotide polymorphism arrays","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W3115716635","mag":"3115716635"},"language":"en","primary_location":{"id":"mag:3115716635","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/68/9_Supplement/1699","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Meng Chen","orcid":"https://orcid.org/0000-0002-2449-5904","observed_orcids":["https://orcid.org/0000-0002-2449-5904"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng Chen","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-2449-5904","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082365305","display_name":"Yuanqing Ye","orcid":"https://orcid.org/0000-0001-5708-8961","observed_orcids":["https://orcid.org/0000-0001-5708-8961"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanqing Ye","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-5708-8961","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088600970","display_name":"Hushan Yang","orcid":"https://orcid.org/0000-0001-9920-1731","observed_orcids":["https://orcid.org/0000-0001-9920-1731"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hushan Yang","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-9920-1731","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085172191","display_name":"Surena F. Matin","orcid":"https://orcid.org/0000-0003-1638-1445","observed_orcids":["https://orcid.org/0000-0003-1638-1445"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surena F. Matin","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-1638-1445","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058115259","display_name":"Nizar M. Tannir","orcid":"https://orcid.org/0000-0001-5559-8060","observed_orcids":["https://orcid.org/0000-0001-5559-8060"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nizar M. Tannir","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-5559-8060","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017537551","display_name":"Christopher G. Wood","orcid":"https://orcid.org/0000-0003-3450-8809","observed_orcids":["https://orcid.org/0000-0003-3450-8809"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G. Wood","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-3450-8809","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050250764","display_name":"Jian Hong Gu","orcid":"https://orcid.org/0000-0003-3499-0973","observed_orcids":["https://orcid.org/0000-0003-3499-0973","https://orcid.org/0009-0001-3520-2513"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Gu","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0003-3499-0973","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066957198","display_name":"Xifeng Wu","orcid":"https://orcid.org/0000-0001-5174-3769","observed_orcids":["https://orcid.org/0000-0001-5174-3769"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xifeng Wu","raw_affiliation_strings":["\u00a7MD Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-5174-3769","affiliations":[{"raw_affiliation_string":"\u00a7MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53905439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":null,"first_page":"1699","last_page":"1699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.6377000212669373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.6377000212669373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.17159999907016754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.14509999752044678,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9789999723434448},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromosome-3p-loss","display_name":"chromosome 3p deletion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chromosome-13q-loss","display_name":"chromosome 13q loss","score":0.7369999885559082},{"id":"https://openalex.org/keywords/chromosome-18q-loss","display_name":"chromosome 18q loss","score":0.6190000176429749},{"id":"https://openalex.org/keywords/chromosome-1p-loss","display_name":"chromosome 1p deletion","score":0.5220000147819519},{"id":"https://openalex.org/keywords/chromosome-10q-loss","display_name":"chromosome 10q loss","score":0.6430000066757202},{"id":"https://openalex.org/keywords/chromosome-16q-loss","display_name":"chromosome 16q loss","score":0.6309999823570251},{"id":"https://openalex.org/keywords/chromosome-17p-deletion","display_name":"chromosome 17p deletion","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.911645770072937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6988248825073242},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.6608297824859619},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5904619097709656},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5397527813911438},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.5255143642425537},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.5212141275405884},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.5189014077186584},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5083445906639099},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4762708842754364},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4302181899547577},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3517923951148987},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23405000567436218},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21923479437828064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20578300952911377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12088674306869507},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.11509472131729126}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3115716635","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/68/9_Supplement/1699","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087423733","https://openalex.org/W1571627051","https://openalex.org/W1986871362","https://openalex.org/W2314379715","https://openalex.org/W2051600147","https://openalex.org/W2006211722","https://openalex.org/W2410337277","https://openalex.org/W2156276820","https://openalex.org/W1481158683","https://openalex.org/W7096093638"],"abstract_inverted_index":{"1699":[0],"Renal":[2],"cell":[3,22],"carcinoma":[4],"(RCC)":[5],"is":[6,74,365],"one":[7],"of":[8,14,29,35,47,55,63,131,238,270,309,360,389],"the":[9,18,43,61,111,236,361,366,387],"top":[10],"ten":[11],"leading":[12],"causes":[13],"cancer":[15],"death":[16],"in":[17,42,102,166,209,215,379,393],"United":[19],"States.":[20],"Clear":[21],"RCC":[23,31,108,394],"(ccRCC)":[24],"accounts":[25],"for":[26,68,299,349],"about":[27],"80%":[28],"all":[30],"cases.":[32],"The":[33,53,118,188,307,381],"accumulation":[34],"genetic":[36,56],"aberrations":[37,57,101,378],"plays":[38],"a":[39,75,218],"pivotal":[40],"role":[41],"initiation":[44],"and":[45,49,65,71,86,152,159,185,211,230,251,265,294,340,344,358,396],"progression":[46],"ccRCC":[48],"most":[50,119,189],"other":[51,222],"cancers.":[52],"identification":[54],"may":[58,384],"help":[59],"understand":[60],"mechanisms":[62],"tumorigenesis":[64],"have":[66],"implications":[67],"diagnosis,":[69],"prognosis":[70],"treatment.":[72],"SNP-CGH":[73],"newly":[76],"developed":[77],"powerful":[78],"tool":[79],"to":[80,98,369,374,386],"detect":[81],"both":[82],"copy":[83],"number":[84],"variations":[85],"LOH":[87,148,155,248,271,312,341],"events.":[88],"In":[89],"this":[90],"study,":[91],"we":[92],"applied":[93],"Illumina\u2019s":[94],"317K":[95],"high-density":[96,371],"SNP-arrays":[97],"profile":[99,375],"chromosomal":[100],"tumors":[103,127],"from":[104],"81":[105,112],"histologically":[106],"confirmed":[107],"patients.":[109],"Of":[110],"tumors,":[113],"73":[114],"exhibited":[115,253],"chromosome":[116,121,170,191,202,224,243,377],"abnormalities.":[117],"common":[120,207,223],"losses":[122,171],"were":[123,193,226,301],"3p,":[124,135],"with":[125,217,245,256,303,311],"67":[126],"(82.7%)":[128],"having":[129],"loss":[130],"heterozygosity":[132],"(LOH)":[133],"at":[134,172,194,227,241,249,272,313,315,324,342],"including":[136,163,199],"35":[137],"(":[138],"43.2%)":[139],"whole":[140,201],"3p":[141],"arm":[142,203,244],"loss,":[143],"31":[144],"(38.3%)":[145],"large":[146],"fragment":[147],"(mostly":[149],"spanning":[150],"3p21-pter),":[151],"1":[153,212],"interstitial":[154],"(spanning":[156],"3p12-14,":[157],"3p21-22,":[158],"3p24,":[160],"but":[161],"not":[162],"VHL":[164],"gene":[165],"3p25),":[167],"followed":[168],"by":[169,399],"14q":[173,285,345],"(29.6%),":[174],"8p21-pter":[175],"(25.9%),":[176],"6q23-25":[177],"(24.7%),":[178],"1p36":[179],"(18.5%),":[180],"9q32-qter":[181],"(16.1%),":[182,184],"10q26":[183],"9p21-23":[186],"(14.8%).":[187],"frequent":[190],"gains":[192,225],"5q":[195,204],"(29":[196],"cases,":[197],"35.8%),":[198],"9":[200],"amplification,":[205],"19":[206],"amplifications":[208],"5q32-ter,":[210],"focal":[213],"amplification":[214,357],"5q35.3":[216],"length":[219],"0.65MB.":[220],"Two":[221],"5p":[228],"(12.4%)":[229],"8q":[231,289],"(11.1%).":[232],"We":[233,331],"then":[234],"analyzed":[235],"association":[237,336,353],"LOH/amplification":[239],"events":[240],"each":[242],"clinicopathological":[246,362],"characteristics.":[247],"13q":[250],"9q":[252,295],"significant":[254,352],"associations":[255,269],"larger":[257],"tumor":[258,338],"size":[259],"(rank":[260],"sum":[261],"p":[262],"=":[263,275,279,283,287,291,297,329,347],"0.025":[264],"0.047,":[266],"respectively).":[267],"Significant":[268],"9p":[273],"(p":[274,278,282,286,290,296,328,346],"0.002),":[276,280],"18q":[277],"17p":[281],"0.011),":[284],"0.023),":[288],"0.033),":[292],"4q":[293],"0.041":[298],"both)":[300],"observed":[302,333],"higher":[304,316],"nuclear":[305],"grade.":[306],"percentage":[308],"samples":[310],"2p":[314,343],"stage":[317,326,339],"(18.52%)":[318],"was":[319,354],"significantly":[320,334],"more":[321],"than":[322],"that":[323],"lower":[325],"(3.8%)":[327],"0.04).":[330],"also":[332],"positive":[335],"between":[337,356],"0.04":[348],"both).":[350],"No":[351],"detected":[355],"any":[359],"parameters.":[363],"This":[364],"first":[367],"study":[368],"use":[370],"SNP-array":[372],"CGH":[373],"whole-genome":[376],"RCC.":[380],"identified":[382],"regions":[383],"lead":[385],"discovery":[388],"novel":[390],"genes":[391],"involved":[392],"development":[395],"progression.":[397],"Supported":[398],"NCI":[400],"grant":[401],"CA098897.":[402]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-01-05T00:00:00"}